HIF/HIF Prolil-Hidroxilase
O Fator Induzido por Hipóxia (HIF) é um fator de transcrição que desempenha um papel crucial nas respostas celulares a níveis baixos de oxigênio (hipóxia). A atividade do HIF é rigidamente regulada pelas prolyl-hidroxilases do HIF, que direcionam o HIF para a degradação em condições normóxicas. Inibidores da prolyl-hidroxilase do HIF podem estabilizar o HIF, promovendo a expressão de genes envolvidos na angiogênese, eritropoiese e metabolismo. Estes inibidores são de grande interesse no tratamento de condições como anemia, doenças isquêmicas e câncer. Na CymitQuimica, oferecemos inibidores de HIF/prolyl-hidroxilase HIF para apoiar sua pesquisa em biologia da hipóxia, terapia do câncer e regulação metabólica.
Foram encontrados 142 produtos de "HIF/HIF Prolil-Hidroxilase"
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HIF-PHD-IN-2
CAS:<p>HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].</p>Fórmula:C17H15N5O3SCor e Forma:SolidPeso molecular:369.4Angiogenesis agent 1
CAS:<p>Compound C-31, a salidroside-based glycoside, activates HIF-1α and may aid in diabetic limb ischemia studies.</p>Fórmula:C20H24O7Pureza:98%Cor e Forma:SolidPeso molecular:376.4BNS
CAS:<p>BNS is a potent, prolyl-hydroxylase 2 (PHD2)-selective inhibitor.</p>Fórmula:C18H16N2O6S2Pureza:98%Cor e Forma:SolidPeso molecular:420.46M1002
CAS:<p>M1002, a HIF-2 agonist, boosts HIF-2alpha/ARNT activation and alters HIF-281alpha PAS-B, working with PHD inhibitors.</p>Fórmula:C15H8F6N2O2SPureza:99.95%Cor e Forma:SolidPeso molecular:394.29103D5R
CAS:<p>103D5R selectively inhibits hif-1α, reducing its levels in hypoxia or with cobalt ions, dose- and time-dependently.</p>Fórmula:C20H21N3O2Cor e Forma:SolidPeso molecular:335.4HIF-IN-33
CAS:<p>HIF-IN-33 is an inhibitor of HIF pathway.</p>Fórmula:C21H17F3N4O2Pureza:98%Cor e Forma:SolidPeso molecular:414.38Langkamide
CAS:<p>Langkamide is a HIF-2 inhibitor with EC₅₀ values of 14.0 uM.</p>Fórmula:C16H17NO5Pureza:98%Cor e Forma:SolidPeso molecular:303.31ENMD-1198
CAS:<p>ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.</p>Fórmula:C20H25NO2Pureza:98%Cor e Forma:SolidPeso molecular:311.42HIF-1/2α-IN-2
CAS:<p>HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α.</p>Fórmula:C16H11FN4O2SCor e Forma:SolidPeso molecular:342.35THS-044
CAS:<p>THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activity</p>Fórmula:C11H12F3N3O3Pureza:99.89%Cor e Forma:SolidPeso molecular:291.23KCN1
CAS:<p>KCN1: a synthetic sulfonamide, nanomolar HIF inhibitor with preclinical anti-glioma and anti-pancreatic cancer effects.</p>Fórmula:C26H27NO5SCor e Forma:SolidPeso molecular:465.56TM6089
CAS:<p>TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.</p>Fórmula:C13H14N4O3SPureza:99.70%Cor e Forma:SolidPeso molecular:306.34HIF-1α inhibitor-1
CAS:<p>HIF-1α inhibitor-1 is a HIF-1 alpha inhibitor.</p>Fórmula:C15H11N3O4Cor e Forma:SolidPeso molecular:297.27KRH102140
CAS:<p>KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.</p>Fórmula:C25H24FNOPureza:98.31% - 99.61%Cor e Forma:SolidPeso molecular:373.46HIF-2α-IN-3
CAS:<p>HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.</p>Fórmula:C12H6ClN5O5Pureza:98.11%Cor e Forma:SolidPeso molecular:335.66TC-S 7009
CAS:<p>TC-S 7009: Strong HIF-2α inhibitor (Kd 81 nM), weak for HIF-1α; disrupts dimerization & gene expression.</p>Fórmula:C12H6ClFN4O3Pureza:99.46% - 99.71%Cor e Forma:SolidPeso molecular:308.65HIF-2α-IN-13
CAS:<p>HIF-2α-IN-13 (18) acts as a HIF-2α inhibitor and exhibits an IC 50 value of 2.7 μM.</p>Fórmula:C15H14ClF4NO2Cor e Forma:SolidPeso molecular:351.72PHD-IN-2
CAS:<p>PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 of</p>Fórmula:C26H27N7O4Pureza:98%Cor e Forma:SolidPeso molecular:501.54Prolyl Hydroxylase inhibitor 1
CAS:<p>Prolyl Hydroxylase inhibitor 1 is an orally active inhibitor of hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) (IC50 of 62.23 nM).</p>Fórmula:C19H18ClN5O4Pureza:98%Cor e Forma:SolidPeso molecular:415.83PHD2-IN-1
CAS:<p>PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 of 22.53 nM and is applicable in anemia research [1].</p>Fórmula:C21H23ClN4O5Pureza:98%Cor e Forma:SolidPeso molecular:446.88
