PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Foram encontrados 169 produtos de "PDE"
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Deltarasin
CAS:Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.Fórmula:C40H37N5OPureza:99.4%Cor e Forma:SolidPeso molecular:603.75ent-Tadalafil
CAS:ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS).Fórmula:C22H19N3O4Pureza:98%Cor e Forma:SolidPeso molecular:389.4Deltasonamide 2
CAS:Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Fórmula:C30H39ClN6O4S2Pureza:98%Cor e Forma:SolidPeso molecular:647.25PDE7-IN-2
CAS:PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.Fórmula:C14H11ClN2O3SPureza:98%Cor e Forma:SolidPeso molecular:322.77Deltasonamide 2 (TFA)
CAS:Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Fórmula:C32H40ClF3N6O6S2Pureza:98%Cor e Forma:SolidPeso molecular:761.28Tilivapram
CAS:Tilivapram is a PDE4 (phosphodiesterase IV) inhibitor that can be used in the study of mental illness.Fórmula:C16H15Cl2N3O4Pureza:99.87%Cor e Forma:SolidPeso molecular:384.21PF-04822163
CAS:PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.Fórmula:C19H17ClN2O2Pureza:99.55%Cor e Forma:SolidPeso molecular:340.8Propentofylline
CAS:Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study of Alzheimer's disease.Fórmula:C15H22N4O3Pureza:99.76% - 99.86%Cor e Forma:Off-White SolidPeso molecular:306.36Ref: TM-T19812
2mgA consultar1mg65,00€5mg69,00€1mL*10mM (DMSO)77,00€10mg105,00€25mg195,00€50mg359,00€100mg523,00€Imazodan
CAS:Imazodan is a compound with positive inotropic activity and is a type III phosphodiesterase inhibitor that can be used to study heart failure.Fórmula:C13H12N4OPureza:98% - 98.31%Cor e Forma:SolidPeso molecular:240.26ATX inhibitor 5
CAS:ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.Fórmula:C22H18ClF3N6OPureza:99.73%Cor e Forma:SolidPeso molecular:474.87Ref: TM-T10409
1mg46,00€5mg94,00€1mL*10mM (DMSO)96,00€10mg149,00€25mg245,00€50mg338,00€100mg460,00€200mg622,00€K134
CAS:K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.Fórmula:C22H29N3O4Pureza:98%Cor e Forma:SolidPeso molecular:399.48Senazodan hydrochloride
CAS:Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.Fórmula:C15H15ClN4OPureza:99.93%Cor e Forma:SolidPeso molecular:302.76PDE9-IN-1
CAS:PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).Fórmula:C17H23FN6O2Pureza:99.86%Cor e Forma:SolidPeso molecular:362.4Ref: TM-T12395
1mg40,00€1mL*10mM (DMSO)88,00€5mg89,00€10mg130,00€25mg222,00€50mg324,00€100mg470,00€200mg665,00€Trequinsin hydrochloride
CAS:Azetirelin (YM 14673) is a new thyrotropin-releasing hormone (TRH) analog.Fórmula:C24H28ClN3O3Pureza:99.95%Cor e Forma:SolidPeso molecular:441.95Autotaxin-IN-1
CAS:Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.Fórmula:C21H23N7O2Pureza:98%Cor e Forma:SolidPeso molecular:405.45AN3199
CAS:AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.Fórmula:C17H18BNO5Pureza:99.45%Cor e Forma:SolidPeso molecular:327.14WAY127093B racemate
CAS:WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.Fórmula:C23H28N4O4Pureza:99.67%Cor e Forma:SolidPeso molecular:424.49Ref: TM-T13331
1mg50,00€5mg105,00€1mL*10mM (DMSO)116,00€10mg155,00€25mg224,00€50mg315,00€100mg424,00€200mg560,00€KD-027
