Desidrogenase
As desidrogenases são enzimas envolvidas nas reações de oxidação-redução das vias metabólicas, desempenhando um papel central na produção de energia e na respiração celular. Estas enzimas são cruciais para processos como o ciclo do ácido cítrico, a glicólise e a oxidação dos ácidos graxos. Os inibidores de desidrogenases são ferramentas importantes no estudo de doenças metabólicas, câncer e estresse oxidativo. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de desidrogenases para apoiar sua pesquisa em metabolismo, biologia do câncer e bioquímica.
Foram encontrados 302 produtos de "Desidrogenase"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
DHODH-IN-14
CAS:DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.Fórmula:C15H7F4N3O3Pureza:99.81%Cor e Forma:SolidPeso molecular:353.23Ref: TM-T11023
1mg109,00€2mg163,00€5mg243,00€10mg355,00€25mg532,00€50mg750,00€100mg1.009,00€500mgA consultar1mL*10mM (DMSO)250,00€IDH1 Inhibitor 2
CAS:IDH1 Inhibitor 2 (compound 13) is a potent IDH1 inhibitor via direct covalent modification of His315 (IC50: 110 nM).Fórmula:C26H22N4OPureza:98%Cor e Forma:SolidPeso molecular:406.48PF-915275
CAS:PF-915275 inhibits 11βHSD1 in humans (Ki=2.3 nM, EC50=15 nM) and affects cortisone-cortisol conversion in hepatocytes.Fórmula:C18H14N4O2SPureza:99.58% - 99.61%Cor e Forma:SolidPeso molecular:350.39Ref: TM-T16510
1mg35,00€2mg50,00€5mg77,00€10mg120,00€25mg241,00€50mg472,00€100mg685,00€500mg1.431,00€1mL*10mM (DMSO)85,00€MK-0736 hydrochloride
CAS:MK-0736 hydrochloride is a potent and selective 11β-HSD-1 inhibitor.Fórmula:C23H31ClF3N3O2SCor e Forma:SolidPeso molecular:506.03α-Pyridoin
CAS:α-Pyridoin (α-pyridoin) is an enediol (enediol) compound that acts as a unique antioxidant.Fórmula:C12H12N2O2Cor e Forma:SolidPeso molecular:216.2415-PGDH-IN-2
CAS:15-PGDH-IN-2 (Compound 2) is an inhibitor of 15-PGDH with an IC50 value of 0.274 nM. This compound is useful for research into hair loss, bone formation, gastric ulcer healing, and dermal wound healing [1].Fórmula:C16H13NO3S2Cor e Forma:SolidPeso molecular:331.41BI-3231
CAS:BI-3231 is a hydroxysteroid 17ß-dehydrogenase 13 HSD17B13 inhibitor that inhibits hHSD17B13 .BI-3231 can be used to study cirrhosis.Fórmula:C16H14F2N4O3SPureza:98.2%Cor e Forma:SolidPeso molecular:380.37Ref: TM-T73446
1mg69,00€5mg147,00€10mg224,00€25mg358,00€50mg512,00€100mg707,00€200mg982,00€1mL*10mM (DMSO)164,00€CB29
CAS:CB29 is a specific inhibitor of aldehyde dehydrogenase 3A1 (ALDH3A1).
Fórmula:C15H15N3O5SPureza:99.36%Cor e Forma:SolidPeso molecular:349.36KB-74935
CAS:KB-74935: enzyme inhibitor, mineralocorticoid blocker, treats cholesterol, hypolipidemia, neurological issues, Alzheimer's.Fórmula:C19H18ClF4N3O3SPureza:99.4%Cor e Forma:SolidPeso molecular:479.88ALDH2 modulator 1
CAS:ALDH2 modulator 1 is a potent and orally active modulator of acetaldehyde dehydrogenase-2 (ALDH2), which reduces blood alcohol levels in mice.
