PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Foram encontrados 169 produtos de "PDE"
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CP671305
CAS:CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.Fórmula:C23H19FN2O7Pureza:99.39%Cor e Forma:SolidPeso molecular:454.4Ziritaxestat
CAS:Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.Fórmula:C30H33FN8O2SPureza:97% - 99.85%Cor e Forma:SolidPeso molecular:588.7Roflumilast N-oxide
CAS:Roflumilast N-oxide is an inhibitor of PDE type 4.Fórmula:C17H14Cl2F2N2O4Pureza:98.19% - 99.69%Cor e Forma:SolidPeso molecular:419.21Ref: TM-T4462
1mg34,00€2mg49,00€1mL*10mM (DMSO)65,00€5mg71,00€10mg94,00€25mg161,00€50mg259,00€100mg333,00€500mg797,00€Ensifentrine
CAS:Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), thatFórmula:C26H31N5O4Pureza:99.76% - 99.94%Cor e Forma:SolidPeso molecular:477.56Ref: TM-T25376
1mg34,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg136,00€25mg268,00€50mg429,00€100mg685,00€200mg888,00€HA 155
CAS:HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.Fórmula:C24H19BFNO5SPureza:99.88%Cor e Forma:SolidPeso molecular:463.29Z-HA155
CAS:Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.Fórmula:C24H19BFNO5SPureza:99.18%Cor e Forma:SolidPeso molecular:463.29Ref: TM-T11533
1mg34,00€5mg71,00€1mL*10mM (DMSO)73,00€10mg101,00€25mg200,00€50mg321,00€100mg475,00€200mg680,00€Crisaborole
CAS:Crisaborole (AN-2728) is a Phosphodiesterase 4 Inhibitor.Fórmula:C14H10BNO3Pureza:99.70%Cor e Forma:SolidPeso molecular:251.05Udenafil
CAS:Udenafil is an inhibitor of PDE5 .Fórmula:C25H36N6O4SPureza:99.90%Cor e Forma:Off-White SolidPeso molecular:516.66Ref: TM-T17199
5mg50,00€1mL*10mM (DMSO)52,00€10mg80,00€25mg140,00€50mg219,00€100mg319,00€200mg457,00€GSK256066
CAS:GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-foldFórmula:C27H26N4O5SPureza:99.60% - 99.66%Cor e Forma:SolidPeso molecular:518.58GSK256066 Trifluoroacetate
CAS:GSK 256066 Trifluoroacetate: selective PDE4 inhibitor, IC50: 3.2 pM for PDE4B, treats COPD.Fórmula:C29H27F3N4O7SCor e Forma:SolidPeso molecular:632.61IBMX
CAS:IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5/26.3/31.7 μMFórmula:C10H14N4O2Pureza:98% - >99.99%Cor e Forma:Off-WhitePeso molecular:222.24ICI 63197
CAS:ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.Fórmula:C9H13N5OPureza:99.70%Cor e Forma:White SolidPeso molecular:207.23Nortadalafil
CAS:Nortadalafil, a demethylated form of Tadalafil, is a PDE5 inhibitor used to treat ED and pulmonary arterial hypertension as Adcirca.Fórmula:C21H17N3O4Pureza:99.42%Cor e Forma:SolidPeso molecular:375.38Ref: TM-T6147
1mg34,00€2mg49,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg105,00€25mg192,00€50mg334,00€100mg537,00€200mg762,00€500mg1.134,00€Cilomilast
CAS:Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.Fórmula:C20H25NO4Pureza:97.37% - 99.52%Cor e Forma:White SolidPeso molecular:343.42Homo Sildenafil
CAS:Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.Fórmula:C23H32N6O4SPureza:99.88%Cor e Forma:White SolidPeso molecular:488.6Ref: TM-T8919
2mg39,00€5mg60,00€1mL*10mM (DMSO)73,00€10mg96,00€25mg177,00€50mg266,00€100mg371,00€200mg523,00€GEBR-7b
CAS:GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) is a phosphodiesterase-4 (PDE4) inhibitor.Fórmula:C13H16O3Pureza:99.533%Cor e Forma:SolidPeso molecular:220.26Enoximone
CAS:Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.Fórmula:C12H12N2O2SPureza:98.53%Cor e Forma:SolidPeso molecular:248.3K-Ras-PDEδ-IN-1
CAS:K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).
