IDO
A indoleamina 2,3-dioxigenase (IDO) é uma enzima envolvida no catabolismo do triptofano, levando à produção de quinurenina e outros metabólitos. A IDO desempenha um papel na tolerância imunológica e é frequentemente regulada em alta em condições como câncer e inflamações crônicas. Inibidores de IDO estão sendo explorados como potenciais agentes imunoterapêuticos no câncer e em doenças autoimunes. Na CymitQuimica, oferecemos inibidores de IDO para apoiar sua pesquisa em imunologia, oncologia e regulação metabólica.
Foram encontrados 88 produtos para "IDO".
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IDO1-IN-16
CAS:IDO1-IN-16 (I-1) is an IDO1 inhibitor that targets holo-IDO1 (IC50: 127 nM).Fórmula:C25H35BrFN5O2Cor e Forma:SolidPeso molecular:536.48IDO1-IN-15
CAS:IDO1-IN-15 is an effective IDO1 inhibitor with IC50 of 127 nM. The potency of IDO1-IN-15 against IDO1 enzyme is comparable with Epacadostat in vitro.Fórmula:C13H14BrFN6O3Cor e Forma:SolidPeso molecular:401.19DP00477
CAS:DP00477, a potent inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), exhibits an inhibitory concentration (IC50) of 7.0 µM.Fórmula:C17H11ClF3N3OSCor e Forma:SolidPeso molecular:397.8IDO1-IN-17
CAS:IDO1-IN-17 (I-4) is an IDO1 inhibitor, with an IC 50 of 0.44 μM in hela cells .Fórmula:C28H32BrClFN5O2Cor e Forma:SolidPeso molecular:604.94IDO-IN-14
CAS:IDO-IN-14 is an IDO inhibitor (IC50: 0.6928 nM).Fórmula:C23H23ClN4O2Cor e Forma:SolidPeso molecular:422.91Roxyl-9
CAS:Roxyl-9 is an inhibitor of IDO1 (Indoleamine 2,3-dioxygenase 1) [1].Fórmula:C18H13N3O2Cor e Forma:SolidPeso molecular:303.3147IDO-IN-12
CAS:IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).Fórmula:C13H11BrFN5O3SPureza:99.72%Cor e Forma:SolidPeso molecular:416.23Ref: TM-T11615
1mg84,00€5mg170,00€1mL*10mM (DMSO)178,00€10mg250,00€25mg394,00€50mg512,00€100mg713,00€IACS-8968 S-enantiomer
CAS:IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).Fórmula:C17H18F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:381.35IACS-8968
CAS:IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).Fórmula:C17H18F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:381.35IDO-IN-8
CAS:IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).Fórmula:C18H21FN2O2Pureza:98%Cor e Forma:SolidPeso molecular:316.37IDO1-IN-2
CAS:IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.Fórmula:C15H17FN6O4Pureza:98%Cor e Forma:SolidPeso molecular:364.33IDO-IN-3
CAS:IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).Fórmula:C11H12BrFN6O2Cor e Forma:SolidPeso molecular:359.15TDO-IN-1
CAS:TDO-IN-1 is a tryptophan 2,3-dioxygenase (TDO) inhibitor with antitumor activity that acts by reversing local immune tolerance in tumor tissues.Fórmula:C16H13F3N4O2Pureza:99.65%Cor e Forma:Orange SolidPeso molecular:350.3(R)-IDO/TDO-IN-1
CAS:(R)-IDO/TDO-IN-1 (compound 25), an indoleamine-2,3-dioxygenase (IDO) inhibitor, demonstrates good pharmacokinetic properties and exerts anti-tumor effects in the MC38 xenograft model. This compound exhibits synergy when combined with the anti-PD-1 monoclonal antibody (SHR-1210) [1].Fórmula:C25H24FN5Cor e Forma:SolidPeso molecular:413.49IDO-IN-9
CAS:IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).Fórmula:C13H13BrFN7O3SPureza:98%Cor e Forma:SolidPeso molecular:446.25IDO1/2-IN-1
CAS:First potent oral dual IDO1/IDO2 inhibitor with antitumor properties; IC50: 28 nM (IDO1), 144 nM (IDO2).Fórmula:C16H18BrFN8O4Cor e Forma:SolidPeso molecular:485.27NUCC-0223619
CAS:NUCC-0223619 is an IDO1 inhibitor that induces the degradation of IDO protein and can be involved in the synthesis of PROTAC.Fórmula:C24H24ClFN2O2Cor e Forma:SolidPeso molecular:426.91IDO1/TDO-IN-6
CAS:IDO1/TDO-IN-6 (compound 11) is a dual inhibitor targeting IDO1 and TDO, exhibiting IC50 values of 2.25 μM for IDO1 and 2.89 μM for TDO.Fórmula:C20H17NO5Pureza:98%Cor e Forma:SolidPeso molecular:351.35IDO1/2-IN-1 hydrochloride
CAS:IDO1/2-IN-1 hydrochloride: Dual IDO1/2 inhibitor, IC50 of 28/144 nM, oral, with antitumor properties.Fórmula:C16H19BrClFN8O4Cor e Forma:SolidPeso molecular:521.731-Isopropyltryptophan
CAS:1-Isopropyltryptophan (1-IsoPT), an IDO1 inhibitor, suppresses the expression of IDO-1 and IDO-2 mRNA induced by IFN-γ stimulation [1].Fórmula:C14H18N2O2Pureza:98%Cor e Forma:SolidPeso molecular:246.3
