NAMPT
A nicotinamida fosforribosiltransferase (NAMPT) é uma enzima envolvida na biossíntese de nicotinamida adenina dinucleotídeo (NAD+), uma coenzima crítica no metabolismo celular e na produção de energia. Os inibidores de NAMPT são de grande interesse na pesquisa do câncer devido à sua capacidade de interromper o metabolismo do NAD+ e induzir a morte celular em células cancerígenas. Esses inibidores também são explorados no contexto de distúrbios metabólicos e envelhecimento. Na CymitQuimica, oferecemos inibidores de NAMPT para apoiar sua pesquisa em biologia do câncer, metabolismo e envelhecimento.
Foram encontrados 40 produtos de "NAMPT"
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SBI-797812
CAS:SBI-797812 is structurally similar to active-site directed inhibitor of NAMPT(NAMPT with EC50 of 0.37 μM).Fórmula:C19H22N4O4SPureza:99.31%Cor e Forma:SolidPeso molecular:402.47Nampt-IN-5
CAS:Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .Fórmula:C25H25N5O2Pureza:99.30%Cor e Forma:SolidPeso molecular:427.5Nampt activator-1
CAS:<p>NAMPT Activator-1, EC50: 3.3-3.7 µM, specific niacinamide phosphotransferase stimulant, shields cells, potential neuroprotectant.</p>Fórmula:C16H17N3O3Pureza:99.84% - 99.98%Cor e Forma:SoildPeso molecular:299.32ALT-100 (Human IgG1)
<p>ALT-100 (HumanIgG1) is a human-derived IgG1 monoclonal antibody that targets NAMPT. For its isotype control, please refer to HumanIgG1kappa, Isotype Control.</p>Cor e Forma:Odour LiquidNampt-IN-10 trihydrochloride
Nampt-IN-10 trihydrochloride, a NAMPT inhibitor, is effective on A2780 & CORL23 cells (IC50: 5/19 nM); potential ADC payload.Fórmula:C27H31Cl3FN5O2Cor e Forma:SolidPeso molecular:582.92Nampt degrader-2
Nampt degrader-2: a fluorescent PROTAC that degrades NAMPT at IC50 41.9 nM, reducing NAD+ and having anti-tumor effects.Fórmula:C59H73N9O7SCor e Forma:SolidPeso molecular:1052.33NAMPT degrader-3
NAMPT Degrader-3 (compound C5) is a NAMPT degrader that functions through a VHL- and proteasome-dependent mechanism.Fórmula:C56H74N8O7SPureza:98%Cor e Forma:SolidPeso molecular:1003.3PROTAC NAMPT Degrader-1
<p>PROTACNAMPT Degrader-1 is an effective NAMPT-targeting PROTAC with a DC50 value of 217 nM. It exhibits antiproliferative activity, with an IC50 value of 0.12 μM against A2780 cells.</p>Fórmula:C57H69N13O8S2Peso molecular:1127.48335LYP-8
<p>LYP-8 is a potent NAMPT degrader that achieves a maximum degradation rate of 97% in NAMPT within SKOV-3 cells at a concentration of 0.5 μM. LYP-8 also demonstrates anticancer activity both in vitro and in vivo.</p>Fórmula:C56H74N8O10SPeso molecular:1050.52486NAMPT activator-7
NAMPTactivator-7 (Compound 232) is an activator of nicotinamide phosphoribosyltransferase (NAMPT) with an EC50 of less than 0.5 μM. It effectively stimulates NAMPT in U2OS cells, demonstrating a cellular EC50 of less than 0.5 μM.Fórmula:C21H17ClN4O3Peso molecular:408.09892Nampt-IN-13 FA
Nampt-IN-13 FA is a NAMPT inhibitor (patent WO2021013693A1) suitable for synthesising antibody-drug conjugates (ADCs).Fórmula:C25H32N6O4Pureza:99.06%Peso molecular:480.56CB 300919
CAS:CB 300919, a quinazoline antitumor, inhibits CH1 ovarian tumor growth (IC50: 2 nM) over 96h.Fórmula:C32H34ClN7O2Cor e Forma:SolidPeso molecular:584.11NAMPT Protein, Human, Recombinant (His)
Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, butPureza:94% - 94%Cor e Forma:Lyophilized PowderPeso molecular:55 KDa (reducing condition)NAT
