Receptor 5-HT
Os receptores 5-HT, também conhecidos como receptores de serotonina, são um grupo de receptores acoplados à proteína G (GPCRs) que mediam os efeitos da serotonina, um neurotransmissor envolvido na regulação do humor, ansiedade, sono, apetite e outros processos fisiológicos. Esses receptores são divididos em vários subtipos, cada um com funções e propriedades farmacológicas distintas. Moduladores de receptores 5-HT são amplamente estudados por seus papéis no tratamento da depressão, distúrbios de ansiedade e outras condições neuropsiquiátricas. Na CymitQuimica, oferecemos uma variedade de moduladores de receptores 5-HT de alta qualidade para apoiar sua pesquisa em neurofarmacologia, transtornos do humor e sinalização GPCR.
Foram encontrados 940 produtos de "Receptor 5-HT"
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Flopropione
CAS:<p>Flopropione (Phloropropiophenone), a spasmolytic or antispasmodic agent, is used as a 5-HT1A receptor antagonist.</p>Fórmula:C9H10O4Pureza:99.93%Cor e Forma:SolidPeso molecular:182.17Levodropropizine
CAS:<p>Levodropropizine ((S)-(-)-Dropropizine) is a histamine receptor inhibitor. It is used as an effective and very well tolerated peripheral antitussive drug.</p>Fórmula:C13H20N2O2Pureza:99.87% - 99.93%Cor e Forma:White Or Off White Crystalline PowderPeso molecular:236.31Alverine citrate
CAS:<p>Alverine citrate (NSC 35459) is utilized in functional gastrointestinal disorders.</p>Fórmula:C26H35NO7Pureza:98.53% - 99.43%Cor e Forma:CoaPeso molecular:473.57Ebalzotan
CAS:<p>NAE-086 is a high-affinity and selective 5-HT(1A) receptor ligand with a K(i) value of 4.5 nM in membranes from rat hippocampus.</p>Fórmula:C19H30N2O2Pureza:98.09% - 99.41%Cor e Forma:SolidPeso molecular:318.45Citalopram hydrobromide
CAS:<p>Citalopram hydrobromide (XU-62-320) , a selective serotonin reuptake inhibitor (SSRI), selectively inhibits the CNS neuronal reuptake of serotonin, thereby</p>Fórmula:C20H22BrFN2OPureza:99.81%Cor e Forma:White Crystalline PowderPeso molecular:405.304Thioridazine hydrochloride
CAS:<p>Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4</p>Fórmula:C21H27ClN2S2Pureza:99.55% - 99.957%Cor e Forma:White To Off-White SolidPeso molecular:407.042-Bromo-6-methoxynaphthalene
CAS:<p>2-Bromo-6-methoxynaphthalene was used in the synthesis of nabumetone [4-(6-methoxy-2-naphthalenyl)-2-butanone] by Heck reaction.</p>Fórmula:C11H9BrOPureza:98.51%Cor e Forma:White To Off-White PowderPeso molecular:237.09Levosulpiride
CAS:<p>Levosulpiride (S-(-)-Sulpiride) is the (S)-enantiomer of sulpiride, which is a D2 receptor antagonist, an atypical antipsychotic drug of the benzamide class.</p>Fórmula:C15H23N3O4SPureza:98.20% - 99.88%Cor e Forma:White Crystalline PowderPeso molecular:341.43Tropanserin
CAS:<p>Tropanserin (MDL 72422) is a 5-hydroxytryptamine receptor antagonist with anxiolytic activity that is used to treat depression and cognitive impairment.</p>Fórmula:C17H23NO2Pureza:99.74%Cor e Forma:SolidPeso molecular:273.37Clomipramine hydrochloride
CAS:<p>Clomipramine HCl (Anafranil) is a serotonin-inhibiting tricyclic antidepressant, well-absorbed and metabolized to desmethylclomipramine in the liver.</p>Fórmula:C19H23ClN2·HClPureza:99.04% - 99.47%Cor e Forma:White To Slightly Yellow Crystalline PowderPeso molecular:351.31Fluoxetine
