FXR
O Receptor Farnesoide X (FXR) é um receptor nuclear que desempenha um papel crucial na regulação da homeostase dos ácidos biliares, do metabolismo dos lipídios e da regulação da glicose. O FXR é um alvo terapêutico potencial para o tratamento de doenças hepáticas, distúrbios metabólicos e doenças cardiovasculares. Os inibidores de FXR podem modular essas vias, oferecendo insights sobre os mecanismos de doenças e estratégias terapêuticas. Na CymitQuimica, oferecemos uma variedade de inibidores de FXR para apoiar sua pesquisa em hepatologia, metabolismo e desenvolvimento de medicamentos.
Foram encontrados 62 produtos de "FXR"
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Chenodeoxycholic Acid 24-Acyl-β-D-Glucuronide
CAS:Chenodeoxycholic acid 24-acyl-β-D-glucuronide (CDCA-24G), a metabolite of CDCA, is synthesized from CDCA via the action of the UDP-glucuronosyltransferase (UG UT) isoform UGT1A3.Fórmula:C30H48O10Cor e Forma:SolidPeso molecular:568.7Chenodeoxycholic Acid 3-Glucuronide
CAS:Chenodeoxycholic acid 3-glucuronide (CDCA-3G), a metabolite of Chenodeoxycholic acid (CDCA), is synthesized in human liver microsomes.Fórmula:C30H48O10Cor e Forma:SolidPeso molecular:568.7GSK-8062
CAS:GSK-8062 is an agonist of farnesoid X receptor (FXR).Fórmula:C30H23Cl2NO4Pureza:98%Cor e Forma:SolidPeso molecular:532.41Omesdafexor
CAS:Omesdafexor is an FXR agonist that can be used to study diseases caused by liver disease or metabolic inflammation.Fórmula:C34H43N3O3Cor e Forma:SolidPeso molecular:541.72Lecufexor
CAS:Lecufexor is an agonist of the farnesoid X receptor (FXR).Fórmula:C32H21Cl3N2O5Cor e Forma:SolidPeso molecular:619.88BAR-2227
CAS:BAR-2227 (compound 3a) functions as an FXR agonist and a LIFR inhibitor. It is utilized in the study of liver fibrosis and inflammation.Fórmula:C24H17Cl2NO4Cor e Forma:SolidPeso molecular:454.30BMS-986339
CAS:BMS-986339: oral, potent FXR agonist; binds to His298/ASN287; for PBC, PSC, NASH, anti-fibrosis research.Fórmula:C35H41F4N3O4Cor e Forma:SolidPeso molecular:643.71Danifexor
CAS:Danifexor is an agonist of the farnesoid X receptor (Farnesoid X receptor).Fórmula:C29H20Cl2N2O5Cor e Forma:SolidPeso molecular:547.386FXR agonist 12
CAS:FXR agonist12 (Compound C7) is an orally active FXR agonist. It downregulates bile acid synthesis-related genes and upregulates bile acid transport-related genes in HepG2 cells. FXR agonist12 alleviates ANIT-induced cholestasis and reduces liver damage and fibrosis in a mouse model of NASH.
Fórmula:C26H44O3Cor e Forma:SolidPeso molecular:404.626FXR agonist 9
CAS:FXR agonist9 (compound 26) is a selective, orally active partial agonist of FXR with an EC50 of 0.09 µM (maximum efficacy of 75.13%). It ameliorates the pathological features of fatty liver disease in mice induced by HFD and CCl4-related metabolic dysfunction.Fórmula:C28H30N2O5Cor e Forma:SolidPeso molecular:474.55NR1H4 activator 1
CAS:NR1H4 activator 1 is a potent and selective agonist of Famesoid X Receptor (FXR).Fórmula:C34H53NO7SPureza:98%Cor e Forma:SolidPeso molecular:619.85FXR/CES2 modulator 1
CAS:Compound LE-77, known as FXR/CES2 modulator 1, functions as a dual regulator that activates FXR and inhibits CES2. It effectively mitigates the intestinal toxicity of irinotecan.Fórmula:C27H21Cl2NO5Cor e Forma:SolidPeso molecular:510.36
