Lipoxigenase
As lipoxigenases são uma família de enzimas que catalisam a oxigenação de ácidos graxos poli-insaturados, levando à produção de mediadores lipídicos bioativos, como os leucotrienos e as lipoxinas. Esses mediadores desempenham papéis críticos na inflamação, nas respostas imunes e no câncer. Inibidores de lipoxigenase são utilizados para estudar seu papel em doenças inflamatórias, asma e câncer. Na CymitQuimica, oferecemos uma variedade de inibidores de lipoxigenase para apoiar sua pesquisa em inflamação, oncologia e metabolismo lipídico.
Foram encontrados 124 produtos de "Lipoxigenase"
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Zileuton
CAS:<p>Zileuton (A 64077) inhibits 5-lipoxygenase, reduces leukotrienes, aids bronchodilation, lessens mucus/edema, and helps manage asthma symptoms.</p>Fórmula:C11H12N2O2SPureza:98.72% - 99.43%Cor e Forma:Crystalline SolidPeso molecular:236.29Diethylcarbamazine citrate
CAS:<p>Diethylcarbamazine citrate treats filariasis, targeting W. bancrofti and L. loa by inhibiting arachidonic acid in microfilaria.</p>Fórmula:C10H21N3O·C6H8O7Pureza:99.61%Cor e Forma:White Crystalline Powder And Animals (Epa 1998)Peso molecular:391.42Meclofenoxate hydrochloride
CAS:<p>Meclofenoxate HCl (Lucidril) boosts memory and cognition; it's a DIMETHYLAMINOETHANOL and p-chlorophenoxyacetic acid ester.</p>Fórmula:C12H16ClNO3·HClPureza:97.05%Cor e Forma:White Crystal PowderPeso molecular:294.17Lagunamycin
CAS:<p>Lagunamycin is used as a novel 5-lipoxygenase inhibitor.</p>Fórmula:C19H21N3O4Cor e Forma:SolidPeso molecular:355.3913-epi-12-oxo Phytodienoic Acid
CAS:<p>13-epi-12-oxo PDA is a lipoxygenase derivative of α-linolenic acid in green plant leaves, often isomerizing during extraction and storage.</p>Fórmula:C18H28O3Cor e Forma:SolidPeso molecular:292.41(±)15-HEDE
CAS:<p>(±)15-HEDE is produced by non-enzymatic oxidation of 11,14-eicosadienoic acid.</p>Fórmula:C20H36O3Cor e Forma:SolidPeso molecular:324.5055-Lipoxygenase-IN-3
CAS:<p>Compound 14, a <1 μM 5-lipoxygenase inhibitor, researches inflammation, cancer, stroke, Alzheimer's.</p>Fórmula:C19H16ClN5OCor e Forma:SolidPeso molecular:365.82Damnacanthol
<p>Damnacanthol is a useful organic compound for research related to life sciences and the catalog number is T131609.</p>Fórmula:C16H12O5Cor e Forma:SolidPeso molecular:284.26715-LOX-1 inhibitor 1
CAS:<p>9c(i472) blocks 15-LO-1 (IC50=0.19μM), lowers NF-κB in RAW-Blue cells, & cuts Nos2/lipid peroxidation in RAW 264.7 at 0.2-5μM.</p>Fórmula:C22H21ClN2O4Cor e Forma:SolidPeso molecular:412.87DKI5
CAS:<p>DKI5, a LOX-1 inhibitor with 22.5 μM IC50, may exhibit anti-inflammatory, antioxidant, and anti-lipid peroxidation effects in vitro.</p>Fórmula:C8H10N4SPureza:98%Cor e Forma:SoildPeso molecular:194.26(-)-Dihydroguaiaretic acid
<p>(-)-Dihydroguaiaretic acid is a useful organic compound for research related to life sciences and the catalog number is T126154.</p>Fórmula:C20H26O4Cor e Forma:SolidPeso molecular:330.424CMI977
CAS:<p>CMI977 is a potent inhibitor of 5-Lipoxygenase (5-LO).</p>Fórmula:C16H19FN2O4Pureza:98%Cor e Forma:SolidPeso molecular:322.33E 6080 HCl
CAS:<p>E 6080 HCl is a 5-lipoxygenase inhibitor and can be used to study bronchial diseases.</p>Fórmula:C17H20ClN3O3S2Pureza:99.80%Cor e Forma:SoildPeso molecular:413.945-LOX-IN-5
