IDO
A indoleamina 2,3-dioxigenase (IDO) é uma enzima envolvida no catabolismo do triptofano, levando à produção de quinurenina e outros metabólitos. A IDO desempenha um papel na tolerância imunológica e é frequentemente regulada em alta em condições como câncer e inflamações crônicas. Inibidores de IDO estão sendo explorados como potenciais agentes imunoterapêuticos no câncer e em doenças autoimunes. Na CymitQuimica, oferecemos inibidores de IDO para apoiar sua pesquisa em imunologia, oncologia e regulação metabólica.
Foram encontrados 84 produtos de "IDO"
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IDO-IN-6
CAS:IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.Fórmula:C18H21FN2O2Pureza:98%Cor e Forma:SolidPeso molecular:316.37IDO1-IN-2
CAS:IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.Fórmula:C15H17FN6O4Pureza:98%Cor e Forma:SolidPeso molecular:364.33IDO-IN-3
CAS:IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).Fórmula:C11H12BrFN6O2Cor e Forma:SolidPeso molecular:359.15IDO-IN-11
CAS:IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).Fórmula:C19H23BrFN7O4SPureza:98%Cor e Forma:SolidPeso molecular:544.4IDO1/TDO-IN-3
CAS:IDO1/TDO-IN-3 inhibits IDO1 (IC50: 0.005 μM) and TDO (IC50: 0.004 μM) with strong anti-tumor activity and low toxicity.Fórmula:C16H6ClF2N3O2Cor e Forma:SolidPeso molecular:345.69IDO-IN-4
CAS:IDO-IN-4 is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor.Fórmula:C26H35N3O3Cor e Forma:SolidPeso molecular:437.57IDO1-IN-16
CAS:IDO1-IN-16 (I-1) is an IDO1 inhibitor that targets holo-IDO1 (IC50: 127 nM).Fórmula:C25H35BrFN5O2Cor e Forma:SolidPeso molecular:536.48IACS-8968 R-enantiomer
CAS:IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).Fórmula:C17H18F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:381.35IDO1/TDO-IN-2
CAS:IDO1/TDO-IN-2: IDO1/TDO inhibitor; IC50s: IDO1, 0.1μM; TDO, 0.07μM; potential for cancer research.Fórmula:C16H9N3O2Cor e Forma:SolidPeso molecular:275.26IDO/TDO-IN-1
CAS:IDO/TDO-IN-1 is an orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50s: 9.7 and 47 nM).Fórmula:C25H24FN5Pureza:98%Cor e Forma:SolidPeso molecular:413.49IDO1-IN-15
CAS:IDO1-IN-15 is an effective IDO1 inhibitor with IC50 of 127 nM. The potency of IDO1-IN-15 against IDO1 enzyme is comparable with Epacadostat in vitro.Fórmula:C13H14BrFN6O3Cor e Forma:SolidPeso molecular:401.19IDO-IN-16
CAS:IDO-IN-16 (compound 5) is an IDO inhibitor (IC50: 36 nM).Fórmula:C22H21F3N4OCor e Forma:SolidPeso molecular:414.42IDO1-IN-17
CAS:IDO1-IN-17 (I-4) is an IDO1 inhibitor, with an IC 50 of 0.44 μM in hela cells .Fórmula:C28H32BrClFN5O2Cor e Forma:SolidPeso molecular:604.94IDO-IN-14
CAS:IDO-IN-14 is an IDO inhibitor (IC50: 0.6928 nM).Fórmula:C23H23ClN4O2Cor e Forma:SolidPeso molecular:422.91MMG-0358
CAS:MMG-0358 is a novel potent IDO1 inhibitor, showing low cytotoxicity and higher selectivity for IDO1 over TDO enzyme.Fórmula:C8H6ClN3OCor e Forma:SolidPeso molecular:195.61IDO1-IN-21
CAS:IDO1-IN-21 (compound 10m), with an IC50 of 0.64 μM, acts as an IDO1 inhibitor and has demonstrated efficacy in suppressing tumor growth in murine models [1].Fórmula:C21H19F2N3O6SPureza:98%Cor e Forma:SolidPeso molecular:479.45IDO-IN-5
CAS:IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).Fórmula:C18H21FN2O2Pureza:98%Cor e Forma:SolidPeso molecular:316.37Roxyl-9
CAS:Roxyl-9 is an inhibitor of IDO1 (Indoleamine 2,3-dioxygenase 1) [1].Fórmula:C18H13N3O2Cor e Forma:SolidPeso molecular:303.31TDO-IN-1
