Fosfolipase
As fosfolipases são um grupo de enzimas que hidrolisam fosfolipídios em ácidos graxos e outras substâncias lipofílicas, desempenhando um papel crítico na biologia das membranas e na geração de moléculas sinalizadoras. Inibidores de fosfolipases são usados para estudar seu papel em doenças inflamatórias, distúrbios cardiovasculares e neurodegeneração. Esses inibidores também são valiosos na exploração de vias de sinalização lipídica e suas implicações nos mecanismos de doenças. Na CymitQuimica, oferecemos uma variedade de inibidores de fosfolipases para apoiar sua pesquisa em inflamação, metabolismo lipídico e sinalização celular.
Foram encontrados 82 produtos de "Fosfolipase"
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Omeprazole
CAS:<p>Omeprazole (Losec) is a proton pump inhibitor (PPI), Omeprazole(Losec) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor.</p>Fórmula:C17H19N3O3SPureza:98.43% - 98.48%Cor e Forma:White SolidPeso molecular:345.42Niflumic acid
CAS:<p>Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.</p>Fórmula:C13H9F3N2O2Pureza:99.47%Cor e Forma:SolidPeso molecular:282.22Tris(2,4-di-tert-butylphenyl)phosphate
CAS:<p>Tris(2,4-di-tert-butylphenyl)phosphate (TDTBPP) inhibits secretory phospholipase A2 (sPLA2) with anti-inflammatory effect. Cost-effective and quality-assured.</p>Fórmula:C42H63O4PPureza:99.73%Cor e Forma:SolidPeso molecular:662.92Lp-PLA2-IN-1
CAS:<p>Lp-PLA2-IN-1 suppresses Lp-PLA2, aiding in treating atherosclerosis and Alzheimer's.</p>Fórmula:C21H17F5N4O3Pureza:99.60%Cor e Forma:SolidPeso molecular:468.38Lansoprazole
CAS:<p>Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON</p>Fórmula:C16H14F3N3O2SPureza:99.18% - 99.84%Cor e Forma:White Crystalline PowderPeso molecular:369.36ML349
CAS:<p>ML349 is an inhibitor of LYPLA2 (IC50: 144 nM). ML349 is an effective and specific acyl protein thioesterase 2 (APT-2) inhibitor (Ki: 120 nM).</p>Fórmula:C23H22N2O4S2Pureza:99.59% - 99.88%Cor e Forma:SolidPeso molecular:454.561-Myristoyl-2-Linoleoyl-sn-glycero-3-PC
CAS:<p>1-Myristoyl-2-Linoleoyl-sn-glycero-3-PC is a phospholipid identified in human plasma, characterized by the presence of Myristic acid and Linoleic acid at the sn-1 and sn-2 positions, respectively.</p>Fórmula:C40H76NO8PCor e Forma:SolidPeso molecular:730.01VU533
CAS:<p>VU533 is a NAPE-PLD activator, EC50=0.30 µM, boosts macrophage activity, potential in cardiometabolic diseases.</p>Fórmula:C21H22FN3O3S2Pureza:99.08%Cor e Forma:SolidPeso molecular:447.55AACOCF3
CAS:<p>AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid.</p>Fórmula:C21H31F3OPureza:99% - 99%Cor e Forma:Yellow LiquidPeso molecular:356.47A3373
CAS:<p>A3373 is a novel inhibitor targeting both Phospholipase D1 (PLD1) and Phospholipase D2 (PLD2), demonstrating half maximal inhibitory concentrations (IC50) of</p>Fórmula:C17H9F7N2OPureza:98%Cor e Forma:SoildPeso molecular:390.26Compound 48/80 trihydrochloride
CAS:<p>Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺和甲醛发生缩合反应后的混合物。Compound 48/80 trihydrochloride 是一种肥大细胞 (mast cell) 脱颗粒剂和组胺 (histamine) 释放剂。Compound 48/80 trihydrochloride 对人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性有抑制作用。</p>Fórmula:C32H48Cl3N3O3Pureza:98%Cor e Forma:SolidPeso molecular:629.1ASM-IN-3
CAS:<p>ASM-IN-3 (Compound 21b) is a selective acid sphingomyelinase (ASM) inhibitor that can penetrate the blood-brain barrier, with an IC50 of 3.37 μM against purified human ASM. By inhibiting ASM activity in the hippocampus and promoting neurogenesis, ASM-IN-3 alleviates depressive-like behavior in reserpine-induced depressive rats.</p>Fórmula:C17H13ClN2O4Cor e Forma:SolidPeso molecular:344.75BIRM 271
CAS:<p>BIRM 271 is a novel arachidonic acid release inhibitor that blocks leukotriene B4 and platelet-activating factor biosynthesis in human neutrophils.</p>Fórmula:C21H25N3OPureza:99.64%Cor e Forma:SoildPeso molecular:335.44SB-435495
