Lipoxigenase
As lipoxigenases são uma família de enzimas que catalisam a oxigenação de ácidos graxos poli-insaturados, levando à produção de mediadores lipídicos bioativos, como os leucotrienos e as lipoxinas. Esses mediadores desempenham papéis críticos na inflamação, nas respostas imunes e no câncer. Inibidores de lipoxigenase são utilizados para estudar seu papel em doenças inflamatórias, asma e câncer. Na CymitQuimica, oferecemos uma variedade de inibidores de lipoxigenase para apoiar sua pesquisa em inflamação, oncologia e metabolismo lipídico.
Foram encontrados 133 produtos de "Lipoxigenase"
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Nordihydroguaiaretic acid
CAS:Nordihydroguaiaretic acid (NDGA) is a natural lipoxygenase (5-LOX) inhibitor. Nordihydroguaiaretic acid has antioxidant effect. Cost-effective and quality-assured.Fórmula:C18H22O4Pureza:97.82% - 99.91%Cor e Forma:SolidPeso molecular:302.36β-Boswellic acid
CAS:β-Boswellic acid (Beta-boswellic acid) and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemicFórmula:C30H48O3Pureza:99.2% - 99.96%Cor e Forma:Off-White SolidPeso molecular:456.70Ref: TM-TN1097
1mg58,00€5mg137,00€10mg212,00€25mg363,00€50mg527,00€100mg747,00€1mL*10mM (DMSO)161,00€ETHYL 5-HYDROXY-2-METHYLINDOLE-3-CARBOXYLATE
CAS:ETHYL 5-HYDROXY-2-METHYLINDOLE-3-CARBOXYLATE is useful for preparation and study of hypoxia-selective cytotoxicity of indolequinone antitumor agents.Fórmula:C12H13NO3Pureza:98.9%Cor e Forma:Off-White To Light Tan Crystalline PowderPeso molecular:219.24BI-0115
CAS:BI-0115 inhibits LOX-1, preventing oxLDL uptake by triggering receptor inhibition and dimer formation.Fórmula:C15H14ClN3OPureza:99.34%Cor e Forma:SolidPeso molecular:287.74Pectolinarigenin
CAS:Pectolinarigenin has hepatoprotective and anti-inflammatory properties, acting through SOD and inhibiting eicosanoids.Fórmula:C17H14O6Pureza:98.67% - 99.88%Cor e Forma:SolidPeso molecular:314.29Ref: TM-T6S0413
1mg46,00€5mg89,00€10mg154,00€25mg265,00€50mg409,00€100mg620,00€1mL*10mM (DMSO)110,00€Caffeic Acid
CAS:Caffeic acid is a dual inhibitor of 5-lipoxygenase and TRPV1 ion channels. High-Quality, Low-Cost!Fórmula:C9H8O4Pureza:98.89% - 99.3%Cor e Forma:Yellow Crystals From Concentrated Aqueous Solutions Alkaline Solns Turn From Yellow To Orange Alkaline Solutions Turn From Yellow To Orange (Ntp 1992)Peso molecular:180.164',5-Dihydroxyflavone
CAS:4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).Fórmula:C15H10O4Pureza:99.81%Cor e Forma:SolidPeso molecular:254.242,5-Di-tert-butylhydroquinone
CAS:2,5-Di-tert-butylhydroquinone (BHQ) is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.Fórmula:C14H22O2Pureza:97.11%Cor e Forma:PelletslargecrystalsPeso molecular:222.32Tepoxalin
CAS:Tepoxalin (RWJ 20485), potential asthma and osteoarthritis drug, inhibits COX-1, COX-2, and 5-LOX with low IC50 values.Fórmula:C20H20ClN3O3Pureza:99.94%Cor e Forma:SolidPeso molecular:385.84Ref: TM-T7724
1mg52,00€5mg113,00€10mg166,00€25mg371,00€50mg557,00€100mg792,00€200mg1.071,00€1mL*10mM (DMSO)126,00€5-O-Demethylnobiletin
CAS:5-O-Demethylnobiletin is a natural anti-inflammatory that inhibits 5-LOX without altering COX-2 expression.
