Beta Amilóide
Os inibidores de beta-amiloide são compostos que visam especificamente inibir a formação ou agregação de peptídeos beta-amiloides, que desempenham um papel crítico na patogênese da doença de Alzheimer. O acúmulo de placas de beta-amiloide no cérebro é uma característica marcante da doença, levando à disfunção neuronal e ao declínio cognitivo. Ao impedir a agregação de beta-amiloide, esses inibidores estão sendo explorados como potenciais agentes terapêuticos para retardar ou prevenir a progressão da doença de Alzheimer. Na CymitQuimica, oferecemos uma variedade de inibidores de beta-amiloide de alta qualidade para apoiar sua pesquisa em neurodegeneração, agregação de proteínas e terapia para Alzheimer.
Foram encontrados 205 produtos de "Beta Amilóide"
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Eprodisate disodium
CAS:<p>Eprodisate disodium (NC-503) is a negatively charged sulfonated inhibitor of fibrillogenesis, that can be used in the treatment of amyloid A (AA) amyloidosis.</p>Fórmula:C3H6Na2O6S2Pureza:99.88%Cor e Forma:White Coarse PowderPeso molecular:248.19Donanemab
CAS:<p>Donanemab (LY3002813), a humanized IgG1 antibody, targets N-terminal Aβ for potential early Alzheimer's research.</p>Pureza:95%Cor e Forma:LiquidLY 2389575 hydrochloride
CAS:<p>LY2389575 hydrochloride is a selective mGlu3 NAM with 190 nM IC50, increases Mrc1, and aids Alzheimer's research.</p>Fórmula:C15H16BrCl3N4Pureza:99.45%Cor e Forma:SolidPeso molecular:438.58ALZ-801
CAS:<p>ALZ-801, an oral valine-prodrug of tramiprosate, enhances treatment of Alzheimer's by inhibiting β-amyloid aggregation with better PK and tolerance.</p>Fórmula:C8H18N2O4SPureza:99.36%Cor e Forma:SolidPeso molecular:238.3Gantenerumab
CAS:<p>Gantenerumab (R-1450) is a humanized antibody targeting amyloid-β (Aβ), used in studies of Alzheimer's disease.</p>Pureza:>95%Cor e Forma:LiquidGlimepiride
CAS:<p>Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity.</p>Fórmula:C24H34N4O5SPureza:97.84% - 98.87%Cor e Forma:White Cyrstalline SolidPeso molecular:490.62Chlorzoxazone
CAS:<p>Chlorzoxazone (Chlorzoxazon) is a Muscle Relaxant. The physiologic effect of chlorzoxazone is by means of Centrally-mediated Muscle Relaxation.</p>Fórmula:C7H4ClNO2Pureza:99.49% - 99.6%Cor e Forma:SolidPeso molecular:169.57Birtamimab
CAS:<p>Birtamimab (NEOD001) is a monoclonal antibody selectively targeting and depleting amyloid protein, used in research on light chain amyloidosis.</p>Pureza:>95%Cor e Forma:LiquidLecanemab
CAS:<p>Lecanemab (BAN-2401) is an IgG1 monoclonal antibody targeting soluble aggregated beta amyloid (Abeta) for the study of cognitive disorders.</p>Pureza:95% - 97.3% (SEC-HPLC)Cor e Forma:LiquidCromolyn sodium
CAS:<p>Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.</p>Fórmula:C23H14Na2O11Pureza:99.4% - 99.95%Cor e Forma:Colorless Crystals From Ethanol + Ether White Crystalline PowderPeso molecular:512.33Trontinemab
CAS:<p>Trontinemab, a bispecific humanized IgG1-κ antibody, targets the amyloid beta A4 precursor protein (APP) and transferrin receptor p90, CD71 (TFRC).</p>Pureza:96.77% - 99%Cor e Forma:LiquidAducanumab
CAS:<p>Aducanumab (BIIB037) is an IgG1 antibody targeting amyloid beta to treat Alzheimer's; it's brain-permeable.</p>Pureza:95% - 97.10%Cor e Forma:LiquidPeso molecular:145.93 kDaβ-Amyloid (33-40)
CAS:<p>β-Amyloid (33-40) is a peptide comprising amino acids 33 to 40 of the beta-amyloid protein.</p>Fórmula:C32H58N8O9SPureza:98%Cor e Forma:SolidPeso molecular:730.92GSK-3β inhibitor 27
