FXR
O Receptor Farnesoide X (FXR) é um receptor nuclear que desempenha um papel crucial na regulação da homeostase dos ácidos biliares, do metabolismo dos lipídios e da regulação da glicose. O FXR é um alvo terapêutico potencial para o tratamento de doenças hepáticas, distúrbios metabólicos e doenças cardiovasculares. Os inibidores de FXR podem modular essas vias, oferecendo insights sobre os mecanismos de doenças e estratégias terapêuticas. Na CymitQuimica, oferecemos uma variedade de inibidores de FXR para apoiar sua pesquisa em hepatologia, metabolismo e desenvolvimento de medicamentos.
Foram encontrados 62 produtos de "FXR"
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Chenodeoxycholic acid
CAS:Chenodeoxycholic acid (CDCA) is a bile acid that inhibits 11β-HSD2 with an IC50 value of 22 mM. High-Quality, Low-Cost!
Fórmula:C24H40O4Pureza:99.70% - 99.93%Cor e Forma:White - Almost White Solid PowderPeso molecular:392.57LY2562175
CAS:LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).Fórmula:C28H27Cl2N3O4Pureza:99.16% - 99.78%Cor e Forma:SolidPeso molecular:540.44Ref: TM-T15806
1mg99,00€5mg215,00€10mg349,00€25mg700,00€50mg1.108,00€100mg1.485,00€200mg2.008,00€1mL*10mM (DMSO)255,00€Ursodeoxycholic acid
CAS:Ursodeoxycholic acid (UDCA) is a potent inhibitor of liver-specific fatty acid transporter 5 (FATP5),inhibits cholesterol absorption. High-Quality, Low-Cost!Fórmula:C24H40O4Pureza:99.74% - ≥95%Cor e Forma:White - Almost White Solid PowderPeso molecular:392.57Alismanol M
CAS:Alismanol M: FXR agonist, EC50 of 50.25 μM, from Alisma orientale, for cholestasis & NASH research.Fórmula:C30H48O6Cor e Forma:SolidPeso molecular:504.7Tauro-β-muricholic acid sodium
CAS:Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).Fórmula:C26H44NNaO7SPureza:98%Cor e Forma:SolidPeso molecular:537.69Nuclear Receptor Compound Library
A unique collection of 531 nuclear receptor signaling targeted compounds for high throughput and high content screening;
Cor e Forma:Odour SolidF44-A13
CAS:F44-A13 is an orally active, highly selective farnesoid X receptor (FXR) antagonist with an IC50 value of 1.1 μM. It optimizes cholesterol metabolism and reduces activity by inducing CYP7A1 expression, lowering cholesterol, triglycerides, and low-density lipoprotein cholesterol (LDL-C) levels in mouse models. F44-A13 is applicable for studying metabolic diseases associated with lipid disorders [1].Fórmula:C28H40N4O5SPeso molecular:544.71Fexarene
CAS:Fexarene is a non-steroidal FXR agonist.Fórmula:C32H33NO3Pureza:98%Cor e Forma:SolidPeso molecular:479.62FXR/TGR5 agonist 1
CAS:FXR/TGR5 agonist 1 acts as an agonist on both FXR and TGR5 receptors and is utilized for treating fatty liver disease.Fórmula:C31H32ClN3O3Cor e Forma:SolidPeso molecular:530.07FXR antagonist 2
CAS:Compound A-26, a diarylamide FXR blocker, may aid hyperlipidemia and diabetes type 2 research.Fórmula:C22H26Cl2N2O2Cor e Forma:SolidPeso molecular:421.36LH10