<p>Compound 29, also known as 5-LOX-IN-5, is a 5-lipoxygenase (5-LOX) inhibitor with an inhibitory concentration 50 (IC50) of 56 nM, utilized in research</p>Fórmula:C19H18BrN3O2SPureza:98%Cor e Forma:SolidPeso molecular:432.33ZD-2138
CAS:<p>ZD-2138: Selective 5-LOX inhibitor, eases allergen-induced asthma attacks and airway constriction in guinea pigs.</p>Fórmula:C23H24FNO4Pureza:99.68% - >99.99%Cor e Forma:SolidPeso molecular:397.44CBS-1114 HCl
CAS:<p>CBS-1114 HCl: 5-lipoxygenase inhibitor, anti-inflammatory, improves heart function, reduces heart's fat.</p>Fórmula:C13H14ClN3Pureza:99.36%Cor e Forma:SoildPeso molecular:247.72h15-LOX-2 inhibitor 2
<p>Compound 10 (h15-LOX-2 inhibitor 2) suppresses h15-LOX activity, exhibiting IC 50 and K i values of 26.9 μM and 16.4 μM, respectively.</p>Fórmula:C22H30Cl2N6O3Cor e Forma:SolidPeso molecular:497.422-Methyl-1-naphthol
CAS:<p>2-Methyl-1-naphthol is a prostaglandin G/H synthase and polyunsaturated fatty acid 5-lipoxygenase inhibitor, suitable for biochemical experiments.</p>Fórmula:C11H10OPureza:98.33%Cor e Forma:SolidPeso molecular:158.21-Naphthyl 3,5-dinitrobenzoate
CAS:<p>1-Naphthyl 3,5-dinitrobenzoate (JMC-4) is an inhibitor of 5-LOX can be used in studies about inflammatory therapy.</p>Fórmula:C17H10N2O6Pureza:99.79%Cor e Forma:SolidPeso molecular:338.27ThioLox
CAS:<p>ThioLox, a 15-LOX-1 inhibitor (IC50: 12 μM), has anti-inflammatory, neuroprotective benefits, and guards against glutamate toxicity.</p>Fórmula:C15H18N2OSPureza:99.98%Cor e Forma:SoildPeso molecular:274.385-LOX/NO-IN-1
<p>5-LOX/NO-IN-1 (Compound 7e) is a dual inhibitor of 5-LOX and nitric oxide release. It exhibits an IC50 value of 2.833 μM for 5-LOX and demonstrates anti-inflammatory properties.</p>Fórmula:C22H18N6O4Cor e Forma:SolidPeso molecular:430.42mPGES-1/5-LOX-IN-1
<p>mPGES-1/5-LOX-IN-1 (compound 3j) is a potent, orally active dual inhibitor of mPGES-1 and 5-LOX, with IC50 values of 0.92 and 1.89 µM, respectively. Additionally, mPGES-1/5-LOX-IN-1 exhibits anti-inflammatory properties.</p>Fórmula:C20H22N4O6SPeso molecular:446.12601Caffeoylcalleryanin
CAS:<p>Caffeoylcalleryanin demonstrated potent inhibitory activity against 15-lipoxygenase (15-LOX), with an IC50 value of 1.59 μM. Furthermore, ethanol extract from A. pulchra leaves (EEAPL) was found to contain compounds exhibiting antiviral properties, particularly effective against Dengue virus type 2 (DENV-2). Among these compounds, Caffeoylcalleryanin emerged as the most potent anti-DENV-2 agent, achieving a selectivity index (SI) of 20.0.</p>Fórmula:C22H24O11Cor e Forma:SolidPeso molecular:464.4Ferroleuton
<p>Ferroleuton is a selective competitive inhibitor of 5-lipoxygenase with an IC50 of 0.21 μM. It demonstrates antioxidant properties, clearing 86% of DPPH at 50 μM and exhibiting activities in ABTS (EC50 = 19.42 μM) and FRAP (EC50 = 3.32 μM) assays.</p>Fórmula:C13H16FeN2O2Cor e Forma:SolidPeso molecular:288.12Myxochelin A
CAS:<p>Myxochelin A from A. disciformis fights Gram-positive bacteria, inhibits 5-LO with IC50 of 1.9 μM, and is cytotoxic to colon cancer cells.</p>Fórmula:C20H24N2O7Cor e Forma:SolidPeso molecular:404.419CJ-13,610 hydrochloride