Fórmula:C25H26FN5O2Pureza:99.48%Cor e Forma:SolidPeso molecular:447.5MY-5445
CAS:MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5).Fórmula:C20H14ClN3Pureza:99.77%Cor e Forma:SolidPeso molecular:331.8Amino Tadalafil
CAS:Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor.Fórmula:C21H18N4O4Pureza:99.85%Cor e Forma:White PowderPeso molecular:390.39Sildenafil Mesylate
CAS:Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.Fórmula:C22H30N6O4S·xCH4O3SPureza:99.84%Cor e Forma:SolidPeso molecular:570.68Lodenafil
CAS:Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)Fórmula:C23H32N6O5SPureza:99.92%Cor e Forma:SolidPeso molecular:504.6Ref: TM-T7346
2mg34,00€5mg52,00€1mL*10mM (DMSO)52,00€10mg77,00€25mg122,00€50mg177,00€100mg245,00€200mg353,00€[11C]MP 10
CAS:[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.Fórmula:C25H20N4OPureza:99.5%Cor e Forma:SolidPeso molecular:391.45Enpp-1-IN-1
CAS:Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)Fórmula:C17H17N3O3SPureza:97.52%Cor e Forma:SolidPeso molecular:343.4Ref: TM-T7888
1mg126,00€5mg260,00€1mL*10mM (DMSO)286,00€10mg394,00€25mg677,00€50mg954,00€100mg1.288,00€PQ-10
CAS:PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.
Fórmula:C22H21N5O3Pureza:99.86%Cor e Forma:SolidPeso molecular:403.43THPP-1
CAS:THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).Fórmula:C23H21ClN6O3Pureza:99.46%Cor e Forma:SolidPeso molecular:464.9Balipodect
CAS:Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.Fórmula:C23H17FN6O2Pureza:98% - 99.79%Cor e Forma:SolidPeso molecular:428.42Ref: TM-T1745
1mg37,00€2mg50,00€5mg74,00€1mL*10mM (DMSO)74,00€10mg87,00€25mg147,00€50mg244,00€100mg421,00€200mg617,00€Osoresnontrine
CAS:Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.Fórmula:C16H17N5O2Pureza:99.93%Cor e Forma:SolidPeso molecular:311.34Ref: TM-T8515
1mg35,00€2mg52,00€5mg77,00€1mL*10mM (DMSO)85,00€10mg113,00€25mg178,00€50mg333,00€100mg495,00€200mg710,00€PDE10-IN-1
CAS:PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.Fórmula:C21H19N7Pureza:99.65%Cor e Forma:SolidPeso molecular:369.42RS-25344
CAS:RS-25344: a strong PDE4 blocker, curbs eosinophil movement, boosts sperm motility in vitro.Fórmula:C19H13N5O4Pureza:98.98%Cor e Forma:SolidPeso molecular:375.34Ref: TM-T9239
1mg84,00€5mg168,00€1mL*10mM (DMSO)177,00€10mg245,00€25mg404,00€50mg567,00€100mg767,00€200mg1.018,00€HA130
CAS:HA130 is a selective ATX (autotaxin) inhibitor.Fórmula:C24H19BFNO5SPureza:98.26% - ≥95%Cor e Forma:SolidPeso molecular:463.29Ref: TM-T2646
2mg37,00€5mg54,00€1mL*10mM (DMSO)55,00€10mg88,00€25mg138,00€50mg222,00€100mg334,00€200mg500,00€Lotamilast
CAS:Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.Fórmula:C26H24N4O5Pureza:97.03% - 99.29%Cor e Forma:SolidPeso molecular:472.49ML-030
CAS:ML-030 is a potent PDE4 inhibitor, selective for subtypes (A1, B1, B2, C1, D2) with IC50 ranging from 6.7 to 452 nM.Fórmula:C20H20N4O4SPureza:97.93%Cor e Forma:SolidPeso molecular:412.46SEP-0372814
CAS:SEP-0372814 is a potent inhibitor of PDE10.Fórmula:C21H19N7Pureza:99.29%Cor e Forma:SolidPeso molecular:369.42Ref: TM-T8454
