Caseína quinase
As caseína quinases são uma família de proteínas quinases serina/treonina que regulam vários processos celulares, incluindo a reparação do DNA, os ritmos circadianos e a transdução de sinais. Essas quinases estão envolvidas na fosforilação de numerosas proteínas e estão implicadas em doenças como o câncer, distúrbios neurodegenerativos e síndromes metabólicas. Na CymitQuimica, oferecemos uma seleção de inibidores de caseína quinase para apoiar sua pesquisa em transdução de sinais, regulação do ciclo celular e desenvolvimento terapêutico.
Foram encontrados 130 produtos de "Caseína quinase"
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Umbralisib
CAS:<p>Umbralisib (TGR 1202) is a PI3Kδ inhibitor.</p>Fórmula:C31H24F3N5O3Pureza:99.56% - 99.56%Cor e Forma:White SolidPeso molecular:571.55TBB
CAS:<p>TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).</p>Fórmula:C6HBr4N3Pureza:98.51% - 99.45%Cor e Forma:Off-White SolidPeso molecular:434.71CKI-7
CAS:<p>CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.</p>Fórmula:C11H14Cl3N3O2SPureza:>99.99%Cor e Forma:SolidPeso molecular:358.67Umbralisib hydrochloride
CAS:<p>Umbralisib hydrochloride: PI3Kδ inhibitor; IC50=22.2 nM, EC50=24.3 nM; active vs CK1ε, EC50=6.0 μM.</p>Fórmula:C31H25ClF3N5O3Pureza:98%Cor e Forma:SolidPeso molecular:608.01MLN8054
CAS:<p>MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.</p>Fórmula:C25H15ClF2N4O2Pureza:98.07% - 98.26%Cor e Forma:SolidPeso molecular:476.86NCC007
CAS:<p>NCC007 is a novel CKIα and CKIδ dual inhibitors by structural modification of N9 and C2 position of longdaysin.</p>Fórmula:C22H28F3N7Pureza:98.88%Cor e Forma:SolidPeso molecular:447.5CK1-IN-1
CAS:<p>CK1-IN-1, a CK1 inhibitor with IC50: 15nM CK1δ, 16nM CK1ε, 73nM p38σ; patent WO2015119579A1.</p>Fórmula:C24H15F2N3Pureza:98.79%Cor e Forma:SolidPeso molecular:383.39TAK-715
CAS:<p>TAK-715 is a p38 MAPK inhibitor for p38α.</p>Fórmula:C24H21N3OSPureza:99.83%Cor e Forma:SolidPeso molecular:399.51DMAT
CAS:<p>DMAT (Casein kinase II Inhibitor) is a potent and specific inhibitor of CK2(IC50 value of 130 nM).</p>Fórmula:C9H7Br4N3Pureza:99.48%Cor e Forma:SolidPeso molecular:476.79Silmitasertib
CAS:<p>Silmitasertib (CX-4945) is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).</p>Fórmula:C19H12ClN3O2Pureza:98% - 99.90%Cor e Forma:SolidPeso molecular:349.77PF-670462
CAS:<p>PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.</p>Fórmula:C19H22Cl2FN5Pureza:99.42% - 99.72%Cor e Forma:SolidPeso molecular:410.32XL413
CAS:<p>XL-413 is an oral CDC7 kinase inhibitor, potentially blocking DNA replication, mitosis, and cancer cell growth.</p>Fórmula:C14H12ClN3O2Pureza:98.40% - >99.99%Cor e Forma:SolidPeso molecular:289.72SSTC3
CAS:<p>SSTC3 is a casein kinase 1α (CK1α) activator with potential antitumor activity that inhibits WNT signaling.</p>Fórmula:C23H17F3N4O3S2Pureza:98.65% - 99.94%Cor e Forma:SolidPeso molecular:518.53AMG-548
CAS:<p>AMG-548, oral p38α inhibitor (Ki=0.5 nM), >1000x selectivity over p38γ/δ, blocks TNFα (IC50=3 nM), also inhibits Wnt/Casein kinase 1δ/ε.</p>Fórmula:C29H27N5OPureza:99.91%Cor e Forma:SolidPeso molecular:461.56SR-1277
CAS:<p>SR-1277 is a potent, highly selective and ATP-competitive CK1δ/ε inhibitor, regulating Wee1 activity at the G2/M cell-cycle interface, and antiproliferative.</p>Fórmula:C21H19N9O3SCor e Forma:SolidPeso molecular:477.5CK2/PIM1-IN-1