CAS:<p>Fluoxetine (LY-110140), a specific serotonin inhibitor, serves as an antidepressant with fewer side-effects.</p>Fórmula:C17H18F3NOPureza:99.07% - 99.28%Cor e Forma:SolidPeso molecular:309.33Quetiapine
CAS:<p>Quetiapine treats schizophrenia and bipolar I, targeting serotonin, dopamine, and adrenoreceptor subtypes, plus H1 histamine receptor.</p>Fórmula:C21H25N3O2SPureza:99.14% - 99.63%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:383.51PF-04995274
CAS:<p>PF-04995274: potent, selective partial 5-HT4R agonist; EC50 0.26-0.47 nM; brain penetrant; may treat Alzheimer's cognitive issues.</p>Fórmula:C23H32N2O6Pureza:99.52%Cor e Forma:SolidPeso molecular:432.51Fluoxetine hydrochloride
CAS:<p>Fluoxetine HCl (Lilly110140), a selective serotonin reuptake inhibitor (SSRI), is an antidepressant with fewer side effects.</p>Fórmula:C17H19ClF3NOPureza:99.6% - 99.98%Cor e Forma:White To Off-White Crystalline Solid White To Off-White PowderPeso molecular:345.787Zolmitriptan
CAS:<p>Zolmitriptan targets 5-HT 1B/1D receptors, constricts cranial vessels, inhibits pain signals, and stops pro-inflammatory neuropeptides, alleviating migraines.</p>Fórmula:C16H21N3O2Pureza:99.69% - 99.91%Cor e Forma:White Or Kind Of White PowderPeso molecular:287.36Frovatriptan succinate hydrate
CAS:<p>Frovatriptan treats all migraine types, nausea, vomiting, light/sound sensitivity, and prevents menstrual migraines; it targets 5-HT1B/D and 5-HT7 receptors.</p>Fórmula:C18H25N3O6Pureza:99.66%Cor e Forma:SolidPeso molecular:379.41Cisapride
CAS:<p>Cisapride (R 51619), a 5-HT4 agonist, enhances gut peristalsis and gastric emptying, reduces reflux.</p>Fórmula:C23H29ClFN3O4Pureza:99.77%Cor e Forma:White To Slightly Biege Powder SolidPeso molecular:465.95Blonanserin
CAS:<p>Blonanserin (AD-5423), approved in Japan (2008), is an atypical antipsychotic with fewer side effects like EPS, sedation, or hypotension.</p>Fórmula:C23H30FN3Pureza:99.85%Cor e Forma:SolidPeso molecular:367.5Protriptyline hydrochloride
CAS:<p>Protriptyline HCl: a tricyclic antidepressant that increases norepinephrine and serotonin levels and has anticholinergic effects.</p>Fórmula:C19H21N·HClPureza:98.54% - 99.98%Cor e Forma:SolidPeso molecular:299.84Olanzapine
CAS:<p>Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.</p>Fórmula:C17H20N4SPureza:99.86% - ≥95%Cor e Forma:Yellowish Crystalline PowderPeso molecular:312.43Ketanserin
CAS:<p>Ketanserin: quinazoline derivative, 5-HT2 receptor antagonist, may lower blood pressure and inhibit blood clots.</p>Fórmula:C22H22FN3O3Pureza:99.19% - 99.73%Cor e Forma:SolidPeso molecular:395.43Metoclopramide hydrochloride
CAS:<p>Metoclopramide hydrochloride (Metoclopramide HCl) is a selective dopamine D2 receptor antagonist, used as an antiemetic.</p>Fórmula:C14H22ClN3O2·HClPureza:99.99%Cor e Forma:White To Off-White PowderPeso molecular:336.26Azatadine dimaleate
CAS:<p>Azatadine dimaleate (SCH10649) is an inhibitor for histamine（IC50=6.5 nM） and cholinergic（IC50=10 nM）.</p>Fórmula:C28H30N2O8Pureza:99.7% - >99.99%Cor e Forma:PowderPeso molecular:522.55RS102895 hydrochloride
CAS:<p>RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).</p>Fórmula:C21H22ClF3N2O2Pureza:98.95%Cor e Forma:SolidPeso molecular:426.86ECPLA