LH10 is an FXR agonist based on fexaramine, with an EC50 of 0.14 μM. It offers hepatoprotective effects, mitigating conditions such as cholestasis induced by alpha naphthylisothiocyanate (ANIT), acute liver injury caused by APAP, and non-alcoholic steatohepatitis (NASH).Fórmula:C34H33N3O2Cor e Forma:SolidPeso molecular:515.64FXR agonist 10
FXR agonist10 (Compound 27) acts as an agonist for FXR with an EC50 of 14.26 μM. It increases the expression of SHP and BSEP proteins while decreasing the expression of NTCP and CYP7A1 proteins. Additionally, FXR agonist10 has been shown to ameliorate ANIT-induced cholestasis in mouse models.Fórmula:C15H22O4Cor e Forma:SolidPeso molecular:266.33FXR agonist 5
CAS:FXR agonist 5 is an FXR agonist used in the study of liver diseases or diseases mediated by metabolic inflammation.Fórmula:C40H53N5O5Pureza:99.74%Cor e Forma:SolidPeso molecular:683.88ZLY28
ZLY28 is a novel, first-in-class compound with specific intestinal restriction and oral activity, serving as a dual modulator of FXR and FABP1.Fórmula:C29H23Cl2NO4Pureza:98%Cor e Forma:SolidPeso molecular:520.4FXR agonist 11
CAS:FXR agonist11 (Compound 14) is an FXR activator with an EC50 of 1.2 μM and a maximal effect of 73.7%. It significantly increases GSH levels in the liver and is used to study drug-induced liver injury.Fórmula:C18H16N2O5Cor e Forma:SolidPeso molecular:340.33LZ-007
CAS:LZ-007 is an agonist of the Farnesoid X receptor (FXR), with an EC50 of 51 nM as determined by TR-FRET assay, and an EC50 of 76 nM in HepG2 cells. It exhibits favorable pharmacokinetic properties in SD rats and can improve metabolic dysfunction-associated steatohepatitis induced by high-fat diets and CCl4 in mice.Fórmula:C27H29F3N2O5Cor e Forma:SolidPeso molecular:518.53NR1H4 Protein, Mouse, Recombinant (His)
NR1H4 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 27.80 kDa.Cor e Forma:Lyophilized PowderPeso molecular:27.80 kDa (predicted)Ref: TM-TMPY-06756
5µg109,00€10µg174,00€20µg289,00€50µg576,00€100µg1.017,00€200µg1.718,00€500µg4.207,00€NR1H4 Protein, Human, Recombinant (His)
NR1H4 Protein, Human, Recombinant (His) is expressed in E.Cor e Forma:Lyophilized PowderPeso molecular:27.83 kDa (predicted)Ref: TM-TMPY-06768
5µg110,00€10µg177,00€20µg289,00€50µg576,00€100µg1.007,00€200µg1.700,00€500µg3.631,00€NDB
CAS:NDB is a hFXRα antagonist that inhibits GW4064-stimulated FXR/RXR interactions in primary mouse hepatocytes.NDB is used in the study of diabetes.Fórmula:C26H28Cl2N2O2Pureza:98.94%Cor e Forma:SolidPeso molecular:471.42FXR agonist 3
FXR agonist 3 is an anti NASH compound with anti-fibrotic and active properties that inhibits the expression of COL1A1, TGF-β1, α-SMA and TIMP1.Fórmula:C28H28BrNO4Pureza:95.04%Cor e Forma:SolidPeso molecular:521.12Turofexorate Isopropyl
CAS:Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM
Fórmula:C25H24F2N2O3Pureza:98.55% - 99.73%Cor e Forma:SolidPeso molecular:438.47Tauro-Obeticholic acid
CAS:Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).Fórmula:C28H49NO6SPureza:99.74% - 99.82%Cor e Forma:SolidPeso molecular:527.76Ref: TM-T13092
1mg111,00€5mg260,00€10mg393,00€25mg650,00€50mg888,00€100mg1.243,00€1mL*10mM (DMSO)331,00€Ursodeoxycholic acid sodium
CAS:Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities.