CAS:<p>CJ-13,610 hydrochloride is an orally active nonredox-type inhibitor of 5-LOX and can be used in studies about the prevention of untoward pathophysiological</p>Fórmula:C22H24ClN3O2SPureza:98.5%Cor e Forma:SoildPeso molecular:429.96LOX-IN-5
CAS:<p>LOX-IN-5 (compound 22) is a non-selective LOX inhibitor.</p>Fórmula:C21H25FN4O2SCor e Forma:SolidPeso molecular:416.51Ruthenoleuton
<p>Ruthenoleuton is a 5-lipoxygenase (5-LOX) inhibitor with an IC50 of 3.49 μM and a Ki of 0.80 μM. It possesses antioxidant properties and is applicable in research on inflammatory diseases.</p>Fórmula:C13H16N2O2RuCor e Forma:SolidPeso molecular:333.35KKII5
CAS:<p>KKII5 is a potent inhibitor of the lipoxygenase LOX-1 with an IC50 of 19 μM.KKII5 inhibits lipid peroxidation and enhances the ability of the active centers of</p>Fórmula:C16H14N2SPureza:99.34%Cor e Forma:SolidPeso molecular:266.36Lipoxygenase
CAS:<p>Lipoxygenase (LOX) is a dioxygenase that catalyzes the peroxidation of linoleic acid (LA) or arachidonic acid (AA) in the presence of molecular oxygen.</p>Cor e Forma:SolidAureusidin
CAS:<p>Aureusidin (Auresidin) shows antioxidant and lipoxygenase inhibitory activity with anti-inflammatory effects.</p>Fórmula:C15H10O6Pureza:98.17% - 99.18%Cor e Forma:SolidPeso molecular:286.24Cinnamyl-3,4-dihydroxy-α-cyanocinnamate
CAS:<p>Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC), 12/15-LO inhibitor for diabetes. Affordable Excellence: Reliable Quality You Can Trust</p>Fórmula:C19H15NO4Cor e Forma:SolidPeso molecular:321.33Zileuton sodium
CAS:<p>Zileuton sodium (A 64077 sodium) is a potent and selective inhibitor of 5-lipoxygenase with anti-inflammatory activities.</p>Fórmula:C11H11N2NaO2SCor e Forma:SolidPeso molecular:258.274',5-Dihydroxyflavone
CAS:<p>4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).</p>Fórmula:C15H10O4Pureza:99.81%Cor e Forma:SolidPeso molecular:254.24Malotilate
CAS:<p>Malotilate (Kantec) is a medicine used for the therapy of liver cirrhosis.</p>Fórmula:C12H16O4S2Pureza:99.79% - 99.79%Cor e Forma:SolidPeso molecular:288.384-MMPB
CAS:<p>15-Lipoxygenase Inhibitor 1 is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM.</p>Fórmula:C16H19N5SPureza:97.18%Cor e Forma:SolidPeso molecular:313.42Xanthatin
CAS:<p>Xanthatin exhibits cytotoxic, antibacterial, antifungal properties, may treat NSCLC, and inhibits melanoma by targeting Wnt/β-catenin and angiogenesis.</p>Fórmula:C15H18O3Pureza:98.48% - 99.96%Cor e Forma:SolidPeso molecular:246.3LOX-IN-3 dihydrochloride
CAS:<p>LOX-IN-3 dihydrochloride is an inhibitor of lysyl oxidase (LOX).</p>Fórmula:C13H15Cl2FN2O2SPureza:99.96%Cor e Forma:SolidPeso molecular:353.24Phenethyl ferulate
CAS:<p>Phenethyl ferulate is a chemopreventive against colon cancer, enhancing apoptosis in tumors and inhibiting COX/5-LOX (IC50: 4.35/5.75 μM).</p>Fórmula:C18H18O4Pureza:99.88% - 99.91%Cor e Forma:SolidPeso molecular:298.33Phenidone
CAS:<p>Phenidone inhibits COX/LOX, reducing rat autoimmune paralysis and lowering blood pressure in hypertensive rats.</p>Fórmula:C9H10N2OPureza:97.24%Cor e Forma:White Solid Solid CrystallinePeso molecular:162.19Chebulagic acid
CAS:<p>Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.</p>Fórmula:C41H30O27Pureza:97.82% - 99.8%Cor e Forma:SolidPeso molecular:954.66Licofelone