CAS:<p>SB-435495 is a compound characterized by its potent, selective, reversible, and non-covalent inhibition of Lp-PLA2, demonstrating an IC50 value of 0.06 nM.</p>Fórmula:C38H40F4N6O2SPureza:99.07%Cor e Forma:SolidPeso molecular:720.82DPTIP hydrochloride
CAS:<p>DPTIP hydrochloride is a potent inhibitor of neutral sphingomyelinase (N-SMase 2) that can cross the blood-brain barrier. It acts as an exosome inhibitor with an IC50 value of 30 nM.</p>Fórmula:C21H19ClN2O3SCor e Forma:SolidPeso molecular:414.91PLA2-IN-1
<p>PLA2-IN-1 (Compound 7) is a potent and selective inhibitor of phospholipase A (PLA2) with an IC50 value of 1 nM. It effectively inhibits PLA2-induced coagulation disorders in vitro and shows potential for use as an antidote for snake bites caused by cobra venom.</p>Cor e Forma:Odour SolidnSMase2-IN-1
<p>nSMase2-IN-1 is an orally active inhibitor of Neutral sphingomyelinase 2 (nSMase2) with a potent IC50 value of 0.13 ± 0.06 μM.</p>Fórmula:C12H17N5OPureza:98%Cor e Forma:SolidPeso molecular:247.3LEI110
CAS:<p>LEI110 inhibits PLA2G16 and HRASLS enzymes, Ki 20 nM, selectively targets related thiol hydrolases.</p>Fórmula:C25H23F3N2O3Pureza:98.66% - 98.8%Cor e Forma:SolidPeso molecular:456.46A4333
<p>A4333, a biotinylated derivative of A3373, selectively inhibits Phospholipase D1 (PLD1) while sparing PLD2.</p>Pureza:98%Cor e Forma:Odour SolidDPTIP
CAS:<p>DPTIP is an effective inhibitor of neutral sphingomyelinase 2 with an IC50 value of 30 nM.</p>Fórmula:C21H18N2O3SPureza:99.88%Cor e Forma:SolidPeso molecular:378.44BMS493
CAS:<p>BMS493 is an inverse agonist of RAR that inhibits retinoic acid-induced differentiation and inhibits the increase in phospholipase A2 activity.</p>Fórmula:C29H24O2Pureza:>99.99%Cor e Forma:SolidPeso molecular:404.5Bromoenol lactone
CAS:<p>NeurokininBromoenol lactone ((6E)-Bromoenol lactone) is an iPLA2β and serine protease inhibitor that attenuates nicotine-induced breast cancer cell proliferation.</p>Fórmula:C16H13BrO2Cor e Forma:SolidPeso molecular:317.18PACOCF3
CAS:<p>PACOCF3, a phospholipase A2 inhibitor, hinders Ca2+ signaling with an IC50 of 3.8 μM in renal cells.</p>Fórmula:C17H31F3OPureza:99.93%Cor e Forma:SolidPeso molecular:308.42MJ33 lithium salt
CAS:<p>MJ33 lithium salt is an inhibitor of NADPH oxidase type 2-mediated ROS generation, inhibits PLA2 activity, and can be used to study acute lung injury.</p>Fórmula:C22H43F3LiO6PPureza:99%Cor e Forma:SolidPeso molecular:498.48LEI-401
CAS:<p>LEI-401 is a NAPE-PLD inhibitor.LEI-401 reduces the level of n-acyl ethanolamines in the brain of free-ranging mice and modulates their emotional behaviour.</p>Fórmula:C24H31N5O2Pureza:99.79% - 99.79%Cor e Forma:SolidPeso molecular:421.54ML-211
CAS:<p>ML-211 is a carbamate-based dual inhibitor of LYPLA1 (IC50 = 17 nM) and the related LYPLA2 (IC50 = 30 nM)</p>Fórmula:C25H30N4O2Pureza:97.07%Cor e Forma:SolidPeso molecular:418.53N-(p-amylcinnamoyl) Anthranilic Acid
CAS:<p>N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker.</p>Fórmula:C21H23NO3Pureza:99.35% - 99.67%Cor e Forma:SolidPeso molecular:337.41Rhamnetin
CAS:<p>Rhamnetin (beta-Rhamnocitrin), a quercetin derivative found in Coriandrum sativum, has antioxidant and anti-inflammatory activities.</p>Fórmula:C16H12O7Pureza:99.61% - 99.905%Cor e Forma:SolidPeso molecular:316.26hnps-PLA Inhibitor
CAS:<p>Hnps-PLA Inhibitor is an inhibitor of human nonpancreatic secretory Phospholipase A (hnps-PLA).</p>Fórmula:C21H21N3O4Pureza:99.68%Cor e Forma:SolidPeso molecular:379.41Varespladib
CAS:<p>Varespladib (LY315920) inhibits hnsPLA2 effectively (IC50=7 nM), studied for sickle cell, VOC, and acute coronary syndrome.</p>Fórmula:C21H20N2O5Pureza:99.97%Cor e Forma:SolidPeso molecular:380.39BAPTA
