NAMPT
A nicotinamida fosforribosiltransferase (NAMPT) é uma enzima envolvida na biossíntese de nicotinamida adenina dinucleotídeo (NAD+), uma coenzima crítica no metabolismo celular e na produção de energia. Os inibidores de NAMPT são de grande interesse na pesquisa do câncer devido à sua capacidade de interromper o metabolismo do NAD+ e induzir a morte celular em células cancerígenas. Esses inibidores também são explorados no contexto de distúrbios metabólicos e envelhecimento. Na CymitQuimica, oferecemos inibidores de NAMPT para apoiar sua pesquisa em biologia do câncer, metabolismo e envelhecimento.
Foram encontrados 36 produtos de "NAMPT"
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SBI-797812
CAS:<p>SBI-797812 is structurally similar to active-site directed inhibitor of NAMPT(NAMPT with EC50 of 0.37 μM).</p>Fórmula:C19H22N4O4SPureza:99.31%Cor e Forma:SolidPeso molecular:402.47Nampt-IN-5
CAS:<p>Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .</p>Fórmula:C25H25N5O2Pureza:99.30%Cor e Forma:SolidPeso molecular:427.5Nampt activator-1
CAS:<p>NAMPT Activator-1, EC50: 3.3-3.7 µM, specific niacinamide phosphotransferase stimulant, shields cells, potential neuroprotectant.</p>Fórmula:C16H17N3O3Pureza:99.84% - 99.98%Cor e Forma:SoildPeso molecular:299.32CB 300919
CAS:<p>CB 300919, a quinazoline antitumor, inhibits CH1 ovarian tumor growth (IC50: 2 nM) over 96h.</p>Fórmula:C32H34ClN7O2Cor e Forma:SolidPeso molecular:584.11NAMPT degrader-3
<p>NAMPT Degrader-3 (compound C5) is a NAMPT degrader that functions through a VHL- and proteasome-dependent mechanism.</p>Fórmula:C56H74N8O7SPureza:98%Cor e Forma:SolidPeso molecular:1003.3Nampt degrader-2
<p>Nampt degrader-2: a fluorescent PROTAC that degrades NAMPT at IC50 41.9 nM, reducing NAD+ and having anti-tumor effects.</p>Fórmula:C59H73N9O7SCor e Forma:SolidPeso molecular:1052.33NAMPT activator-7
<p>NAMPTactivator-7 (Compound 232) is an activator of nicotinamide phosphoribosyltransferase (NAMPT) with an EC50 of less than 0.5 μM. It effectively stimulates NAMPT in U2OS cells, demonstrating a cellular EC50 of less than 0.5 μM.</p>Fórmula:C21H17ClN4O3Peso molecular:408.09892Nampt-IN-10 trihydrochloride
<p>Nampt-IN-10 trihydrochloride, a NAMPT inhibitor, is effective on A2780 & CORL23 cells (IC50: 5/19 nM); potential ADC payload.</p>Fórmula:C27H31Cl3FN5O2Cor e Forma:SolidPeso molecular:582.92LYP-8
<p>LYP-8 is a potent NAMPT degrader that achieves a maximum degradation rate of 97% in NAMPT within SKOV-3 cells at a concentration of 0.5 μM. LYP-8 also demonstrates anticancer activity both in vitro and in vivo.</p>Fórmula:C56H74N8O10SPeso molecular:1050.52486PROTAC NAMPT Degrader-1
<p>PROTACNAMPT Degrader-1 is an effective NAMPT-targeting PROTAC with a DC50 value of 217 nM. It exhibits antiproliferative activity, with an IC50 value of 0.12 μM against A2780 cells.</p>Fórmula:C57H69N13O8S2Peso molecular:1127.48335ALT-100 (Human IgG1)
<p>ALT-100 (HumanIgG1) is a human-derived IgG1 monoclonal antibody that targets NAMPT. For its isotype control, please refer to HumanIgG1kappa, Isotype Control.</p>Cor e Forma:Odour LiquidNAMPT Protein, Human, Recombinant (His)
<p>Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but</p>Pureza:94% - 94%Cor e Forma:Lyophilized PowderPeso molecular:55 KDa (reducing condition)NAT
CAS:<p>NAT is a nicotinamide phosphoribosyltransferase (NAMPT) activator that increases intracellular NAD levels.</p>Fórmula:C18H21NO3Pureza:99.65%Cor e Forma:SolidPeso molecular:299.36CHS-828
CAS:<p>CHS-828 (GMX1778), a pyridyl cyanoguanidine, is an effective inhibitor of NAD+ biosynthesis enzyme NAMPT (IC50 <25 nM).</p>Fórmula:C19H22ClN5OPureza:98% - 99.9%Cor e Forma:SolidPeso molecular:371.86STF-118804
CAS:<p>STF-118804 is a highly specific NAMPT inhibitor; reduces the viability of most B-ALL cell lines with IC50 <10 nM.</p>Fórmula:C25H23N3O4SPureza:98.66%Cor e Forma:SolidPeso molecular:461.53GNE-617
CAS:<p>GNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer.</p>Fórmula:C21H15F2N3O3SPureza:99.28% - 99.71%Cor e Forma:SolidPeso molecular:427.42LB-60-OF61 hydrochloride
CAS:<p>LB-60-OF61 hydrochloride is a potent NAMPT enzyme inhibitor with cytotoxic effects, targeting MYC-overexpressing cell lines.</p>Fórmula:C29H31ClN6O2Cor e Forma:SolidPeso molecular:531.06KPT9274