<p>GSK-3β inhibitor27 (Compound 1c) is a reversible, competitive inhibitor of GSK-3β with an IC50 value of 2.2 μM. It inhibits tau hyperphosphorylation and reduces Aβ protein aggregation, demonstrating metal chelation and neuroprotective potential. GSK-3β inhibitor27 is promising for research into neurodegenerative diseases, such as Alzheimer's disease.</p>Fórmula:C16H17ClN4O2Cor e Forma:SolidPeso molecular:332.79Methoxy-X04
CAS:<p>Methoxy-X04, a derivative of Congo red and Chrysamine-G, is a brain-permeable fluorescent probe for amyloid-β (Aβ).</p>Fórmula:C23H20O3Pureza:98.96%Cor e Forma:SolidPeso molecular:344.4β-Amyloid (10-20)
CAS:<p>Amyloid β-Protein (10-20) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.Amyloid β protein fragment containing the α-</p>Fórmula:C71H99N17O16Pureza:98%Cor e Forma:Lyophilized PowderPeso molecular:1446.65β-Amyloid (10-35), amide
CAS:<p>β-Amyloid (10-35), amide, is a chemical compound consisting of 26 amino acids, specifically residues 10-35 of the Aβ peptide.</p>Fórmula:C133H205N35O36SPureza:98%Cor e Forma:SolidPeso molecular:2902.33δ-secretase inhibitor 11
CAS:<p>δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.</p>Fórmula:C10H12N4O2Pureza:99.84%Cor e Forma:SolidPeso molecular:220.23LPYFD-NH2
CAS:<p>neuroprotective peptide that binds to amyloid beta (Aβ)</p>Fórmula:C33H44N6O8Pureza:98%Cor e Forma:SolidPeso molecular:652.74BSB
CAS:<p>BSB is a Congo red-derived fluorescent probe, an amyloid protein imaging agent, interacting with amyloid fibrils formed by Aβ (1-40) peptides in rodents.</p>Fórmula:C24H17BrO6Pureza:95.53%Cor e Forma:SolidPeso molecular:481.29β-Amyloid (22-35)
CAS:<p>β-Amyloid (22-35) is a 14-aa peptide, shows aggregates and induces neurotoxicity in the hippocampal cells.</p>Fórmula:C59H102N16O21SPureza:98%Cor e Forma:SolidPeso molecular:1403.62β-Amyloid (22-40)
CAS:<p>This synthetic peptide consists of amino acids 22 to 40 of beta amyloid protein.</p>Fórmula:C78H135N21O26SPureza:98%Cor e Forma:SolidPeso molecular:1815.1β-Amyloid (13-27)
CAS:β-Amyloid (13-27) is a peptide consisting of amino acid of 13 to 27 of beta amyloid protein.Fórmula:C84H126N24O24Pureza:98%Cor e Forma:SolidPeso molecular:1856.05β-Amyloid (1-16)
CAS:<p>β-Amyloid (1-16) is an amyloidogenic protein fragment with a sequence derived from β-amyloid.</p>Fórmula:C84H119N27O28Pureza:98%Cor e Forma:SolidPeso molecular:1955.04Amyloid β Peptide (42-1)(human) acetate
<p>Amyloid β Peptide (42-1)(human) acetate is the inactive form of Amyloid β Peptide (1-42).</p>Pureza:95.20%Cor e Forma:SoildPep63
CAS:Pep63, a neuroprotective peptide (VFQVRARTVA), enhances synaptic plasticity and memory. It competitively binds with Aβ1-42 oligomers, thereby inhibiting the formation of Aβ fibrils. Pep63 is employed in research focused on Alzheimer's disease (AD).Fórmula:C51H87N17O13Peso molecular:1146.34Chemerin-9 (149-157) TFA
<p>Chemerin-9 (149-157) TFA is a peptide located at positions 149-157 of chemerin-9, acting as a ChemR23/CMKLR1 agonist.</p>Fórmula:C56H67F3N10O15Pureza:99.77%Cor e Forma:SolidPeso molecular:1177.18β-Amyloid Protein Precursor 770 (135-155)
CAS:<p>Beta-Amyloid Protein Precursor 770 (135-155)Aβ Protein Precursor 770 (135-155)</p>Fórmula:C116H172N35O31S2Pureza:98%Cor e Forma:SolidPeso molecular:2617.96Crenezumab