Fórmula:C20H20O8Pureza:99.83% - ≥95%Cor e Forma:SolidPeso molecular:388.37FPL 62064
CAS:FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandinFórmula:C16H15N3OPureza:98.79%Cor e Forma:SolidPeso molecular:265.31Ref: TM-T8356
2mg35,00€5mg52,00€10mg86,00€25mg136,00€50mg198,00€100mg298,00€200mg414,00€1mL*10mM (DMSO)73,00€ML351
CAS:ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).Fórmula:C15H11N3OPureza:97.67%Cor e Forma:SolidPeso molecular:249.27Ref: TM-T21902
1mg50,00€5mg105,00€10mg167,00€25mg334,00€50mg505,00€100mg713,00€1mL*10mM (DMSO)117,00€Linoleyl alcohol
CAS:Linoleyl alcohol (CIS,CIS-9,12-OCTADECADIENOL), fatty alcohol, is a structural analog of Linoleic acid with no a-carboxyl group[1].Fórmula:C18H34OPureza:98.12%Cor e Forma:SolidPeso molecular:266.463-Hydroxycoumarin
CAS:3-Hydroxycoumarin is a natural compound, and is human 15-LOX-1 inhibitorsFórmula:C9H6O3Pureza:99.5% - 99.77%Cor e Forma:SolidPeso molecular:162.1411-Keto-β-boswellic acid
CAS:11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor, exerts dose dependent cardioprotective effect manifested.Fórmula:C30H46O4Pureza:99.68%Cor e Forma:SolidPeso molecular:470.68Ref: TM-TN1182
1mg57,00€5mg130,00€10mg200,00€25mg338,00€50mg497,00€100mg710,00€1mL*10mM (DMSO)133,00€Terameprocol
CAS:Terameprocol (EM-1421), a synthetic NDGA derivative, shows potent anti-HIV, antiangiogenic, and anticancer properties.Fórmula:C22H30O4Pureza:99.38%Cor e Forma:SolidPeso molecular:358.47Wedelolactone
CAS:Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.Fórmula:C16H10O7Pureza:98.07% - 99.87%Cor e Forma:SolidPeso molecular:314.25Ref: TM-T3384
1mg34,00€5mg71,00€10mg109,00€25mg175,00€50mg314,00€100mg414,00€500mg954,00€1mL*10mM (DMSO)50,00€CAY10698
CAS:CAY10698 is a 12-lipoxygenase inhibitor (12-LO; IC50 of 5.1 μM).Fórmula:C17H17N3O4S2Pureza:98.97%Cor e Forma:SolidPeso molecular:391.46Ref: TM-T8950
2mg38,00€5mg52,00€10mg88,00€25mg161,00€50mg243,00€100mg355,00€200mg502,00€1mL*10mM (DMSO)62,00€U-73122
CAS:U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.Fórmula:C29H40N2O3Pureza:97.50%Cor e Forma:Solid Off-WhitePeso molecular:464.64a-Boswellic Acid
CAS:Produto ControladoApplications The principal constitutents of frankincense (olibanum). A specific, nonredox inhibitor of 5-lipoxygenase used to treat inflammation.
References Safayhi, H. et al.: J. Pharmacol. Exp. Therap., 261, 1143 (1992); Siemoneit, U., et al.: Eur. J. Pharmacol., 606, 246 (2009); Cao, H. et al.: Pharamacol. Res., 61, 519 (2010);Fórmula:C30H48O3Cor e Forma:NeatPeso molecular:456.74-(2-Methylpropyl)benzenemethanol
CAS:Produto ControladoFórmula:C11H16OCor e Forma:NeatPeso molecular:164.24MLS000536924
CAS:MLS000536924 is a potent and selective competitive human epithelial 15-lipoxygenase-2 inhibitor.Fórmula:C16H15N3SCor e Forma:SolidPeso molecular:281.38tHGA
CAS:tHGA is a potent inhibitor of lipoxygenase.Fórmula:C18H24O4Pureza:98%Cor e Forma:SolidPeso molecular:304.38L 652343
CAS:L 652343 is an inhibitor of cyclooxygenase and 5-lipoxygenase in vitro. It also inhibits the synthesis of the products of both these pathways in whole cells.Fórmula:C22H14F3NO2S2Cor e Forma:SolidPeso molecular:445.48AHR-5333
CAS:AHR-5333 an antiallergy agent.Fórmula:C30H33F2NO4Pureza:98%Cor e Forma:SolidPeso molecular:509.58PF-4191834
CAS:PF-4191834: Non-iron, non-redox 5-LOX inhibitor, IC50 = 229 nM, 300x selective over 12/15-LOX, inactive on COX enzymes.Fórmula:C22H23N3O2SPureza:99.83% - 99.98%Cor e Forma:SolidPeso molecular:393.5Ref: TM-T16503
5mg50,00€10mg79,00€25mg146,00€50mg245,00€100mg355,00€500mg772,00€1mL*10mM (DMSO)55,00€Texasin
CAS:Texasin is a selective inhibitor of human leukocyte 5-lipoxygenase.Fórmula:C16H12O5Pureza:98%Cor e Forma:SolidPeso molecular:284.26L-651392
CAS:L-651392 is an inhibitor of leukotriene.Fórmula:C14H10BrNO3SCor e Forma:SolidPeso molecular:352.2SB 210661
CAS:SB 210661 is a potent and selective 5-lipoxygenase inhibitor.Fórmula:C16H14F2N2O4Pureza:98%Cor e Forma:SolidPeso molecular:336.29Enazadrem
CAS:Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.
