ROR
Os receptores órfãos relacionados ao ácido retinoico (RORs) são receptores nucleares que regulam vários processos fisiológicos, incluindo ritmo circadiano, resposta imune e metabolismo. Inibidores de RORs são de grande interesse no estudo de doenças autoimunes, distúrbios metabólicos e câncer, pois podem modular a expressão gênica e influenciar as funções celulares. Na CymitQuimica, oferecemos inibidores de RORs para apoiar sua pesquisa em imunologia, endocrinologia e oncologia.
Foram encontrados 45 produtos de "ROR"
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RORγ antagonist 1
RORγ antagonist 1 (compound 22), a potent derivative of betulinic acid, acts as an antagonist to RORγ with a dissociation constant (K D) of 0.18 μM.Fórmula:C35H60N2O2Pureza:98%Cor e Forma:SolidPeso molecular:540.86RORγt inverse agonist 33
<p>RORγt inverse agonist 33 (compound (R)-D4) is an orally bioavailable RORγt inverse agonist with an IC50 of 21 nM, playing a significant role in rheumatoid arthritis research.</p>Fórmula:C27H37NO5SCor e Forma:SolidPeso molecular:487.651RORγt inverse agonist 31
RORγt inverse agonist 31 (14g) is a potent antagonist of the retinoic acid receptor-related orphan receptor γt (RORγt), exhibiting an inhibitory concentration (Fórmula:C23H15Cl2F3N4O3SPureza:98%Cor e Forma:SolidPeso molecular:555.36Bevurogant
CAS:<p>Bevurogant is an antagonist of RORγt receptor and can be used in studies about the treatment of chronic inflammatory diseases.</p>Fórmula:C26H28N8O3SPureza:99.32%Cor e Forma:SolidPeso molecular:532.62XY039
XY039 (compound 13e) is an RORγ inverse agonist with an IC50 value of 0.55 μM. XY039 induces cell apoptosis and exhibits antiproliferative activity both in vivo and in vitro.Fórmula:C23H19F5N2O4S2Peso molecular:546.07064RORγ agonist 2
RORγ agonist2 (Compound 34) is a selective RORγ agonist with an EC50 of 0.03 μM for hRORγ. It significantly inhibits tumor growth in an MC38 tumor mouse model with the same genetic background.Cor e Forma:Odour SolidROR1-IN-2
<p>ROR1-IN-2 (compound 9I) is a potent and selective inhibitor of ROR1. It exhibits antiproliferative activity in various cancer cell lines and significantly inhibits tumor growth in vivo.</p>Fórmula:C30H27N3O4Cor e Forma:SolidPeso molecular:493.20016TMP-778
CAS:TMP-778 is a selective inverse agonist of RORγt.Fórmula:C31H30N2O4Pureza:99.68%Cor e Forma:SolidPeso molecular:494.58ROR1 ligand-1
<p>ROR1ligand-1 (9-1) serves as the ligand for PROTAC ROR1 degrader-1. By linking with ligands of either the VHL type or CRBN, the first selective and efficient ROR1 PROTAC molecule was designed and synthesized.</p>Fórmula:C23H30BrN7Cor e Forma:SolidPeso molecular:484.44XY018
CAS:<p>XY018 is a ROR-γ antagonist with anti-tumor activity, inhibits ROR-γ activity, and can be used to study drug-resistant prostate cancer.</p>Fórmula:C23H15F7N2O4Pureza:99.95% - 99.96%Cor e Forma:SolidPeso molecular:516.37TMP920
CAS:TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.Fórmula:C29H30N2O3Pureza:98%Cor e Forma:SolidPeso molecular:454.56SR3335
CAS:<p>SR3335 (ML 176) is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).</p>Fórmula:C13H9F6NO3S2Pureza:99.77%Cor e Forma:SolidPeso molecular:405.34GSK805
CAS:<p>GSK805 is a potent, orally bioavailable and CNS-penetrant RORγt inhibitor.Cost-effective and quality-assured.</p>Fórmula:C23H18Cl2F3NO4SPureza:98% - ≥95%Cor e Forma:SolidPeso molecular:532.36Cintirorgon
CAS:Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.Fórmula:C27H23F6NO6SPureza:99.92%Cor e Forma:SolidPeso molecular:603.53SR1001
CAS:SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).Fórmula:C15H13F6N3O4S2Pureza:98.93%Cor e Forma:SolidPeso molecular:477.4GSK2981278
CAS:GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).Fórmula:C25H35NO5SPureza:99.31% - 99.67%Cor e Forma:SolidPeso molecular:461.61RORγt inverse agonist 13
CAS:RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1].Fórmula:C23H17Cl2F3N2O4Pureza:99.04%Cor e Forma:SolidPeso molecular:513.29Neoruscogenin
CAS:1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors.Fórmula:C27H40O4Pureza:99.5% - 99.92%Cor e Forma:SolidPeso molecular:428.60S18-000003
CAS:S18-000003: Oral retinoic acid receptor gamma-t inhibitor, IC50 29 nM, reduces IL-17 production.Fórmula:C26H25F3N2O4SPureza:99.24% - 99.31%Cor e Forma:SolidPeso molecular:518.55SR1078
CAS:SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.Fórmula:C17H10F9NO2Pureza:99.58%Cor e Forma:SolidPeso molecular:431.25T0901317
CAS:T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).Fórmula:C17H12F9NO3SPureza:98% - 99.64%Cor e Forma:SolidPeso molecular:481.33Cedirogant
CAS:<p>Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.</p>Fórmula:C24H20Cl3F3N2O3Pureza:99.20%Cor e Forma:SolidPeso molecular:547.78SR0987
