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IDO

IDO

A indoleamina 2,3-dioxigenase (IDO) é uma enzima envolvida no catabolismo do triptofano, levando à produção de quinurenina e outros metabólitos. A IDO desempenha um papel na tolerância imunológica e é frequentemente regulada em alta em condições como câncer e inflamações crônicas. Inibidores de IDO estão sendo explorados como potenciais agentes imunoterapêuticos no câncer e em doenças autoimunes. Na CymitQuimica, oferecemos inibidores de IDO para apoiar sua pesquisa em imunologia, oncologia e regulação metabólica.

Foram encontrados 84 produtos de "IDO"

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  • IDO1-IN-15
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    IDO1-IN-15

    CAS:
    IDO1-IN-15 is an effective IDO1 inhibitor with IC50 of 127 nM. The potency of IDO1-IN-15 against IDO1 enzyme is comparable with Epacadostat in vitro.
    Fórmula:C13H14BrFN6O3
    Cor e Forma:Solid
    Peso molecular:401.19

    Ref: TM-T61944

  • IDO-IN-16
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    IDO-IN-16

    CAS:
    IDO-IN-16 (compound 5) is an IDO inhibitor (IC50: 36 nM).
    Fórmula:C22H21F3N4O
    Cor e Forma:Solid
    Peso molecular:414.42

    Ref: TM-T62130

  • IDO1-IN-17
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    IDO1-IN-17

    CAS:
    IDO1-IN-17 (I-4) is an IDO1 inhibitor, with an IC 50 of 0.44 μM in hela cells .
    Fórmula:C28H32BrClFN5O2
    Cor e Forma:Solid
    Peso molecular:604.94

    Ref: TM-T73111

  • IDO-IN-14
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    IDO-IN-14

    CAS:
    IDO-IN-14 is an IDO inhibitor (IC50: 0.6928 nM).
    Fórmula:C23H23ClN4O2
    Cor e Forma:Solid
    Peso molecular:422.91

    Ref: TM-T62270

  • MMG-0358
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    MMG-0358

    CAS:
    MMG-0358 is a novel potent IDO1 inhibitor, showing low cytotoxicity and higher selectivity for IDO1 over TDO enzyme.
    Fórmula:C8H6ClN3O
    Cor e Forma:Solid
    Peso molecular:195.61

    Ref: TM-T71954

  • IDO1-IN-21
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    IDO1-IN-21

    CAS:
    IDO1-IN-21 (compound 10m), with an IC50 of 0.64 μM, acts as an IDO1 inhibitor and has demonstrated efficacy in suppressing tumor growth in murine models [1].
    Fórmula:C21H19F2N3O6S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:479.45

    Ref: TM-T78687

  • IDO-IN-5
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    IDO-IN-5

    CAS:
    IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
    Fórmula:C18H21FN2O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:316.37

    Ref: TM-T11619

  • Roxyl-9
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    Roxyl-9

    CAS:
    Roxyl-9 is an inhibitor of IDO1 (Indoleamine 2,3-dioxygenase 1) [1].
    Fórmula:C18H13N3O2
    Cor e Forma:Solid
    Peso molecular:303.31

    Ref: TM-T60698

  • TDO-IN-1
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    TDO-IN-1

    CAS:
    <p>TDO-IN-1 is a tryptophan 2,3-dioxygenase (TDO) inhibitor with antitumor activity that acts by reversing local immune tolerance in tumor tissues.</p>
    Fórmula:C16H13F3N4O2
    Pureza:99.86%
    Cor e Forma:Solid
    Peso molecular:350.3

    Ref: TM-T61202

  • IDO1/2-IN-1
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    IDO1/2-IN-1

    CAS:
    First potent oral dual IDO1/IDO2 inhibitor with antitumor properties; IC50: 28 nM (IDO1), 144 nM (IDO2).
    Fórmula:C16H18BrFN8O4
    Cor e Forma:Solid
    Peso molecular:485.27

    Ref: TM-T63222

  • (R)-IDO/TDO-IN-1
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    (R)-IDO/TDO-IN-1

    CAS:
    (R)-IDO/TDO-IN-1 (compound 25), an indoleamine-2,3-dioxygenase (IDO) inhibitor, demonstrates good pharmacokinetic properties and exerts anti-tumor effects in the MC38 xenograft model. This compound exhibits synergy when combined with the anti-PD-1 monoclonal antibody (SHR-1210) [1].
    Fórmula:C25H24FN5
    Cor e Forma:Solid
    Peso molecular:413.49

    Ref: TM-T84728

  • NUCC-0223619
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    NUCC-0223619

    CAS:
    NUCC-0223619 is an IDO1 inhibitor that induces the degradation of IDO protein and can be involved in the synthesis of PROTAC.
    Fórmula:C24H24ClFN2O2
    Cor e Forma:Solid
    Peso molecular:426.91

    Ref: TM-T62326

  • IDO1/2-IN-1 hydrochloride
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    IDO1/2-IN-1 hydrochloride

    CAS:
    IDO1/2-IN-1 hydrochloride: Dual IDO1/2 inhibitor, IC50 of 28/144 nM, oral, with antitumor properties.
    Fórmula:C16H19BrClFN8O4
    Cor e Forma:Solid
    Peso molecular:521.73

    Ref: TM-T63651

  • IDO1/TDO-IN-6
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    IDO1/TDO-IN-6

    CAS:
    IDO1/TDO-IN-6 (compound 11) is a dual inhibitor targeting IDO1 and TDO, exhibiting IC50 values of 2.25 μM for IDO1 and 2.89 μM for TDO.
    Fórmula:C20H17NO5
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:351.35

    Ref: TM-T78795

  • IDO-IN-9
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    IDO-IN-9

    CAS:
    IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).
    Fórmula:C13H13BrFN7O3S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:446.25

    Ref: TM-T11622

  • 1-Isopropyltryptophan
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    1-Isopropyltryptophan

    CAS:
    1-Isopropyltryptophan (1-IsoPT), an IDO1 inhibitor, suppresses the expression of IDO-1 and IDO-2 mRNA induced by IFN-γ stimulation [1].
    Fórmula:C14H18N2O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:246.3

    Ref: TM-T79189

  • IDO1 ligand-1
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    IDO1 ligand-1

    CAS:
    <p>IDO1ligand-1 is the target protein ligand for PROTAC NU227326, which is utilized for degrading IDO1.</p>
    Fórmula:C29H34FN3O2
    Cor e Forma:Solid
    Peso molecular:475.598

    Ref: TM-T206464

  • IDO2-IN-1
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    IDO2-IN-1

    CAS:
    <p>IDO2-IN-1: potent oral IDO2 inhibitor, IC50 = 112 nM, for inflammatory autoimmunity research.</p>
    Fórmula:C21H21BrN10O3
    Cor e Forma:Solid
    Peso molecular:541.36

    Ref: TM-T63814

  • VS-15
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    VS-15

    CAS:
    VS-15 is a selective inhibitor of IDO1, specifically binding to its apo-heme form. Additionally, VS-15 serves as an inhibitor of iNOS.
    Fórmula:C29H27N5O3
    Cor e Forma:Solid
    Peso molecular:493.56

    Ref: TM-T200480

  • Logotipo do CymitQuimica
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    IDO1-IN-13

    IDO1-IN-13 is a potent IDO1 inhibitor (IC50: 61.6 nM, EC50: 30 nM in HeLa) that reduces kyn/trp ratio by 51% in SK-OV-3 tumors.
    Fórmula:C20H16BrN5O2S
    Cor e Forma:Solid
    Peso molecular:470.34

    Ref: TM-T63034