CAS:<p>CK2/PIM1-IN-1 inhibits CK2 & PIM1 (IC50s: 3.787 & 4.327 μM), aimed for cancer research.</p>Fórmula:C15H9NO4S2Pureza:98%Cor e Forma:SolidPeso molecular:331.374,5,6,7-Tetrabromobenzimidazole
CAS:<p>4,5,6,7-Tetrabromobenzimidazole is a selective and ATP-competitive inhibitor of protein kinase CK2 [1].</p>Fórmula:C7H2Br4N2Cor e Forma:SolidPeso molecular:433.72CK2-IN-9
CAS:<p>CK2-IN-9, a potent and selective CK2 kinase inhibitor, exhibits an inhibitory concentration (IC50) of 3 nM against its target enzyme and hampers Wnt reporter</p>Fórmula:C23H29N9OCor e Forma:SolidPeso molecular:447.54Quinalizarin
CAS:<p>Quinalizarin, the most selective CK2 inhibitor, is superior to CX-4945 which is the first-in-class CK2 inhibitor.</p>Fórmula:C14H8O6Pureza:98%Cor e Forma:SolidPeso molecular:272.21Tyrphostin AG 1112
CAS:<p>Tyrphostin AG 1112 is a Bcr-Abl kinase blocker. It can activate the terminal differentiation of K562 cells and the purging of Ph+ cells.</p>Fórmula:C15H10N6Cor e Forma:SolidPeso molecular:274.28PF 4800567 hydrochloride
CAS:<p>casein kinase 1ε inhibitor</p>Fórmula:C17H19Cl2N5O2Pureza:98%Cor e Forma:SolidPeso molecular:396.27IQA
CAS:<p>IQA is a casein kinase 2 (CK2) inhibitor.</p>Fórmula:C17H12N2O3Cor e Forma:SolidPeso molecular:292.29(R)-DRF053 dihydrochloride
CAS:<p>cdk/CK1 inhibitor,potent and ATP-competitive</p>Fórmula:C23H29Cl2N7OPureza:98%Cor e Forma:SolidPeso molecular:490.43TMCB
CAS:<p>CK2 and ERK8 inhibitor</p>Fórmula:C11H9Br4N3O2Pureza:98%Cor e Forma:SolidPeso molecular:534.82CK2-IN-6
CAS:<p>CK2-IN-6: Potent CK2 inhibitor for cancer, inflammation, pain, and immune research.</p>Fórmula:C19H16ClN7O2Cor e Forma:SolidPeso molecular:409.83SRPIN-803
CAS:<p>SRPIN-803 is a selective dual SRPK1 and CK2 inhibitor.</p>Fórmula:C14H9F3N4O3SPureza:98%Cor e Forma:SolidPeso molecular:370.31Umbralisib sulfate
CAS:<p>Umbralisib sulfate, an oral dual PI3Kδ/CK1ε inhibitor (EC50: 22.2 nM/6.0 μM), targets CLL T cells for blood cancer research.</p>Fórmula:C31H26F3N5O7SCor e Forma:SolidPeso molecular:669.63Umbralisib tosylate
CAS:<p>Umbralisib tosylate, an oral PI3Kδ/CK1ε inhibitor (EC50: 22.2 nM/6.0 μM), shows promise for CLL research.</p>Fórmula:C38H32F3N5O6SCor e Forma:SolidPeso molecular:743.75BTX161
CAS:<p>BTX161: potent CKIα degrader, surpasses Lenalidomide in AML, triggers DDR + p53, stabilizes MDM2.</p>Fórmula:C15H16N2O3Cor e Forma:SolidPeso molecular:272.3HDAC/CK2-IN-1
CAS:<p>HDAC/CK2-IN-1 (compound 38) acts as an inhibitor of HDAC1 (IC 50 = 1.46 μM), HDAC6 (IC 50 = 0.66 μM), and CK2 (IC 50 = 3.67 μM). It demonstrates promising antiproliferative effects on various cell lines, including Jurkat, MCF-7, HCT-116, and HL-60.</p>Fórmula:C15H18Br4N4O2Cor e Forma:SolidPeso molecular:605.95CK2-IN-4
CAS:<p>CK2-IN-4 is a protein kinase (CK2) inhibitor with an IC50 value of 8.6 µM.</p>Fórmula:C18H11N3O4SPureza:99.72%Cor e Forma:SolidPeso molecular:365.36CK2α-IN-1
CAS:<p>CK2α-IN-1 is a selective non-ATP-competitive CK2α inhibitor with an IC50 of 7.0 µM and a Ki of 1.6 µM.CK2α-IN-1 exhibits potential anticancer activity and can</p>Fórmula:C16H11N3O4SPureza:98%Cor e Forma:SolidPeso molecular:341.34CK1-IN-2
CAS:<p>CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor p38a, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.</p>Fórmula:C17H12FN3O2Pureza:99.31%Cor e Forma:SolidPeso molecular:309.29PI-828