CAS:<p>TDO-IN-1 is a tryptophan 2,3-dioxygenase (TDO) inhibitor with antitumor activity that acts by reversing local immune tolerance in tumor tissues.</p>Fórmula:C16H13F3N4O2Pureza:99.86%Cor e Forma:SolidPeso molecular:350.3IDO1/2-IN-1
CAS:First potent oral dual IDO1/IDO2 inhibitor with antitumor properties; IC50: 28 nM (IDO1), 144 nM (IDO2).Fórmula:C16H18BrFN8O4Cor e Forma:SolidPeso molecular:485.27(R)-IDO/TDO-IN-1
CAS:(R)-IDO/TDO-IN-1 (compound 25), an indoleamine-2,3-dioxygenase (IDO) inhibitor, demonstrates good pharmacokinetic properties and exerts anti-tumor effects in the MC38 xenograft model. This compound exhibits synergy when combined with the anti-PD-1 monoclonal antibody (SHR-1210) [1].Fórmula:C25H24FN5Cor e Forma:SolidPeso molecular:413.49NUCC-0223619
CAS:NUCC-0223619 is an IDO1 inhibitor that induces the degradation of IDO protein and can be involved in the synthesis of PROTAC.Fórmula:C24H24ClFN2O2Cor e Forma:SolidPeso molecular:426.91IDO1/2-IN-1 hydrochloride
CAS:IDO1/2-IN-1 hydrochloride: Dual IDO1/2 inhibitor, IC50 of 28/144 nM, oral, with antitumor properties.Fórmula:C16H19BrClFN8O4Cor e Forma:SolidPeso molecular:521.73IDO1/TDO-IN-6
CAS:IDO1/TDO-IN-6 (compound 11) is a dual inhibitor targeting IDO1 and TDO, exhibiting IC50 values of 2.25 μM for IDO1 and 2.89 μM for TDO.Fórmula:C20H17NO5Pureza:98%Cor e Forma:SolidPeso molecular:351.35IDO-IN-9
CAS:IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).Fórmula:C13H13BrFN7O3SPureza:98%Cor e Forma:SolidPeso molecular:446.251-Isopropyltryptophan
CAS:1-Isopropyltryptophan (1-IsoPT), an IDO1 inhibitor, suppresses the expression of IDO-1 and IDO-2 mRNA induced by IFN-γ stimulation [1].Fórmula:C14H18N2O2Pureza:98%Cor e Forma:SolidPeso molecular:246.3IDO1 ligand-1
CAS:<p>IDO1ligand-1 is the target protein ligand for PROTAC NU227326, which is utilized for degrading IDO1.</p>Fórmula:C29H34FN3O2Cor e Forma:SolidPeso molecular:475.598IDO2-IN-1
CAS:<p>IDO2-IN-1: potent oral IDO2 inhibitor, IC50 = 112 nM, for inflammatory autoimmunity research.</p>Fórmula:C21H21BrN10O3Cor e Forma:SolidPeso molecular:541.36VS-15
CAS:VS-15 is a selective inhibitor of IDO1, specifically binding to its apo-heme form. Additionally, VS-15 serves as an inhibitor of iNOS.Fórmula:C29H27N5O3Cor e Forma:SolidPeso molecular:493.56IDO1-IN-13
IDO1-IN-13 is a potent IDO1 inhibitor (IC50: 61.6 nM, EC50: 30 nM in HeLa) that reduces kyn/trp ratio by 51% in SK-OV-3 tumors.Fórmula:C20H16BrN5O2SCor e Forma:SolidPeso molecular:470.34IDO1-IN-25
CAS:IDO1-IN-25, a dual inhibitor of IDO1/TDO2, showcases IC50 values of 0.17 μM for IDO1 and 3.2 μM for TDO2. It effectively suppresses NO production in RAW264.7 cells following stimulation with lipopolysaccharide (LPS). Additionally, IDO1-IN-25 demonstrates anti-inflammatory properties in a mouse ear edema model of acute inflammation induced by croton oil.Fórmula:C14H8Cl3NO2SCor e Forma:SolidPeso molecular:360.64IDO1-IN-14
IDO1-IN-14 is an IDO1 enzyme inhibitor with an IC50 of 396.9 nM and suppresses HeLa cell activity with an EC50 of 3393 nM.Fórmula:C18H12Cl2FN3O2Cor e Forma:SolidPeso molecular:392.21IDO antagonist-1
CAS:<p>IDO antagonist-1 (compound 163), an IDO antagonist, effectively inhibits the growth of pancreatic adenocarcinoma cells in C57BL/6 mice [1].</p>Fórmula:C39H53N7O5Cor e Forma:SolidPeso molecular:699.884-Phenyl-1H-1,2,3-triazole
CAS:<p>4-Phenyl-1H-1,2,3-triazole, an inhibitor of the enzyme IDO1 (IC50: 60 µM), is utilized in cancer research [1].</p>Fórmula:C8H7N3Pureza:98%Cor e Forma:SolidPeso molecular:145.16