Fórmula:C18H18ClFN2O3Pureza:99.68%Cor e Forma:SoildPeso molecular:364.817β-HSD1-IN-1
17β-HSD1-IN-1 (Compound 1) can be used in the non-small cell lung cancer (NSCLC) research.Fórmula:C21H21NO3Cor e Forma:SolidPeso molecular:335.4LDHA-IN-5
CAS:LDHA-IN-5 is a novel and potent inhibitor targeting both glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), designed for the treatment of primaryFórmula:C27H22FN7O6S3Cor e Forma:SolidPeso molecular:655.7FXR/HSD17B13 modulator 1
CAS:FXR/HSD17B13 modulator 1 (compound 6) is an effective modulator of FXR/HSD17B13, playing a significant role in studies related to metabolic dysfunction-associated steatohepatitis (MASH).Fórmula:C26H19Cl2NO4Cor e Forma:SolidPeso molecular:480.339T-3764518
CAS:T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).Fórmula:C20H17F6N5O2Pureza:98%Cor e Forma:SolidPeso molecular:473.37MDH1/2-IN-1
CAS:MDH1/2-IN-1 is an MDH1/2 inhibitor with IC50 values of 1.07 nM and 1.06 nM, respectively. It suppresses mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 exhibits significant antitumor potential and offers new avenues for developing drugs targeting cancer metabolism.Fórmula:C25H33NO4Cor e Forma:SolidPeso molecular:411.534PDHK-IN-4
PDHK-IN-4 inhibits PDHK2 (IC50: 0.0051 μM) & PDHK4 (IC50: 0.0122 μM), with potential for cancer research.Fórmula:C24H25N5O3Cor e Forma:SolidPeso molecular:431.49DSM705 hydrochloride
DSM705 hydrochloride: potent antimalarial, pyrrole-based DHODH inhibitor effective against Plasmodium, non-toxic to mammalian DHODH.Fórmula:C19H20ClF3N6OCor e Forma:SolidPeso molecular:440.85BRD7539
CAS:BRD7539B: PfDHODH inhibitor, IC50 0.033μM; selective vs HsDHODH, IC50 >50μM.Fórmula:C23H22FN3O2Pureza:98%Cor e Forma:SolidPeso molecular:391.447-Hydroxy-4-phenylcoumarin
CAS:7-Hydroxy-4-phenylcoumarin is a dual inhibitor of ALDH-2 and MAO, with IC50 values of 1.5 µM and 0.5 µM, respectively.Fórmula:C15H10O3Cor e Forma:SolidPeso molecular:238.238BI-4916
CAS:BI-4916 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor that inhibits SSP and reduces cancer cell migration.Fórmula:C23H24Cl2N2O6SPureza:98.55% - 98.55%Cor e Forma:SolidPeso molecular:527.42PDHK-IN-3
PDHK-IN-3 (compound 7) is a potent inhibitor of pyruvate dehydrogenase kinase(PDHK) with IC50s of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively [1].Fórmula:C17H16N2O2Cor e Forma:SolidPeso molecular:280.32Deamino-NAD sodium
CAS:Deamino-NAD sodium, a structural analog of NAD+, serves as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH) in glycolysis. It exhibits a Km of 2300 pm and a Kd of 112 pm.Fórmula:C21H25N6NaO15P2Cor e Forma:SolidPeso molecular:686.39PHGDH-IN-2
PHGDH-IN-2: potent PHGDH inhibitor, IC50=5.2μM; hinders PHGDH cancer cell growth & serine synthesis in MDA-MB-468.Fórmula:C22H20N4O3SCor e Forma:SolidPeso molecular:420.48GSK864
CAS:GSK864 is an inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant. GSK864 inhibits IDH1 mutants R132C, R132H, and R132G (IC50: 8.8, 15.2, and 16.6 nM).Fórmula:C30H31FN6O4Pureza:97.07%Cor e Forma:SolidPeso molecular:558.6HSD17B13-IN-40
CAS:HSD17B13-IN-40 (compound 6) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of less than 0.1 μM using estradiol as substrates. This compound is significant in the treatment of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Fórmula:C23H14Cl2F3N3O3Cor e Forma:SolidPeso molecular:508.28HSD17B13-IN-32
