Receptor de Retinóide
Os receptores de retinoides são receptores nucleares que mediam os efeitos dos retinoides (derivados da vitamina A) na expressão gênica. Esses receptores desempenham um papel vital na diferenciação celular, proliferação e apoptose. Inibidores dos receptores de retinoides são utilizados para estudar seu envolvimento em várias doenças, incluindo câncer, distúrbios de pele e condições metabólicas. Ao modular a atividade dos receptores de retinoides, esses inibidores podem fornecer insights sobre os mecanismos de sinalização dos retinoides e seu potencial terapêutico. Na CymitQuimica, oferecemos inibidores dos receptores de retinoides para apoiar sua pesquisa em dermatologia, oncologia e regulação metabólica.
Foram encontrados 29 produtos de "Receptor de Retinóide"
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LG-100064
CAS:<p>LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)</p>Fórmula:C23H26O3Pureza:98.65%Cor e Forma:SolidPeso molecular:350.45BMS 195614
CAS:<p>BMS 195614 (BMS614) is a selective RARα antagonist. BMS 195614 can bind to the RARα subunit.</p>Fórmula:C29H24N2O3Pureza:97.7%Cor e Forma:SolidPeso molecular:448.51CD3254
CAS:<p>CD3254 is a selective and potent retinoid X receptor-like (RXR) agonist that inhibits neuronal cell death with OGD/reoxygenation.</p>Fórmula:C24H28O3Pureza:98.71% - 98.71%Cor e Forma:SolidPeso molecular:364.48CD437
CAS:<p>CD437 (AHPN) is a specifc Retinoic Acid Receptor γ (RARγ) agonist.</p>Fórmula:C27H26O3Pureza:98.92% - 99.63%Cor e Forma:SolidPeso molecular:398.49Tazarotene
CAS:<p>Tazarotene (Zorac), a synthetic topical retinoid, treats psoriasis by normalizing keratinocytes and reducing growth.</p>Fórmula:C21H21NO2SPureza:97.01% - 99.14%Cor e Forma:White SolidPeso molecular:351.46Fenretinide
CAS:<p>Fenretinide (4-HPR) is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.</p>Fórmula:C26H33NO2Pureza:98% - 99.68%Cor e Forma:Yellow PowderPeso molecular:391.55AGN 193109
CAS:<p>AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ).</p>Fórmula:C28H24O2Pureza:99.87% - 99.89%Cor e Forma:SolidPeso molecular:392.49UVI 3003
CAS:<p>UVI 3003 blocks retinoid X receptor (RXRα) in Xenopus/human Cos7 cells; IC50: 0.22/0.24 μM.</p>Fórmula:C28H36O4Pureza:99.82%Cor e Forma:SolidPeso molecular:436.58AR7
CAS:<p>AR7 is a retinoic acid receptor α (RARα) antagonist.</p>Fórmula:C15H12ClNOPureza:98.12% - 99.86%Cor e Forma:SolidPeso molecular:257.71palovarotene
CAS:<p>Palovarotene (Ro 3300074) is an agonist of nuclear retinoic acid receptor γ (RAR-γ).</p>Fórmula:C27H30N2O2Pureza:97.88% - 98.05%Cor e Forma:SolidPeso molecular:414.54Tarenflurbil
CAS:<p>Tarenflurbil, the R-enantiomer of flurbiprofen, lacks COX inhibition and was tested for Alzheimer's treatment.</p>Fórmula:C15H13FO2Pureza:98% - 99.9%Cor e Forma:SolidPeso molecular:244.26trifarotene
CAS:<p>Trifarotene (CD5789) is a RARγ agonist, 65x more selective than RARα and 16x than RARβ, with EC50 of 7.7 nM.</p>Fórmula:C29H33NO4Pureza:99.51%Cor e Forma:SolidPeso molecular:459.58Bexarotene
CAS:<p>Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).</p>Fórmula:C24H28O2Pureza:99% - 99.65%Cor e Forma:White SolidPeso molecular:348.48BMS270394