Fórmula:C24H40NaO4Pureza:99.66% - 99.96%Cor e Forma:SolidPeso molecular:415.56GW 4064
CAS:GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).Fórmula:C28H22Cl3NO4Pureza:98% - 99.94%Cor e Forma:SolidPeso molecular:542.84Ref: TM-T2233
5mg52,00€10mg79,00€25mg132,00€50mg222,00€100mg403,00€200mg605,00€500mg954,00€1mL*10mM (DMSO)59,00€Obeticholic Acid
CAS:Obeticholic Acid (6-ECDCA, INT-747) is a high-affinity, semisynthetic, bile acid-derived FXR agonist.Cost-effective and quality-assured.Fórmula:C26H44O4Pureza:99.88% - 99.97%Cor e Forma:SolidPeso molecular:420.63Ref: TM-T1789
5mg46,00€10mg50,00€25mg78,00€50mg94,00€100mg155,00€200mg259,00€500mg477,00€1mL*10mM (DMSO)50,00€Sevelamer hydrochloride
CAS:Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption
Fórmula:(C3H7N·C3H5ClO·HCl)xPureza:98%Cor e Forma:SolidPeso molecular:186.08Tropifexor
CAS:Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
Fórmula:C29H25F4N3O5SPureza:99.3% - 99.85%Cor e Forma:SolidPeso molecular:603.58Ref: TM-T4379
1mg87,00€5mg166,00€10mg248,00€25mg437,00€50mg665,00€100mg1.008,00€200mg1.520,00€500mg2.252,00€DY268
CAS:DY268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist.Fórmula:C30H32N4O5SPureza:99.43% - 99.75%Cor e Forma:SolidPeso molecular:560.66Ref: TM-T31587
1mg38,00€5mg84,00€10mg119,00€25mg233,00€50mg430,00€100mg620,00€500mg1.333,00€1mL*10mM (DMSO)93,00€BAR 501 impurity
CAS:BAR 501 impurity 在 BAR501 制剂中发现的一种杂质，可作为 G 蛋白偶联胆汁酸激活受体 (GP-BAR1) 的激动剂。 BAR501 杂质 (10 µM) 在 GP-BAR1 报告基因检测中诱导荧光素酶活性增加 150%。Fórmula:C26H46O3Pureza:98.78%Cor e Forma:SolidPeso molecular:406.64BAR502
CAS:BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).Fórmula:C25H44O3Pureza:99.95%Cor e Forma:SolidPeso molecular:392.62Guggulsterone
CAS:Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.Fórmula:C21H28O2Pureza:99.4% - 99.8%Cor e Forma:Light Yellow PowderPeso molecular:312.45Ref: TM-T5574
1mg34,00€5mg50,00€10mg93,00€25mg152,00€50mg205,00€100mg289,00€200mg432,00€1mL*10mM (DMSO)55,00€Nidufexor
CAS:Nidufexor is an agonist for the farnesoid X receptor (FXR).Fórmula:C27H22ClN3O4Pureza:98.67%Cor e Forma:SolidPeso molecular:487.93T0901317
CAS:T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).Fórmula:C17H12F9NO3SPureza:98% - 99.64%Cor e Forma:SolidPeso molecular:481.33Vidofludimus
CAS:Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).Fórmula:C20H18FNO4Pureza:98.33% - 99.58%Cor e Forma:SolidPeso molecular:355.36Glyco-Obeticholic acid
CAS:Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).Fórmula:C28H47NO5Pureza:99.77% - 99.95%Cor e Forma:SolidPeso molecular:477.68Ref: TM-T11428
1mg49,00€2mgA consultar5mg105,00€10mg160,00€25mg313,00€50mg1.320,00€1mL*10mM (DMSO)126,00€Fexaramine
