Desidrogenase
As desidrogenases são enzimas envolvidas nas reações de oxidação-redução das vias metabólicas, desempenhando um papel central na produção de energia e na respiração celular. Estas enzimas são cruciais para processos como o ciclo do ácido cítrico, a glicólise e a oxidação dos ácidos graxos. Os inibidores de desidrogenases são ferramentas importantes no estudo de doenças metabólicas, câncer e estresse oxidativo. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de desidrogenases para apoiar sua pesquisa em metabolismo, biologia do câncer e bioquímica.
Foram encontrados 267 produtos de "Desidrogenase"
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ML-148
CAS:<p>ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM).</p>Fórmula:C20H21N3OPureza:99.88%Cor e Forma:SolidPeso molecular:319.4DS18561882
CAS:<p>DS18561882: Potent MTHFD2 inhibitor (IC50=0.0063), inhibits MTHFD1 (IC50=0.57), good oral kinetics.</p>Fórmula:C28H31F3N4O6SPureza:98.19% - >99.99%Cor e Forma:SolidPeso molecular:608.63Olorofim
CAS:<p>Olorofim（F-901318）is a new selective antifungal compound that inhibits Aspergillus fumigatus DHODH (IC50: 44 nM). Cost-effective and quality-assured.</p>Fórmula:C28H27FN6O2Pureza:99.28%Cor e Forma:SolidPeso molecular:498.55Qc1
CAS:<p>Qc1 is an inhibitor of threonine dehydrogenase (TDH) inhibitor and can be used in studies about metabolic diseases.</p>Fórmula:C23H16F3N3O2SPureza:99.75%Cor e Forma:SolidPeso molecular:455.45CPS-11
CAS:<p>CPS-11, a Thalidomide analogue, shows potent, broad antitumor activity, especially in multiple myeloma cells.</p>Fórmula:C14H12N2O5Pureza:99.8% - 99.98%Cor e Forma:SolidPeso molecular:288.26ALDH1A3-IN-2
CAS:<p>ALDH1A3-IN-2 is a potent ALDH1A3 inhibitor with an IC50 of 0.30 μM.ALDH1A3-IN-2 has potential for cancer disease research.</p>Fórmula:C13H17NOPureza:99.84%Cor e Forma:SolidPeso molecular:203.28PHGDH-IN-3
CAS:<p>PHGDH-IN-3, an oral PHGDH blocker with 2.8 μM IC50, may help in cancer research.</p>Fórmula:C24H18FN3O4S2Pureza:97.24% - 98.55%Cor e Forma:SolidPeso molecular:495.55HSD-016
CAS:<p>HSD-016: Oral 11β-HSD1 inhibitor, active in humans, mice, rats (IC50: 11, 1, 8 nM), potential for type 2 diabetes research.</p>Fórmula:C21H21F7N2O3SPureza:99.40% - >99.99%Cor e Forma:SolidPeso molecular:514.46CM037
CAS:<p>CM037 (A-37) is a selective ALDH1A1 (acetaldehyde dehydrogenase 1A1) inhibitor (IC50; 4.6 µM) with antitumor activity and may be used in studies to eliminate</p>Fórmula:C21H25N3O3S2Pureza:99.34%Cor e Forma:SolidPeso molecular:431.57IDH2R140Q-IN-2
CAS:<p>IDH2R140Q-IN-2 is an IDH2R140Q inhibitor indicated for the study of acute myeloid leukaemia (AML).</p>Fórmula:C21H18F6N6OPureza:99.92%Cor e Forma:SolidPeso molecular:484.4IGP-1
CAS:<p>iGP-1 is a cell-permeable mitochondrial sn-Glycerol 3-phosphate dehydrogenase (mGPDH) inhibitor.</p>Fórmula:C17H15N3O3Pureza:99.12% - 99.15%Cor e Forma:SolidPeso molecular:309.32PKUMDL-WQ-2101