CAS:HSD17B13-IN-32 (Compound 67) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤0.1 μM for estradiol. It can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) [1].Fórmula:C23H15Cl2N5O3Cor e Forma:SolidPeso molecular:480.3RORγt/DHODH-IN-3
RORγt/DHODH-IN-3 (compound (S)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.098 μM) and DHODH (IC50: 0.432 μM).RORγt/DHODH-IN-1 hasFórmula:C24H26ClF6N3O3SCor e Forma:SolidPeso molecular:585.99Mirivadelgat
CAS:Mirivadelgat is an activator of aldehyde dehydrogenase 2 (aldehyde dehydrogenase2). It is anticipated to be useful in research related to interstitial lung disease, pulmonary arterial hypertension, and cancer.Fórmula:C30H34FN3O5Cor e Forma:SolidPeso molecular:535.607HSD17B13-IN-28
CAS:HSD17B13-IN-28 (compound 47) is a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), with an IC50 of < 0.1 μM using estradiol as a substrate. HSD17B13-IN-28 plays an important role in nonalcoholic fatty liver diseases (NAFLDs), including NASH (nonalcoholic steatohepatitis) [1].Fórmula:C23H16Cl2FN3O3Cor e Forma:SolidPeso molecular:472.3Indoluidin E
Indoluidin E selectively inhibits DHODH and has an inhibitory effect on cancer cell growth.Fórmula:C28H30N4O2Cor e Forma:SolidPeso molecular:454.56AKR1C3-IN-7
AKR1C3-IN-7 (Compound 13) is an effective and selective AKR1C3 inhibitor (IC50=0.19 μM). AKR1C3-IN-7 has antitumor activity.Fórmula:C24H20N2O4Cor e Forma:SolidPeso molecular:400.43AKR1C3-IN-8
AKR1C3-IN-8 (Compound 5) is an effective and selective AKR1C3 inhibitor (IC50=0.069 μM). AKR1C3-IN-8 has antitumor activity.Fórmula:C23H20N4O3Cor e Forma:SolidPeso molecular:400.43(6S)-CP-470711
CAS:(6S)-CP-470711 (Compound 8) acts as an inhibitor of sorbitol dehydrogenase (SDH) in both humans and rats, exhibiting inhibitory concentrations (IC50) of 19 nM and 27 nM, respectively. Additionally, (6S)-CP-470711 has been shown to ameliorate diabetes in rats induced by Streptozotocin.Fórmula:C18H26N6O2Cor e Forma:SolidPeso molecular:358.4411β-HSD2-IN-2
CAS:11β-HSD2-IN-2 (compound 3) is a selective 17β-HSD2 (17β-hydroxysteroid dehydrogenase type 2) inhibitor with an IC50 of 300 nM, studying osteoporosis.Fórmula:C22H21NO2Pureza:99.61%Cor e Forma:SolidPeso molecular:331.41HSD17B13-IN-84
CAS:HSD17B13-IN-84 (182) serves as an inhibitor of 17β-Hydroxysteroid dehydrogenases (HSD17B13), exhibiting an IC50 of less than 0.1 μM for Estradiol. It is primarily utilized in the study of NAFLD (Nonalcoholic fatty liver diseases) [1].Fórmula:C19H12Cl2F3N3O3SPeso molecular:490.28Oxamic acid
CAS:Oxamic acid is an LDHA inhibitor, antitumor, induces apoptosis, downregulates EGFR expression, and inhibits cancer stem cell properties and EMT.Fórmula:C2H3NO3Cor e Forma:SolidPeso molecular:89.05AXKO-0046
AXKO-0046 is an indole derivative and small-molecule LDHB selective inhibitor.Fórmula:C25H33N3Cor e Forma:SolidPeso molecular:375.55HSD17B13-IN-95
CAS:HSD17B13-IN-95 (1) serves as an inhibitor for 17 β-hydroxysteroid dehydrogenase (HSD17B13), exhibiting an IC50 value of <0.1 μM for estradiol. It is applicable in researching nonalcoholic fatty liver disease [1].Fórmula:C24H16F6N4O4Peso molecular:538.40HSD17B13-IN-17
