FXR
O Receptor Farnesoide X (FXR) é um receptor nuclear que desempenha um papel crucial na regulação da homeostase dos ácidos biliares, do metabolismo dos lipídios e da regulação da glicose. O FXR é um alvo terapêutico potencial para o tratamento de doenças hepáticas, distúrbios metabólicos e doenças cardiovasculares. Os inibidores de FXR podem modular essas vias, oferecendo insights sobre os mecanismos de doenças e estratégias terapêuticas. Na CymitQuimica, oferecemos uma variedade de inibidores de FXR para apoiar sua pesquisa em hepatologia, metabolismo e desenvolvimento de medicamentos.
Foram encontrados 67 produtos para "FXR".
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FXR agonist 3
FXR agonist 3 is an anti NASH compound with anti-fibrotic and active properties that inhibits the expression of COL1A1, TGF-β1, α-SMA and TIMP1.Fórmula:C28H28BrNO4Pureza:95.04%Cor e Forma:Yellow SolidPeso molecular:521.12Guggulsterone
CAS:Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.Fórmula:C21H28O2Pureza:99.4% - 99.80%Cor e Forma:SolidPeso molecular:312.4458Tauro-Obeticholic acid
CAS:Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).Fórmula:C28H49NO6SPureza:99.74% - 99.82%Cor e Forma:SolidPeso molecular:527.757Ursodeoxycholic acid sodium
CAS:Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities.Fórmula:C24H39NaO4Pureza:99.66% - 99.96%Cor e Forma:SolidPeso molecular:414.5538GW 4064
CAS:GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).Fórmula:C28H22Cl3NO4Pureza:98% - 99.94%Cor e Forma:White SolidPeso molecular:542.84Obeticholic Acid
CAS:Obeticholic Acid (6-ECDCA, INT-747) is a high-affinity, semisynthetic, bile acid-derived FXR agonist.Cost-effective and quality-assured.Fórmula:C26H44O4Pureza:99.88% - 99.97%Cor e Forma:SolidPeso molecular:420.6252Sevelamer hydrochloride
CAS:Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorptionFórmula:C6H13Cl2NOPureza:98%Cor e Forma:SolidPeso molecular:186.08Tropifexor
CAS:Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.Fórmula:C29H25F4N3O5SPureza:99.3% - 99.85%Cor e Forma:SolidPeso molecular:603.585Turofexorate Isopropyl
CAS:Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nMFórmula:C25H24F2N2O3Pureza:98.55% - 99.73%Cor e Forma:Yellow SolidPeso molecular:438.4665BAR502
CAS:BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).Fórmula:C25H44O3Pureza:99.95%Cor e Forma:SolidPeso molecular:392.6151DY268
CAS:DY268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist.Fórmula:C30H32N4O5SPureza:99.43% - 99.75%Cor e Forma:SolidPeso molecular:560.66Nidufexor
CAS:Nidufexor is an agonist for the farnesoid X receptor (FXR).Fórmula:C27H22ClN3O4Pureza:98.67%Cor e Forma:White SolidPeso molecular:487.934T0901317
CAS:T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).Fórmula:C17H12F9NO3SPureza:98% - 99.64%Cor e Forma:SolidPeso molecular:481.33Vidofludimus
CAS:Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).Fórmula:C20H18FNO4Pureza:98.33% - 99.58%Cor e Forma:SolidPeso molecular:355.3596Glyco-Obeticholic acid
CAS:Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).Fórmula:C28H47NO5Pureza:99.77% - 99.95%Cor e Forma:SolidPeso molecular:477.6765Fexaramine
CAS:Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.Fórmula:C32H36N2O3Pureza:98.87% - 99.61%Cor e Forma:Yellow SolidPeso molecular:496.64Forskolin
CAS:Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM).Fórmula:C22H34O7Pureza:98.83% - 99.86%Cor e Forma:White SolidPeso molecular:410.50Cilofexor
CAS:Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.Fórmula:C28H22Cl3N3O5Pureza:99.86% - ≥95%Cor e Forma:SolidPeso molecular:586.85Vonafexor
CAS:Vonafexor (EYP001) is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effectsFórmula:C19H15Cl3N2O5SPureza:98.74%Cor e Forma:White SolidPeso molecular:489.757Teduglutide
CAS:Teduglutide (ALX-0600) is a glucagon-like peptide-2 analog that increases intestinal absorption and can be used in research on short bowel syndrome (SBS).Fórmula:C164H252N44O55SPureza:98.08% - 99.29%Cor e Forma:White SolidPeso molecular:3752.08
