Desidrogenase
As desidrogenases são enzimas envolvidas nas reações de oxidação-redução das vias metabólicas, desempenhando um papel central na produção de energia e na respiração celular. Estas enzimas são cruciais para processos como o ciclo do ácido cítrico, a glicólise e a oxidação dos ácidos graxos. Os inibidores de desidrogenases são ferramentas importantes no estudo de doenças metabólicas, câncer e estresse oxidativo. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de desidrogenases para apoiar sua pesquisa em metabolismo, biologia do câncer e bioquímica.
Foram encontrados 302 produtos de "Desidrogenase"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
17β-HSD1-IN-1
17β-HSD1-IN-1 (Compound 1) can be used in the non-small cell lung cancer (NSCLC) research.Fórmula:C21H21NO3Cor e Forma:SolidPeso molecular:335.4LDHA-IN-5
CAS:LDHA-IN-5 is a novel and potent inhibitor targeting both glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), designed for the treatment of primaryFórmula:C27H22FN7O6S3Cor e Forma:SolidPeso molecular:655.7FXR/HSD17B13 modulator 1
CAS:FXR/HSD17B13 modulator 1 (compound 6) is an effective modulator of FXR/HSD17B13, playing a significant role in studies related to metabolic dysfunction-associated steatohepatitis (MASH).Fórmula:C26H19Cl2NO4Cor e Forma:SolidPeso molecular:480.339T-3764518
CAS:T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).Fórmula:C20H17F6N5O2Pureza:98%Cor e Forma:SolidPeso molecular:473.37MDH1/2-IN-1
CAS:MDH1/2-IN-1 is an MDH1/2 inhibitor with IC50 values of 1.07 nM and 1.06 nM, respectively. It suppresses mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 exhibits significant antitumor potential and offers new avenues for developing drugs targeting cancer metabolism.Fórmula:C25H33NO4Cor e Forma:SolidPeso molecular:411.534PDHK-IN-4
PDHK-IN-4 inhibits PDHK2 (IC50: 0.0051 μM) & PDHK4 (IC50: 0.0122 μM), with potential for cancer research.Fórmula:C24H25N5O3Cor e Forma:SolidPeso molecular:431.49DSM705 hydrochloride
DSM705 hydrochloride: potent antimalarial, pyrrole-based DHODH inhibitor effective against Plasmodium, non-toxic to mammalian DHODH.Fórmula:C19H20ClF3N6OCor e Forma:SolidPeso molecular:440.85BRD7539
CAS:BRD7539B: PfDHODH inhibitor, IC50 0.033μM; selective vs HsDHODH, IC50 >50μM.Fórmula:C23H22FN3O2Pureza:98%Cor e Forma:SolidPeso molecular:391.447-Hydroxy-4-phenylcoumarin
CAS:7-Hydroxy-4-phenylcoumarin is a dual inhibitor of ALDH-2 and MAO, with IC50 values of 1.5 µM and 0.5 µM, respectively.Fórmula:C15H10O3Cor e Forma:SolidPeso molecular:238.238BI-4916
CAS:BI-4916 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor that inhibits SSP and reduces cancer cell migration.Fórmula:C23H24Cl2N2O6SPureza:98.55% - 98.55%Cor e Forma:SolidPeso molecular:527.42PDHK-IN-3
PDHK-IN-3 (compound 7) is a potent inhibitor of pyruvate dehydrogenase kinase(PDHK) with IC50s of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively [1].Fórmula:C17H16N2O2Cor e Forma:SolidPeso molecular:280.32Deamino-NAD sodium
CAS:Deamino-NAD sodium, a structural analog of NAD+, serves as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH) in glycolysis. It exhibits a Km of 2300 pm and a Kd of 112 pm.Fórmula:C21H25N6NaO15P2Cor e Forma:SolidPeso molecular:686.39PHGDH-IN-2
PHGDH-IN-2: potent PHGDH inhibitor, IC50=5.2μM; hinders PHGDH cancer cell growth & serine synthesis in MDA-MB-468.Fórmula:C22H20N4O3SCor e Forma:SolidPeso molecular:420.48GSK864
CAS:GSK864 is an inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant. GSK864 inhibits IDH1 mutants R132C, R132H, and R132G (IC50: 8.8, 15.2, and 16.6 nM).Fórmula:C30H31FN6O4Pureza:97.07%Cor e Forma:SolidPeso molecular:558.6HSD17B13-IN-40
CAS:HSD17B13-IN-40 (compound 6) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of less than 0.1 μM using estradiol as substrates. This compound is significant in the treatment of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Fórmula:C23H14Cl2F3N3O3Cor e Forma:SolidPeso molecular:508.28HSD17B13-IN-32
CAS:HSD17B13-IN-32 (Compound 67) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤0.1 μM for estradiol. It can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) [1].Fórmula:C23H15Cl2N5O3Cor e Forma:SolidPeso molecular:480.3RORγt/DHODH-IN-3
RORγt/DHODH-IN-3 (compound (S)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.098 μM) and DHODH (IC50: 0.432 μM).RORγt/DHODH-IN-1 hasFórmula:C24H26ClF6N3O3SCor e Forma:SolidPeso molecular:585.99Mirivadelgat
CAS:Mirivadelgat is an activator of aldehyde dehydrogenase 2 (aldehyde dehydrogenase2). It is anticipated to be useful in research related to interstitial lung disease, pulmonary arterial hypertension, and cancer.Fórmula:C30H34FN3O5Cor e Forma:SolidPeso molecular:535.607HSD17B13-IN-28
CAS:HSD17B13-IN-28 (compound 47) is a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), with an IC50 of < 0.1 μM using estradiol as a substrate. HSD17B13-IN-28 plays an important role in nonalcoholic fatty liver diseases (NAFLDs), including NASH (nonalcoholic steatohepatitis) [1].Fórmula:C23H16Cl2FN3O3Cor e Forma:SolidPeso molecular:472.3Indoluidin E
Indoluidin E selectively inhibits DHODH and has an inhibitory effect on cancer cell growth.Fórmula:C28H30N4O2Cor e Forma:SolidPeso molecular:454.56
