HMG-CoA Reductase
A HMG-CoA Redutase é uma enzima chave na via do mevalonato, responsável pela síntese de colesterol e outros isoprenoides. Inibidores da HMG-CoA redutase, comumente conhecidos como estatinas, são amplamente utilizados para reduzir os níveis de colesterol e o risco de doenças cardiovasculares. Estes inibidores também têm potenciais benefícios na pesquisa sobre câncer e doenças neurodegenerativas. Na CymitQuimica, oferecemos uma variedade de inibidores da HMG-CoA redutase para apoiar sua pesquisa em metabolismo lipídico, saúde cardiovascular e desenvolvimento terapêutico.
Foram encontrados 33 produtos de "HMG-CoA Reductase"
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Atorvastatin lactone
CAS:Atorvastatin lactone is a prodrug form of atorvastatin. Which is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.Fórmula:C33H33FN2O4Pureza:98.05% - 98.16%Cor e Forma:SolidPeso molecular:540.62Lipid Metabolism Compound Library
<p>A unique collection of 492 compounds targeting lipid metabolism, can be used for high-throughput screening (HTS) and high-content screening (HCS).</p>Cor e Forma:Odour SolidGanoderenic acid K
CAS:<p>Ganoderenic acid K, from Ganoderma lucidum, inhibits HMG-CoA reductase with an IC50 of 16.5 μM.</p>Fórmula:C32H44O9Cor e Forma:SolidPeso molecular:572.69HMG-CoA Reductase-IN-1
HMG-CoA Reductase-IN-1 is an inhibitor of HMG-CoA reductase, demonstrating strong inhibitory activity on HMGR and affinity for OATP1B1, with pIC50 and pKmFórmula:C27H29N3O7Cor e Forma:SolidPeso molecular:507.54(Rac)-5-Keto Fluvastatin
CAS:(Rac)-5-Keto Fluvastatin (rac 5-Keto Fluvastatin) is an impurity of Fluvastatin which is an inhibitor of HMG-CoA reductase.Fórmula:C24H24FNO4Pureza:95.04%Cor e Forma:SolidPeso molecular:409.45(3S,5R)-Fluvastatin D6 sodium
CAS:(3S,5R)-Fluvastatin D6 sodium: deuterium-labeled synthetic HMG-CoA reductase inhibitor with 8 nM IC50.Fórmula:C24H25FNNaO4Pureza:98%Cor e Forma:SolidPeso molecular:439.49Rawsonol
CAS:Rawsonol is a HMG-CoA reductase inhibitor from the tropical green alga Avrainvillea rawsoni.Fórmula:C29H24Br4O7Cor e Forma:SolidPeso molecular:804.11L 645164
CAS:L 645164 is an inhibitor of hydroxymethylglutaryl-CoA reductase.Fórmula:C22H23FO3Cor e Forma:SolidPeso molecular:354.4124,25-Epoxycholesterol
CAS:24,25-Epoxycholesterol is an oxysterol agonist of the liver X receptor, known to inhibit the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) in hepatic cells. Additionally, 24,25-Epoxycholesterol plays a role in regulating cholesterol metabolism within the liver.Fórmula:C27H44O2Peso molecular:400.64Rosuvastatin Sodium
CAS:Rosuvastatin Sodium (ZD4522 Sodium) is a competitive HMG-CoA reductase (HMGCR) inhibitor (IC50=11 nM) with lipid-lowering and anti-atherosclerotic effects.Fórmula:C22H27FN3NaO6SCor e Forma:SolidPeso molecular:503.52Pravastatin lactone
CAS:<p>Pravastatin lactone, a non-enzymatic stomach derivative of pravastatin, inhibits HMG-CoA reductase and stems from mevastatin.</p>Fórmula:C23H34O6Cor e Forma:SolidPeso molecular:406.519Atorvastatin calcium trihydrate
CAS:Atorvastatin is used to inhibits HMG-CoA reductase for lowering blood cholesterol and for prevention of events associated with cardiovascular disease.Fórmula:C66H74CaF2N4O13Cor e Forma:SolidPeso molecular:1209.39PPD 10558
CAS:PPD 10558, a HMG-CoA reductase inhibitor, is used potentially for treatment of primary hypercholesterolemia.Fórmula:C34H37FN2O6Cor e Forma:SolidPeso molecular:588.677-Ketocholesterol
CAS:7-Ketocholesterol is a metabolite of CholesterolFórmula:C27H44O2Pureza:97.59% - 98.84%Cor e Forma:SolidPeso molecular:400.65Tenivastatin
CAS:Tenivastatin (Simvastatin acid) is an anti-hyperlipidemic HMG-CoA reductase inhibitor used in the study of primary hyperlipidemia.Fórmula:C25H40O6Pureza:99.56%Cor e Forma:SolidPeso molecular:436.58Simvastatin acid ammonium
