Desidrogenase
As desidrogenases são enzimas envolvidas nas reações de oxidação-redução das vias metabólicas, desempenhando um papel central na produção de energia e na respiração celular. Estas enzimas são cruciais para processos como o ciclo do ácido cítrico, a glicólise e a oxidação dos ácidos graxos. Os inibidores de desidrogenases são ferramentas importantes no estudo de doenças metabólicas, câncer e estresse oxidativo. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de desidrogenases para apoiar sua pesquisa em metabolismo, biologia do câncer e bioquímica.
Foram encontrados 302 produtos de "Desidrogenase"
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ASP3662
CAS:ASP3662/SPI-62: Potent, selective CNS-penetrable 11β-HSD1 inhibitor; potential neuropathic pain treatment.Fórmula:C19H16ClF3N4O2Cor e Forma:SolidPeso molecular:424.8TM-1
CAS:TM-1: PDHK inhibitor, IC50 - PDHK1: 2.97μM, PDHK2: 5.2μM, prevents PDHC phosphorylation, inhibits cancer cell growth.Fórmula:C26H32N2O6Cor e Forma:SolidPeso molecular:468.54DHODH-IN-3
CAS:DHODH-IN-3: Human DHODH inhibitor with IC50 of 261 nM, Kiapp 32 nM, potential anti-malaria drug.Fórmula:C17H13ClN2O2Pureza:98%Cor e Forma:SolidPeso molecular:312.75ALDH3A1-IN-2
CAS:ALDH3A1-IN-2 is a potent inhibitor targeting ALDH3A1 (IC50=1.29µM), potentially useful in cancer research.Fórmula:C11H14N2O3Cor e Forma:SolidPeso molecular:222.2411β-HSD1-IN-10
CAS:11β-HSD1-IN-10, a potent inhibitor of 11β-HSD1 with an IC50 value of 1.8 µM for humans, is suitable for research into obesity, hyperglycemia, and cognitiveFórmula:C16H10F3NO2Cor e Forma:SolidPeso molecular:305.2511β-HSD1-IN-9
CAS:11β-HSD1-IN-9 is a potent inhibitor of 11β-HSD1, displaying IC50 values of 0.48 µM for human and 1.3 µM for murine variants, respectively.Fórmula:C13H9F3N2OCor e Forma:SolidPeso molecular:266.22DHODH-IN-21
CAS:DHODH-IN-21, orally active DHODH blocker with 1.1 nM IC50, shows anticancer activity, potential for AML research.Fórmula:C20H19ClF4N6O4Cor e Forma:SolidPeso molecular:518.85BRD9185
CAS:BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.Fórmula:C23H21F6N3O2Pureza:98%Cor e Forma:SolidPeso molecular:485.42P1788
CAS:P1788 is a dihydroorotate dehydrogenase (DHODH) inhibitor that can induce DNA damage [1].Fórmula:C15H17NO3Cor e Forma:SolidPeso molecular:259.3ML-148
CAS:ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM).Fórmula:C20H21N3OPureza:99.88%Cor e Forma:SolidPeso molecular:319.4Ref: TM-T38163
1mg60,00€5mg165,00€10mg254,00€25mg459,00€50mg658,00€100mg935,00€200mg1.283,00€1mL*10mM (DMSO)188,00€AMG-221
CAS:AMG-221: potent 11β-HSD1 inhibitor, lowers glucose & insulin, reduces obesity in mice.Fórmula:C14H22N2OSPureza:98%Cor e Forma:SolidPeso molecular:266.4hDHODH-IN-11
CAS:hDHODH-IN-11: potent hDHODH inhibitor, IC50 7.2 nM, low cytotoxicity, for AML research.Fórmula:C24H23N3O3Cor e Forma:SolidPeso molecular:401.46MEDS433