CAS:<p>SR0987 is a RORγt agonist,</p>Fórmula:C16H10ClF6NO2Pureza:99.43%Cor e Forma:SolidPeso molecular:397.7Nobiletin
CAS:Nobiletin: a citrus-derived flavone with anti-inflammatory and anti-cancer properties; water-insoluble, very weak acid.Fórmula:C21H22O8Pureza:98.65% - 99.76%Cor e Forma:SolidPeso molecular:402.39XY101
CAS:XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).Fórmula:C25H20F7NO4SPureza:99.83%Cor e Forma:SolidPeso molecular:563.48TF-S14
CAS:TF-S14 is an inverse agonist of RORγt. It functions by binding to RORγt and inhibiting its activity, leading to a reduction in Th17 cell-associated cytokine production, including IL-17A, IL-21, and IL-22. TF-S14 is applicable in research related to autoimmune diseases and allogeneic transplant rejection.Fórmula:C22H27N3O2SCor e Forma:SolidPeso molecular:397.53MRL-871
CAS:MRL-871 is a selective RORγt allosteric inhibitor, reducing IL-17a mRNA production in EL4 cells, interacting with PPARgamma in partial agonistic binding modes.Fórmula:C22H12ClF3N2O3Pureza:99.66%Cor e Forma:SolidPeso molecular:444.79RORγt Inverse agonist 8
CAS:RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).Fórmula:C26H33N7O2Pureza:98%Cor e Forma:SolidPeso molecular:475.59Methyl-3β-hydroxycholenate
CAS:Methyl-3β-hydroxycholenate (Methyl 3beta-hydroxychol-5-enoate) is a modulator of RORγ.Fórmula:C25H40O3Pureza:98.78%Cor e Forma:SolidPeso molecular:388.58AZD-0284
CAS:AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].Fórmula:C21H18F6N2O5SPureza:99.82%Cor e Forma:SolidPeso molecular:524.43ML 209
CAS:<p>ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription</p>Fórmula:C25H31NO6Pureza:99.87%Cor e Forma:SolidPeso molecular:441.52SR2211
CAS:SR2211 is a specific modulator and an inverse agonist of RORγ(IC50 = 320 nM, Ki = 105 nM).Fórmula:C26H24F7N3OPureza:98.75%Cor e Forma:SolidPeso molecular:527.48RORγt inverse agonist 14
CAS:RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, exhibiting anti-inflammatory activity.Fórmula:C26H26F8N2O6S2Pureza:98%Cor e Forma:SolidPeso molecular:678.613-Oxo-5β-cholanoic acid
CAS:3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directlyFórmula:C24H38O3Pureza:98.01% - 99.86%Cor e Forma:SolidPeso molecular:374.56TMP780
CAS:TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.Fórmula:C31H30N2O4Pureza:98%Cor e Forma:SolidPeso molecular:494.58FM26
CAS:FM26, an isoxazole-based RORγt inverse agonist, cuts EL4 IL-17a mRNA; potent with 264 nM IC50.Fórmula:C22H15ClF3N3O3Pureza:98%Cor e Forma:SolidPeso molecular:461.82RORγt Inverse agonist 6
CAS:<p>RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.</p>Fórmula:C28H29ClN6O5Pureza:99.52%Cor e Forma:SolidPeso molecular:565.02TAK-828F
CAS:<p>TAK-828F: potent, selective RORγt inverse agonist. Oral. IC50=1.9 nM; reporter gene IC50=6.1 nM.</p>Fórmula:C28H32FN3O5Pureza:98%Cor e Forma:SolidPeso molecular:509.57RORγ-IN-2
CAS:<p>RORγ-IN-2 (Compound 22) is an inhibitor of RORγ, with a Ki value of 16.6 nM for hRORγ. It is useful for research in IL-17-dependent autoimmune diseases.</p>Fórmula:C28H32F3N5O4S2Cor e Forma:SolidPeso molecular:623.71RORγt inverse agonist 32
CAS:RORγt inverse agonist 32 (compound b14) exhibits oral activity and can be utilized in inflammatory research studies.Fórmula:C24H28F3NO5SCor e Forma:SolidPeso molecular:499.54JTE-151
CAS:JTE-151, a RORγ inhibitor, suppresses the overactive immune response by inhibiting RORγ, which is linked to the activation of Th17 cells. This action positions JTE-151 as a potential candidate for autoimmune disease research [1].Fórmula:C28H37ClN2O4Peso molecular:501.06RORγt inhibitor 4
CAS:<p>RORγt inhibitor 4 (Compound 9a) is an orally active RORγt inhibitor capable of penetrating the central nervous system. It has been shown to improve experimental autoimmune encephalomyelitis.</p>Fórmula:C22H16Cl2F3NO4SCor e Forma:SolidPeso molecular:518.333ROR1-IN-1
CAS:ROR1-IN-1 (Compound 19h) is an inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with a Ki of 0.10 μM. It inhibits the proliferation of cancer cell lines H1975, A549, and MDA-MB-231, with IC50 values of 0.36 μM, 1.37 μM, and 0.47 μM, respectively. In mice, ROR1-IN-1 demonstrates antitumor efficacy and exhibits favorable pharmacokinetic properties in a rat model.Fórmula:C33H27N5O3Peso molecular:541.60Vimirogant
CAS:<p>Vimirogant is a RORγ inhibitor (Ki: <100 nM).</p>Fórmula:C27H35F3N4O3SPureza:98%Cor e Forma:SolidPeso molecular:552.65RORγt inverse agonist 34
CAS:<p>RORγt inverse agonist 34 (compound 5a) is an inverse agonist for RORγt, exhibiting an IC50 of 0.094 μM for the inhibition of RORγt-LBD. This compound is utilized in psoriasis research.</p>Fórmula:C31H37N3O3SCor e Forma:SolidPeso molecular:531.709