CAS:<p>ECPLA is an LSD analog and a potent 5-HT2A agonist (EC50 of 14.6 nM), capable of stimulating Gq-mediated calcium flux. It exhibits high affinity for most serotonin receptors, α2-adrenergic receptors, and D2-like dopamine receptors.</p>Fórmula:C21H25N3OCor e Forma:SolidPeso molecular:335.44SB 216641
CAS:<p>SB 216641 is a 5-HT (1B/1D) antagonist with anxiolytic activity for the study of anxiety disorders and depression.</p>Fórmula:C28H30N4O4Pureza:98.09%Cor e Forma:SolidPeso molecular:486.56(+)-OSU 6162
CAS:<p>(+)-OSU 6162 (Piperidine, 3-[3-(methylsulfonyl)phenyl]-1-propyl-, (3R)-) is an agonist of 5-HT Receptor with anti-Alzheimer and antidepressant activities.</p>Fórmula:C15H23NO2SPureza:98.19%Cor e Forma:SoildPeso molecular:281.41MR33317
<p>MR33317 is an inhibitor of acetylcholinesterase with an IC50 value of 41 nM. Additionally, it acts as an agonist for brain 5-HT4 receptors.</p>Fórmula:C22H28ClN3O2Peso molecular:401.187Minesapride
CAS:<p>Minesapride: novel 5-HT4 partial agonist, may treat constipation-predominant IBS.</p>Fórmula:C21H31ClN4O5Pureza:99.85% - 99.88%Cor e Forma:SolidPeso molecular:454.95Cinanserin hydrochloride
CAS:<p>Cinanserin hydrochloride (SQ 10643) is a 5-HT2 receptor blocker (Ki: 41 nM) and SARS-CoV 3C-like protease inhibitor.</p>Fórmula:C20H25ClN2OSPureza:99.57%Cor e Forma:SolidPeso molecular:376.94Neocarzinostatin
CAS:<p>Neocarzinostatin is an effective DNA-damaging, anti-tumor antibiotic.</p>Pureza:98%Cor e Forma:SolidPeso molecular:N/ADapoxetine
CAS:<p>Dapoxetine (Dapoxetina) is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation.</p>Fórmula:C21H23NOPureza:99.73%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:305.425-HT2C agonist-4
CAS:<p>Compound 3i, a 5-HT2C agonist-4, acts as an agonist for the 5-HT2C receptor with an EC50 of 5.7 nM. It is capable of reducing locomotor activity in zebrafish larvae.</p>Fórmula:C24H25N5OCor e Forma:SolidPeso molecular:399.49ALEPH hydrochloride
CAS:<p>ALEPH (hydrochloride) acts as a partial agonist of h5-HT2A and h5-HT2B receptors, with EC50 values of 10.3 nM and 19.2 nM, respectively. It can induce head twitch responses in mice, with an ED50 of 0.80 mg/kg.</p>Fórmula:C12H20ClNO2SCor e Forma:SolidPeso molecular:277.81Donitriptan hydrochloride
CAS:<p>Donitriptan hydrochloride (Donitriptan monohydrochloride) is a potent, high efficacy agonist of 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively</p>Fórmula:C23H26ClN5O2Pureza:99.8% - 99.86%Cor e Forma:SolidPeso molecular:439.94SB 699551
CAS:<p>SB 699551 is a selective 5-HT5A antagonist (Ki=6.31 nM) that enhances 5-HT neuronal function. It inhibits SERT (Ki=25.12 nM),inhibit breast cancer.</p>Fórmula:C34H45N3OPureza:99.83%Peso molecular:511.74Lisuride maleate
CAS:<p>Lisuride maleate is a non-selective dopamine agonist and G-protein-biased 5-HT2A receptor agonist capable of blocking prolactin release.</p>Fórmula:C24H30N4O5Pureza:99.85%Cor e Forma:SolidPeso molecular:454.52Asenapine citrate
CAS:<p>Asenapine citrate: atypical antipsychotic for schizophrenia, bipolar disorder; targets serotonin, adrenoceptors, dopamine, histamine (pKi: 8.2-10.5).</p>Fórmula:C23H24ClNO8Cor e Forma:SolidPeso molecular:477.89(R,R)-Palonosetron Hydrochloride
CAS:<p>(R,R)-Palonosetron Hydrochloride is the active enantiomer of Palonosetron</p>Fórmula:C19H25ClN2OPureza:98%Cor e Forma:SolidPeso molecular:332.875-MeO-pyr-T