CAS:<p>PKUMDL-WQ-2101 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase with anti-tumor activity.</p>Fórmula:C14H11N3O6Pureza:99.57%Cor e Forma:SolidPeso molecular:317.25hDHODH-IN-7
CAS:<p>hDHODH-IN-7 (DHODH-IN-9) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor.</p>Fórmula:C21H23FN4OPureza:99.87%Cor e Forma:SolidPeso molecular:366.43BMS-823778
CAS:<p>BMS-823778 is a potent inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) for the study of type 2 diabetes.</p>Fórmula:C18H18ClN3OPureza:99.39% - 99.75%Cor e Forma:SolidPeso molecular:327.81IMPDH2-IN-2
CAS:<p>IMPDH2-IN-2 is an IMPDH inhibitor with antimicrobial activity and potential anti-tuberculosis activity for the study of inflammation and immune dysfunction.</p>Fórmula:C21H15Cl2N3O3Pureza:99.02%Cor e Forma:SolidPeso molecular:428.27G6PD activator AG1
CAS:<p>G6PD activator AG1 is a G6PD agonist that promotes G6PD oligomerization to a catalytically competent form.</p>Fórmula:C24H30N4S2Pureza:98.38% - 99.51%Cor e Forma:SolidPeso molecular:438.65DSM421
CAS:<p>DSM421 (DSM-421) is a dihydrodehydrogenase inhibitor (DHODH) that is in preclinical development as a potential treatment option for malaria and has shown</p>Fórmula:C14H11F5N6Pureza:98.23% - 99.82%Cor e Forma:SolidPeso molecular:358.27HSD17B13-IN-2
CAS:<p>HSD17B13-IN-2 (compound 1) serves as a potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) with demonstrable activity in cellular experiments [1</p>Fórmula:C21H23F2NO4Cor e Forma:SolidPeso molecular:391.41α-Pyridoin
CAS:<p>α-Pyridoin (α-pyridoin) is an enediol (enediol) compound that acts as a unique antioxidant.</p>Fórmula:C12H12N2O2Cor e Forma:SolidPeso molecular:216.24IDH1 Inhibitor 2
CAS:<p>IDH1 Inhibitor 2 (compound 13) is a potent IDH1 inhibitor via direct covalent modification of His315 (IC50: 110 nM).</p>Fórmula:C26H22N4OPureza:98%Cor e Forma:SolidPeso molecular:406.48AZD 4017
CAS:<p>AZD 4017 is an inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) (IC50: 7 nM).</p>Fórmula:C22H33N3O3SPureza:99.61%Cor e Forma:SolidPeso molecular:419.5815-PGDH-IN-1
CAS:<p>15-PGDH-IN-1: potent oral 15-PGDH inhibitor, IC50=3nM, useful for tissue repair research.</p>Fórmula:C24H22N4O2Cor e Forma:SolidPeso molecular:398.46GSK321
CAS:<p>GSK321 is an IDH1 inhibitor that prevents cytoplasmic glutamine reductive carboxylation.GSK321 is used in the study of leukemia.</p>Fórmula:C28H28FN5O3Pureza:99.73%Cor e Forma:SolidPeso molecular:501.55CHK-336
CAS:<p>CHK-336 (Example 1), an orally active LDHA inhibitor (IC50 <1 nM), suppresses lactate production in mouse hepatocytes and is applicable in hyperoxaluria</p>Fórmula:C24H20F2N4O4S2Cor e Forma:SolidPeso molecular:530.5715-PGDH-IN-2
CAS:<p>15-PGDH-IN-2 (Compound 2) is an inhibitor of 15-PGDH with an IC50 value of 0.274 nM. This compound is useful for research into hair loss, bone formation, gastric ulcer healing, and dermal wound healing [1].</p>Fórmula:C16H13NO3S2Cor e Forma:SolidPeso molecular:331.41hDHODH-IN-1