CAS:<p>BMS270394 is a RARγ agonist used in the study of breast cancer and skin diseases.</p>Fórmula:C23H26FNO4Cor e Forma:SolidPeso molecular:399.46CD 1530
CAS:<p>CD 1530 is an ARγ agonist (Kd:150 nM) with potential anticancer activity for the study of oral carcinogenesis.</p>Fórmula:C27H26O3Pureza:98.13%Cor e Forma:SolidPeso molecular:398.49CD2665
CAS:<p>CD2665 is an orally active antagonist of retinoic acid receptor (RAR). For RARγ and RARβ, the Kis are 110 nM and 306 nM.</p>Fórmula:C31H34O5Pureza:99.71%Cor e Forma:SolidPeso molecular:486.6Ch55
CAS:<p>Ch55, a potent HL60 cell differentiator (EC50=200nM), binds well to RAR-α/β, useful for cancer research.</p>Fórmula:C24H28O3Pureza:99.55%Cor e Forma:SolidPeso molecular:364.48AGN 196996
CAS:<p>AGN 196996: strong RARα inhibitor (Ki: 2 nM), weak for RARβ/γ (Ki: 1087/8523 nM).</p>Fórmula:C24H20BrNO5Pureza:98.74%Cor e Forma:SolidPeso molecular:482.32BMS 753
CAS:<p>BMS 753 is an agonist of isotype-selective retinoic acid receptor α (RARα, Ki= 2 nM).</p>Fórmula:C21H21NO4Pureza:98.55%Cor e Forma:SolidPeso molecular:351.4Fluorobexarotene
CAS:<p>Fluorobexarotene, a potent RXR agonist, has 75% higher affinity than Bexarotene with Ki of 12 nM and EC50 of 43 nM for RXRα.</p>Fórmula:C24H27FO2Pureza:99.08%Cor e Forma:SolidPeso molecular:366.47MM 11253
CAS:<p>MM 11253 is a RARγ antagonist with IC50 of 44nM.</p>Fórmula:C28H30O2S2Pureza:99.41%Cor e Forma:SolidPeso molecular:462.67AC-261066
CAS:<p>AC-261066 is an orally available and isoform-selective agonist of RARβ2 with a pEC50 of 8.0.</p>Fórmula:C17H20FNO4SPureza:99.64%Cor e Forma:SolidPeso molecular:353.41BMS641
CAS:<p>BMS641 (BMS-209641) is a RARβ agonist with affinity for RARβ that synergistically activates RARβ and RARgamma to induce cell maturation.</p>Fórmula:C27H23ClO2Pureza:98.98%Cor e Forma:SolidPeso molecular:414.92KCL-286
CAS:<p>KCL-286 is an available and potent retinoic acid receptor beta agonist for the amelioration of spinal cord injury (SCI).</p>Fórmula:C19H14N2O4Pureza:99.93%Cor e Forma:SolidPeso molecular:334.33ER 50891
CAS:<p>ER-50891 is a potent RARα antagonist, countering retinoic acid inhibition and aiding BMP2-induced osteoblast differentiation.</p>Fórmula:C29H24N2O2Pureza:>99.99%Cor e Forma:SolidPeso molecular:432.51LE135
CAS:<p>LE135: RARα/RARβ antagonist (Ki: 1.4 μM/220 nM), favors RARβ, selective vs RARγ/RXRs; also activates TRPV1/TRPA1 (EC50s: 2.5/20 μM).</p>Fórmula:C29H30N2O2Pureza:97.94%Cor e Forma:SolidPeso molecular:438.56PA452
CAS:<p>PA452 is a selective antagonist of retinoic X receptor (RXR) and suppresses the effect of Retinoic acid on Th1/Th2 development.</p>Fórmula:C26H37N3O3Pureza:97.14%Cor e Forma:SolidPeso molecular:439.59ZSH-2208
CAS:<p>ZSH-2208 is a retinoic acid A analogue that inhibits tumour cell proliferation and survival through RARγ-TNFAIP3 and retinoid receptors.</p>Fórmula:C20H18O3SPureza:99.81%Cor e Forma:SolidPeso molecular:338.42BMS453
CAS:<p>BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin.</p>Fórmula:C27H24O2Pureza:99.93%Cor e Forma:SolidPeso molecular:380.48
