PKM
A Piruvato Quinase M2 (PKM2) é uma isoforma da piruvato quinase que desempenha um papel crucial na glicólise, convertendo fosfoenolpiruvato em piruvato. PKM2 está envolvida na regulação da reprogramação metabólica em células cancerosas, tornando-se um alvo potencial para a terapia do câncer. Inibidores de PKM2 podem alterar as vias metabólicas, reduzir o crescimento tumoral e induzir a morte celular em células cancerígenas. Na CymitQuimica, oferecemos inibidores de PKM2 para apoiar sua pesquisa em metabolismo do câncer, oncologia e desenvolvimento terapêutico.
Foram encontrados 17 produtos de "PKM"
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PKR-IN-2
CAS:PKR-IN-2 is a activator of pyruvate kinase (PKR).Fórmula:C24H28N4O4SPureza:99.14%Cor e Forma:SolidPeso molecular:468.57Ref: TM-T12499
1mg81,00€5mg145,00€10mg207,00€25mg334,00€50mg467,00€100mg655,00€200mg883,00€1mL*10mM (DMSO)149,00€Dimethylaminomicheliolide HCl
CAS:Dimethylaminomicheliolide HCl has potential anti-inflammatory and anti-tumor activity and inhibits the proliferation of glioblastoma cells by targeting pyruvateFórmula:C17H28ClNO3Pureza:99.91%Cor e Forma:SoildPeso molecular:329.86PKM2 inhibitor G
CAS:PKM2 inhibitor G is a inhibitor of pyruvate kinase.Fórmula:C16H15NO3SPureza:99.89%Cor e Forma:SoildPeso molecular:301.36Ref: TM-T67900
1mg109,00€5mg243,00€10mg355,00€25mg532,00€50mg745,00€100mg1.018,00€1mL*10mM (DMSO)230,00€PKM2 activator 7
PKM2 activator 7 (Compd B4) is a PKM2 activator with an AC50 value of 0.144 μM. It functions by inhibiting the growth of T cells, thereby alleviating DSS-induced colitis in mice.Fórmula:C16H19F3O4Peso molecular:332.12354PKM2-IN-10
PKM2-IN-10 is a PKM2 inhibitor. It effectively suppresses the proliferation of A549 and HCC1833 cell lines with IC50 values of 3.36 μM and 9.20 μM, respectively. PKM2-IN-10 demonstrates antitumor activity in human non-small cell lung cancer (NSCLC) and mouse lung adenocarcinoma models. It is applicable for research in lung cancer.Fórmula:C21H15F4N5Cor e Forma:SolidPeso molecular:413.12636PKCζ/ι pseudosubstrate inhibitor
CAS:PKCζ/ι pseudosubstrate inhibitor demonstrates comprehensive inhibitory activity across the protein kinase C (PKC) family and is associated with the induction ofFórmula:C76H128N30O16Cor e Forma:SolidPeso molecular:1718.02Mitapivat sulfate hydrate
CAS:Mitapivat sulfate hydrate (AG 348 sulfate hydrate) is a pyruvate kinase (PK) allosteric activator, used to study pyruvate kinase deficiency.Fórmula:C24H26N4O3S1H2SO43H2OPureza:99.22%Cor e Forma:SolidPeso molecular:526.6DASA-58
CAS:DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.Fórmula:C19H23N3O6S2Pureza:96.96% - 99.28%Cor e Forma:SolidPeso molecular:453.53Mitapivat
CAS:Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.Fórmula:C24H26N4O3SPureza:99.47% - 99.83%Cor e Forma:SolidPeso molecular:450.55PKM2-IN-1
CAS:PKM2-IN-1 (compound 3k) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.Fórmula:C18H19NO2S2Pureza:99.49% - 99.68%Cor e Forma:SolidPeso molecular:345.48TEPP-46
CAS:TEPP-46 (ML265) is an activator of pyruvate kinase M2 (PKM2), selective for PKM1, PKL and PKR. TEPP-46 has antitumor activity. Cost-effective and quality-assured.Fórmula:C17H16N4O2S2Pureza:98.21% - 99.65%Cor e Forma:SolidPeso molecular:372.46Ref: TM-T7214
1mg48,00€5mg96,00€10mg144,00€25mg235,00€50mg354,00€100mg528,00€500mg1.159,00€1mL*10mM (DMSO)96,00€PKM2 activator 5
CAS:PKM2 activator 5 is a novel and potent PKM2 activator (AC50: 0.316 µM) with potential anticancer activity for the study of cancer metabolism-related diseases.Fórmula:C18H19FN2O6S2Pureza:98%Cor e Forma:SolidPeso molecular:442.48PKM2 activator 2
CAS:PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuates
Fórmula:C20H18F2N2O4S2Pureza:99.92%Cor e Forma:SolidPeso molecular:452.49NPD10084
CAS:NPD10084 is an inhibitor of pyruvate kinase PKM2 that blocks non-glycolytic signaling in cancer cells by disrupting PKM2's interaction with β-catenin or STAT3, thus inhibiting downstream pathways. It demonstrates antiproliferative effects against colorectal cancer cells both in vitro and in vivo [1].Fórmula:C21H19N3O2Cor e Forma:SolidPeso molecular:345.39Mitapivat hydrochloride
CAS:Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric activator of pyruvate kinase R (PK-R). It enhances the PK-R-catalyzed conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolysis pathway, increasing ATP production in red blood cells, and decreasing 2,3-diphosphoglycerate (2,3-DPG) levels. Mitapivat hydrochloride is being investigated for potential use in the study of pyruvate kinase deficiency and other anemia-related disorders.Fórmula:C24H27ClN4O3SCor e Forma:SolidPeso molecular:487.014PKM2-IN-9
CAS:PKM2-IN-9 (compound C1) is a potent inhibitor of PKM2, demonstrating a 75% inhibition rate at 50 μM. It plays a significant role in cancer research.Fórmula:C24H22N4O2Cor e Forma:SolidPeso molecular:398.457PKR Inhibitor, negative control
CAS:The PKR Inhibitor, negative control, is an inactive structural analog of RNA-dependent protein kinase (PKR) inhibitors, serving as a negative control. Additionally, it can inhibit LK-induced neuronal death, demonstrating significant neuroprotective properties.Fórmula:C15H8Cl3NO2Peso molecular:340.59