Fórmula:C18H25N3OPureza:98%Cor e Forma:SolidPeso molecular:299.41Nafazatrom
CAS:Nafazatrom: pyrazolinone lipoxygenase inhibitor, anticancer & antithrombotic, boosts PGI2, reduces arrhythmias.Fórmula:C16H16N2O2Cor e Forma:SolidPeso molecular:268.31LY 221068
CAS:LY 221068 is a potent antioxidant with anti-inflammatory activity.Fórmula:C20H30N2O2SPureza:98%Cor e Forma:SolidPeso molecular:362.5315(S)-HETrE
CAS:15(S)-HETrE, a 15-lipoxygenated DGLA derivative, inhibits human 5-LO with IC50 of 4.6μM; 5% as effective in RBL cells.Fórmula:C20H34O3Cor e Forma:SolidPeso molecular:322.48AHR-5333 mandelate
CAS:AHR-5333 mandelate is an anti-allergy agent preventing anaphylaxis and skin hypersensitivity; inhibits 5-HETE, LTB4, LTC4 synthesis.Fórmula:C38H41F2NO7Cor e Forma:SolidPeso molecular:661.7413(S)-HpOTrE(γ)
CAS:13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid.Fórmula:C18H30O4Cor e Forma:SolidPeso molecular:310.43Leukotriene A3 methyl ester
CAS:LTA3, made from 5,8,11-eicosatrienoic acid via 5-LO, is unstable; its stable methyl ester form turns into free acid when needed.Fórmula:C21H34O3Cor e Forma:SolidPeso molecular:334.49Setileuton tosylate
CAS:Setileuton (MK0633): a potent 5-lipoxygenase inhibitor, researched for asthma and atherosclerosis treatment.Fórmula:C29H25F4N3O7SCor e Forma:SolidPeso molecular:635.58Atreleuton
CAS:Atreleuton (ABT-761), reversible oral 5-LO inhibitor, selectively blocks leukotriene formation.Fórmula:C16H15FN2O2SPureza:98%Cor e Forma:SolidPeso molecular:318.37YS-121
CAS:YS121 inhibits mPGES-1 (IC50=3.4μM) & 5-LOX (IC50=6.5μM), and lowers PGE2 in A549 cells (EC50=12μM).Fórmula:C20H26ClN3O2SCor e Forma:SolidPeso molecular:407.96LP117
CAS:LP117 is a novel and effective inhibitor of 5-Lipoxygenase (5-LO) product synthesis (IC50: 1.1 μM).Fórmula:C21H23ClN4O2SPureza:98%Cor e Forma:SolidPeso molecular:430.95Fenleuton
CAS:Fenleuton is a 5-lipoxygenase inhibitor.Fórmula:C17H15FN2O3Pureza:98%Cor e Forma:SolidPeso molecular:314.31L 656224
CAS:L 656224 is a 5-LO inhibitor.Fórmula:C20H21ClO3Pureza:98%Cor e Forma:SolidPeso molecular:344.83RG 6866
CAS:RG 6866 is a inhibitor of 5-lipoxygenase.Fórmula:C16H17NO3Pureza:98%Cor e Forma:SolidPeso molecular:271.31ICI 211965
CAS:ICI 211965 is a selective and orally potent of 5-Lipoxygenase (5-LPO).Fórmula:C24H23NO2SPureza:98%Cor e Forma:SolidPeso molecular:389.51EP6
CAS:EP6 blocks 5-LO, key in the AA cascade, reducing leukotrienes to curb inflammation and allergies.Fórmula:C24H30N4OPureza:98%Cor e Forma:SolidPeso molecular:390.52HZ52
CAS:HZ52: Potent reversible 5-LO inhibitor; IC50 0.7 μM; blocks LTs in human leukocytes.Fórmula:C24H26ClN3O2SCor e Forma:SolidPeso molecular:456Cgp 8065
CAS:Cgp 8065 is a filaricidal compound, a dithiocarbamate-derivative of amoscanate.Fórmula:C16H15N3O4S2Cor e Forma:SolidPeso molecular:377.44Fluindione
CAS:Fluindione is a hematologic drug.Fórmula:C15H9FO2Cor e Forma:SolidPeso molecular:240.23Lipoxygenin
CAS:Lipoxygenin: IC50 of 5 μM inhibits 5-LO, hedgehog, TGF-β, activin A, BMP, Wnt signaling, and boosts cardiac marker TnnT in iPSCs.Fórmula:C24H22N2O4Cor e Forma:SolidPeso molecular:402.44BI-L 357
CAS:BI-L 357, a prodrug of BL-L 226, is a selective, orally active inhibitor of 5-lipoxygenase.Fórmula:C18H18O4SCor e Forma:SolidPeso molecular:330.4