CAS:<p>hDHODH-IN-1 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an anti-inflammatory effect.</p>Fórmula:C17H14N2O2Pureza:99.97%Cor e Forma:SolidPeso molecular:278.31YG1702
CAS:<p>YG1702, a potent inhibitor specific to ALDH18A1, suppresses the proliferation of MYCN-amplified neuroblastoma (NB) and reduces MYCN expression.</p>Fórmula:C23H30N2O7SCor e Forma:SolidPeso molecular:478.56PF-915275
CAS:<p>PF-915275 inhibits 11βHSD1 in humans (Ki=2.3 nM, EC50=15 nM) and affects cortisone-cortisol conversion in hepatocytes.</p>Fórmula:C18H14N4O2SPureza:99.58% - 99.61%Cor e Forma:SolidPeso molecular:350.39Anticancer agent 121
CAS:<p>Anticancer agent 121, a human lactate dehydrogenase A (hLDHA) inhibitor, exhibits potent anticancer activities, suitable for use in anticancer research [1].</p>Fórmula:C19H18N2O3SCor e Forma:SolidPeso molecular:354.42MK-0736
CAS:<p>MK-0736 is a potent and selective 11β-HSD-1 inhibitor.</p>Fórmula:C23H30F3N3O2SCor e Forma:SolidPeso molecular:469.56HSD17B13-IN-3
CAS:<p>HSD17B13-IN-3 (compound 2) is a potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13), lacking cellular experimental activity [1].</p>Fórmula:C22H21NO6S2Cor e Forma:SolidPeso molecular:459.54Tetrahydro-11-dehydrocorticosterone
CAS:<p>Tetrahydro-11-dehydrocorticosterone is an inhibitor of 11β-hydroxysteroid dehydrogenase [1].</p>Fórmula:C21H32O4Cor e Forma:SolidPeso molecular:348.48DHODH-IN-22
CAS:<p>DHODH-IN-22: potent, selective DHODH inhibitor, orally active, IC50: 0.3 nM, for AML research.</p>Fórmula:C21H21ClF4N6O5Cor e Forma:SolidPeso molecular:548.88DHODH-IN-14
CAS:<p>DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.</p>Fórmula:C15H7F4N3O3Pureza:99.81%Cor e Forma:SolidPeso molecular:353.23IDH889
CAS:<p>IDH889: Brain-penetrant, mutant-specific IDH1 inhibitor; selective for IDH1 R132* mutations. IC50: 0.02μM (R132H), 0.072μM (R132C), 1.38μM (wild-type).</p>Fórmula:C23H25FN6O2Pureza:≥98%Cor e Forma:SolidPeso molecular:436.48Anticancer agent 122
CAS:<p>Anticancer agent 122, a potent inhibitor of human lactate dehydrogenase A (h LDHA), exhibits significant anticancer activities, rendering it suitable for use in</p>Fórmula:C18H15ClN2O2SCor e Forma:SolidPeso molecular:358.84KB-74935
CAS:<p>KB-74935: enzyme inhibitor, mineralocorticoid blocker, treats cholesterol, hypolipidemia, neurological issues, Alzheimer's.</p>Fórmula:C19H18ClF4N3O3SPureza:99.4%Cor e Forma:SolidPeso molecular:479.88ALDH2 modulator 1
CAS:<p>ALDH2 modulator 1 is a potent and orally active modulator of acetaldehyde dehydrogenase-2 (ALDH2), which reduces blood alcohol levels in mice.</p>Fórmula:C18H18ClFN2O3Pureza:99.68%Cor e Forma:SoildPeso molecular:364.8CB29
CAS:<p>CB29 is a specific inhibitor of aldehyde dehydrogenase 3A1 (ALDH3A1).</p>Fórmula:C15H15N3O5SPureza:99.36%Cor e Forma:SolidPeso molecular:349.36BI-3231