CAS:<p>Licofelone (ML-3000) is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis.</p>Fórmula:C23H22ClNO2Pureza:99.25%Cor e Forma:Yellowish SolidPeso molecular:379.88S-(+)-Marmesin
CAS:<p>S-(+)-Marmesin (marmesin) is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.</p>Fórmula:C14H14O4Pureza:98.00% - ≥98%Cor e Forma:SolidPeso molecular:246.26PGS-IN-1
CAS:<p>PGS-IN-1 (KME-4) is a potent inhibitor of prostaglandin synthetase (PGS, IC50: 0.28 μM) and 5-lipoxygenase (IC50: 1.05 μM).</p>Fórmula:C19H26O3Pureza:99.39%Cor e Forma:SolidPeso molecular:302.41Psoralidin
CAS:<p>Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally.</p>Fórmula:C20H16O5Pureza:98% - 99.61%Cor e Forma:SolidPeso molecular:336.34SKF-86002
CAS:<p>SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).</p>Fórmula:C16H12FN3SPureza:98% - 99.85%Cor e Forma:SolidPeso molecular:297.35Indirubin-3'-monoxime
CAS:<p>Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/</p>Fórmula:C16H11N3O2Pureza:99.55%Cor e Forma:Dark Red SolidPeso molecular:277.283-O-Acetyl-11-hydroxy-β-boswellic acid
CAS:<p>3-O-Acetyl-11-hydroxy-beta-boswellic acid is the precursor of 3-O-acetyl-9, 11-dehydro-beta-boswellic acid(a 5-lipoxygenase inhibitor ).</p>Fórmula:C32H50O5Pureza:98.24%Cor e Forma:SolidPeso molecular:514.74Nordihydroguaiaretic acid
CAS:<p>Nordihydroguaiaretic acid (NDGA) is a natural lipoxygenase (5-LOX) inhibitor. Nordihydroguaiaretic acid has antioxidant effect. Cost-effective and quality-assured.</p>Fórmula:C18H22O4Pureza:97.82% - 99.91%Cor e Forma:SolidPeso molecular:302.36β-Aminopropionitrile hydrochloride
CAS:<p>β-Aminopropionitrile hydrochloride is a selective, oral, irreversible inhibitor of lysyl oxidase (LOX) that reduces metastatic seeding potential.</p>Fórmula:C3H7ClN2Pureza:99.32%Cor e Forma:SolidPeso molecular:106.55β-Boswellic acid
CAS:<p>β-Boswellic acid (Beta-boswellic acid) and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic</p>Fórmula:C30H48O3Pureza:99.2% - 99.91%Cor e Forma:Off-White SolidPeso molecular:456.7ETHYL 5-HYDROXY-2-METHYLINDOLE-3-CARBOXYLATE
CAS:<p>ETHYL 5-HYDROXY-2-METHYLINDOLE-3-CARBOXYLATE is useful for preparation and study of hypoxia-selective cytotoxicity of indolequinone antitumor agents.</p>Fórmula:C12H13NO3Pureza:98.9%Cor e Forma:Off-White To Light Tan Crystalline PowderPeso molecular:219.24BI-0115
CAS:<p>BI-0115 inhibits LOX-1, preventing oxLDL uptake by triggering receptor inhibition and dimer formation.</p>Fórmula:C15H14ClN3OPureza:99.34%Cor e Forma:SolidPeso molecular:287.74Pectolinarigenin
CAS:<p>Pectolinarigenin has hepatoprotective and anti-inflammatory properties, acting through SOD and inhibiting eicosanoids.</p>Fórmula:C17H14O6Pureza:98.67% - 99.88%Cor e Forma:SolidPeso molecular:314.29Caffeic Acid
CAS:<p>Caffeic acid is a dual inhibitor of 5-lipoxygenase and TRPV1 ion channels. High-Quality, Low-Cost!</p>Fórmula:C9H8O4Pureza:98.89% - 99.3%Cor e Forma:Yellow Crystals From Concentrated Aqueous Solutions Alkaline Solns Turn From Yellow To Orange Alkaline Solutions Turn From Yellow To Orange (Ntp 1992)Peso molecular:180.162,5-Di-tert-butylhydroquinone
CAS:<p>2,5-Di-tert-butylhydroquinone (BHQ) is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.</p>Fórmula:C14H22O2Pureza:97.11%Cor e Forma:PelletslargecrystalsPeso molecular:222.32Tepoxalin
