PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Foram encontrados 170 produtos de "PDE"
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CI-1044
CAS:CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).Fórmula:C23H19N5O2Cor e Forma:SolidPeso molecular:397.43BIO-32546
CAS:BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.Fórmula:C28H31F6NO3Pureza:98.4%Cor e Forma:SolidPeso molecular:543.54Gisadenafil besylate
CAS:Gisadenafil besylate (UK 369003-26) is a potent and orally active PDE5 inhibitor, for lower urinary tract symptoms associated with benign prostatic hyperplasia.Fórmula:C29H39N7O8S2Cor e Forma:SolidPeso molecular:677.79TP-10
CAS:TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.Fórmula:C26H19F3N4OPureza:99.21%Cor e Forma:SolidPeso molecular:460.45Ref: TM-T13189
1mg87,00€2mg114,00€5mg177,00€1mL*10mM (DMSO)178,00€10mg264,00€25mg460,00€50mg668,00€100mg945,00€500mg1.783,00€Enpp-1-IN-16
CAS:Enpp-1-IN-16 is an ENPP1 inhibitor, yo anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance and chondrocalcinosis.Fórmula:C23H32N4O4Pureza:99.87%Cor e Forma:SolidPeso molecular:428.52Cudetaxestat
CAS:Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.Fórmula:C21H15Cl2F2N3O2SPureza:99.9%Cor e Forma:SolidPeso molecular:482.33Ref: TM-T63190
1mg73,00€5mg161,00€1mL*10mM (DMSO)166,00€10mg235,00€25mg420,00€50mg627,00€100mg880,00€200mg1.161,00€PDE9-IN-(S)-C33
CAS:PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.Fórmula:C18H20ClN5OPureza:98.75%Cor e Forma:SolidPeso molecular:357.84Ref: TM-T28352
1mg37,00€5mg70,00€1mL*10mM (DMSO)79,00€10mg88,00€25mg144,00€50mg207,00€100mg309,00€200mg440,00€TPN171
CAS:TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary
Fórmula:C24H35N5O3Pureza:>99.99%Cor e Forma:SolidPeso molecular:441.57AMG 579
CAS:AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).Fórmula:C25H23N5O3Pureza:99.87%Cor e Forma:SolidPeso molecular:441.48Ref: TM-T14217
25mgA consultar50mgA consultar1mg34,00€2mg44,00€5mg70,00€1mL*10mM (DMSO)78,00€10mg100,00€PDE1-IN-7
CAS:PDE1-IN-7 (Compound 13h), with an IC50 value of 10 nM, selectively inhibits bPDE1. This compound demonstrates significant anti-fibrotic effects in a BDL-induced liver fibrosis rat model and is useful for research purposes in studying liver fibrosis [1].Fórmula:C32H36F2N2O6SPeso molecular:614.7BMS-341400 mesylate
CAS:BMS-341400 mesylate (Compound 6) is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM and is useful in the study of erectile dysfunction.Fórmula:C24H26ClN9O5SCor e Forma:SolidPeso molecular:588.039Deltasonamide 2 hydrochloride
Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.Fórmula:C30H40Cl2N6O4S2Pureza:98%Cor e Forma:SolidPeso molecular:683.71TAK-915
CAS:TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.Fórmula:C19H18F4N4O5Pureza:98%Cor e Forma:SolidPeso molecular:458.36Z21090
CAS:Z21090 (ZL40) is a highly effective inhibitor of PDE 4, exhibiting an IC 50 value of 37.4 nM, and possesses oral bioavailability. It is significant in the study of alcohol-related diseases [1].Fórmula:C12H14ClN3O3Cor e Forma:SolidPeso molecular:283.71ASP9831
CAS:ASP9831 is an orally active PDE4 inhibitor. It suppresses LPS-induced TNF-α production and exhibits anti-inflammatory properties. ASP9831 is useful in the study of steatohepatitis.Fórmula:C20H23N3O3Cor e Forma:SolidPeso molecular:353.42Thioquinapiperifil dihydrochloride
CAS:Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.Fórmula:C24H29ClN6OSPureza:99.81%Cor e Forma:SolidPeso molecular:485.05Ref: TM-T9773
1mg55,00€5mg123,00€1mL*10mM (DMSO)140,00€10mg177,00€25mg289,00€50mg371,00€100mg522,00€200mg687,00€Tovinontrine
CAS:Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.Fórmula:C21H26N6O2Pureza:98.8%Cor e Forma:SolidPeso molecular:394.47NHTD
CAS:NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).Fórmula:C24H26N2O5Cor e Forma:SolidPeso molecular:422.47PF-00489791
CAS:PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.Fórmula:C20H28N8O4SPureza:99.97%Cor e Forma:SolidPeso molecular:476.55Roflupram
CAS:Roflupram, Selective PDE4 inhibitor (IC50=26.2 nM), oral/BBB permeable, reverses cognitive deficits, suppresses pro-inflammatory factors.Fórmula:C16H20F2O4Cor e Forma:SolidPeso molecular:314.32
