Beta Amilóide
Os inibidores de beta-amiloide são compostos que visam especificamente inibir a formação ou agregação de peptídeos beta-amiloides, que desempenham um papel crítico na patogênese da doença de Alzheimer. O acúmulo de placas de beta-amiloide no cérebro é uma característica marcante da doença, levando à disfunção neuronal e ao declínio cognitivo. Ao impedir a agregação de beta-amiloide, esses inibidores estão sendo explorados como potenciais agentes terapêuticos para retardar ou prevenir a progressão da doença de Alzheimer. Na CymitQuimica, oferecemos uma variedade de inibidores de beta-amiloide de alta qualidade para apoiar sua pesquisa em neurodegeneração, agregação de proteínas e terapia para Alzheimer.
Foram encontrados 227 produtos de "Beta Amilóide"
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QM-FN-SO3
CAS:QM-FN-SO3 is a blood-brain barrier (BBB)-penetrable, near-infrared (NIR) probe with aggregation-induced emission (AIE) activity, specifically designed for the detection of Aβ plaques. It exhibits ultra-high signal-to-noise (S/N) ratio, binding affinity, and high-performance NIR emission, making it suitable for in vivo detection of Aβ plaques [1].Fórmula:C29H25N4NaO3S2Cor e Forma:SolidPeso molecular:564.65γ-Secretase-IN-1
CAS:γ-Secretase-IN-1 is a γ-secretase inhibitor that displays partial antiproliferative activity against T-47D cells.Fórmula:C27H24F2N4O3Pureza:99.56%Cor e Forma:SolidPeso molecular:490.5Ref: TM-T3521
1mg127,00€5mg406,00€10mg652,00€25mg1.293,00€50mg1.738,00€100mg2.357,00€1mL*10mM (DMSO)439,00€MDR-1339
CAS:MDR-1339 is a blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.Fórmula:C20H22O4Pureza:98.57%Cor e Forma:SolidPeso molecular:326.39Aβ-IN-2
Aβ-IN-2 is a peptide inhibitor of Aβ1-42.Fórmula:C37H51NOCor e Forma:SolidPeso molecular:525.81Thiazolo[5,4-c]pyridin-4(5H)-one
CAS:Thiazolo[5,4-c]pyridin-4(5H)-one is a compound used for diagnostic imaging of TDP-43, in PET imaging of neurodegenerative diseases ALS、AD、FTD、LATE.Fórmula:C22H22FN5O2SPureza:98.75%Cor e Forma:SolidPeso molecular:439.51MAO-B-IN-45
CAS:MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B. It selectively inhibits MAO-B with an IC50 of 87.47 nM, demonstrating a selectivity over MAO-A by more than 229 times. In vitro, MAO-B-IN-45 exhibits significant anti-ferroptosis activity by modulating iron metabolism pathways and the GSH-GPX4 axis. Additionally, it improves cognitive and behavioral deficits in 3×Tg (APP/Tau/Ps1) Alzheimer's disease mice and significantly reduces levels of ferritin heavy chain 1 (FTH1), β-amyloid protein (APP), and Tau protein phosphorylation (p-Tau) in their brains.Fórmula:C17H14ClNO3Cor e Forma:SolidPeso molecular:315.75IXA62
CAS:IXA62 is an orally active, selective IRE1/XBP1s agonist (EC50= 0.31 μM) that can reduce Aβ secretion.Fórmula:C24H23N3O3Cor e Forma:SolidPeso molecular:401.458Glutaminyl Cyclase Inhibitor 3
CAS:Designed anti-Alzheimer’s compound; potent Glutaminyl Cyclase inhibitor; IC50 at 4.5 nM; reduces brain Aβ; improves cognition.Fórmula:C24H32N6O2SPureza:98%Cor e Forma:SolidPeso molecular:468.61Aβ42 agonist-1
CAS:Aβ42 agonist-1 is a small molecule compound with anti-cancer activity and NF-κB inhibitory properties, inducing Aβ42 aggregation.Fórmula:C15H11NO2Pureza:99.77%Cor e Forma:SolidPeso molecular:237.252002-G12
CAS:2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. It is applicable in Alzheimer's research.Fórmula:C20H16N6Cor e Forma:SolidPeso molecular:340.381Amilo-5MER