CAS:<p>Tepoxalin (RWJ 20485), potential asthma and osteoarthritis drug, inhibits COX-1, COX-2, and 5-LOX with low IC50 values.</p>Fórmula:C20H20ClN3O3Pureza:99.94%Cor e Forma:SolidPeso molecular:385.845-O-Demethylnobiletin
CAS:<p>5-O-Demethylnobiletin is a natural anti-inflammatory that inhibits 5-LOX without altering COX-2 expression.</p>Fórmula:C20H20O8Pureza:99.83% - ≥95%Cor e Forma:SolidPeso molecular:388.37FPL 62064
CAS:<p>FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin</p>Fórmula:C16H15N3OPureza:98.79%Cor e Forma:SolidPeso molecular:265.31ML351
CAS:<p>ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).</p>Fórmula:C15H11N3OPureza:97.67%Cor e Forma:SolidPeso molecular:249.27Linoleyl alcohol
CAS:<p>Linoleyl alcohol (CIS,CIS-9,12-OCTADECADIENOL), fatty alcohol, is a structural analog of Linoleic acid with no a-carboxyl group[1].</p>Fórmula:C18H34OPureza:98.12%Cor e Forma:SolidPeso molecular:266.463-Hydroxycoumarin
CAS:<p>3-Hydroxycoumarin is a natural compound, and is human 15-LOX-1 inhibitors</p>Fórmula:C9H6O3Pureza:99.5% - 99.77%Cor e Forma:SolidPeso molecular:162.14ML355
CAS:<p>ML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 μM), possess favorable ADME properties.</p>Fórmula:C21H19N3O4S2Pureza:98.02% - 98.2%Cor e Forma:SolidPeso molecular:441.5211-Keto-β-boswellic acid
CAS:<p>11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor, exerts dose dependent cardioprotective effect manifested.</p>Fórmula:C30H46O4Pureza:99.68%Cor e Forma:SolidPeso molecular:470.68Terameprocol
CAS:<p>Terameprocol (EM-1421), a synthetic NDGA derivative, shows potent anti-HIV, antiangiogenic, and anticancer properties.</p>Fórmula:C22H30O4Pureza:99.38%Cor e Forma:SolidPeso molecular:358.47Wedelolactone
CAS:<p>Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.</p>Fórmula:C16H10O7Pureza:98.07% - 99.87%Cor e Forma:SolidPeso molecular:314.25CAY10698
CAS:<p>CAY10698 is a 12-lipoxygenase inhibitor (12-LO; IC50 of 5.1 μM).</p>Fórmula:C17H17N3O4S2Pureza:98.97%Cor e Forma:SolidPeso molecular:391.46U-73122
CAS:<p>U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.</p>Fórmula:C29H40N2O3Pureza:97.50%Cor e Forma:Solid Off-WhitePeso molecular:464.645-LOX inhibitor
CAS:<p>5-LOX inhibitor (1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one) is an itraconazole impurity, a LOX-5 inhibitor.</p>Fórmula:C22H27N5O2Pureza:98.01%Cor e Forma:SolidPeso molecular:393.48a-Boswellic Acid
CAS:Produto Controlado<p>Applications The principal constitutents of frankincense (olibanum). A specific, nonredox inhibitor of 5-lipoxygenase used to treat inflammation.<br>References Safayhi, H. et al.: J. Pharmacol. Exp. Therap., 261, 1143 (1992); Siemoneit, U., et al.: Eur. J. Pharmacol., 606, 246 (2009); Cao, H. et al.: Pharamacol. Res., 61, 519 (2010);<br></p>Fórmula:C30H48O3Cor e Forma:NeatPeso molecular:456.70Golocdacimab
CAS:<p>Golocdacimab (anti-LOX-1 mAb) targets LOX-1, with potential applications for type 2 diabetes complications and preventing HAE attacks.</p>Pureza:95%Cor e Forma:Liquid4-(2-Methylpropyl)benzenemethanol
CAS:Produto ControladoFórmula:C11H16OCor e Forma:NeatPeso molecular:164.24tHGA
