NAMPT
A nicotinamida fosforribosiltransferase (NAMPT) é uma enzima envolvida na biossíntese de nicotinamida adenina dinucleotídeo (NAD+), uma coenzima crítica no metabolismo celular e na produção de energia. Os inibidores de NAMPT são de grande interesse na pesquisa do câncer devido à sua capacidade de interromper o metabolismo do NAD+ e induzir a morte celular em células cancerígenas. Esses inibidores também são explorados no contexto de distúrbios metabólicos e envelhecimento. Na CymitQuimica, oferecemos inibidores de NAMPT para apoiar sua pesquisa em biologia do câncer, metabolismo e envelhecimento.
Foram encontrados 36 produtos de "NAMPT"
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(E)-Daporinad
CAS:<p>(E)-Daporinad (FK866) is a highly specific, non-competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT） .Cost-effective and quality-assured.</p>Fórmula:C24H29N3O2Pureza:98.44% - >99.99%Cor e Forma:SolidPeso molecular:391.51Nampt-IN-9
CAS:<p>Nampt-IN-9 (Compound 8) is a potent inhibitor of NAMPT with anticancer properties.Nampt-IN-9 can be used to study ductal adenocarcinoma of the pancreas.</p>Fórmula:C26H33N3O4Cor e Forma:SolidPeso molecular:451.56Nampt-IN-7
CAS:<p>Nampt-IN-7 (GF8) inhibits NAMPT (IC50: 7.31 μM) and kills HepG2 cells (IC50: 24.28 μM).</p>Fórmula:C20H21N5O3Cor e Forma:SolidPeso molecular:379.41Nampt activator-3
CAS:<p>NAMPT activator-3: a NAT derivative, EC50 of 2.6 μM, KD 132 nM, protects cells, prevents FK866 toxicity, and is neuroprotective in CIPN mice.</p>Fórmula:C19H20N2O3Cor e Forma:SolidPeso molecular:324.37A-1293201
CAS:<p>A-1293201 is a potent and selective NAMPT inhibitor.</p>Fórmula:C21H23N3O3Cor e Forma:SolidPeso molecular:365.43Teglarinad chloride
CAS:<p>Teglarinad chloride (GMX-1777 chloride) is an inhibitor of NAMPT with antitumor activity that acts by interfering with DNA repair and inhibiting angiogenesis.</p>Fórmula:C30H43Cl2N5O8Pureza:98.09%Cor e Forma:SolidPeso molecular:672.6LB-60-OF61
CAS:<p>LB-60-OF61 is a NAMPT inhibitor, a NAMPT inhibitor that displays antiproliferative activity against MYC oncogene-dependent cancer cell lines.</p>Fórmula:C29H30N6O2Pureza:99.47%Cor e Forma:SolidPeso molecular:494.59JGB-1-155
CAS:<p>JGB-1-155, serving as a positive allosteric modulator (N-PAMs), effectively enhances the activity of nicotinamide phosphoribosyltransferase (NAMPT) with an EC 50 of 3.29 μM. It mitigates oxidative stress by elevating NAD+ levels in THP-1 human monocytes and reduces TNFα-induced reactive oxygen species (ROS) in HT-22 cells [1].</p>Fórmula:C26H38N2O3Cor e Forma:SolidPeso molecular:426.59Nampt-IN-10 TFA
CAS:<p>Nampt-IN-10 TFA, a NAMPT inhibitor, shows potency in A2780 (IC50: 5 nM) and CORL23 (IC50: 19 nM), suitable for ADC payloads.</p>Fórmula:C29H29F4N5O4Cor e Forma:SolidPeso molecular:587.21557GNE-618
CAS:<p>GNE-618 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (IC50: 6 nM).</p>Fórmula:C21H15F3N4O3SCor e Forma:SolidPeso molecular:460.43NAMPT activator-6
CAS:<p>NAMPT activator-6, a regulatory molecule for the optical control system of NAMPT and NAD+, can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) for light-dependent, reversible regulation of NAMPT and NAD+, thereby reducing toxicity associated with inhibitor-based PS-PROTACs. This enables antitumor activity and in vivo modulation of NAMPT and NAD+ through optical manipulation [1].</p>Fórmula:C17H21N5O3SCor e Forma:SolidPeso molecular:375.45Nampt activator-4
CAS:<p>Nampt activator-4, a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT), has an EC50 of 0.058 μM and can enhance nicotinamide adenine dinucleotide (NAD+) levels in cells [1].</p>Fórmula:C26H22F3N7OSCor e Forma:SolidPeso molecular:537.56CB30865
CAS:<p>CB30865 (ZM 242421) is a selective and highly effective nicotinamide phosphoribosyltransferase (Nampt) inhibitor with potential antitumor activity.</p>Fórmula:C26H22BrN5O2Pureza:99.04%Cor e Forma:SolidPeso molecular:516.39Nampt-IN-15
CAS:<p>Nampt-IN-15 (Example 3) is a Nampt inhibitor that exhibits cytotoxic effects on various cell lines, including BxPC-3, HepG2, L540cy, and MOLM-13. The respective IC50 values for these cell lines are 38.5 nM, 8 nM, 8.5 nM, and 7 nM.</p>Fórmula:C24H30N4O2Cor e Forma:SolidPeso molecular:406.52Nampt-IN-13
CAS:<p>Nampt-IN-13 (example 58m) is an NAMPT inhibitor used in the synthesis of antibody-drug conjugates (ADCs).</p>Fórmula:C24H30N6O2Cor e Forma:SolidPeso molecular:434.53Nampt-IN-14
CAS:<p>Nampt-IN-14 (example 3) is an effective NAMPT inhibitor with an IC50 of 0.2 nM, suited for use in the synthesis of antibody-drug conjugates (ADCs).</p>Fórmula:C33H35N7O2Cor e Forma:SolidPeso molecular:561.68
