Desidrogenase
As desidrogenases são enzimas envolvidas nas reações de oxidação-redução das vias metabólicas, desempenhando um papel central na produção de energia e na respiração celular. Estas enzimas são cruciais para processos como o ciclo do ácido cítrico, a glicólise e a oxidação dos ácidos graxos. Os inibidores de desidrogenases são ferramentas importantes no estudo de doenças metabólicas, câncer e estresse oxidativo. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de desidrogenases para apoiar sua pesquisa em metabolismo, biologia do câncer e bioquímica.
Foram encontrados 302 produtos de "Desidrogenase"
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MTHFD2-IN-3
MTHFD2-IN-3 (compound 10), a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2), demonstrates significant efficacy in obstructing the activityFórmula:C22H19NO7SCor e Forma:SolidPeso molecular:441.45(Rac)-BMS-816336
(Rac)-BMS-816336 is a racemic 11β-HSD1 inhibitor; IC50: 10 nM (human), 68 nM (mouse), metabolically stable.Fórmula:C21H27NO3Pureza:98%Cor e Forma:SolidPeso molecular:341.44IGUANA-1
CAS:IGUANA-1 is a highly efficient and selective ALDH1B1 inhibitor that inhibits the growth of colorectal cancer cells and colorectal cancer cell-derived organoids.Fórmula:C27H26ClN3O4Pureza:99.08%Cor e Forma:SolidPeso molecular:491.97Ref: TM-T73377
1mg86,00€5mg180,00€10mg283,00€25mg530,00€50mg797,00€100mg1.159,00€1mL*10mM (DMSO)188,00€DSM705
CAS:DSM705: Pyrrole-based, potent nanomolar Plasmodium DHODH inhibitor with strong antimalarial efficacy; spares mammalian DHODH.Fórmula:C19H19F3N6OCor e Forma:SolidPeso molecular:404.397Octanoyl Coenzyme A (sodium salt)
Octanoyl Coenzyme A (sodium salt) inhibits citrate synthase and glutamate dehydrogenase with an IC50 of 0.4–1.6 mM.Fórmula:C29H49N7NaO17P3SCor e Forma:SolidPeso molecular:915.71MTHFD2-IN-4 sodium
MTHFD2-IN-4 sodium, a potent inhibitor of MTHFD2 and a tricyclic coumarin derivative, is applicable in cancer research [1].Fórmula:C26H21F6N2NaO5Cor e Forma:SolidPeso molecular:578.44hDHODH-IN-12
hDHODH-IN-12 is a potent inhibitor of dihydroorotate dehydrogenase (DHODH), exhibiting an inhibitory concentration (IC50) of 0.421 μM.Fórmula:C22H15F3N4O3Pureza:98%Cor e Forma:SolidPeso molecular:440.37D-Lactate dehydrogenase
CAS:D-LDH is an oxidoreductase turning D-lactate into pyruvate, using NAD+/NADP+; prevalent in bacteria and fungi, key for biochemical research.Cor e Forma:SolidBMS-770767
CAS:BMS-770767 is a novel 11-betahydroxysteroid dehydrogenase type I (11ß-HSD1) inhibitor.Fórmula:C19H18ClN3O2Cor e Forma:SolidPeso molecular:355.82IGUANA-1 free base
CAS:IGUANA-1: selective ALDH1 B1 inhibitor, IC50=30 nM, hinders SW480 cell growth with IC50=2.46/0.39 μM in adherent/spheroid forms, for cancer research.Fórmula:C26H24ClN3O2Cor e Forma:SolidPeso molecular:445.94SCD1 inhibitor-3
CAS:SCD1 inhibitor-3 (ML-270) is a highly effective and orally available compound that inhibits SCD1 with remarkable safety.Fórmula:C19H16FN7O2Pureza:99.5%Cor e Forma:SolidPeso molecular:393.37Ref: TM-T38683
1mg92,00€5mg187,00€10mg298,00€25mg507,00€50mg730,00€100mg1.026,00€1mL*10mM (DMSO)205,00€PDK-IN-2
PDK-IN-2 (Compound 1F), with an IC50 of 68 nM, is a potent PDK inhibitor that downregulates the expression of PDK1 and PDK4 in cells.Fórmula:C17H23AsCl2N2O2S2Cor e Forma:SolidPeso molecular:497.3311β-HSD1 inibitor 17
CAS:11β-HSD1 inibitor 17 is an inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD1).Fórmula:C22H20F3N3O2SPureza:99.26% - 99.72%Cor e Forma:SoildPeso molecular:447.47LDHA-IN-3
CAS:LDHA-IN-3 is a potent selenobenzene-based LDHA inhibitor with a 145.2 nM IC50, useful in cancer research.Fórmula:C13H9F3SePureza:99.71%Cor e Forma:SolidPeso molecular:301.17Ref: TM-T39805
1mg52,00€5mg113,00€10mg177,00€25mg371,00€50mg517,00€100mg707,00€200mg973,00€1mL*10mM (DMSO)124,00€WAY-311610
CAS:WAY-311610 is an HSD11B1 inhibitor targeting 11β-HSD1 enzyme with 0.34 μM IC; used for neuropathic and inflammatory pain research.Fórmula:C16H13F3N4O2Pureza:99.75%Cor e Forma:SolidPeso molecular:350.3DSM1465
DSM1465 (Compound 82) is a potent and selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 15 nM. It inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC50 value of 1.4 nM and demonstrates significant in vivo efficacy in humanized P. falciparum mouse models.Fórmula:C17H12ClF6N5O2Cor e Forma:SolidPeso molecular:467.753DHODH-IN-18
CAS:DHODH-IN-18 is a human DHODH inhibitor ( IC 50 = 0.2 nM).Fórmula:C21H16ClF5N6O4Cor e Forma:SolidPeso molecular:546.8418β-Glycyrrhetyl-3-O-sulfate
CAS:18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)), a major metabolite of Glycyrrhetinic acid (GA), serves as a potent inhibitor of type 2Fórmula:C30H46O7SCor e Forma:SolidPeso molecular:550.75MCI-INI-3
CAS:MCI-INI-3 is a selective competitive inhibitor of human ALDH1A3, with a Ki value of 0.55 μM for ALDH1A3 and 78.2 μM for ALDH1A1. It inhibits retinoic acid biosynthesis and can reduce the viability of glioblastoma cells GSC-83 and GSC-326.Fórmula:C21H15N3O4Cor e Forma:SolidPeso molecular:373.36PDK-IN-1
CAS:PDK-IN-1, a PDK inhibitor, IC50: 0.03μM (PDK1), 0.1μM (HSP90), reduces tumor mass.Fórmula:C20H16BrN7OCor e Forma:SolidPeso molecular:450.29