CAS:<p>tHGA is a potent inhibitor of lipoxygenase.</p>Fórmula:C18H24O4Pureza:98%Cor e Forma:SolidPeso molecular:304.38BI-L 357
CAS:<p>BI-L 357, a prodrug of BL-L 226, is a selective, orally active inhibitor of 5-lipoxygenase.</p>Fórmula:C18H18O4SCor e Forma:SolidPeso molecular:330.4L 652343
CAS:<p>L 652343 is an inhibitor of cyclooxygenase and 5-lipoxygenase in vitro. It also inhibits the synthesis of the products of both these pathways in whole cells.</p>Fórmula:C22H14F3NO2S2Cor e Forma:SolidPeso molecular:445.482-TEDC
CAS:<p>2-TEDC: Potent LOX inhibitor, blocks 5-LOX, 12-LOX, 15-LOX (IC50: 0.09, 0.013, 0.5 μM); aids atherosclerosis research.</p>Fórmula:C16H13NO4SPureza:99.75%Cor e Forma:SolidPeso molecular:315.34Atreleuton
CAS:<p>Atreleuton (ABT-761), reversible oral 5-LO inhibitor, selectively blocks leukotriene formation.</p>Fórmula:C16H15FN2O2SPureza:98%Cor e Forma:SolidPeso molecular:318.37RWJ 63556
CAS:<p>RWJ 63556 is an orally active inhibitor of COX-2 selective/5-lipoxygenase, shows anti-inflammatory activities.</p>Fórmula:C11H10FNO3S2Pureza:99.92%Cor e Forma:SolidPeso molecular:287.33AHR-5333
CAS:<p>AHR-5333 an antiallergy agent.</p>Fórmula:C30H33F2NO4Pureza:98%Cor e Forma:SolidPeso molecular:509.58PF-4191834
CAS:<p>PF-4191834: Non-iron, non-redox 5-LOX inhibitor, IC50 = 229 nM, 300x selective over 12/15-LOX, inactive on COX enzymes.</p>Fórmula:C22H23N3O2SPureza:99.83% - 99.98%Cor e Forma:SolidPeso molecular:393.5Enazadrem
CAS:<p>Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.</p>Fórmula:C18H25N3OPureza:98%Cor e Forma:SolidPeso molecular:299.41Fluindione
CAS:<p>Fluindione is a hematologic drug.</p>Fórmula:C15H9FO2Cor e Forma:SolidPeso molecular:240.23LY 269415
CAS:<p>LY 269415 is an anti-inflammatory agent with antioxidant properties in vitro and could be beneficial as therapeutic agents in inflammatory arthritis.</p>Fórmula:C19H28N2O2SCor e Forma:SolidPeso molecular:348.5YS-121
CAS:<p>YS121 inhibits mPGES-1 (IC50=3.4μM) & 5-LOX (IC50=6.5μM), and lowers PGE2 in A549 cells (EC50=12μM).</p>Fórmula:C20H26ClN3O2SCor e Forma:SolidPeso molecular:407.96Lipoxygenin
CAS:<p>Lipoxygenin: IC50 of 5 μM inhibits 5-LO, hedgehog, TGF-β, activin A, BMP, Wnt signaling, and boosts cardiac marker TnnT in iPSCs.</p>Fórmula:C24H22N2O4Cor e Forma:SolidPeso molecular:402.44LP117
CAS:<p>LP117 is a novel and effective inhibitor of 5-Lipoxygenase (5-LO) product synthesis (IC50: 1.1 μM).</p>Fórmula:C21H23ClN4O2SPureza:98%Cor e Forma:SolidPeso molecular:430.95ICI 211965
CAS:<p>ICI 211965 is a selective and orally potent of 5-Lipoxygenase (5-LPO).</p>Fórmula:C24H23NO2SPureza:98%Cor e Forma:SolidPeso molecular:389.51Fenleuton
CAS:<p>Fenleuton is a 5-lipoxygenase inhibitor.</p>Fórmula:C17H15FN2O3Pureza:98%Cor e Forma:SolidPeso molecular:314.31LY 221068
CAS:<p>LY 221068 is a potent antioxidant with anti-inflammatory activity.</p>Fórmula:C20H30N2O2SPureza:98%Cor e Forma:SolidPeso molecular:362.53L 656224
CAS:<p>L 656224 is a 5-LO inhibitor.</p>Fórmula:C20H21ClO3Pureza:98%Cor e Forma:SolidPeso molecular:344.83Texasin
CAS:<p>Texasin is a selective inhibitor of human leukocyte 5-lipoxygenase.</p>Fórmula:C16H12O5Pureza:98%Cor e Forma:SolidPeso molecular:284.26Cgp 8065
CAS:<p>Cgp 8065 is a filaricidal compound, a dithiocarbamate-derivative of amoscanate.</p>Fórmula:C16H15N3O4S2Cor e Forma:SolidPeso molecular:377.44EP6