CAS:<p>KPT9274 (PAK4-IN-1) is a non-competitive dual inhibitor of PAK4 and NAMPT(IC50= ~120 nM). It is an orally bioavailable small molecule.</p>Fórmula:C35H29F3N4O3Pureza:99.75% - 99.93%Cor e Forma:SolidPeso molecular:610.62GNE-617 hydrochloride
CAS:<p>GNE-617 hydrochloride is a specific inhibitor of NAMPT and inhibits NAMPT activity (IC50: 5 nM).</p>Fórmula:C21H16ClF2N3O3SCor e Forma:SolidPeso molecular:463.88Nampt-IN-1
CAS:<p>Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.</p>Fórmula:C20H25N3O5SPureza:99.28% - 99.4%Cor e Forma:SolidPeso molecular:419.49(E)-Daporinad
CAS:<p>(E)-Daporinad (FK866) is a highly specific, non-competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT） .Cost-effective and quality-assured.</p>Fórmula:C24H29N3O2Pureza:98.44% - >99.99%Cor e Forma:SolidPeso molecular:391.51Nampt-IN-9
CAS:<p>Nampt-IN-9 (Compound 8) is a potent inhibitor of NAMPT with anticancer properties.Nampt-IN-9 can be used to study ductal adenocarcinoma of the pancreas.</p>Fórmula:C26H33N3O4Cor e Forma:SolidPeso molecular:451.56Nampt-IN-7
CAS:<p>Nampt-IN-7 (GF8) inhibits NAMPT (IC50: 7.31 μM) and kills HepG2 cells (IC50: 24.28 μM).</p>Fórmula:C20H21N5O3Cor e Forma:SolidPeso molecular:379.41Nampt activator-3
CAS:<p>NAMPT activator-3: a NAT derivative, EC50 of 2.6 μM, KD 132 nM, protects cells, prevents FK866 toxicity, and is neuroprotective in CIPN mice.</p>Fórmula:C19H20N2O3Cor e Forma:SolidPeso molecular:324.37A-1293201
CAS:<p>A-1293201 is a potent and selective NAMPT inhibitor.</p>Fórmula:C21H23N3O3Cor e Forma:SolidPeso molecular:365.43Teglarinad chloride
CAS:<p>Teglarinad chloride (GMX-1777 chloride) is an inhibitor of NAMPT with antitumor activity that acts by interfering with DNA repair and inhibiting angiogenesis.</p>Fórmula:C30H43Cl2N5O8Pureza:98.09%Cor e Forma:SolidPeso molecular:672.6LB-60-OF61
CAS:<p>LB-60-OF61 is a NAMPT inhibitor, a NAMPT inhibitor that displays antiproliferative activity against MYC oncogene-dependent cancer cell lines.</p>Fórmula:C29H30N6O2Pureza:99.47%Cor e Forma:SolidPeso molecular:494.59JGB-1-155
CAS:<p>JGB-1-155, serving as a positive allosteric modulator (N-PAMs), effectively enhances the activity of nicotinamide phosphoribosyltransferase (NAMPT) with an EC 50 of 3.29 μM. It mitigates oxidative stress by elevating NAD+ levels in THP-1 human monocytes and reduces TNFα-induced reactive oxygen species (ROS) in HT-22 cells [1].</p>Fórmula:C26H38N2O3Cor e Forma:SolidPeso molecular:426.59Nampt-IN-10 TFA
CAS:<p>Nampt-IN-10 TFA, a NAMPT inhibitor, shows potency in A2780 (IC50: 5 nM) and CORL23 (IC50: 19 nM), suitable for ADC payloads.</p>Fórmula:C29H29F4N5O4Cor e Forma:SolidPeso molecular:587.21557GNE-618
CAS:<p>GNE-618 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (IC50: 6 nM).</p>Fórmula:C21H15F3N4O3SCor e Forma:SolidPeso molecular:460.43NAMPT activator-6
CAS:<p>NAMPT activator-6, a regulatory molecule for the optical control system of NAMPT and NAD+, can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) for light-dependent, reversible regulation of NAMPT and NAD+, thereby reducing toxicity associated with inhibitor-based PS-PROTACs. This enables antitumor activity and in vivo modulation of NAMPT and NAD+ through optical manipulation [1].</p>Fórmula:C17H21N5O3SCor e Forma:SolidPeso molecular:375.45Nampt activator-4
CAS:<p>Nampt activator-4, a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT), has an EC50 of 0.058 μM and can enhance nicotinamide adenine dinucleotide (NAD+) levels in cells [1].</p>Fórmula:C26H22F3N7OSCor e Forma:SolidPeso molecular:537.56CB30865
CAS:<p>CB30865 (ZM 242421) is a selective and highly effective nicotinamide phosphoribosyltransferase (Nampt) inhibitor with potential antitumor activity.</p>Fórmula:C26H22BrN5O2Pureza:99.04%Cor e Forma:SolidPeso molecular:516.39Nampt-IN-15
CAS:<p>Nampt-IN-15 (Example 3) is a Nampt inhibitor that exhibits cytotoxic effects on various cell lines, including BxPC-3, HepG2, L540cy, and MOLM-13. The respective IC50 values for these cell lines are 38.5 nM, 8 nM, 8.5 nM, and 7 nM.</p>Fórmula:C24H30N4O2Cor e Forma:SolidPeso molecular:406.52Nampt-IN-13
CAS:<p>Nampt-IN-13 (example 58m) is an NAMPT inhibitor used in the synthesis of antibody-drug conjugates (ADCs).</p>Fórmula:C24H30N6O2Cor e Forma:SolidPeso molecular:434.53Nampt-IN-14
CAS:<p>Nampt-IN-14 (example 3) is an effective NAMPT inhibitor with an IC50 of 0.2 nM, suited for use in the synthesis of antibody-drug conjugates (ADCs).</p>Fórmula:C33H35N7O2Cor e Forma:SolidPeso molecular:561.68