CAS:<p>Crenezumab (MABT 5102A) is a fully humanized anti-amyloid-beta antibody that binds to multiple forms of amyloid-beta (Aβ) for the study of Alzheimer's disease.</p>Pureza:97.5% (SDS-PAGE); 95.3% (SEC-HPLC) - 97.5% (SDS-PAGE); 95.3% (SEC-HPLC)Cor e Forma:Liquidβ-Amyloid (4-10)
CAS:<p>Antibodies corresponding to beta-amyloid (4-10) are effective in vivo inhibitors of cytotoxicity, amyloid plaque formation and special memory disturbances in</p>Fórmula:C39H52N12O12Pureza:98%Cor e Forma:SolidPeso molecular:880.9p-HTAA
CAS:<p>Pentamer Hydrogen Thiophene Acetic Acid (p-HTAA) is a compound that specifically targets and labels amyloid-beta (Aβ) deposits in the brains of living mice [1].</p>Fórmula:C24H16O4S5Cor e Forma:SolidPeso molecular:528.71β-Amyloid (12-28)
CAS:<p>Amyloid β-peptide fragment; minimum section required to bind to brain proteins.</p>Fórmula:C89H135N25O25Pureza:98%Cor e Forma:SolidPeso molecular:1955.18RAGE antagonist peptide
CAS:<p>RAGE antagonist blocks S100P/A4, HMGB-1; hinders glioma growth, metastasis; reduces PDAC cell growth, NF-κB activity; counters TDI effects in mice.</p>Fórmula:C57H101N13O17SPureza:98%Cor e Forma:SolidPeso molecular:1272.56Biotinoyl tripeptide-1
CAS:<p>Biotinoyl tripeptide-1 can produce hair follicles by promoting scalp micro-circulation and reduce follicle atrophy and aging.</p>Fórmula:C24H38N8O6SPureza:98%Cor e Forma:SolidPeso molecular:566.67β-Amyloid (1-28)
CAS:<p>β-Amyloid (1-28) is a β-Amyloid protein fragment involved in metal binding.</p>Fórmula:C145H209N41O46Pureza:98%Cor e Forma:SolidPeso molecular:3262.51β-Amyloid (1-40)
CAS:<p>Amyloid β1-40 is one of the fragments generated after cleavage of the amyloid peptide precursor protein by β and γ secretases.</p>Fórmula:C194H295N53O58SPureza:98%Cor e Forma:SolidPeso molecular:4329.82γ-Secretase Modulators
CAS:<p>gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β.</p>Fórmula:C26H24F3N3O3Pureza:98%Cor e Forma:SolidPeso molecular:483.48Glycerophosphorylethanolamine (sodium salt)
CAS:<p>Glycerophosphorylethanolamine, a phosphatidylethanolamine metabolite, elevates in Alzheimer's and promotes Aβ40 aggregation.</p>Fórmula:C5H13NNaO6PCor e Forma:SolidPeso molecular:237.12Aβ-IN-6
<p>Aβ-IN-6 is an orally active compound exhibiting anti-inflammatory, antioxidant, and anti-oligomeric activities, with significant implications for Alzheimer's</p>Fórmula:C28H31N3O4Cor e Forma:SolidPeso molecular:473.56JNK3 inhibitor-9
<p>JNK3inhibitor-9 (Compound 24a) is a potent, selective JNK3 inhibitor capable of crossing the blood-brain barrier (BBB), demonstrating an IC50 value of 12 nM. It effectively inhibits GSK3α/β, which is involved in Tau phosphorylation, with IC50 values of 14 nM and 35 nM, respectively. JNK3inhibitor-9 also reduces the phosphorylation of c-Jun and APP and protects neurons from Aβ1-42 toxicity.</p>Fórmula:C25H27N7O2Cor e Forma:SolidPeso molecular:457.528Biphenyl-3′,3,4,4′-tetrol
CAS:<p>Biphenyl-3′,3,4,4′-tetrol (BPT) is a potent inhibitor of Aβ40 aggregation and can be utilized in research related to neurodegenerative diseases such as Alzheimer's.</p>Fórmula:C12H10O4Cor e Forma:SolidPeso molecular:218.21β-Amyloid (1-20)
CAS:<p>This synthetic peptide consists of amino acids 1 to 20 of beta amyloid protein.</p>Fórmula:C113H157N31O32Pureza:98%Cor e Forma:SolidPeso molecular:2461.7β-Amyloid (35-42)
CAS:<p>β-Amyloid (35-42) is a peptide derived from the beta-amyloid protein, encompassing amino acids 35 through 42.</p>Fórmula:C33H60N8O9SPureza:98%Cor e Forma:SolidPeso molecular:744.94AZD4694 Precursor