CAS:<p>BAPTA is a neuroprotective agent in cerebral ischemia, acting as an intercellular Ca2+ chelator.</p>Fórmula:C22H24N2O10Pureza:96.28% - ≥95%Cor e Forma:White SolidPeso molecular:476.43Rapanone
CAS:<p>Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.</p>Fórmula:C19H30O4Pureza:99.56%Cor e Forma:SolidPeso molecular:322.44U-73343
CAS:<p>U-73343 is an inactive analog of U-73122 and can be used as a negative control. U-73122 dose-dependently inhibits acid secretion irrespective of the stimulant.</p>Fórmula:C29H42N2O3Pureza:99.06%Cor e Forma:SolidPeso molecular:466.66Tanshinone I
CAS:<p>Tanshinone I (Tanshinone A), an active principle isolated from the herbal medicine Salvia miltiorrhiza, displays cytotoxicity against tumor cells.</p>Fórmula:C18H12O3Pureza:98.31% - 98.70%Cor e Forma:SolidPeso molecular:276.29ML348
CAS:<p>ML348 (GNF-Pf-1127) is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM).</p>Fórmula:C18H17ClF3N3O3Pureza:99% - 99.88%Cor e Forma:SolidPeso molecular:415.79FIPI
CAS:<p>FIPI, a halopemide derivative, strongly blocks PLD1 and PLD2 (IC50s: 25 nM, 20 nM) and hinders PLD-mediated cell activity.</p>Fórmula:C23H24FN5O2Pureza:97.21% - 98.68%Cor e Forma:SolidPeso molecular:421.47ML-298
CAS:<p>ML-298 (CID53393915) is a potent, specific inhibitor of Phospholipase D2 (PLD2, IC50 of 355 nM).</p>Fórmula:C22H23F3N4O2Pureza:99.35%Cor e Forma:SolidPeso molecular:432.441-Naphthaleneacetic acid
CAS:<p>1-Naphthaleneacetic acid, an auxin-like synthetic plant hormone, boosts rooting in horticulture.</p>Fórmula:C12H10O2Pureza:98.67%Cor e Forma:Needles From Water White To Off White CrystalsPeso molecular:186.21ST271
CAS:<p>ST271 is an effective protein tyrosine kinase (PTK) inhibitor.</p>Fórmula:C16H20N2O2Pureza:98.94%Cor e Forma:SolidPeso molecular:272.34Darapladib
CAS:<p>Darapladib (SB-480848) is a lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with an IC50 value of 0.25 nM.Cost-effective and quality-assured.</p>Fórmula:C36H38F4N4O2SPureza:99.82% - >99.99%Cor e Forma:SolidPeso molecular:666.77RHC 80267
CAS:<p>RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets)</p>Fórmula:C20H34N4O4Pureza:99.54%Cor e Forma:White SolidPeso molecular:394.51GW4869
CAS:<p>GW4869 (GW69A) is a selective and non-competitive inhibitor of neutral sphingomyelinase N-SMase (IC50=1 μM).</p>Fórmula:C30H30Cl2N6O2Pureza:98.12% - 98.47%Cor e Forma:SolidPeso molecular:577.5RPI-1
CAS:<p>RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.</p>Fórmula:C17H15NO4Pureza:98.91% - ≥95%Cor e Forma:SolidPeso molecular:297.311-Linoleoyl Glycerol
CAS:<p>1-Linoleoyl Glycerol (Monolinolein) is fatty acid glycerol that has been isolated from Saururus Chinensis roots.</p>Fórmula:C21H38O4Pureza:98.95% - 99.56%Cor e Forma:Less Oil Colourless OilPeso molecular:354.52ONO-RS-082
CAS:<p>ONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor. </p>Fórmula:C21H22ClNO3Pureza:99.35%Cor e Forma:SolidPeso molecular:371.86AA26-9
CAS:<p>AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.</p>Fórmula:C7H10N4OPureza:99.88%Cor e Forma:SolidPeso molecular:166.181-Naphthaleneacetic acid potassium salt
CAS:<p>1-Naphthaleneacetic acid potassium salt (1-NAA Potassium Salt) is a synthetic phytogrowth hormone that promotes plant growth and a PLA2 inhibitor.</p>Fórmula:C12H9O2·KPureza:97.68%Cor e Forma:Off-White To Beige PowderPeso molecular:224.3Difluprednate
CAS:<p>Difluprednate (Myser)(Durezol) is a corticosteroid, approved for the treatment of post-operative ocular inflammation and pain.</p>Fórmula:C27H34F2O7Pureza:99.23% - 99.86%Cor e Forma:SolidPeso molecular:508.55Cambinol
CAS:<p>Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.</p>Fórmula:C21H16N2O2SPureza:98.02% - 99.83%Cor e Forma:SolidPeso molecular:360.43CAY10594
CAS:<p>CAY10594, a PLD2 inhibitor, mitigates acetaminophen liver damage via the p-GSK-3β/JNK pathway.</p>Fórmula:C26H28N4O2Pureza:98%Cor e Forma:SolidPeso molecular:428.53