1mg62,00€5mg123,00€1mL*10mM (DMSO)136,00€10mg180,00€25mg298,00€50mg419,00€100mg567,00€200mg752,00€Mardepodect
CAS:Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE.Fórmula:C25H20N4OPureza:99.81% - 99.94%Cor e Forma:SolidPeso molecular:392.45Ref: TM-T16499
1mg43,00€5mg92,00€1mL*10mM (DMSO)92,00€10mg150,00€25mg235,00€50mg365,00€100mg547,00€200mg783,00€Ro 20-1724
CAS:Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1Fórmula:C15H22N2O3Pureza:98.82% - 99.79%Cor e Forma:SolidPeso molecular:278.35Olprinone
CAS:Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuateFórmula:C14H10N4OPureza:99.68%Cor e Forma:SolidPeso molecular:250.26YM976
CAS:YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)Fórmula:C17H16ClN3OPureza:99.84%Cor e Forma:SolidPeso molecular:313.78Cilostamide
CAS:Cilostamide (OPC3689) is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively)Fórmula:C20H26N2O3Pureza:98.87%Cor e Forma:White To Off-White SolidPeso molecular:342.43D159687
CAS:D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant benefit.Fórmula:C21H19ClN2O2Pureza:97.57%Cor e Forma:SolidPeso molecular:366.842,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide
CAS:2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide is a PDE inhibitor.Fórmula:C9H9Cl2F2NO3SPureza:98.60%Cor e Forma:SolidPeso molecular:320.14Ref: TM-T50062
1mg52,00€2mg71,00€5mg98,00€1mL*10mM (DMSO)102,00€10mg146,00€25mg243,00€50mg355,00€100mg507,00€200mg690,00€RS-25344 hydrochloride
CAS:RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitorFórmula:C19H14ClN5O4Pureza:99.25%Cor e Forma:SolidPeso molecular:411.8BRL-50481
CAS:BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.Fórmula:C9H12N2O4SPureza:99.66%Cor e Forma:SolidPeso molecular:244.27BW-A 78U
CAS:BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.Fórmula:C13H12FN5Pureza:99.45%Cor e Forma:SolidPeso molecular:257.27Ref: TM-T5101
1mg37,00€1mL*10mM (DMSO)42,00€5mg96,00€10mg144,00€25mg235,00€50mg339,00€100mg480,00€200mg658,00€Piclamilast
CAS:Piclamilast (RP 73401) is a PDE4 inhibitor.Fórmula:C18H18Cl2N2O3Pureza:98.28% - 99.57%Cor e Forma:SolidPeso molecular:381.25Ibudilast
CAS:Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan.Fórmula:C14H18N2OPureza:99.83% - >99.99%Cor e Forma:White SolidPeso molecular:230.31MBCQ
CAS:MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.Fórmula:C16H12ClN3O2Pureza:99.45%Cor e Forma:SolidPeso molecular:313.74Ref: TM-T21965
5mg44,00€1mL*10mM (DMSO)50,00€10mg75,00€25mg138,00€50mg220,00€100mg318,00€200mg442,00€PF-8380
CAS:PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood).Fórmula:C22H21Cl2N3O5Pureza:98.70% - 99.25%Cor e Forma:SolidPeso molecular:478.33Crisaborole-d4
Crisaborole-d4 (AN-2728-d4) is the deuterated form of Crisaborole. Crisaborole is a PDE4 inhibitor and also a cytokine release inhibitor.Fórmula:C14H6D4BNO3Cor e Forma:SolidPeso molecular:255.078-CPT-Cyclic AMP sodium
CAS:8-CPT-Cyclic AMP sodium is an activator of cAMP-dependent PKA and cAMP receptor activator, an inhibitor of cAMP-specific phosphodiesterase (PDE VA).Fórmula:C16H14ClN5NaO6PSCor e Forma:White PowderPeso molecular:493.79
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