CAS:Simvastatin acid ammonium (Tenivastatin ammonium) is an HMG-CoA reductase (HMGCR) inhibitor.Fórmula:C25H43NO6Pureza:98.3%Cor e Forma:SolidPeso molecular:453.61Pravastatin
CAS:Pravastatin (CS-514) is a competitive HMG-CoA reductase inhibitor with an IC50 of 5.6 μM for sterol synthesis, capable of lowering serum cholesterol.Fórmula:C23H36O7Pureza:99.99%Cor e Forma:White PowderPeso molecular:424.534-Acetylsimvastatin
CAS:<p>4-Acetylsimvastatin is acetylated simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki: 0.2 nM).</p>Fórmula:C27H40O6Pureza:98%Cor e Forma:SolidPeso molecular:460.6(3S,5R)-Pitavastatin calcium
CAS:(3S,5R)-Pitavastatin calcium is the enantiomer of Pitavastatin which is a potent HMG-CoA reductase inhibitor.Fórmula:C25H26CaFNO4Pureza:98%Cor e Forma:SolidPeso molecular:463.562(3S,5S)-Pitavastatin calcium
CAS:(3S,5S)-Pitavastatin calcium is the 3-epimer of Pitavastatin which is a potent HMG-CoA reductase inhibitor.Fórmula:C25H26CaFNO4Pureza:98%Cor e Forma:SolidPeso molecular:463.562Lovastatin hydroxy acid sodium
CAS:<p>Lovastatin Sodium is an HMG-CoA reductase inhibitor.</p>Fórmula:C24H38NaO6Cor e Forma:SolidPeso molecular:445.54(3S,5R)-Fluvastatin sodium
CAS:(3S,5R)-Fluvastatin sodium: synthetic HMG-CoA reductase inhibitor, IC50 8 nM, boosts vascular cell antioxidant defense.Fórmula:C24H26FNNaO4Pureza:98%Cor e Forma:SolidPeso molecular:434.463L 669262
CAS:L 669262 is a potent inhibitor of HMG-CoA reductase.Fórmula:C25H36O6Cor e Forma:SolidPeso molecular:432.55Simvastatin acid calcium hydrate
CAS:Simvastatin (Tenivastatin) calcium hydrate is an oral HMG-CoA reductase inhibitor that reduces ROS by blocking indoxyl sulfate.Fórmula:C25H40O6Cor e Forma:SolidPeso molecular:436.28249Crilvastatin
CAS:Crilvastatin (PMD 387) is an HMGCR inhibitor with cholesterol-lowering activity that inhibits cholesterol uptake in rats with hereditary hypercholesterolemia.Fórmula:C14H23NO3Pureza:98.69% - 99.54%Cor e Forma:SolidPeso molecular:253.342'-Ethyl Simvastatin
CAS:2'-Ethyl Simvastatin is a Mevinolin analog with HMG-CoA reductase inhibition.Fórmula:C23H34O5Pureza:98%Cor e Forma:SolidPeso molecular:390.51(Z)-Pitavastatin calcium
CAS:(Z)-Pitavastatin calcium is the Z-Isomer of Pitavastatin hemicacium. Pitavastatin calcium is a potent of hydroxymethylglutaryl-CoA (HMG-CoA) reductase.Fórmula:C50H50CaF2N2O8Pureza:98%Cor e Forma:SolidPeso molecular:885.031Dalvastatin
CAS:Dalvastatin (RG-12561) is an orally available inhibitor of HMG-CoA reductase and cholesterol-lowering synthesis.Dalvastatin competitively inhibits rat hepaticFórmula:C24H31FO3Pureza:98.07%Cor e Forma:SolidPeso molecular:386.5(3R,5R)-Rosuvastatin calcium
CAS:(3R,5R)-Rosuvastatin, a potential impurity detected in bulk rosuvastatin formulations, arises as a degradation product through various stresses including acid or base hydrolysis, thermal, photolytic, hydrolytic, oxidative stress, or during storage. This compound is associated with the HMG-CoA reductase inhibitor class to which rosuvastatin belongs.Fórmula:C22H28FN3O6SCaCor e Forma:SolidPeso molecular:500.6Rosuvastatin zinc salt
CAS:Rosuvastatin zinc salt (Rosuvastatin zinc), a zinc-infused variant of Rosuvastatin, functions as an HMG-CoA reductase inhibitor, utilized primarily inFórmula:C44H54F2N6O12S2ZnCor e Forma:SolidPeso molecular:1026.47QH536
CAS:QH536 degrades HMGCR (EC50: 0.22 μM), has anti-inflammatory properties, and avoids cholesterol buildup; useful for cardiovascular and NASH research.Fórmula:C33H49N3O3Cor e Forma:SolidPeso molecular:535.76Bemfivastatin hemicalcium
CAS:Bemfivastatin hemicalcium (PPD 10558), an orally active HMG-CoA reductase inhibitor, serves as a lipid-lowering agent.Fórmula:C34H36FN2O6CaCor e Forma:SolidPeso molecular:607.67L 668411
CAS:L 668411, the 2,3-ditritiated methyl ester of L 659699, inhibits HMG-CoA synthase.Fórmula:C19H30O5Pureza:98%Cor e Forma:SolidPeso molecular:338.44