CAS:<p>BI-3231 is a hydroxysteroid 17ß-dehydrogenase 13 HSD17B13 inhibitor that inhibits hHSD17B13 .BI-3231 can be used to study cirrhosis.</p>Fórmula:C16H14F2N4O3SPureza:98.2%Cor e Forma:SolidPeso molecular:380.377-Hydroxy-4-phenylcoumarin
CAS:<p>7-Hydroxy-4-phenylcoumarin is a dual inhibitor of ALDH-2 and MAO, with IC50 values of 1.5 µM and 0.5 µM, respectively.</p>Fórmula:C15H10O3Cor e Forma:SolidPeso molecular:238.238T-3764518
CAS:<p>T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).</p>Fórmula:C20H17F6N5O2Pureza:98%Cor e Forma:SolidPeso molecular:473.37DSM705 hydrochloride
<p>DSM705 hydrochloride: potent antimalarial, pyrrole-based DHODH inhibitor effective against Plasmodium, non-toxic to mammalian DHODH.</p>Fórmula:C19H20ClF3N6OCor e Forma:SolidPeso molecular:440.85FXR/HSD17B13 modulator 1
CAS:<p>FXR/HSD17B13 modulator 1 (compound 6) is an effective modulator of FXR/HSD17B13, playing a significant role in studies related to metabolic dysfunction-associated steatohepatitis (MASH).</p>Fórmula:C26H19Cl2NO4Cor e Forma:SolidPeso molecular:480.339RORγt/DHODH-IN-3
<p>RORγt/DHODH-IN-3 (compound (S)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.098 μM) and DHODH (IC50: 0.432 μM).RORγt/DHODH-IN-1 has</p>Fórmula:C24H26ClF6N3O3SCor e Forma:SolidPeso molecular:585.99PHGDH-IN-2
<p>PHGDH-IN-2: potent PHGDH inhibitor, IC50=5.2μM; hinders PHGDH cancer cell growth & serine synthesis in MDA-MB-468.</p>Fórmula:C22H20N4O3SCor e Forma:SolidPeso molecular:420.48BI-4916
CAS:<p>BI-4916 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor that inhibits SSP and reduces cancer cell migration.</p>Fórmula:C23H24Cl2N2O6SPureza:98.55%Cor e Forma:SolidPeso molecular:527.42PDHK-IN-4
<p>PDHK-IN-4 inhibits PDHK2 (IC50: 0.0051 μM) & PDHK4 (IC50: 0.0122 μM), with potential for cancer research.</p>Fórmula:C24H25N5O3Cor e Forma:SolidPeso molecular:431.49PDHK-IN-3
<p>PDHK-IN-3 (compound 7) is a potent inhibitor of pyruvate dehydrogenase kinase(PDHK) with IC50s of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively [1].</p>Fórmula:C17H16N2O2Cor e Forma:SolidPeso molecular:280.32BRD7539
CAS:<p>BRD7539B: PfDHODH inhibitor, IC50 0.033μM; selective vs HsDHODH, IC50 >50μM.</p>Fórmula:C23H22FN3O2Pureza:98%Cor e Forma:SolidPeso molecular:391.44PDHK-IN-5
<p>PDHK-IN-5, potent PDHK2 (0.006 μM IC50) & PDHK4 (0.0329 μM IC50) inhibitor, may be explored for cancer and diabetes treatment.</p>Fórmula:C30H31N5O2Cor e Forma:SolidPeso molecular:493.6Deamino-NAD sodium
CAS:<p>Deamino-NAD sodium, a structural analog of NAD+, serves as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH) in glycolysis. It exhibits a Km of 2300 pm and a Kd of 112 pm.</p>Fórmula:C21H25N6NaO15P2Cor e Forma:SolidPeso molecular:686.39Etamicastat
CAS:<p>Etamicastat can be used in the research of cardiovascular diseases.</p>Fórmula:C14H15F2N3OSPureza:98%Cor e Forma:SolidPeso molecular:311.3511β-HSD2-IN-2
CAS:<p>11β-HSD2-IN-2 (compound 3) is a selective 17β-HSD2 (17β-hydroxysteroid dehydrogenase type 2) inhibitor with an IC50 of 300 nM, studying osteoporosis.</p>Fórmula:C22H21NO2Pureza:99.61%Cor e Forma:SolidPeso molecular:331.41GSK864