CAS:<p>PI-828 (LY 294002), a PI3K inhibitor, researches PI3K function and aids stem cell differentiation into mesoderm.</p>Fórmula:C19H18N2O3Pureza:99.95%Cor e Forma:SolidPeso molecular:322.36XL413 xHCl
CAS:<p>BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215</p>Fórmula:C14H12ClN3O2·xHClPureza:99.37% - 99.67%Cor e Forma:SolidPeso molecular:326.18BioE-1115
CAS:<p>BioE-1115 is a selective and potent inhibitor of serine-threonine protein kinase (PASK, IC50 = 4 nM). BioE-1115 is a potent inhibitor of CK2α (IC50 = 10 μM).</p>Fórmula:C19H18FN3O2Pureza:97.54%Cor e Forma:SolidPeso molecular:339.36Casein kinase 1δ-IN-1
CAS:<p>Casein kinase 1δ-IN-1 (WAY-643895) is an inhibitor of casein kinase 1δ (CK1δ), which inhibits CK1δ.</p>Fórmula:C11H7N3OSPureza:99.46%Cor e Forma:SolidPeso molecular:229.26Ac-VDVAD-CHO
CAS:<p>Ac-VDVAD-CHO is an inhibitor of caspase-2 and caspase-3 (IC50: 46 nM for caspase-2 and 15 nM for caspase-3) [1].</p>Fórmula:C23H37N5O10Pureza:98%Cor e Forma:SolidPeso molecular:543.57ON 108600
CAS:<p>ON 108600 is a chemical inhibitor targeting CK2 (Casein Kinase 2), TNIK, and DYRK1, demonstrating IC50 values of 0.016 μM and 0.007 μM for DYRK1A and DYRK1B, 0.</p>Fórmula:C22H14Cl2N2O6S2Pureza:98%Cor e Forma:SolidPeso molecular:537.39Casein kinase 1δ-IN-5
CAS:<p>Casein kinase 1δ-IN-5 is a potent and selective CK-1δ inhibitor, exhibiting an IC50 of 47 nM, and demonstrates neuroprotective and anti-inflammatory effects in</p>Fórmula:C16H11F3N2OSPureza:98%Cor e Forma:SolidPeso molecular:336.33Casein kinase 1δ-IN-10
CAS:<p>Casein kinase 1δ-IN-10 is an inhibitor of casein kinase 1δ (CK1δ).</p>Fórmula:C21H17N3O3Pureza:98%Cor e Forma:SolidPeso molecular:359.38TID43
CAS:<p>TID43, a CK2 inhibitor, exhibits potent inhibition with an IC50 value of 0.3 μM. It is applicable in anti-angiogenic research [1].</p>Fórmula:C10H3I4NO4Cor e Forma:SolidPeso molecular:708.755XL413 hydrochloride
CAS:<p>XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7. XL413 hydrochloride also inhibits CK2 and PIM1.</p>Fórmula:C14H13Cl2N3O2Pureza:98.81% - 99.8%Cor e Forma:SolidPeso molecular:326.18Casein kinase 1δ-IN-4
CAS:<p>"Casein kinase 1δ-IN-4 (compound 567) is a potent inhibitor of casein kinase 1δ with potential application in Alzheimer's disease research [1]."</p>Fórmula:C16H12N6SPureza:98%Cor e Forma:SolidPeso molecular:320.37Casein Kinase II Inhibitor IV
CAS:<p>Casein kinase II inhibitor IV is an effective small molecule inducer, which can be used to induce epidermal keratinocyte differentiation.</p>Fórmula:C24H23N5O3Pureza:99.65% - 99.75%Cor e Forma:SolidPeso molecular:429.47Casein kinase 1δ-IN-13
CAS:Casein kinase1δ-IN-13 (compound 401) is an inhibitor of Casein kinase1δ. It is utilized in the research of neurodegenerative diseases.Fórmula:C15H13N3O2SCor e Forma:SolidPeso molecular:299.35Casein kinase 1δ-IN-28
CAS:<p>Casein kinase1δ-IN-28 (Compound 4) is an inhibitor of CK1ε, with an IC50 of 0.0146 μM. The human liver microsome metabolism rate for Casein kinase1δ-IN-28 is 52%.</p>Fórmula:C23H23FN6Cor e Forma:SolidPeso molecular:402.467CK1δ-IN-6
CAS:<p>CK1δ-IN-6 (Compound 303) is an inhibitor of Casein kinase 1δ, with potential applications in Alzheimer's disease research.</p>Fórmula:C23H17N3O4Cor e Forma:SolidPeso molecular:399.399WAY-606344
CAS:<p>WAY-606344 (Compound 97) is an inhibitor of Casein kinase 1δ and shows potential for Alzheimer's disease research.</p>Fórmula:C14H8ClN3O2Cor e Forma:SolidPeso molecular:285.685