CAS:MEDS433 inhibits dihydroorotate dehydrogenase (IC50 1.2 nM) and blocks replication of hCoV-OC43, hCoV-229E, SARS-CoV-2 at nanomolar levels.Fórmula:C20H11F4N3O2Cor e Forma:SolidPeso molecular:401.31Epostane
CAS:Epostane is a 3β-hydroxysteroid dehydrogenase inhibitor that blocks the biosynthesis of progesterone and pregnenolone.Cost-effective and quality-assured.Fórmula:C22H31NO3Pureza:>99.99%Cor e Forma:SolidPeso molecular:357.4911β-HSD1-IN-6
CAS:11β-HSD1-IN-6 is a potent inhibitor of 11β hydroxysteroid dehydrogenase enzymes (11β-HSDs).Fórmula:C21H19ClN4OCor e Forma:SolidPeso molecular:378.86Nitrefazole
CAS:Nitrefazole: a 4-nitroimidazole, inhibits ALDH enzyme crucial for alcohol metabolism, has potent, durable effects.Fórmula:C10H8N4O4Cor e Forma:SolidPeso molecular:248.19CM39
CAS:CM39 inhibits ALDH, linked to cancer stem-like cells & chemoresistance.Fórmula:C19H15FN4OSCor e Forma:SolidPeso molecular:366.41DHODH-IN-24
CAS:DHODH-IN-24 (compound 16) serves as a powerful inhibitor of human dihydroorotate dehydrogenase (DHODH), exhibiting an IC50 value of 91 nM [1].Fórmula:C26H26N4Cor e Forma:SolidPeso molecular:394.51PHGDH-IN-3
CAS:PHGDH-IN-3, an oral PHGDH blocker with 2.8 μM IC50, may help in cancer research.Fórmula:C24H18FN3O4S2Pureza:97.24% - 99.1%Cor e Forma:SolidPeso molecular:495.55DS18561882
CAS:DS18561882: Potent MTHFD2 inhibitor (IC50=0.0063), inhibits MTHFD1 (IC50=0.57), good oral kinetics.Fórmula:C28H31F3N4O6SPureza:98.19% - >99.99%Cor e Forma:SolidPeso molecular:608.63Ref: TM-T11103
1mg109,00€5mg260,00€10mg409,00€25mg737,00€50mg1.198,00€100mg1.611,00€1mL*10mM (DMSO)358,00€DSM421
CAS:DSM421 (DSM-421) is a dihydrodehydrogenase inhibitor (DHODH) that is in preclinical development as a potential treatment option for malaria and has shownFórmula:C14H11F5N6Pureza:99.67% - 99.82%Cor e Forma:SolidPeso molecular:358.27Ref: TM-T27214
1mg110,00€5mg259,00€10mg353,00€25mg533,00€50mg718,00€100mg945,00€200mg1.251,00€1mL*10mM (DMSO)301,00€PBRM
CAS:PBRM (17β-HSD1-IN-2) is a selective covalent inhibitor of 17β-HSD1, used in breast cancer and endometriosis research.Fórmula:C28H34BrNO2Pureza:99.56% - 99.59%Cor e Forma:SolidPeso molecular:496.48G6PD activator AG1
CAS:G6PD activator AG1 is a G6PD agonist that promotes G6PD oligomerization to a catalytically competent form.Fórmula:C24H30N4S2Pureza:98.38% - 99.51%Cor e Forma:SolidPeso molecular:438.65CPS-11
CAS:CPS-11, a Thalidomide analogue, shows potent, broad antitumor activity, especially in multiple myeloma cells.Fórmula:C14H12N2O5Pureza:99.8% - 99.98%Cor e Forma:SolidPeso molecular:288.26PKUMDL-WQ-2101
CAS:PKUMDL-WQ-2101 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase with anti-tumor activity.Fórmula:C14H11N3O6Pureza:99.57%Cor e Forma:SolidPeso molecular:317.25ALDH1A3-IN-2
CAS:ALDH1A3-IN-2 is a potent ALDH1A3 inhibitor with an IC50 of 0.30 μM.ALDH1A3-IN-2 has potential for cancer disease research.Fórmula:C13H17NOPureza:99.84%Cor e Forma:SolidPeso molecular:203.28CM037