CAS:<p>5-MeO-pyr-T (5-Methoxy pyrrolidinyltryptamine) acts as a 5-HT1AR agonist, exhibiting Ki values of 0.577 μM and 373 μM for 5-HT1AR and 5-HT2AR, respectively. It inhibits the reuptake of 5-HT and triggers its release. Additionally, 5-MeO-pyr-T can induce reduced motor activity.</p>Fórmula:C15H20N2OCor e Forma:SolidPeso molecular:244.335-HT1AR/5-HT6R ligand-1
<p>5-HT1AR/5-HT6R ligand-1 (Compound PP13) functions as a ligand for the 5-HT receptor, demonstrating high affinity for 5-HT1AR, 5-HT6R, and 5-HT7R with Ki values of 19, 69, and 198 nM, respectively. In HEK293 cells, it inhibits cAMP production with EC50 values of 1535, 488, and 53 nM for these receptors. Additionally, 5-HT1AR/5-HT6R ligand-1 exhibits antiproliferative effects on several cancer cell lines, including 1321N1, U87MG, MCF7, and AsPC-1, with IC50 values of 9.6, 13.6, 19.3, and 14.6 μM, respectively. The compound also shows antagonistic activity towards the dopamine receptor D2R, with a Ki of 1903 nM.</p>Fórmula:C25H29ClN4O2SCor e Forma:SolidPeso molecular:485.045-HT6R antagonist 6
<p>5-HT6R antagonist 6 (Compound PP15) exhibits high affinity and selectivity for the 5-HT6R receptor, with a Ki of 42 nM. It demonstrates weak antiproliferative activity on tumor cells and low toxicity toward normal cells. 5-HT6R antagonist 6 is applicable in tumor research.</p>Fórmula:C24H26N4O2SCor e Forma:SolidPeso molecular:434.55(-)-Eseroline fumarate
CAS:<p>(-)-Eseroline fumarate, a Physostigmine metabolite and AChE inhibitor, triggers cancer cell LDH release and neuronal cell death.</p>Fórmula:C17H22N2O5Cor e Forma:SolidPeso molecular:334.37Paynantheine
CAS:<p>Paynantheine is an alkaloid with antinociceptive properties, found in Mitragyna speciosa. It also acts as an agonist at 5-HT1AR and 5-HT2BR receptors, inducing lower lip contraction and providing antinociception in rats.</p>Fórmula:C23H28N2O4Cor e Forma:SolidPeso molecular:396.48LY 344864 racemate
CAS:<p>LY 344864 racemate is a 5-HT1F receptor agonist.</p>Fórmula:C21H22FN3OPureza:99.75%Cor e Forma:SoildPeso molecular:351.42Imipramine N-oxide
CAS:<p>Imipramine N-oxide is a tricyclic antidepressant (TCA) and imipramine analogue used to treat depression.</p>Fórmula:C19H24N2OPureza:99.80%Cor e Forma:SolidPeso molecular:296.41LEK 8804
CAS:<p>LEK 8804 is a 5-HT(2) receptor antagonist and 5-HT(1A) receptor agonist.</p>Fórmula:C19H19N3OCor e Forma:SolidPeso molecular:305.37HTR2A antagonist 1
<p>HTR2A antagonist 1 (Compound 15f) is an HTR2A antagonist with an IC50 of 42.79 nM. It induces sub-G1 cell cycle arrest and apoptosis in colorectal cancer cells by activating the p53/p21/caspase 3 signaling pathway. HTR2A antagonist 1 exhibits good liver microsomal stability and is useful for colorectal cancer research.</p>Fórmula:C35H43Cl2F2N5O4Cor e Forma:SolidPeso molecular:706.65SC-53116
CAS:<p>SC-53116 HCl can increase the production of serotonin in central nervous system tissues and is a psychoactive agent.</p>Fórmula:C16H22ClN3O2Cor e Forma:SolidPeso molecular:323.82Syk Inhibitor II hydrochloride
CAS:<p>Syk signaling is key in lupus. Syk inhibitors reduce inflammation and sepsis severity in FcgRIIb-/- mice, lowering cytokines and organ damage.</p>Fórmula:C14H16ClF3N6OPureza:99.05%Cor e Forma:SolidPeso molecular:376.77
