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PDE

PDE

As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.

Foram encontrados 166 produtos de "PDE"

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  • PF-04957325
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    PF-04957325

    CAS:
    <p>PF-04957325 is an inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A.PF-04957325 can be used for the study of autoimmune encephalomyelitis.</p>
    Fórmula:C14H15F3N8OS
    Pureza:99.02%
    Cor e Forma:Solid
    Peso molecular:400.38

    Ref: TM-T12422

  • Enpp-1-IN-16
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    Enpp-1-IN-16

    CAS:
    <p>Enpp-1-IN-16 is an ENPP1 inhibitor, yo anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance and chondrocalcinosis.</p>
    Fórmula:C23H32N4O4
    Pureza:99.87%
    Cor e Forma:Solid
    Peso molecular:428.52

    Ref: TM-T78169

  • AMG 579
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    AMG 579

    CAS:
    <p>AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).</p>
    Fórmula:C25H23N5O3
    Pureza:99.87%
    Cor e Forma:Solid
    Peso molecular:441.48

    Ref: TM-T14217

  • Cudetaxestat
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    Cudetaxestat

    CAS:
    <p>Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.</p>
    Fórmula:C21H15Cl2F2N3O2S
    Pureza:99.9%
    Cor e Forma:Solid
    Peso molecular:482.33

    Ref: TM-T63190

  • TP-10
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    TP-10

    CAS:
    <p>TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.</p>
    Fórmula:C26H19F3N4O
    Pureza:99.21%
    Cor e Forma:Solid
    Peso molecular:460.45

    Ref: TM-T13189

  • TPN171
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    TPN171

    CAS:
    <p>TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary</p>
    Fórmula:C24H35N5O3
    Pureza:>99.99%
    Cor e Forma:Solid
    Peso molecular:441.57

    Ref: TM-T13193

  • PDE9-IN-(S)-C33
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    PDE9-IN-(S)-C33

    CAS:
    <p>PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.</p>
    Fórmula:C18H20ClN5O
    Pureza:98.75%
    Cor e Forma:Solid
    Peso molecular:357.84

    Ref: TM-T28352

  • Thioquinapiperifil dihydrochloride
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    Thioquinapiperifil dihydrochloride

    CAS:
    <p>Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.</p>
    Fórmula:C24H29ClN6OS
    Pureza:98.73%
    Cor e Forma:Solid
    Peso molecular:485.05

    Ref: TM-T9773

  • PF-00489791
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    PF-00489791

    CAS:
    <p>PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.</p>
    Fórmula:C20H28N8O4S
    Pureza:99.97%
    Cor e Forma:Solid
    Peso molecular:476.55

    Ref: TM-T28360

  • Deltasonamide 2 hydrochloride
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    Deltasonamide 2 hydrochloride

    <p>Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.</p>
    Fórmula:C30H40Cl2N6O4S2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:683.71

    Ref: TM-T10994L

  • ASP9831
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    ASP9831

    CAS:
    <p>ASP9831 is an orally active PDE4 inhibitor. It suppresses LPS-induced TNF-α production and exhibits anti-inflammatory properties. ASP9831 is useful in the study of steatohepatitis.</p>
    Fórmula:C20H23N3O3
    Cor e Forma:Solid
    Peso molecular:353.42

    Ref: TM-T207494

  • Tovinontrine
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    Tovinontrine

    CAS:
    <p>Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.</p>
    Fórmula:C21H26N6O2
    Pureza:98.14%
    Cor e Forma:Solid
    Peso molecular:394.47

    Ref: TM-T61833

  • BMS-341400 mesylate
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    BMS-341400 mesylate

    CAS:
    <p>BMS-341400 mesylate (Compound 6) is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM and is useful in the study of erectile dysfunction.</p>
    Fórmula:C24H26ClN9O5S
    Cor e Forma:Solid
    Peso molecular:588.039

    Ref: TM-T204188

  • TAK-915
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    TAK-915

    CAS:
    <p>TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.</p>
    Fórmula:C19H18F4N4O5
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:458.36

    Ref: TM-T16976

  • Z21090
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    Z21090

    CAS:
    <p>Z21090 (ZL40) is a highly effective inhibitor of PDE 4, exhibiting an IC 50 value of 37.4 nM, and possesses oral bioavailability. It is significant in the study of alcohol-related diseases [1].</p>
    Fórmula:C12H14ClN3O3
    Cor e Forma:Solid
    Peso molecular:283.71

    Ref: TM-T87655

  • NHTD
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    NHTD

    CAS:
    <p>NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).</p>
    Fórmula:C24H26N2O5
    Cor e Forma:Solid
    Peso molecular:422.47

    Ref: TM-T200095