CAS:Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.Fórmula:C32H36N2O3Pureza:98.87% - 99.61%Cor e Forma:SolidPeso molecular:496.64Forskolin
CAS:Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM).Fórmula:C22H34O7Pureza:98.83% - 99.96%Cor e Forma:Less Crystalline Solid Colorless Crystalline SolidPeso molecular:410.50Ref: TM-T2939
5mg43,00€10mg56,00€25mg86,00€50mg96,00€100mg144,00€200mg182,00€500mg306,00€1mL*10mM (DMSO)56,00€Cilofexor
CAS:Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.Fórmula:C28H22Cl3N3O5Pureza:99.86% - ≥95%Cor e Forma:SolidPeso molecular:586.85Ref: TM-T7436
1mg50,00€2mg77,00€5mg124,00€10mg188,00€25mg376,00€50mg567,00€100mg747,00€200mg1.017,00€1mL*10mM (DMSO)158,00€Vonafexor
CAS:Vonafexor (EYP001) is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effectsFórmula:C19H15Cl3N2O5SPureza:98.74%Cor e Forma:SolidPeso molecular:489.76Teduglutide
CAS:Teduglutide (ALX-0600) is a glucagon-like peptide-2 analog that increases intestinal absorption and can be used in research on short bowel syndrome (SBS).Fórmula:C164H252N44O55SPureza:98.08%Cor e Forma:SolidPeso molecular:3752.08Fexarine
CAS:Fexarine is a potent, selective agonist of farnesoid X receptor.Fórmula:C31H31NO5Cor e Forma:SolidPeso molecular:497.58ST-1892
CAS:ST-1892 is a soluble partial FXR agonist.Fórmula:C16H12N2O3Pureza:98%Cor e Forma:SolidPeso molecular:280.28LY367385
CAS:LY367385 is a highly effective and selective mGluR1a antagonist.Fórmula:C10H11NO4Pureza:98%Cor e Forma:SolidPeso molecular:209.2HPG1860
CAS:HPG1860, an agonist of the farnesoid X receptor (FXR), induces luminescence in reporter gene assays utilizing HEK293T cells expressing human FXR, with an EC50 value of 18 nM. In vivo studies demonstrate that HPG1860 (administered at 1, 3, or 10 mg/kg daily) reduces serum alanine aminotransferase (ALT) and total cholesterol levels in a mouse model of non-alcoholic steatohepatitis (NASH), which was induced by a high-fat diet and carbon tetrachloride (CCl4). Additionally, this compound decreases hepatic inflammation, fat levels, and fibrosis.Fórmula:C27H26Cl2N4O4SCor e Forma:SolidPeso molecular:573.49FXR agonist 4
FXR agonist 4: EC50 of 1.05μM, treats hyperlipidemia, steatosis, insulin resistance, inflammation in DIO mice, for NAFLD research.Fórmula:C21H28ClN3OCor e Forma:SolidPeso molecular:373.92PX20606
CAS:PX20606 is an orally active farnesoid X receptor (FXR) agonist, demonstrating EC50 values of 220 nM (mFXR) and 50 nM (hFXR) in Gal4-FXR assays. It induces the expression of the tumor suppressor gene NDRG2 and inhibits tumor growth and metastasis in a mouse HCC model. Additionally, PX20606 exhibits hepatoprotective properties.