CAS:Amilo-5MER (5-MP) is an orally active and selective inhibitor of serum amyloid A (SAA). It specifically suppresses the release of pro-inflammatory cytokines IL-6 and IL-1β in SAA-activated cells. Amilo-5MER reduces chronic inflammation and alleviates symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). It holds potential for research in autoimmune and chronic inflammatory diseases.Fórmula:C23H40N6O9SCor e Forma:SolidPeso molecular:576.664BF-168
CAS:BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).Fórmula:C18H17FN2O2Cor e Forma:SolidPeso molecular:312.34MAO-B-IN-10
MAO-B-IN-10: Potent, selective MAO-B inhibitor; crosses blood-brain barrier; IC50 5.3 μM; reduces Aβ aggregation 58.2%, disaggregates 43.3%.Fórmula:C23H26N2O4Cor e Forma:SolidPeso molecular:394.46γ-secretase modulator 6
CAS:<p>Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.</p>Fórmula:C25H26N6O2Cor e Forma:SolidPeso molecular:442.513cSPM
cSPM (Cyclic spermine) is an Aβ42 inhibitor. cSPM inhibits the aggregation of three different peptides, Aβ42, tryptophan and insulin, and reduces cytotoxicity.Fórmula:C27H57N7Cor e Forma:SolidPeso molecular:479.79γ-secretase modulator 5
Compound 22d is a GSM that crosses the blood-brain barrier, inhibits Aβ42 production (IC50: 60 nM), and may help study Alzheimer's.Cor e Forma:SolidBuntanetap L-Tartrate
CAS:Buntanetap (L-Tartrate) functions as an oral small molecule inhibitor targeting multiple neurotoxic proteins. It decreases the production of amyloid precursor protein (APP) by inhibiting the translation of its mRNA [1].Fórmula:C24H29N3O8Cor e Forma:SolidPeso molecular:487.50Anti-Aβ agent 1A
Anti-Aβ agent 1A is a potent anti-amyloid-β agent.Fórmula:C35H49NO4Cor e Forma:SolidPeso molecular:547.77QP5020
CAS:QP5020 is a QPCTL inhibitor with an IC50 value of 15 nM, demonstrating antitumor efficacy.Fórmula:C20H19FN6Peso molecular:362.40(9R)-RO7185876
CAS:(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.Fórmula:C25H28F3N7Cor e Forma:SolidPeso molecular:483.532Amyloid-β-IN-2
CAS:Amyloid-β-IN-2 (Compound EX.112) is a selective inhibitor of γ-secretase. In H4 cells, it demonstrates inhibitory activity on Aβ42 secretion, with an EC50 value of 226 nM. Amyloid-β-IN-2 holds potential for research in Alzheimer's disease (AD) and diseases associated with Aβ deposition.Fórmula:C22H21F2N3O2Cor e Forma:SolidPeso molecular:397.42Aβ aggregation-IN-1
CAS:Aβ aggregation-IN-1 (Compound 1b) is an inhibitor of amyloid-beta precursor protein. It suppresses the aggregation and disaggregation of amyloid-beta fibrils with IC50 values of 3.92 and 7.19 M, respectively. Additionally, Aβ aggregation-IN-1 reduces malondialdehyde formation in neuronal cells, increases intracellular levels of reduced glutathione (GSH), and inhibits caspase 3.Fórmula:C9H8BF3O2Cor e Forma:SolidPeso molecular:215.965Amyloid-β-IN-3
CAS:Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.Fórmula:C22H21F2N3O2Cor e Forma:SolidPeso molecular:397.42Antioxidant agent-8
Antioxidant agent-8, an oral Aβ 1-42 inhibitor, reduces fibril aggregation & promotes disaggregation; it's neuroprotective & BBB permeable.Fórmula:C13H12O5Cor e Forma:SolidPeso molecular:248.23BMS 299897
CAS:<p>BMS 299897, a sulfonamide γ-secretase inhibitor, inhibits Aβ production with an IC50 of 7 nM in HEK293 cells overexpressing APP.</p>Fórmula:C24H21ClF3NO4SPureza:99.82%Cor e Forma:SolidPeso molecular:511.94Xanthocillin X permethyl ether
CAS:Xanthocillin X permethyl ether, a natural product extracted from fungal sources, exhibits Aβ-42 lowering activity.Fórmula:C20H16N2O2Pureza:98%Cor e Forma:SolidPeso molecular:316.35BF 227
CAS:BF 227 is a candidate for an amyloid imaging probe for PET [Ki: 4.3 nM for Aβ1-42 fibrils].Fórmula:C16H16FN3O2SCor e Forma:SolidPeso molecular:333.38
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