FAAH
A Hidrolase de Amida de Ácido Graxo (FAAH) é uma enzima que degrada amidas de ácidos graxos, incluindo endocanabinoides como a anandamida. Esses compostos estão envolvidos na regulação da dor, humor, apetite e memória. A inibição da FAAH pode aumentar os níveis dessas moléculas de sinalização, oferecendo potenciais benefícios terapêuticos para dor, ansiedade e doenças neurodegenerativas. Na CymitQuimica, oferecemos uma seleção de inibidores de FAAH para apoiar sua pesquisa em neurociência, manejo da dor e sinalização endocanabinoide.
Foram encontrados 64 produtos de "FAAH"
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OMDM-5
CAS:OMDM-5 is a potent vanilloid receptor type 1 (TRPV1, EC50 = 75 nM) agonist, showing weak ligand activity at cannabinoid type 1 receptor (CB1, Ki=4.9 μM).Fórmula:C26H44N2O3Pureza:99.73%Cor e Forma:SolidPeso molecular:432.64Ref: TM-T12306
1mg93,00€5mg177,00€1mL*10mM (DMSO)210,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.071,00€JP104
CAS:JP104 is an aryl carbamate that irreversibly inhibits fatty acid amide hydrolase (FAAH) with a pIC50 value of approximately 8 [1].Fórmula:C25H30N2O3Pureza:98%Cor e Forma:SolidPeso molecular:406.523-Decyl-5,5'-diphenyl-2-thioxo-4-imidazolidinone
CAS:3-Decyl-5,5'-diphenyl-2-thioxo-4-imidazolidinone (compound 45), having a pI50 of 5.89, shows promise as an inhibitor of fatty acid amide hydrolase (FAAH). Despite its activity, it demonstrates a lack of affinity for cannabinoid receptors CB(1) and CB(2) [1].Fórmula:C25H32N2OSCor e Forma:SolidPeso molecular:408.6PDP-EA
CAS:PDP-EA is an activator of fatty acid amide hydrolase(FAAH) and enhances the amidohydrolase activity of FAAH.Fórmula:C25H43NO3Pureza:99.59%Cor e Forma:SolidPeso molecular:405.61Ref: TM-T28353
1mL*10mM (DMSO)A consultar2mg33,00€5mg48,00€10mg75,00€25mg110,00€50mg166,00€100mg245,00€200mg353,00€NRMA-8
CAS:NRMA-8 is a small-molecule nuclear receptor modulator capable of penetrating the brain. It holds potential for research into central nervous system (CNS) diseases, including Alzheimer's disease, Parkinson's disease, demyelinating diseases, and glioblastoma.Fórmula:C20H23ClN2O3Cor e Forma:SolidPeso molecular:374.86Sob-AM2
CAS:Sob-AM2 is an effective substrate targeting the fatty acid amide hydrolase (FAAH) expressed in the brain, with a Km of 1.3 μM. It delivers higher concentrations of Sobetirome to the central nervous system at minimal peripheral systemic doses, thereby activating the central thyroid hormone receptor β (TRβ).Fórmula:C21H27NO3Cor e Forma:SolidPeso molecular:341.44FAAH/MAGL-IN-1
FAAH/MAGL-IN-1 (SIH 3) inhibits FAAH & MAGL with IC50 of 31 & 29 nM, useful in neuropathic pain research.Fórmula:C15H9Cl2N3O3Cor e Forma:SolidPeso molecular:350.16AZ513
CAS:AZ513 is a reversible FAAH inhibitor, exhibiting an IC50 of 551 nM for human FAAH and 27 nM for rat FAAH. It inhibits the hydrolysis of arachidonoyl ethanolamide in HEK293 cells transfected with human FAAH, with an IC50 of 360 nM.Fórmula:C14H9Cl2N3OCor e Forma:SolidPeso molecular:306.147MK-3168 (12C)
CAS:MK-3168 (12C) functions as a FAAH inhibitor, exhibiting IC50 values of 1.0 nM, 5.5 nM, and 1.7 nM for human, rhesus, and rat respectively. It demonstrates effective brain uptake and FAAH-specific signaling. Additionally, 11 C MK-3168 is applicable as a FAAH PET tracer.Fórmula:C21H21ClN4OSCor e Forma:SolidPeso molecular:412.94Irafamdastat
CAS:Irafamdastat (BMS-986368) [Example 74] is an inhibitor of FAAH and MAGL, with IC50 values of ≤ 100 nM for human FAAH and 100 nM-1 μM for human MAGL. It exhibits anticonvulsant properties.Fórmula:C20H21F3N4O4Cor e Forma:SolidPeso molecular:438.40FAAH/MAGL-IN-2
CAS:FAAH/MAGL-IN-2: potent, reversible, oral FAAH & MAGL inhibitor, IC50: 11/36 nM, may research neuropathic pain, no locomotion issue.Fórmula:C15H13Cl2N3O3SCor e Forma:SolidPeso molecular:386.25FAAH/MAGL-IN-3
FAAH/MAGL-IN-3 irreversibly inhibits FAAH (IC50: 179 nM) & MAGL (IC50: 759 nM) with low PAMPA permeability.Fórmula:C21H25N3O6SCor e Forma:SolidPeso molecular:447.5Dual FAAH/sEH-IN-1
CAS:Dual FAAH/sEH-IN-1 inhibits both sEH (IC50: 9.6 nM) and FAAH (IC50: 7 nM), offering potent anti-inflammatory effects.
Fórmula:C25H22ClN3O3S2Pureza:99.89%Cor e Forma:SolidPeso molecular:512.04TC-F 2
CAS:TC-F 2 is a FAAH inhibitor.Fórmula:C26H25N5O2Pureza:98%Cor e Forma:SolidPeso molecular:439.51