Fórmula:C29H22Cl3NO4Cor e Forma:SolidPeso molecular:554.85EDP-305
CAS:EDP-305, an oral FXR agonist, has EC50s of 34 nM/8 nM in CHO/HEK cells, aids in PBC and NASH research with antifibrotic properties.Fórmula:C36H58N2O5SCor e Forma:SolidPeso molecular:630.92BMS-986318
CAS:BMS-986318: potent FXR agonist, EC50=53/350 nM, good ADME, effective in liver disease models, for nonalcoholic steatohepatitis research.Fórmula:C30H23Cl2F3N4O3Cor e Forma:SolidPeso molecular:615.43GSK2324
CAS:GSK2324 is a potent FXR agonist for the treatment of NAFLD by controlling hepatic lipids through reduced uptake and selective reduction of fatty acid synthesis.Fórmula:C29H22Cl2N2O4Pureza:98.09% - 99.02%Cor e Forma:SolidPeso molecular:533.4FXR antagonist 1
CAS:"Oral FXR antagonist 1 selectively blocks intestinal FXR, with IC50 of 2.1 μM, aiding in NASH research by improving liver health."Fórmula:C36H59NO5Cor e Forma:SolidPeso molecular:585.86Chenodeoxycholic Acid 24-Acyl-β-D-Glucuronide
CAS:Chenodeoxycholic acid 24-acyl-β-D-glucuronide (CDCA-24G), a metabolite of CDCA, is synthesized from CDCA via the action of the UDP-glucuronosyltransferase (UG UT) isoform UGT1A3.Fórmula:C30H48O10Cor e Forma:SolidPeso molecular:568.7Chenodeoxycholic Acid 3-Glucuronide
CAS:Chenodeoxycholic acid 3-glucuronide (CDCA-3G), a metabolite of Chenodeoxycholic acid (CDCA), is synthesized in human liver microsomes.Fórmula:C30H48O10Cor e Forma:SolidPeso molecular:568.7GSK-8062
CAS:GSK-8062 is an agonist of farnesoid X receptor (FXR).Fórmula:C30H23Cl2NO4Pureza:98%Cor e Forma:SolidPeso molecular:532.41Omesdafexor
CAS:Omesdafexor is an FXR agonist that can be used to study diseases caused by liver disease or metabolic inflammation.Fórmula:C34H43N3O3Cor e Forma:SolidPeso molecular:541.72Lecufexor
CAS:Lecufexor is an agonist of the farnesoid X receptor (FXR).Fórmula:C32H21Cl3N2O5Cor e Forma:SolidPeso molecular:619.88BAR-2227
CAS:BAR-2227 (compound 3a) functions as an FXR agonist and a LIFR inhibitor. It is utilized in the study of liver fibrosis and inflammation.Fórmula:C24H17Cl2NO4Cor e Forma:SolidPeso molecular:454.30BMS-986339
CAS:BMS-986339: oral, potent FXR agonist; binds to His298/ASN287; for PBC, PSC, NASH, anti-fibrosis research.Fórmula:C35H41F4N3O4Cor e Forma:SolidPeso molecular:643.71Danifexor
CAS:Danifexor is an agonist of the farnesoid X receptor (Farnesoid X receptor).Fórmula:C29H20Cl2N2O5Cor e Forma:SolidPeso molecular:547.386FXR agonist 12
CAS:FXR agonist12 (Compound C7) is an orally active FXR agonist. It downregulates bile acid synthesis-related genes and upregulates bile acid transport-related genes in HepG2 cells. FXR agonist12 alleviates ANIT-induced cholestasis and reduces liver damage and fibrosis in a mouse model of NASH.
Fórmula:C26H44O3Cor e Forma:SolidPeso molecular:404.626FXR agonist 9
CAS:FXR agonist9 (compound 26) is a selective, orally active partial agonist of FXR with an EC50 of 0.09 µM (maximum efficacy of 75.13%). It ameliorates the pathological features of fatty liver disease in mice induced by HFD and CCl4-related metabolic dysfunction.Fórmula:C28H30N2O5Cor e Forma:SolidPeso molecular:474.55NR1H4 activator 1
CAS:NR1H4 activator 1 is a potent and selective agonist of Famesoid X Receptor (FXR).Fórmula:C34H53NO7SPureza:98%Cor e Forma:SolidPeso molecular:619.85FXR/CES2 modulator 1
CAS:Compound LE-77, known as FXR/CES2 modulator 1, functions as a dual regulator that activates FXR and inhibits CES2. It effectively mitigates the intestinal toxicity of irinotecan.Fórmula:C27H21Cl2NO5Cor e Forma:SolidPeso molecular:510.36