CAS:NAT is a nicotinamide phosphoribosyltransferase (NAMPT) activator that increases intracellular NAD levels.Fórmula:C18H21NO3Pureza:99.65%Cor e Forma:SolidPeso molecular:299.36(E)-Daporinad
CAS:(E)-Daporinad (FK866) is a highly specific, non-competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT） .Cost-effective and quality-assured.Fórmula:C24H29N3O2Pureza:98.44% - >99.99%Cor e Forma:SolidPeso molecular:391.51Nampt-IN-1
CAS:Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.Fórmula:C20H25N3O5SPureza:99.28% - 99.4%Cor e Forma:SolidPeso molecular:419.49GNE-617 hydrochloride
CAS:GNE-617 hydrochloride is a specific inhibitor of NAMPT and inhibits NAMPT activity (IC50: 5 nM).Fórmula:C21H16ClF2N3O3SCor e Forma:SolidPeso molecular:463.88KPT9274
CAS:KPT9274 (PAK4-IN-1) is a non-competitive dual inhibitor of PAK4 and NAMPT(IC50= ~120 nM). It is an orally bioavailable small molecule.Fórmula:C35H29F3N4O3Pureza:99.75% - 99.93%Cor e Forma:SolidPeso molecular:610.62STF-118804
CAS:STF-118804 is a highly specific NAMPT inhibitor; reduces the viability of most B-ALL cell lines with IC50 <10 nM.Fórmula:C25H23N3O4SPureza:98.66%Cor e Forma:SolidPeso molecular:461.53LB-60-OF61 hydrochloride
CAS:LB-60-OF61 hydrochloride is a potent NAMPT enzyme inhibitor with cytotoxic effects, targeting MYC-overexpressing cell lines.Fórmula:C29H31ClN6O2Cor e Forma:SolidPeso molecular:531.06CHS-828
CAS:CHS-828 (GMX1778), a pyridyl cyanoguanidine, is an effective inhibitor of NAD+ biosynthesis enzyme NAMPT (IC50 <25 nM).Fórmula:C19H22ClN5OPureza:98% - 99.9%Cor e Forma:SolidPeso molecular:371.86GNE-617
CAS:GNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer.Fórmula:C21H15F2N3O3SPureza:99.28% - 99.71%Cor e Forma:SolidPeso molecular:427.42Nampt-IN-12
CAS:Nampt-IN-12 (compound 9), a derivative of N-Pyridinylthiophene carboxamid, exhibits activity against peripheral nerve sheath cancer cells. It is metabolized by the enzymes NAMPT and NMNAT1 within the NAD salvage pathway into an adenine dinucleotide (AD) derivative, an analog of NAD that can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) within the cells. Nampt-IN-12's effective blood-brain barrier permeability makes it suitable for research into cancers of the central and peripheral nervous system.Fórmula:C10H8N2OSPeso molecular:204.25Nampt-IN-9
CAS:Nampt-IN-9 (Compound 8) is a potent inhibitor of NAMPT with anticancer properties.Nampt-IN-9 can be used to study ductal adenocarcinoma of the pancreas.Fórmula:C26H33N3O4Cor e Forma:SolidPeso molecular:451.56Teglarinad chloride
CAS:<p>Teglarinad chloride (GMX-1777 chloride) is an inhibitor of NAMPT with antitumor activity that acts by interfering with DNA repair and inhibiting angiogenesis.</p>Fórmula:C30H43Cl2N5O8Pureza:98.09%Cor e Forma:SolidPeso molecular:672.6Nampt-IN-7
CAS:Nampt-IN-7 (GF8) inhibits NAMPT (IC50: 7.31 μM) and kills HepG2 cells (IC50: 24.28 μM).Fórmula:C20H21N5O3Cor e Forma:SolidPeso molecular:379.41A-1293201
CAS:A-1293201 is a potent and selective NAMPT inhibitor.Fórmula:C21H23N3O3Cor e Forma:SolidPeso molecular:365.43Nampt activator-3
CAS:NAMPT activator-3: a NAT derivative, EC50 of 2.6 μM, KD 132 nM, protects cells, prevents FK866 toxicity, and is neuroprotective in CIPN mice.Fórmula:C19H20N2O3Cor e Forma:SolidPeso molecular:324.37Nampt activator-2