CAS:<p>EP6 blocks 5-LO, key in the AA cascade, reducing leukotrienes to curb inflammation and allergies.</p>Fórmula:C24H30N4OPureza:98%Cor e Forma:SolidPeso molecular:390.52HZ52
CAS:<p>HZ52: Potent reversible 5-LO inhibitor; IC50 0.7 μM; blocks LTs in human leukocytes.</p>Fórmula:C24H26ClN3O2SCor e Forma:SolidPeso molecular:456RG 6866
CAS:<p>RG 6866 is a inhibitor of 5-lipoxygenase.</p>Fórmula:C16H17NO3Pureza:98%Cor e Forma:SolidPeso molecular:271.31L-651392
CAS:<p>L-651392 is an inhibitor of leukotriene.</p>Fórmula:C14H10BrNO3SCor e Forma:SolidPeso molecular:352.2MLS000536924
CAS:<p>MLS000536924 is a potent and selective competitive human epithelial 15-lipoxygenase-2 inhibitor.</p>Fórmula:C16H15N3SCor e Forma:SolidPeso molecular:281.38A-69412
CAS:<p>A-69412 is a reversible 5-lipoxygenase inhibitor, potentially treating ulcerative colitis and asthma.</p>Fórmula:C7H10N2O3Pureza:99.54%Cor e Forma:SolidPeso molecular:170.17Utreloxastat
CAS:<p>Utreloxastat (PTC857) is a novel 15-lipoxygenase inhibitor that can be used to study amyotrophic lateral sclerosis<br>.</p>Fórmula:C18H28O2Pureza:99.95%Cor e Forma:SolidPeso molecular:276.41Butibufen
CAS:<p>Butibufen (FF-106) is a non-steroidal anti-inflammatory compound and LOX inhibitor with analgesic and antipyretic activity for the study of rheumatic diseases.</p>Fórmula:C14H20O2Pureza:98.11% - 98.91%Cor e Forma:SolidPeso molecular:220.31Lonapalene
CAS:<p>Lonapalene is a topically effective inhibitor of 5-lipoxygenase.</p>Fórmula:C16H15ClO6Pureza:98.67% - 99.33%Cor e Forma:SolidPeso molecular:338.74S-2474
CAS:<p>S-2474, an inhibitor of COX-2 and 5-lipoxygenase, has anti-inflammatory and neuroprotective activities, and inhibits cell death.</p>Fórmula:C20H31NO3SPureza:99.03%Cor e Forma:SolidPeso molecular:365.535-LOX-IN-1
CAS:<p>5-LOX-IN-1 is a 5-Lipoxygenase (5-LOX) inhibitor (IC50: 2.3 μM).5-LOX-IN-1 can be used for cancer research.</p>Fórmula:C20H18N2O2SPureza:97.45%Cor e Forma:SolidPeso molecular:350.43h15-LOX-2 inhibitor 1
CAS:<p>Compound 105 (h15-LOX-2 inhibitor 1) is a potent inhibitor of human epithelial 15-lipoxygenase-2 (h15-LOX-2), exhibiting an IC50 of 0.34 μM [1].</p>Fórmula:C17H13F3N2SPureza:98%Cor e Forma:SolidPeso molecular:334.365,6-dehydro Arachidonic Acid
CAS:<p>5,6-dehydro Arachidonic acid, an arachidonic acid analog with a 5,6 acetylene, inhibits 5-LO; Ki=15 μM in RBL cells, IC50=10 μM in guinea pig leukocytes.</p>Fórmula:C20H30O2Cor e Forma:SolidPeso molecular:302.45A 78773
CAS:<p>A 78773: potent reversible 5-lipoxygenase inhibitor; active in cells/tissues; targets inflammation, asthma, IBD.</p>Fórmula:C15H13FN2O4Cor e Forma:SolidPeso molecular:304.27L 670630
CAS:<p>L 670630 is a potent and orally active 5-lipoxygenase inhibitor.</p>Fórmula:C25H26O3Pureza:98%Cor e Forma:SolidPeso molecular:374.47AA 863
CAS:<p>AA 863 is a 5-lipoxygenase inhibitor, it inhibits the proliferation of human glioma cell lines in dose-dependent.</p>Fórmula:C21H26O5Pureza:98%Cor e Forma:SolidPeso molecular:358.43A 79175
CAS:<p>A 79175 is a 5-lipoxygenase inhibitor that increases bone formation.</p>Fórmula:C15H13FN2O4Pureza:98%Cor e Forma:SolidPeso molecular:304.27CMI-392