CAS:HSD17B13-IN-17 (compound 9) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13). It demonstrates inhibitory efficacy with IC50 values of ＜0.1 μM for estradiol and ＜1 μM for Leukotriene B3 as substrates. This compound is significant in the management of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Fórmula:C20H16ClFN2O3SCor e Forma:SolidPeso molecular:418.87HSD17B13-IN-19
CAS:HSD17B13-IN-19 (compound 16) acts as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting IC50 values under 0.1 μM and under 1 μM when using estradiol and Leukotriene B3 as substrates, respectively. This compound is crucial in the treatment of nonalcoholic fatty liver diseases (NAFLDs), such as nonalcoholic steatohepatitis (NASH) [1].Fórmula:C23H23FN2O4SCor e Forma:SolidPeso molecular:442.5HSD17B13-IN-44
CAS:HSD17B13-IN-44 (Compound 23) functions as an inhibitor targeting hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of < 0.1 μM against estradiol. This compound is applicable in the study of liver diseases or metabolic disorders [1].Fórmula:C18H14FNO5S2Cor e Forma:SolidPeso molecular:407.44PDHK-IN-5
PDHK-IN-5, potent PDHK2 (0.006 μM IC50) & PDHK4 (0.0329 μM IC50) inhibitor, may be explored for cancer and diabetes treatment.Fórmula:C30H31N5O2Cor e Forma:SolidPeso molecular:493.6Etamicastat
CAS:Etamicastat can be used in the research of cardiovascular diseases.Fórmula:C14H15F2N3OSPureza:98%Cor e Forma:SolidPeso molecular:311.35HSD17B13-IN-30
CAS:HSD17B13-IN-30 (compound 64) serves as a potent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), exhibiting an IC 50 value of less than 0.1 μM? with estradiol? as substrates. This compound is significantly implicated in the management of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Fórmula:C24H16Cl2F3N3O4Cor e Forma:SolidPeso molecular:538.315-epi-PGE1
CAS:15-epi-PGE1 (15R-Prostaglandin E1; 15-Epiprostaglandin E1), a stereoisomer of PGE1, exhibits reduced biological activity [2]. This compound acts as a non-competitive inhibitor of human placental 15-Hydroxyprostaglandin dehydrogenase (15-PGDH), with an inhibitory concentration 50 (IC50) value of 170 μM [1].Fórmula:C20H34O5Cor e Forma:SolidPeso molecular:354.48RORγt/DHODH-IN-1
CAS:RORγt/DHODH-IN-1 (compound (R)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.083 μM) and DHODH (IC50: 0.172 μM), which exhibits significantFórmula:C24H26ClF6N3O3SCor e Forma:SolidPeso molecular:585.99hDHODH-IN-10
hDHODH-IN-10: selective oral inhibitor of hDHODH (IC50: 10.9 nM); blocks cancer cell growth, aids cancer research.Fórmula:C21H15ClF4N2O4Cor e Forma:SolidPeso molecular:470.8Etamicastat hydrochloride
CAS:Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a peripherally selective dopamine beta-hydroxylase inhibitor that reduces hypertension.Fórmula:C14H16ClF2N3OSPureza:98.54%Cor e Forma:SolidPeso molecular:347.81Ref: TM-T11238L
1mg80,00€5mg173,00€10mg259,00€25mg423,00€50mg577,00€100mg827,00€1mL*10mM (DMSO)190,00€CP-642931
CAS:CP-642931 (Sorbitol dehydrogenase-IN-1) is a sorbitol dehydrogenase inhibitor used in the study of diabetes mellitus and cardiovascular disease.Fórmula:C17H25N7OPureza:99.67% - >99.99%Cor e Forma:SolidPeso molecular:343.43GNE-140 racemate
CAS:GNE-140 is a potent inhibitor of lactate dehydrogenase A (LDHA). GNE-140 is a racemate mixture of (R)-GNE-140 and (S)-GNE-140.Fórmula:C25H23ClN2O3S2Cor e Forma:SolidPeso molecular:499.04
