PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Foram encontrados 166 produtos de "PDE"
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Deltarasin
CAS:<p>Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.</p>Fórmula:C40H37N5OPureza:99.4%Cor e Forma:SolidPeso molecular:603.75K134
CAS:<p>K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.</p>Fórmula:C22H29N3O4Pureza:98%Cor e Forma:SolidPeso molecular:399.48PAT-048
CAS:<p>PAT-048 is an effective and selective autotaxin inhibitor.</p>Fórmula:C22H18ClF2N3O2SPureza:98%Cor e Forma:SolidPeso molecular:461.91Propentofylline
CAS:<p>Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study of Alzheimer's disease.</p>Fórmula:C15H22N4O3Pureza:99.76% - 99.86%Cor e Forma:Off-White SolidPeso molecular:306.36Deltasonamide 2
CAS:<p>Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.</p>Fórmula:C30H39ClN6O4S2Pureza:98%Cor e Forma:SolidPeso molecular:647.25Deltasonamide 2 (TFA)
CAS:<p>Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.</p>Fórmula:C32H40ClF3N6O6S2Pureza:98%Cor e Forma:SolidPeso molecular:761.28PDE9-IN-1
CAS:<p>PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).</p>Fórmula:C17H23FN6O2Pureza:99.86%Cor e Forma:SolidPeso molecular:362.4Tilivapram
CAS:<p>Tilivapram is a PDE4 (phosphodiesterase IV) inhibitor that can be used in the study of mental illness.</p>Fórmula:C16H15Cl2N3O4Pureza:99.87%Cor e Forma:SolidPeso molecular:384.21AN3199
CAS:<p>AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.</p>Fórmula:C17H18BNO5Pureza:99.45%Cor e Forma:SolidPeso molecular:327.14Imazodan hydrochloride
CAS:<p>Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.</p>Fórmula:C13H13ClN4OPureza:98.97%Cor e Forma:SolidPeso molecular:276.72BAY 73-6691
CAS:<p>BAY 73-6691 is an inhibitor of brain penetrant PDE9A.</p>Fórmula:C15H12ClF3N4OCor e Forma:SolidPeso molecular:356.73Lirimilast
CAS:<p>Lirimilast: oral PDE4 inhibitor (IC50: 49 nM), anti-inflammatory, treats asthma/COPD.</p>Fórmula:C17H12Cl2N2O6SPureza:98%Cor e Forma:SolidPeso molecular:443.26WAY127093B racemate
CAS:<p>WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.</p>Fórmula:C23H28N4O4Pureza:99.67%Cor e Forma:SolidPeso molecular:424.49PDE7-IN-2
CAS:<p>PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.</p>Fórmula:C14H11ClN2O3SPureza:98%Cor e Forma:SolidPeso molecular:322.77(R)-DNMDP
CAS:<p>(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.</p>Fórmula:C15H20N4O3Cor e Forma:SolidPeso molecular:304.34Autotaxin-IN-1
CAS:<p>Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.</p>Fórmula:C21H23N7O2Pureza:98%Cor e Forma:SolidPeso molecular:405.45Senazodan hydrochloride
CAS:<p>Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.</p>Fórmula:C15H15ClN4OPureza:99.93%Cor e Forma:SolidPeso molecular:302.76KD-027
CAS:<p>KD-027 is a novel and long-acting PDE5A(phosphodiesterase 5A) inhibitor with potential antihypertensive activity.</p>Fórmula:C25H35N7O6SPureza:99.55%Cor e Forma:SolidPeso molecular:561.65ATX inhibitor 5
CAS:<p>ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.</p>Fórmula:C22H18ClF3N6OPureza:98.77%Cor e Forma:SolidPeso molecular:474.87PF-04822163
CAS:<p>PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.</p>Fórmula:C19H17ClN2O2Pureza:99.55%Cor e Forma:SolidPeso molecular:340.8Imazodan
CAS:<p>Imazodan is a compound with positive inotropic activity and is a type III phosphodiesterase inhibitor that can be used to study heart failure.</p>Fórmula:C13H12N4OPureza:98% - 98.31%Cor e Forma:SolidPeso molecular:240.26PDE IV-IN-1
CAS:<p>PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary disease</p>Fórmula:C20H23ClN4O2Pureza:99.79%Cor e Forma:SolidPeso molecular:386.88Tanimilast
CAS:<p>Tanimilast (CHF-6001) is a potent PDE4 inhibitor with IC50 of 0.026 nM, used topically for obstructive lung disease.</p>Fórmula:C30H30Cl2F2N2O8SPureza:98.34%Cor e Forma:SolidPeso molecular:687.54uk-50001
CAS:<p>UK-50001 is a PDE4 inhibitor for treating inflammation, allergies, respiratory issues, and wounds.</p>Fórmula:C26H24F3N3O4Pureza:99.90%Cor e Forma:SolidPeso molecular:499.48PDE4B-IN-2
CAS:<p>PDE4B-IN-2 (A 33), an oral PDE4B inhibitor, IC50: 15 nM; less potent on PDE4D (IC50: 1.7 µM), has anti-inflammatory properties.</p>Fórmula:C19H18ClN3O2SPureza:99.32%Cor e Forma:SolidPeso molecular:387.88Nanterinone
CAS:<p>Nanterinone: oral phosphodiesterase inhibitor, improves acute heart failure hemodynamics.</p>Fórmula:C15H15N3OPureza:99.53%Cor e Forma:SolidPeso molecular:253.3Dovramilast