CAS:KD-027 is a novel and long-acting PDE5A(phosphodiesterase 5A) inhibitor with potential antihypertensive activity.Fórmula:C25H35N7O6SPureza:99.55%Cor e Forma:SolidPeso molecular:561.65Lirimilast
CAS:Lirimilast: oral PDE4 inhibitor (IC50: 49 nM), anti-inflammatory, treats asthma/COPD.Fórmula:C17H12Cl2N2O6SPureza:98%Cor e Forma:SolidPeso molecular:443.26(R)-DNMDP
CAS:(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.Fórmula:C15H20N4O3Cor e Forma:SolidPeso molecular:304.34Imazodan hydrochloride
CAS:Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.Fórmula:C13H13ClN4OPureza:98.97%Cor e Forma:SolidPeso molecular:276.72PAT-048
CAS:PAT-048 is an effective and selective autotaxin inhibitor.Fórmula:C22H18ClF2N3O2SPureza:98%Cor e Forma:SolidPeso molecular:461.91BAY 73-6691
CAS:BAY 73-6691 is an inhibitor of brain penetrant PDE9A.Fórmula:C15H12ClF3N4OCor e Forma:SolidPeso molecular:356.73Verofylline
CAS:Verofylline (Verofyllinum) is an orally available, long-acting, multiacting, methylxanthine-substituted bronchodilator with inhibitory effects on PDE4 for theFórmula:C12H18N4O2Pureza:98.4% - 99.8%Cor e Forma:SolidPeso molecular:250.3Nanterinone
CAS:Nanterinone: oral phosphodiesterase inhibitor, improves acute heart failure hemodynamics.Fórmula:C15H15N3OPureza:99.96%Cor e Forma:SolidPeso molecular:253.3PF-04447943
CAS:PF-04447943, a selective PDE9A inhibitor (IC50=12nM), may aid sickle cell anemia research with its anti-inflammatory properties.Fórmula:C20H25N7O2Pureza:97.01% - 99.36%Cor e Forma:SolidPeso molecular:395.46Isomazole
CAS:Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.
Fórmula:C14H13N3O2SPureza:98.66%Cor e Forma:SolidPeso molecular:287.34Dovramilast
CAS:Dovramilast (CC-11050) is a PDE4 inhibitor that reduces the production of pro-inflammatory mediators in lupus erythematosus.Fórmula:C24H28N2O6SPureza:98.75% - 99.62%Cor e Forma:SolidPeso molecular:472.55MK-0873
CAS:MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.Fórmula:C25H18N4O3Pureza:99.14%Cor e Forma:SolidPeso molecular:422.44Dasantafil
CAS:Dasantafil (SCH446132) is a small molecule phosphodiesterase-5A (PDE5A) inhibitor used to treat genitourinary disorders and study erectile dysfunction.Fórmula:C22H28BrN5O5Pureza:99.4% - 99.50%Cor e Forma:SolidPeso molecular:522.39PDE IV-IN-1
CAS:PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary diseaseFórmula:C20H23ClN4O2Pureza:99.79%Cor e Forma:SolidPeso molecular:386.88Ref: TM-T10201
1mg225,00€5mg480,00€1mL*10mM (DMSO)540,00€10mg642,00€25mg964,00€50mg1.288,00€100mg1.738,00€200mg2.332,00€Carbazeran
CAS:Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases.Fórmula:C18H24N4O4Pureza:99.3%Cor e Forma:SolidPeso molecular:360.41Ref: TM-T21457
1mL*10mM (DMSO)A consultar2mg42,00€5mg62,00€10mg96,00€25mg170,00€50mg256,00€100mg385,00€Autotaxin-IN-3
CAS:Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma.Fórmula:C22H21N9O2Pureza:99.54% - 99.79%Cor e Forma:SolidPeso molecular:443.46Ref: TM-T10415
2mg43,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg96,00€25mg173,00€50mg269,00€100mg432,00€200mg592,00€Filaminast
CAS:Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.Fórmula:C15H20N2O4Pureza:98.93% - 99.99%Cor e Forma:SolidPeso molecular:292.33Ref: TM-T31792