CAS:<p>GSK864 is an inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant. GSK864 inhibits IDH1 mutants R132C, R132H, and R132G (IC50: 8.8, 15.2, and 16.6 nM).</p>Fórmula:C30H31FN6O4Pureza:97.07%Cor e Forma:SolidPeso molecular:558.6MDH1/2-IN-1
CAS:<p>MDH1/2-IN-1 is an MDH1/2 inhibitor with IC50 values of 1.07 nM and 1.06 nM, respectively. It suppresses mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 exhibits significant antitumor potential and offers new avenues for developing drugs targeting cancer metabolism.</p>Fórmula:C25H33NO4Cor e Forma:SolidPeso molecular:411.534AXKO-0046
<p>AXKO-0046 is an indole derivative and small-molecule LDHB selective inhibitor.</p>Fórmula:C25H33N3Cor e Forma:SolidPeso molecular:375.55Indoluidin E
<p>Indoluidin E selectively inhibits DHODH and has an inhibitory effect on cancer cell growth.</p>Fórmula:C28H30N4O2Cor e Forma:SolidPeso molecular:454.56LDHA-IN-5
CAS:<p>LDHA-IN-5 is a novel and potent inhibitor targeting both glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), designed for the treatment of primary</p>Fórmula:C27H22FN7O6S3Cor e Forma:SolidPeso molecular:655.7hDHODH-IN-10
<p>hDHODH-IN-10: selective oral inhibitor of hDHODH (IC50: 10.9 nM); blocks cancer cell growth, aids cancer research.</p>Fórmula:C21H15ClF4N2O4Cor e Forma:SolidPeso molecular:470.8RORγt/DHODH-IN-1
CAS:<p>RORγt/DHODH-IN-1 (compound (R)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.083 μM) and DHODH (IC50: 0.172 μM), which exhibits significant</p>Fórmula:C24H26ClF6N3O3SCor e Forma:SolidPeso molecular:585.99Etamicastat hydrochloride
CAS:<p>Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a peripherally selective dopamine beta-hydroxylase inhibitor that reduces hypertension.</p>Fórmula:C14H16ClF2N3OSPureza:98.54%Cor e Forma:SolidPeso molecular:347.81CP-642931
CAS:<p>CP-642931 (Sorbitol dehydrogenase-IN-1) is a sorbitol dehydrogenase inhibitor used in the study of diabetes mellitus and cardiovascular disease.</p>Fórmula:C17H25N7OPureza:99.67% - >99.99%Cor e Forma:SolidPeso molecular:343.43PS10
CAS:<p>PS10 is a broad-spectrum PDK inhibitor that inhibits PDK2 and significantly increases the activity of the pyruvate dehydrogenase complex.</p>Fórmula:C14H13NO6SPureza:99.01%Cor e Forma:SolidPeso molecular:323.32GNE-140 racemate
CAS:<p>GNE-140 is a potent inhibitor of lactate dehydrogenase A (LDHA). GNE-140 is a racemate mixture of (R)-GNE-140 and (S)-GNE-140.</p>Fórmula:C25H23ClN2O3S2Cor e Forma:SolidPeso molecular:499.04(S)-GNE-140
CAS:<p>(S)-GNE-140 is the less active enantiomer of GNE-140.</p>Fórmula:C25H23ClN2O3S2Cor e Forma:SolidPeso molecular:499.0511β-HSD1-IN-8
CAS:<p>11β-HSD1-IN-8 is a useful organic compound for research related to life sciences. The catalog number is T65743 and the CAS number is 386704-15-0.</p>Fórmula:C10H8F3NO3Cor e Forma:SolidPeso molecular:247.173