CAS:<p>AZD4694 Precursor used for synthesizing [18F]AZD4694, a high-affinity amyloid-β imaging agent.</p>Fórmula:C22H25N3O7Cor e Forma:SolidPeso molecular:443.45DDC 2′,3′-O-disulfate
<p>DDC 2′,3′-O-disulfate (compound 4) inhibits the fibrillization and oligomerization of Aβ42, showing promise for Alzheimer's disease (AD) research [1].</p>Fórmula:C17H16O11S2Cor e Forma:SolidPeso molecular:460.43Aβ-IN-8
<p>Aβ-IN-8, also known as compound 7e, is a potent inhibitor of Aβ aggregation [1].</p>Fórmula:C22H16F3N3O3SCor e Forma:SolidPeso molecular:459.44β-Amyloid (1-9)
CAS:<p>This is an N-terminal fragment of beta amyloid.</p>Fórmula:C42H60N14O17Pureza:98%Cor e Forma:SolidPeso molecular:1033.01Aβ-IN-7
<p>Aβ-IN-7 (compound 5a) acts as a potent inhibitor of Aβ aggregation, stabilizing Aβ monomers at 50 μM concentration to prevent them from forming larger oligomers</p>Fórmula:C14H10N2SCor e Forma:SolidPeso molecular:238.31AC 253
CAS:<p>Amylin (AMY3) receptor antagonist; blocks cAMP, Ca2+, PKA, MAPK, Akt, and cFOS activity; prevents Aβ-induced neuronal death. Cyclic AC 253 variant exists.</p>Fórmula:C122H196N40O39Pureza:98%Cor e Forma:SolidPeso molecular:2847.11β-Amyloid (1-11)
CAS:<p>Anionic interaction of Beta-amyloid (1-11) with Factor XII is suspected to cause massive activation of the C4 (complement 4) system in the cerebrospinal fluid</p>Fórmula:C56H76N16O22Pureza:98%Cor e Forma:SolidPeso molecular:1325.3β-Amyloid (18-28)
CAS:<p>Intracerebroventricular administration of synthetic peptides Beta-amyloid (12-20), (12-28), and (18-28) causes amnesia in mice.</p>Fórmula:C55H81N13O18Pureza:98%Cor e Forma:SolidPeso molecular:1212.31BIBD-124
CAS:<p>BIBD-124, with an IC50 value of 9.51 nM, effectively binds to amyloid beta (Aβ) plaques.</p>Fórmula:C19H24FN3O3Cor e Forma:SolidPeso molecular:361.41(Gln22)-Amyloid β-Protein (1-42)
CAS:<p>(Gln22)-Amyloid β-Protein (1-42), a Dutch mutation (E22Q) variant of β-Amyloid (1-42), demonstrates increased fibrillogenic and pathogenic characteristics [1].</p>Fórmula:C203H312N56O59SCor e Forma:SolidPeso molecular:4513.05β-Amyloid (1-34)
CAS:<p>This is a fragment of beta-amyloid peptide. It has amino acids 1 through 34.</p>Fórmula:C170H253N47O52Pureza:98%Cor e Forma:SolidPeso molecular:3787.21H-Indole-3-carboxylic acid, 5-[2-hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]propoxy]-2-methyl-1-(4-methylphenyl)-, ethyl ester
CAS:<p>Compound 5936-0108对β-淀粉样蛋白可能具有调节作用。</p>Fórmula:C26H34N2O7Pureza:99.44%Cor e Forma:SoildPeso molecular:486.56Anti-Amyloid β Antibody (scFv59)
<p>Anti-Amyloid Beta Antibody (scFv59) is a human-derived antibody produced in CHO cells that targets Amyloid-β. For isotype control, please refer to Human IgG1 kappa, Isotype Control.</p>Cor e Forma:Odour Liquidβ-Amyloid (12-20)
CAS:<p>β-Amyloid (12-20) is a peptide fragment of β-Amyloid.Thsis peptide contain the amino acid residues VFF at position (18-20), suggesting that this triad has</p>Fórmula:C57H83N15O11Pureza:98%Cor e Forma:SolidPeso molecular:1154.36β-Amyloid (29-40)
CAS:<p>β-Amyloid (29-40) is a fragment of Amyloid-β peptide.Alzheimer's beta amyloid peptide (29-40/42) C-terminal fragments have physical and chemical properties</p>Fórmula:C49H88N12O13SPureza:98%Cor e Forma:SolidPeso molecular:1085.362002-H20
CAS:<p>2002-H20 is an Aβ42-induced cytotoxicity inhibitor. It acts by binding the Alzheimer's Aβ peptide and reducing its cytotoxicity.</p>Fórmula:C20H15N3O3Pureza:98%Cor e Forma:SolidPeso molecular:345.358BSBM6