CAS:CM037 (A-37) is a selective ALDH1A1 (acetaldehyde dehydrogenase 1A1) inhibitor (IC50; 4.6 µM) with antitumor activity and may be used in studies to eliminateFórmula:C21H25N3O3S2Pureza:99.77%Cor e Forma:SolidPeso molecular:431.57IGP-1
CAS:iGP-1 is a cell-permeable mitochondrial sn-Glycerol 3-phosphate dehydrogenase (mGPDH) inhibitor.Fórmula:C17H15N3O3Pureza:99.12% - 99.15%Cor e Forma:SolidPeso molecular:309.32Ref: TM-T25526
2mg34,00€5mg49,00€10mg71,00€25mg126,00€50mg192,00€100mg304,00€200mg444,00€1mL*10mM (DMSO)84,00€BMS-823778
CAS:BMS-823778 is a potent inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) for the study of type 2 diabetes.Fórmula:C18H18ClN3OPureza:99.39% - 99.75%Cor e Forma:SolidPeso molecular:327.81Ref: TM-T71394
1mg164,00€2mg234,00€5mg389,00€10mg532,00€25mg820,00€50mg1.063,00€100mg1.350,00€200mg1.783,00€hDHODH-IN-7
CAS:hDHODH-IN-7 (DHODH-IN-9) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor.Fórmula:C21H23FN4OPureza:99.87%Cor e Forma:SolidPeso molecular:366.43Ref: TM-T11031
1mg115,00€2mg172,00€5mg255,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€500mg2.147,00€1mL*10mM (DMSO)266,00€IDH2R140Q-IN-2
CAS:IDH2R140Q-IN-2 is an IDH2R140Q inhibitor indicated for the study of acute myeloid leukaemia (AML).Fórmula:C21H18F6N6OPureza:99.92%Cor e Forma:SolidPeso molecular:484.4Qc1
CAS:Qc1 is an inhibitor of threonine dehydrogenase (TDH) inhibitor and can be used in studies about metabolic diseases.Fórmula:C23H16F3N3O2SPureza:99.75%Cor e Forma:SolidPeso molecular:455.45HSD-016
CAS:HSD-016: Oral 11β-HSD1 inhibitor, active in humans, mice, rats (IC50: 11, 1, 8 nM), potential for type 2 diabetes research.Fórmula:C21H21F7N2O3SPureza:99.40% - >99.99%Cor e Forma:SolidPeso molecular:514.46Ref: TM-T63569
1mg84,00€5mg280,00€10mg439,00€25mg888,00€50mg1.485,00€100mg2.358,00€1mL*10mM (DMSO)310,00€GSK321
CAS:GSK321 is an IDH1 inhibitor that prevents cytoplasmic glutamine reductive carboxylation.GSK321 is used in the study of leukemia.Fórmula:C28H28FN5O3Pureza:99.73%Cor e Forma:SolidPeso molecular:501.55DHODH-IN-22
CAS:DHODH-IN-22: potent, selective DHODH inhibitor, orally active, IC50: 0.3 nM, for AML research.Fórmula:C21H21ClF4N6O5Cor e Forma:SolidPeso molecular:548.88Anticancer agent 122
CAS:Anticancer agent 122, a potent inhibitor of human lactate dehydrogenase A (h LDHA), exhibits significant anticancer activities, rendering it suitable for use inFórmula:C18H15ClN2O2SCor e Forma:SolidPeso molecular:358.84AKR1C3-IN-6
CAS:AKR1C3-IN-6: Strong AKR1C3 inhibitor (IC50: 0.31 μM); weak on AKR1C2 (IC50: 73.23 μM); shows antitumor effects.Fórmula:C18H15F3N4O3Cor e Forma:SolidPeso molecular:392.3311α-Hydroxyprogesterone