1mg156,00€1mL*10mM (DMSO)333,00€5mg366,00€10mg487,00€25mg737,00€50mg982,00€100mg1.324,00€200mg1.791,00€uk-50001
CAS:UK-50001 is a PDE4 inhibitor for treating inflammation, allergies, respiratory issues, and wounds.Fórmula:C26H24F3N3O4Pureza:99.90%Cor e Forma:SolidPeso molecular:499.48Ref: TM-T67815
1mg150,00€5mg360,00€1mL*10mM (DMSO)445,00€10mg540,00€25mg863,00€50mg1.153,00€100mg1.575,00€500mg3.142,00€Mopidamol
CAS:Mopidamol (RA 233) is a phosphodiesterase inhibitor, a dipyridamole derivative, with anticancer activity that prevents retinal vascular defects in experimentalFórmula:C19H31N7O4Pureza:99.31% - 99.78%Cor e Forma:SolidPeso molecular:421.49PDE4B-IN-2
CAS:PDE4B-IN-2 (A 33), an oral PDE4B inhibitor, IC50: 15 nM; less potent on PDE4D (IC50: 1.7 µM), has anti-inflammatory properties.Fórmula:C19H18ClN3O2SPureza:99.32%Cor e Forma:SolidPeso molecular:387.88Ref: TM-T36832
1mg37,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg111,00€25mg216,00€50mg354,00€100mg567,00€500mg1.198,00€AWD 12-281
CAS:AWD 12-281 is a PDE4 inhibitor with anti-inflammatory activity and bronchodilator activity for the study of chronic obstructive pulmonary disease (COPD).Fórmula:C22H14Cl2FN3O3Pureza:99.25% - 99.85%Cor e Forma:SolidPeso molecular:458.27Tofimilast
CAS:Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease.Fórmula:C18H21N5SPureza:99.55%Cor e Forma:SolidPeso molecular:339.46Adibendan
CAS:Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.Fórmula:C16H14N4OPureza:99.52% - >99.99%Cor e Forma:SolidPeso molecular:278.31Autotaxin-IN-5
CAS:Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Fórmula:C30H29N9O2Pureza:98%Cor e Forma:SolidPeso molecular:547.61GSK356278
CAS:GSK356278: selective PDE4A/B/D inhibitor, pIC50~8.7, anti-inflammatory, anxiolytic, cognition-enhancing.Fórmula:C21H25N7O2SPureza:99.90% - 99.97%Cor e Forma:SolidPeso molecular:439.53Gisadenafil
CAS:Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.Fórmula:C23H33N7O5SPureza:98.82% - 99.50%Cor e Forma:SolidPeso molecular:519.62Ref: TM-T15381
1mg175,00€5mg394,00€1mL*10mM (DMSO)492,00€10mg582,00€25mg888,00€50mg1.243,00€100mg1.674,00€PDE5-IN-2
CAS:PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)Fórmula:C25H21N3O6SPureza:98%Cor e Forma:SolidPeso molecular:491.52Autotaxin-IN-4
CAS:Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Fórmula:C22H21N9O2Pureza:98%Cor e Forma:SolidPeso molecular:443.46MK-8189
CAS:MK-8189 is a potent and selective pyrimidine PDE10A inhibitor, with excellent PDE (phosphodiesterase) selectivity for the treatment of schizophrenia.Fórmula:C19H22N6OSPureza:99.38% - 99.67%Cor e Forma:SolidPeso molecular:382.48Gisadenafil besylate
CAS:Gisadenafil besylate (UK 369003-26) is a potent and orally active PDE5 inhibitor, for lower urinary tract symptoms associated with benign prostatic hyperplasia.Fórmula:C29H39N7O8S2Cor e Forma:SolidPeso molecular:677.79BIO-32546
CAS:BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.Fórmula:C28H31F6NO3Pureza:98.4%Cor e Forma:SolidPeso molecular:543.54CI-1044
CAS:CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).Fórmula:C23H19N5O2Cor e Forma:SolidPeso molecular:397.43Difamilast
CAS:Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).Fórmula:C23H24F2N2O5Pureza:99.47% - 99.64%Cor e Forma:SolidPeso molecular:446.44