CAS:<p>BSBM6 is an inhibitor of Aβ aggregation and neuronal toxicity that acts by reversing the aggregation and toxicity of amyloid-β peptides.</p>Fórmula:C23H29N3O5Pureza:98%Cor e Forma:SolidPeso molecular:427.49C18 L-erythro Ceramide (d18:1/18:0)
CAS:<p>C18 L-erythro Ceramide, a natural stereoisomer, inhibits rat brain mt-CDase with IC50 of 8.8 μM.</p>Fórmula:C36H71NO3Cor e Forma:SolidPeso molecular:565.95FITC-β-Ala-Amyloid β-Protein (1-42)
CAS:<p>FITC-β-Ala-Amyloid β-Protein (1-42) is a polypeptide identified through peptide screening. This screening method predominantly utilizes immunoassays to gather active polypeptides and is used in studying protein interactions, conducting functional analyses, and screening antigen epitopes, with particular application in the research and development of active molecules.</p>Fórmula:C227H327N57O66S2Peso molecular:4971.34251β-Amyloid (35-25)
CAS:<p>β-Amyloid (35-25) is the reverse sequence of β-Amyloid (25-35).</p>Fórmula:C45H81N13O14SPeso molecular:1060.27Amyloid β-Protein (1-24)
CAS:<p>Amyloid β-Protein (1-24) is a peptide identified through peptide screening. This tool predominantly employs immunoassays to gather and analyze active peptides. Peptide screening is utilized in studies involving protein interactions, functional analysis, and epitope screening, particularly relevant in the research and development of active molecules.</p>Fórmula:C130H183N35O40Peso molecular:2876.05β-Amyloid (11-22)
CAS:<p>β-Amyloid (11-22) is a peptide fragment of β-Amyloid.Beta-amyloid peptide (Abeta), the major constituent of amyloid plaques in the brains of Alzheimer’s</p>Fórmula:C70H102N18O18Pureza:98%Cor e Forma:SolidPeso molecular:1483.677-Deoxy-trans-dihydronarciclasine
CAS:<p>7-Deoxy-trans-dihydronarciclasine is an alkaloid that functions as a tobacco mosaic virus (TMV) inhibitor with an IC50 of 1.80 μM and also serves as an anti-</p>Fórmula:C14H15NO6Cor e Forma:SolidPeso molecular:293.27Aβ1-14-εK-KKK-MvF5 Th
<p>Aβ1-14-εK-KKK-MvF5 Th (UB311 immunogen I) is a biologically active peptide and one of the Aβ1–14 targeting peptides (B-cell epitope) used in UB-311.</p>Fórmula:C199H318N56O55Peso molecular:4372.38081Dalidnetug
CAS:<p>Dalidnetug is a humanized monoclonal antibody that targets human β-amyloid precursor protein (APP). By specifically binding to APP, Dalidnetug reduces the production of β-amyloid (Aβ), thereby demonstrating activity in clearing β-amyloid. This compound holds potential for research in Alzheimer's disease.</p>Cor e Forma:LiquidAmyloid-Forming peptide GNNQQNY
CAS:<p>Amyloid-Forming peptide GNNQQNY, a biologically active heptapeptide derived from the N-terminal prion-determining domain of yeast Sup35, is instrumental in</p>Fórmula:C33H48N12O14Cor e Forma:SolidPeso molecular:836.81G923-0271
CAS:<p>G923-0271 is a TDP-43 inhibitor that improves disease phenotypes in TDP-43 nematode models and reduces the overexpression of human TDP-43, ALS FTD.</p>Fórmula:C28H23FN4OCor e Forma:SolidPeso molecular:450.51(Glu20)-Amyloid β-Protein (1-42)
CAS:<p>(Glu20)-Amyloid β-Protein (1-42) represents a variant of amyloid β-protein (Aβ) that fibrillizes more slowly.</p>Fórmula:C199H309N55O62SCor e Forma:SolidPeso molecular:4495.98(D-Asp1)-Amyloid β-Protein (1-42)
CAS:<p>(D-Asp1)-Amyloid β-Protein (1-42), a peptide fragment of amyloid β-protein (Aβ), serves as the primary constituent of vascular and parenchymal amyloid deposits</p>Fórmula:C203H311N55O60SCor e Forma:SolidPeso molecular:4514.04Acetyl-Tau Peptide (273-284) amide