CAS:Nampt activator-2: Potent NAMPT activator (EC50: 0.023 μM), binds CYP2C9 (0.060 μM), 2D6 (0.41 μM), 2C19 (0.59 μM); useful in metabolic disease research.Fórmula:C17H15ClN4O3SPureza:98.59% - 98.88%Cor e Forma:SolidPeso molecular:390.84GNE-618
CAS:GNE-618 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (IC50: 6 nM).Fórmula:C21H15F3N4O3SCor e Forma:SolidPeso molecular:460.43Nampt-IN-10 TFA
CAS:Nampt-IN-10 TFA, a NAMPT inhibitor, shows potency in A2780 (IC50: 5 nM) and CORL23 (IC50: 19 nM), suitable for ADC payloads.Fórmula:C29H29F4N5O4Cor e Forma:SolidPeso molecular:587.21557LB-60-OF61
CAS:<p>LB-60-OF61 is a NAMPT inhibitor, a NAMPT inhibitor that displays antiproliferative activity against MYC oncogene-dependent cancer cell lines.</p>Fórmula:C29H30N6O2Pureza:99.47%Cor e Forma:SolidPeso molecular:494.59JGB-1-155
CAS:JGB-1-155, serving as a positive allosteric modulator (N-PAMs), effectively enhances the activity of nicotinamide phosphoribosyltransferase (NAMPT) with an EC 50 of 3.29 μM. It mitigates oxidative stress by elevating NAD+ levels in THP-1 human monocytes and reduces TNFα-induced reactive oxygen species (ROS) in HT-22 cells [1].Fórmula:C26H38N2O3Cor e Forma:SolidPeso molecular:426.59Nampt activator-4
CAS:Nampt activator-4, a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT), has an EC50 of 0.058 μM and can enhance nicotinamide adenine dinucleotide (NAD+) levels in cells [1].Fórmula:C26H22F3N7OSCor e Forma:SolidPeso molecular:537.56Nampt-IN-15
CAS:Nampt-IN-15 (Example 3) is a Nampt inhibitor that exhibits cytotoxic effects on various cell lines, including BxPC-3, HepG2, L540cy, and MOLM-13. The respective IC50 values for these cell lines are 38.5 nM, 8 nM, 8.5 nM, and 7 nM.Fórmula:C24H30N4O2Cor e Forma:SolidPeso molecular:406.52PD-L1/Nampt-IN-1
CAS:PD-L1/Nampt-IN-1 is an orally active inhibitor that targets both PD-L1 and NAMPT (nicotinamide phosphoribosyltransferase), with IC50 values of 63 nM and 582 nM, respectively. It exhibits cross-species affinity, with KD values of 52.6 nM for hPD-L1 and 49.1 nM for mPD-L1. This compound effectively suppresses tumor growth by activating the tumor immune microenvironment and is applicable in melanoma research.Fórmula:C28H28N4O2Cor e Forma:SolidPeso molecular:452.55Nampt-IN-14
CAS:Nampt-IN-14 (example 3) is an effective NAMPT inhibitor with an IC50 of 0.2 nM, suited for use in the synthesis of antibody-drug conjugates (ADCs).Fórmula:C33H35N7O2Cor e Forma:SolidPeso molecular:561.68Nampt-IN-13
CAS:Nampt-IN-13 (example 58m) is an NAMPT inhibitor used in the synthesis of antibody-drug conjugates (ADCs).Fórmula:C24H30N6O2Cor e Forma:SolidPeso molecular:434.53CB30865
CAS:CB30865 (ZM 242421) is a selective and highly effective nicotinamide phosphoribosyltransferase (Nampt) inhibitor with potential antitumor activity.Fórmula:C26H22BrN5O2Pureza:99.04%Cor e Forma:SolidPeso molecular:516.39NAMPT activator-6
CAS:<p>NAMPT activator-6, a regulatory molecule for the optical control system of NAMPT and NAD+, can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) for light-dependent, reversible regulation of NAMPT and NAD+, thereby reducing toxicity associated with inhibitor-based PS-PROTACs. This enables antitumor activity and in vivo modulation of NAMPT and NAD+ through optical manipulation [1].</p>Fórmula:C17H21N5O3SCor e Forma:SolidPeso molecular:375.45