CAS:<p>Dovramilast (CC-11050) is a PDE4 inhibitor that reduces the production of pro-inflammatory mediators in lupus erythematosus.</p>Fórmula:C24H28N2O6SPureza:98.75% - 99.62%Cor e Forma:SolidPeso molecular:472.55Verofylline
CAS:<p>Verofylline (Verofyllinum) is an orally available, long-acting, multiacting, methylxanthine-substituted bronchodilator with inhibitory effects on PDE4 for the</p>Fórmula:C12H18N4O2Pureza:98.33% - 98.83%Cor e Forma:SolidPeso molecular:250.3Carbazeran
CAS:<p>Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases.</p>Fórmula:C18H24N4O4Pureza:99.3%Cor e Forma:SolidPeso molecular:360.41AWD 12-281
CAS:<p>AWD 12-281 is a PDE4 inhibitor with anti-inflammatory activity and bronchodilator activity for the study of chronic obstructive pulmonary disease (COPD).</p>Fórmula:C22H14Cl2FN3O3Pureza:99.25% - 99.85%Cor e Forma:SolidPeso molecular:458.27Autotaxin-IN-3
CAS:<p>Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma.</p>Fórmula:C22H21N9O2Pureza:99.54% - 99.79%Cor e Forma:SolidPeso molecular:443.46Filaminast
CAS:<p>Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.</p>Fórmula:C15H20N2O4Pureza:98.53% - 98.93%Cor e Forma:SolidPeso molecular:292.33MK-0873
CAS:<p>MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.</p>Fórmula:C25H18N4O3Pureza:98.40%Cor e Forma:SolidPeso molecular:422.44Mopidamol
CAS:<p>Mopidamol (RA 233) is a phosphodiesterase inhibitor, a dipyridamole derivative, with anticancer activity that prevents retinal vascular defects in experimental</p>Fórmula:C19H31N7O4Pureza:99.05% - 99.78%Cor e Forma:SolidPeso molecular:421.49Isomazole
CAS:<p>Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.</p>Fórmula:C14H13N3O2SPureza:98.66%Cor e Forma:SolidPeso molecular:287.34Tofimilast
CAS:<p>Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease.</p>Fórmula:C18H21N5SPureza:99.55%Cor e Forma:SolidPeso molecular:339.46Dasantafil
CAS:<p>Dasantafil (SCH446132) is a small molecule phosphodiesterase-5A (PDE5A) inhibitor used to treat genitourinary disorders and study erectile dysfunction.</p>Fórmula:C22H28BrN5O5Pureza:99.4% - 99.50%Cor e Forma:SolidPeso molecular:522.39PF-04447943
CAS:<p>PF-04447943, a selective PDE9A inhibitor (IC50=12nM), may aid sickle cell anemia research with its anti-inflammatory properties.</p>Fórmula:C20H25N7O2Pureza:99.36% - 99.59%Cor e Forma:SolidPeso molecular:395.46GSK356278
CAS:<p>GSK356278: selective PDE4A/B/D inhibitor, pIC50~8.7, anti-inflammatory, anxiolytic, cognition-enhancing.</p>Fórmula:C21H25N7O2SPureza:99.90% - 99.97%Cor e Forma:SolidPeso molecular:439.53MK-8189
CAS:<p>MK-8189 is a potent and selective pyrimidine PDE10A inhibitor, with excellent PDE (phosphodiesterase) selectivity for the treatment of schizophrenia.</p>Fórmula:C19H22N6OSPureza:99.38% - 99.67%Cor e Forma:SolidPeso molecular:382.48Autotaxin-IN-5
CAS:<p>Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.</p>Fórmula:C30H29N9O2Pureza:98%Cor e Forma:SolidPeso molecular:547.61Gisadenafil
CAS:<p>Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.</p>Fórmula:C23H33N7O5SPureza:98.82% - 99.50%Cor e Forma:SolidPeso molecular:519.62PDE5-IN-2
CAS:<p>PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)</p>Fórmula:C25H21N3O6SPureza:98%Cor e Forma:SolidPeso molecular:491.52CI-1044
CAS:<p>CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).</p>Fórmula:C23H19N5O2Cor e Forma:SolidPeso molecular:397.43BIO-32546
CAS:<p>BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.</p>Fórmula:C28H31F6NO3Pureza:98.03%Cor e Forma:SolidPeso molecular:543.54Gisadenafil besylate
CAS:<p>Gisadenafil besylate (UK 369003-26) is a potent and orally active PDE5 inhibitor, for lower urinary tract symptoms associated with benign prostatic hyperplasia.</p>Fórmula:C29H39N7O8S2Cor e Forma:SolidPeso molecular:677.79Difamilast
CAS:<p>Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).</p>Fórmula:C23H24F2N2O5Pureza:99.64%Cor e Forma:SolidPeso molecular:446.44Siguazodan
CAS:<p>Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.</p>Fórmula:C14H16N6OPureza:99.62% - 99.87%Cor e Forma:SolidPeso molecular:284.32Adibendan
CAS:<p>Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.</p>Fórmula:C16H14N4OPureza:99.52% - >99.99%Cor e Forma:SolidPeso molecular:278.31Autotaxin-IN-4
CAS:<p>Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.</p>Fórmula:C22H21N9O2Pureza:98%Cor e Forma:SolidPeso molecular:443.46
