Receptor 5-HT
Os receptores 5-HT, também conhecidos como receptores de serotonina, são um grupo de receptores acoplados à proteína G (GPCRs) que mediam os efeitos da serotonina, um neurotransmissor envolvido na regulação do humor, ansiedade, sono, apetite e outros processos fisiológicos. Esses receptores são divididos em vários subtipos, cada um com funções e propriedades farmacológicas distintas. Moduladores de receptores 5-HT são amplamente estudados por seus papéis no tratamento da depressão, distúrbios de ansiedade e outras condições neuropsiquiátricas. Na CymitQuimica, oferecemos uma variedade de moduladores de receptores 5-HT de alta qualidade para apoiar sua pesquisa em neurofarmacologia, transtornos do humor e sinalização GPCR.
Foram encontrados 940 produtos de "Receptor 5-HT"
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D3/5-HT receptor modulator-1
CAS:<p>D3/5-HT receptor modulator-1 (compound 5i) is a selective antagonist of the dopamine D3 and 5-HT2A receptors, and a partial agonist at the 5-HT1A receptor. It exhibits Ki values of 4.5 nM, 11.9 nM, and 15.3 nM for the dopamine D3, 5-HT2A, and 5-HT1A receptors respectively. The compound shows lower affinity for the dopamine D2 receptor, 5-HT2C receptor, and hERG channel. D3/5-HT receptor modulator-1 possesses atypical antipsychotic properties.</p>Fórmula:C24H29N3O2Cor e Forma:SolidPeso molecular:391.50625B-NBOH hydrochloride
CAS:<p>25B-NBOH hydrochloride is a phenethylamine that exhibits high affinity for serotonin (5-HT) receptors 5-HT2A and 5-HT2C, with pKi values of 8.3 and 9.4, respectively.</p>Fórmula:C17H21BrClNO3Cor e Forma:SolidPeso molecular:402.7115-IAI hydrochloride
CAS:<p>5-IAI hydrochloride is a psychoactive analog of para-iodoamphetamine. 5-IAI hydrochloride significantly reduces serotonin uptake sites and hippocampal serotonin levels in rats.</p>Fórmula:C9H11ClINCor e Forma:SolidPeso molecular:295.548Ro4368554
CAS:<p>Ro4368554 is a selective 5-HT6 antagonist capable of crossing the blood-brain barrier. It can reverse memory deficits caused by scopolamine and tryptophan depletion. Ro4368554 is applicable for research related to memory impairments.</p>Fórmula:C19H21N3O2SCor e Forma:SolidPeso molecular:355.454AAZ-A 154 hydrobromide
CAS:<p>AAZ-A 154 hydrobromide is a selective, competitive, non-hallucinogenic 5-HT2AR antagonist. It promotes neuronal growth in rodents and yields enduring beneficial behavioral effects.</p>Fórmula:C14H21BrN2OCor e Forma:SolidPeso molecular:313.23LB-102
CAS:<p>LB-102 is an orally active inhibitor of dopamine D2, D3, and serotonin 5-HT7 receptors, utilized in the study of schizophrenia and other psychiatric disorders.</p>Fórmula:C18H29N3O4SCor e Forma:SolidPeso molecular:383.51Revexepride
CAS:<p>Revexepride, a 5-HT4 agonist, may boost CYP3A4, used for treating GERD.</p>Fórmula:C21H32ClN3O4Pureza:98%Cor e Forma:SolidPeso molecular:425.95Rodatristat
CAS:<p>Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively).</p>Fórmula:C27H27ClF3N5O3Pureza:98%Cor e Forma:SolidPeso molecular:561.98LP 12 hydrochloride hydrate
<p>LP 12 hydrochloride hydrate: potent, selective 5-HT7 agonist (Ki: 0.13 nM); less affinity for D2, 5-HT1A/2A receptors.</p>Fórmula:C32H39N3O·HCl·xH2OCor e Forma:SolidLY 215840
CAS:<p>5-HT2/5-HT7 receptor antagonist</p>Fórmula:C24H33N3O2Pureza:98%Cor e Forma:SolidPeso molecular:395.54(S)-Praziquantel
CAS:<p>(S)-Praziquantel is the inactive isomer of R-praziquantel.</p>Fórmula:C19H24N2O2Cor e Forma:SolidPeso molecular:312.406VA012
CAS:<p>VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.</p>Fórmula:C21H19N3Cor e Forma:SolidPeso molecular:313.40Remlifanserin
CAS:<p>Remlifanserin is a potent inverse agonist of the serotonin receptor (5-HT2A).</p>Fórmula:C24H29F2N3O2Cor e Forma:SolidPeso molecular:429.505-HT2A/5-HT2C inverse agonist 1
CAS:<p>5-HT2A/5-HT2C inverse agonist 1 serves as a dual and potent inverse agonist for the 5-HT2A and 5-HT2C receptors, with hERG inhibition properties that mitigate cardiovascular risks. Demonstrating significant antipsychotic efficacy in the MK-801-induced mouse model, this compound holds potential for psychosis research.</p>Fórmula:C24H35N5O2Cor e Forma:SolidPeso molecular:425.57Befiradol hydrochloride
CAS:<p>Befiradol HCl (NLX-112) is a selective 5-HT1A receptor agonist with anxiolytic effects and prevents ATXN3 aggregation.</p>Fórmula:C20H23Cl2F2N3OPureza:99.1%Cor e Forma:SolidPeso molecular:430.32Serotonin maleate
CAS:<p>Serotonin hydrogen maleate serves as a monoaminergic neurotransmitter and an endogenous 5-HT receptor agonist within the central nervous system (CNS). It also functions as an inhibitor of catechol O-methyltransferase (COMT), exhibiting a Ki value of 44 μM.</p>Fórmula:C14H16N2O5Cor e Forma:SolidPeso molecular:292.287CB2R/5-HT1AR agonist 1
CAS:<p>Compound 2o, also known as CB2R/5-HT1AR agonist 1, serves as a partial orally active agonist for the CB2 receptor (EC50 = 479.6 nM) and a full agonist for the 5-HT1A receptor (EC50 = 2.7 μM). This compound demonstrates both anti-anxiety and anti-depressive effects and has favorable pharmacokinetic properties [1].</p>Fórmula:C24H33NO3Cor e Forma:SolidPeso molecular:383.52SB 243213 dihydrochloride
CAS:<p>SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 for</p>Fórmula:C22H21Cl2F3N4O2Pureza:98%Cor e Forma:SolidPeso molecular:501.33AAZ-A 154
CAS:<p>AAZ-A 154 is a selective, competitive, and non-hallucinogenic antagonist of the 5-HT2AR. It promotes neuronal growth in rodents and results in lasting beneficial behavioral effects.</p>Fórmula:C14H20N2OCor e Forma:SolidPeso molecular:232.32R-96544 hydrochloride
CAS:<p>5-HT2 receptor antagonist</p>Fórmula:C22H29NO3Pureza:98%Cor e Forma:SolidPeso molecular:355.47