CAS:<p>CMI-392 is a dual 5-lipoxygenase inhibitor and platelet-activating factor (PAF) receptor antagonist (IC50s: 100 and 10 nM).</p>Fórmula:C31H37ClN2O8SPureza:98%Cor e Forma:SolidPeso molecular:633.15MLS000545091
CAS:<p>MLS000545091 is a potent and selective human epithelial 15-lipoxygenase-2 mixed-type inhibitor.</p>Fórmula:C14H15ClN2OPureza:99.84%Cor e Forma:SolidPeso molecular:262.73Benoxaprofen
CAS:<p>Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.</p>Fórmula:C16H12ClNO3Pureza:98.87%Cor e Forma:SolidPeso molecular:301.725-Lipoxygenase-In-1
CAS:<p>5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor.</p>Fórmula:C23H28N4O2SCor e Forma:SolidPeso molecular:424.5617(S)-HpDHA
CAS:<p>17(S)-HpDHA, primarily produced by the 15-Lipoxygenase (LOX) isoenzymes h15-LOX-1 and h15-LOX-2 from docosahexaenoic acid (DHA), is a key regulator in epoxide synthesis through allosteric modulation. Additionally, it effectively inhibits platelet aggregation, demonstrating an EC50 of approximately 1 μM [1].</p>Fórmula:C22H32O4Cor e Forma:SolidPeso molecular:360.49CCT365623
CAS:<p>CCT365623: oral Lysyl Oxidase inhibitor, potent, selective, good pharmacokinetics, anti-metastatic.</p>Fórmula:C18H17NO4S3Pureza:97.299% - 99.49%Cor e Forma:SolidPeso molecular:407.53PXS-6302 hydrochloride
CAS:<p>PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3</p>Fórmula:C10H11ClF3NO2SPureza:99.89%Cor e Forma:SoildPeso molecular:301.71Setileuton
CAS:<p>Setileuton (MK0633) is a specific 5-LOX inhibitor and can be used in research on asthma and atherosclerosis.</p>Fórmula:C22H17F4N3O4Pureza:98.85% - 99.35%Cor e Forma:SolidPeso molecular:463.38h15-LOX-2 inhibitor 3
CAS:<p>Compound 13, identified as h15-LOX-2 inhibitor 3, exhibits inhibitory activity against h15-LOX, with IC50 and Ki values of 25 μM and 15.1 μM, respectively.</p>Fórmula:C22H13N5O3Cor e Forma:SolidPeso molecular:395.37AZD 4407
CAS:<p>AZD 4407 is a potent inhibitor of 5-lipoxygenase.</p>Fórmula:C19H21NO3S2Pureza:98%Cor e Forma:SolidPeso molecular:375.5ALOX15-IN-1
<p>ALOX15-IN-1 (8b) inhibits rabbit/human ALOX15; IC50: 0.04 μM for LA, 2.06 μM for AA.</p>Fórmula:C24H31N3O5SCor e Forma:SolidPeso molecular:473.595-LOX/MAOs-IN-1
CAS:<p>Compound 3, known as 5-LOX/MAOs-IN-1, acts as an inhibitor of 5-LOX/MAOs and is an effective free radical scavenger, displaying antioxidant characteristics. It has demonstrated neuroprotective effects in cell models damaged by oxidative stress and is capable of activating the neurogenesis microenvironment in adult mouse neural stem cells. This compound is utilized in research focused on neurodegenerative diseases.</p>Fórmula:C18H18N2O2Cor e Forma:SolidPeso molecular:294.35L 691816
CAS:<p>L 691816 is an effective inhibitor of the 5-LO reaction.</p>Fórmula:C36H35ClN6OSPureza:98%Cor e Forma:SolidPeso molecular:635.22ALOX15-IN-2
CAS:<p>ALOX15-IN-2: Potent ALOX15 inhibitor. IC50: 1.55 μM for LA; 2.79 μM for AA. Stops linoleic/arachidonic acid oxidation.</p>Fórmula:C23H29N3O4SPureza:98.10%Cor e Forma:SolidPeso molecular:443.56CJ-13,610
CAS:<p>CJ-13,610 is an orally active and nonredox-type inhibitor of 5-lipoxygenase (5-LOX). CJ-13,610 inhibits the biosynthesis of leukotriene B4 and regulates the expression of IL-6 mRNA in macrophages.</p>Fórmula:C22H23N3O2SPureza:99.64%Cor e Forma:SolidPeso molecular:393.5