CAS:11alpha-Hydroxyprogesterone, an inactive analogue of 11beta-Hydroxyprogesterone, serves as an experimental control. Meanwhile, 11beta-Hydroxyprogesterone functions as a potent inhibitor of 11β-Hydroxysteroid dehydrogenase and activates the human mineralocorticoid receptor in COS-7 cells, with an effective dose (ED)50 of 10 nM.Fórmula:C21H30O3Cor e Forma:SolidPeso molecular:330.468Tetrahydro-11-dehydrocorticosterone
CAS:Tetrahydro-11-dehydrocorticosterone is an inhibitor of 11β-hydroxysteroid dehydrogenase [1].Fórmula:C21H32O4Cor e Forma:SolidPeso molecular:348.48HSD17B13-IN-3
CAS:HSD17B13-IN-3 (compound 2) is a potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13), lacking cellular experimental activity [1].Fórmula:C22H21NO6S2Cor e Forma:SolidPeso molecular:459.5415-PGDH-IN-1
CAS:15-PGDH-IN-1: potent oral 15-PGDH inhibitor, IC50=3nM, useful for tissue repair research.Fórmula:C24H22N4O2Cor e Forma:SolidPeso molecular:398.46IDH889
CAS:IDH889: Brain-penetrant, mutant-specific IDH1 inhibitor; selective for IDH1 R132* mutations. IC50: 0.02μM (R132H), 0.072μM (R132C), 1.38μM (wild-type).Fórmula:C23H25FN6O2Pureza:≥98%Cor e Forma:SolidPeso molecular:436.48YG1702
CAS:YG1702, a potent inhibitor specific to ALDH18A1, suppresses the proliferation of MYCN-amplified neuroblastoma (NB) and reduces MYCN expression.Fórmula:C23H30N2O7SCor e Forma:SolidPeso molecular:478.56CHK-336
CAS:CHK-336 (Example 1), an orally active LDHA inhibitor (IC50 <1 nM), suppresses lactate production in mouse hepatocytes and is applicable in hyperoxaluriaFórmula:C24H20F2N4O4S2Cor e Forma:SolidPeso molecular:530.57hDHODH-IN-1
CAS:hDHODH-IN-1 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an anti-inflammatory effect.Fórmula:C17H14N2O2Pureza:99.97%Cor e Forma:SolidPeso molecular:278.31Ref: TM-T11546
1mg34,00€5mg71,00€10mg103,00€25mg200,00€50mg290,00€100mg404,00€200mg545,00€1mL*10mM (DMSO)78,00€AZD 4017
CAS:AZD 4017 is an inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) (IC50: 7 nM).Fórmula:C22H33N3O3SPureza:99.61%Cor e Forma:SolidPeso molecular:419.58Ref: TM-T14388
1mg70,00€5mg152,00€10mg260,00€25mg520,00€50mg750,00€100mg1.035,00€1mL*10mM (DMSO)166,00€Anticancer agent 121
CAS:Anticancer agent 121, a human lactate dehydrogenase A (hLDHA) inhibitor, exhibits potent anticancer activities, suitable for use in anticancer research [1].Fórmula:C19H18N2O3SCor e Forma:SolidPeso molecular:354.42MK-0736
CAS:MK-0736 is a potent and selective 11β-HSD-1 inhibitor.Fórmula:C23H30F3N3O2SCor e Forma:SolidPeso molecular:469.56HSD17B13-IN-2
CAS:HSD17B13-IN-2 (compound 1) serves as a potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) with demonstrable activity in cellular experiments [1Fórmula:C21H23F2NO4Cor e Forma:SolidPeso molecular:391.41S07-1066
CAS:S07-1066, an aldo-keto reductase 1C3 (AKR1C3) inhibitor, enhances doxorubicin (DOX) cytotoxicity by selectively inhibiting AKR1C3-mediated reduction of DOX andFórmula:C16H11Cl2FO2Pureza:98%Cor e Forma:SolidPeso molecular:325.16
