HIF/HIF Prolil-Hidroxilase
O Fator Induzido por Hipóxia (HIF) é um fator de transcrição que desempenha um papel crucial nas respostas celulares a níveis baixos de oxigênio (hipóxia). A atividade do HIF é rigidamente regulada pelas prolyl-hidroxilases do HIF, que direcionam o HIF para a degradação em condições normóxicas. Inibidores da prolyl-hidroxilase do HIF podem estabilizar o HIF, promovendo a expressão de genes envolvidos na angiogênese, eritropoiese e metabolismo. Estes inibidores são de grande interesse no tratamento de condições como anemia, doenças isquêmicas e câncer. Na CymitQuimica, oferecemos inibidores de HIF/prolyl-hidroxilase HIF para apoiar sua pesquisa em biologia da hipóxia, terapia do câncer e regulação metabólica.
Foram encontrados 142 produtos de "HIF/HIF Prolil-Hidroxilase"
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HIF-2α-IN-9
CAS:<p>HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes within</p>Fórmula:C12H13F5O4S2Pureza:98%Cor e Forma:SolidPeso molecular:380.35PHD-IN-1
CAS:<p>PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM.</p>Fórmula:C24H23N7O2Pureza:98%Cor e Forma:SolidPeso molecular:441.49AKB-6899
CAS:<p>AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated</p>Fórmula:C14H11FN2O4Pureza:97.87%Cor e Forma:SolidPeso molecular:290.25HIF-2α-IN-1
CAS:<p>HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.</p>Fórmula:C16H8F5NO4SPureza:97.99%Cor e Forma:SolidPeso molecular:405.3CLB-016
CAS:<p>CLB-016 is an inhibitor of hypoxia-inducible factor (HIF)-1.</p>Fórmula:C17H20N6O3Pureza:98%Cor e Forma:SolidPeso molecular:356.38HIF-2α-IN-6
CAS:<p>HIF-2α-IN-6 (117) is a HIF-2α inhibitor [1].</p>Fórmula:C15H13F4NO3SCor e Forma:SolidPeso molecular:363.33NPAS3-IN-1
CAS:<p>NPAS3-IN-1 is an NPAS3-ARNT heterodimerization inhibitor that regulates NPAS3 transcription by modulating the heterodimerization of NPAS3 with ARNT.</p>Fórmula:C10H5N3O2S3Pureza:99.56%Cor e Forma:SolidPeso molecular:295.36HIF-2α agonist 2
CAS:HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α.Fórmula:C13H8Br2N2O2SPureza:98.87%Cor e Forma:SoildPeso molecular:416.09HIF-2α-IN-7
CAS:<p>HIF-2α-IN-7 is a hypoxia inducible factor 2α (HIF-2α) inhibitor.</p>Fórmula:C18H9F6NO2Cor e Forma:SolidPeso molecular:385.26HIF-2α-IN-5
CAS:<p>HIF-2α-IN-5 is a potent HIF-2α inhibitor with an IC 50 of < 50 nM [1].</p>Fórmula:C15H12F4O3S2Cor e Forma:SolidPeso molecular:380.38(Rac)-PT2399
CAS:<p>(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).</p>Fórmula:C17H10F5NO4SCor e Forma:SolidPeso molecular:419.32JTZ-951 HCl
CAS:<p>JTZ-951 is a potent and orally active inhibitor of hypoxia inducible factor prolyl hydroxylase (PHD).</p>Fórmula:C17H17ClN4O4Pureza:98%Cor e Forma:SolidPeso molecular:376.79AFP464 free base
CAS:<p>AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.</p>Fórmula:C22H23F3N4O3Pureza:98%Cor e Forma:SolidPeso molecular:448.44HIF-1α-IN-5
<p>HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A.</p>Fórmula:C16H15N3O2Cor e Forma:SolidPeso molecular:281.31DDO-3055
CAS:<p>DDO-3055 is an orally active PHD2 inhibitor utilized in studies related to anemia associated with chronic kidney disease.</p>Fórmula:C17H13ClN2O5Cor e Forma:SolidPeso molecular:360.749JPHM-2-167
CAS:<p>PHM-2-167 (Compound 11) is a selective inhibitor of the prolyl hydroxylase domain enzyme (PHD). It inhibits PHD2 and PHD3 with IC50 values of 0.253 μM and 3.95 μM, respectively. PHM-2-167 is applicable for research in chronic kidney disease.</p>Fórmula:C30H28N6O2Cor e Forma:SolidPeso molecular:504.582HIF-1α-IN-4
<p>HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects.</p>Fórmula:C16H12N2O3Cor e Forma:SolidPeso molecular:280.28DS44470011
CAS:<p>DS44470011 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) with oral bioavailability. It enhances the release of erythropoietin (EPO) from cells and is utilized in research related to renal anemia.</p>Fórmula:C21H19N3O4Cor e Forma:SolidPeso molecular:377.39PHD2-IN-4
CAS:<p>PHD2-IN-4 (compound 1) is an inhibitor of PHD2, with an IC50 of 4 nM. It is utilized in research related to chronic kidney disease.</p>Fórmula:C21H19N5O3Cor e Forma:SolidPeso molecular:389.407HIF-1/2α-IN-1
<p>HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α.</p>Fórmula:C17H16N6O4Cor e Forma:SolidPeso molecular:368.35
