Desidrogenase
As desidrogenases são enzimas envolvidas nas reações de oxidação-redução das vias metabólicas, desempenhando um papel central na produção de energia e na respiração celular. Estas enzimas são cruciais para processos como o ciclo do ácido cítrico, a glicólise e a oxidação dos ácidos graxos. Os inibidores de desidrogenases são ferramentas importantes no estudo de doenças metabólicas, câncer e estresse oxidativo. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de desidrogenases para apoiar sua pesquisa em metabolismo, biologia do câncer e bioquímica.
Foram encontrados 302 produtos de "Desidrogenase"
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hDHODH-IN-13
CAS:hDHODH-IN-13 (compound w2), an inhibitor of human dihydroorotate dehydrogenase (hDHODH), exhibits an IC50 of 173.4 nM and has potential research applications inCor e Forma:SoildPDK-IN-2
PDK-IN-2 (Compound 1F), with an IC50 of 68 nM, is a potent PDK inhibitor that downregulates the expression of PDK1 and PDK4 in cells.Fórmula:C17H23AsCl2N2O2S2Cor e Forma:SolidPeso molecular:497.33KOTX1
CAS:KOTX1 is an orally active and selective inhibitor of ALDH1A3. In a diabetic mouse model, KOTX1 improves glucose tolerance, insulin secretion, and blood glucose levels.Fórmula:C17H16FN3O2Cor e Forma:SolidPeso molecular:313.33D-Lactate dehydrogenase
CAS:D-LDH is an oxidoreductase turning D-lactate into pyruvate, using NAD+/NADP+; prevalent in bacteria and fungi, key for biochemical research.Cor e Forma:SolidMCI-INI-3
CAS:MCI-INI-3 is a selective competitive inhibitor of human ALDH1A3, with a Ki value of 0.55 μM for ALDH1A3 and 78.2 μM for ALDH1A1. It inhibits retinoic acid biosynthesis and can reduce the viability of glioblastoma cells GSC-83 and GSC-326.Fórmula:C21H15N3O4Cor e Forma:SolidPeso molecular:373.36Necroptosis-IN-3
CAS:Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis.Fórmula:C12H17NOSPureza:99.85%Cor e Forma:SoildPeso molecular:223.33DHODH-IN-23
CAS:DHODH-IN-23 is a DHODH inhibitor with oral activity. DHODH-IN-23 is often used in cancer research.
Fórmula:C24H21ClFNO4Pureza:99.7%Cor e Forma:SolidPeso molecular:441.88CM121
CAS:CM121, a reversible ALDH1A2 inhibitor, targets active site with IC50=0.54μM, Kd=1.1μM, using hydrophobic interactions.Fórmula:C24H17FN4O3SCor e Forma:SolidPeso molecular:460.482,3-Dihydroxybenzaldehyde
CAS:2,3-Dihydroxybenzaldehyde exhibits activity against NADH dehydrogenase (Km = 35 µM) and can be used in biochemical experiments and drug synthesis.Fórmula:C7H6O3Cor e Forma:SolidPeso molecular:138.12Osmanthuside H
CAS:Osmanthuside H is a useful organic compound for research related to life sciences. The catalog number is T125796 and the CAS number is 149155-70-4.Fórmula:C19H28O11Cor e Forma:SolidPeso molecular:432.422WQQ-345
WQQ-345, a BCAT1 inhibitor, exhibits an IC50 of 10.8 mM. In 67R cells, it reduces α-KG levels and upregulates H3K27me3 expression while downregulating the expression of glycolytic enzymes (PFKP and LDHA), leading to impaired glycolytic activity. Additionally, WQQ-345 demonstrates tumor-suppressive activity in a 67R subcutaneous xenograft model.Fórmula:C10H17NO2Cor e Forma:SolidPeso molecular:183.25SCD1 inhibitor-3
CAS:SCD1 inhibitor-3 (ML-270) is a highly effective and orally available compound that inhibits SCD1 with remarkable safety.Fórmula:C19H16FN7O2Pureza:99.5%Cor e Forma:SolidPeso molecular:393.37Ref: TM-T38683
1mg92,00€5mg187,00€10mg298,00€25mg507,00€50mg730,00€100mg1.026,00€1mL*10mM (DMSO)205,00€11β-HSD1-IN-11
CAS:11β-HSd1-in-11 is a potent and competitive inhibitor of 11-β-hydroxysteroid dehydrogenase 1 (11β-HSD1) IN rats and humans with IC50 values of 0.34 μM and 0.13Fórmula:C15H11F3O3SPureza:99.61%Cor e Forma:SoildPeso molecular:328.31Ref: TM-T60149
1mg109,00€5mg241,00€10mg355,00€25mg532,00€50mg745,00€100mg1.018,00€500mg2.043,00€1mL*10mM (DMSO)239,00€BMS-770767
CAS:BMS-770767 is a novel 11-betahydroxysteroid dehydrogenase type I (11ß-HSD1) inhibitor.Fórmula:C19H18ClN3O2Cor e Forma:SolidPeso molecular:355.82SW209049
CAS:SW209049 is a stearoyl-CoA 9-desaturase inhibitor. SW209049 exhivits potent activity against H2122 cell with IC50 of 0.13uM.Fórmula:C25H18N2O4SPureza:99.72%Cor e Forma:SolidPeso molecular:442.49Ref: TM-T9859
1mg73,00€5mg149,00€10mg213,00€25mg319,00€50mg450,00€100mg605,00€200mg802,00€1mL*10mM (DMSO)167,00€PDK-IN-1
CAS:PDK-IN-1, a PDK inhibitor, IC50: 0.03μM (PDK1), 0.1μM (HSP90), reduces tumor mass.Fórmula:C20H16BrN7OCor e Forma:SolidPeso molecular:450.29DSM705
CAS:DSM705: Pyrrole-based, potent nanomolar Plasmodium DHODH inhibitor with strong antimalarial efficacy; spares mammalian DHODH.Fórmula:C19H19F3N6OCor e Forma:SolidPeso molecular:404.397ALDH1A3-IN-1
CAS:ALDH1A3-IN-1 (Compound 14) is a potent inhibitor of ALDH1A3 which can be used in prostate cancer research (IC50 = 0.63 μM; Ki = 0.46 μM) [1].Fórmula:C13H18BrNOCor e Forma:SolidPeso molecular:284.19Trilostane-d3
Trilostane-d3 is a deuterium-substituted isotope-labeled compound of Trilostane, usually used as a quantitative tracer. Trilostane is an inhibitor of 3β-HSD.Fórmula:C20H24D3NO3Cor e Forma:SolidPeso molecular:332.45XTT sodium
CAS:XTT sodium is a cell viability detector that can be metabolized by mitochondrial dehydrogenase in live cells to produce a highly colored formic acid product.Fórmula:C22H16N7NaO13S2Pureza:98.69%Cor e Forma:SolidPeso molecular:673.52