CAS:<p>Acetyl-Tau Peptide (273-284) amide inhibits Ac-Aβ(25–35)-NH2 aggregation and models Aβ/Tau interaction.</p>Fórmula:C64H116N18O17Cor e Forma:SolidPeso molecular:1409.72CHF-5022
CAS:<p>CHF-5022 is a nonsteroidal anti-inflammatory drug that selectively inhibits the production of beta-amyloid protein (1-42) (ABETA42).</p>Fórmula:C17H12F4O2Cor e Forma:SolidPeso molecular:324.27FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium)
<p>FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium) is a FITC-labeled amyloid beta monomer, Alzheimer’s research, drug screening, and biomolecular studies.</p>Fórmula:C227H330N58O66S2Cor e Forma:SolidPeso molecular:4991.532,3-Dehydrosilybin A
CAS:<p>2,3-Dehydrosilybin A is a useful organic compound for research related to life sciences and the catalog number is T125202.</p>Fórmula:C25H20O10Cor e Forma:SolidPeso molecular:480.425β-Amyloid (1-38), mouse, rat
CAS:<p>β-Amyloid (1-38), derived from mice and rats, is a chemical compound comprising 38 amino acids, specifically residues 1-38 of the Aβ peptide.</p>Cor e Forma:Solidβ-Amyloid (1-43)(human) TFA
<p>β-Amyloid (1-43)(human) TFA exhibits greater aggregation tendencies and heightened toxicity compared to its well-established counterpart, Aβ1-42.</p>Fórmula:C209H319F3N56O64SCor e Forma:SolidPeso molecular:4729.215-FAM-β-Amyloid (1-28)
<p>5-FAM-β-Amyloid (1-28) is a fluorescently-labeled peptide corresponding to the first 28 amino acids of the β-Amyloid protein.</p>Fórmula:C166H219N41O52Cor e Forma:SolidPeso molecular:3620.76β-Amyloid (1-17)
CAS:<p>This synthetic peptide consists of amino acids 1 to 17 of beta amyloid protein. This peptide can be employed in beta amyloid solubility studies.</p>Fórmula:C90H130N28O29Pureza:98%Cor e Forma:SolidPeso molecular:2068.2AChE/Aβ-IN-6
<p>BACE1-IN-15 (compound 4j) serves as an effective inhibitor of BACE1 (β-secretase), efficiently mitigating the copper-induced toxicity of Aβ, with an EC50 value of 0.68 μM.</p>Cor e Forma:Odour SolidBiotin-β-Amyloid (1-42), human TFA
<p>Biotin-β-Amyloid (1-42), human TFA, also known as Biotin-Amyloid β-Peptide (1-42) (human) TFA, is a biotin-labeled 42-amino acid peptide implicated in the</p>Fórmula:C215H326F3N57O64S2Cor e Forma:SolidPeso molecular:4854.36mcK6A1
<p>mcK6A1 serves as an inhibitor of amyloid-β (Aβ) aggregation, selectively binding to the 16KLVFFA21 fragment of Aβ42, leading to the formation of an extended β-sheet structure and preventing the formation of Aβ42 oligomers. This compound is valuable for research into Alzheimer's disease and other amyloid-related disorders.</p>Fórmula:C71H99N17O16Cor e Forma:SolidPeso molecular:1446.65(Met(O)35)-Amyloid β-Protein (1-42)
<p>(Met(O)35)-Amyloid β-Protein (1-42) represents the oxidized form of Methionine 35 in Aβ42, capable of producing an oligomer size distribution akin to that of</p>Fórmula:C203H311N55O61SCor e Forma:SolidPeso molecular:4530.04(Met(O2)35)-Amyloid β-Protein (1-42)
<p>(Met(O2)35)-Amyloid β-Protein (1-42) is a peptide [1] .</p>Fórmula:C203H311N55O62SCor e Forma:SolidPeso molecular:4546.04Amyloid β-Protein (3-42)
CAS:<p>Amyloid β-Protein (3-42), the precursor of Pyr peptide, serves as the foundation of the amyloid template block in Alzheimer's disease when modified to</p>Cor e Forma:SolidSabirnetug
CAS:<p>Sabirnetug is a humanized IgG2κ monoclonal antibody that specifically targets the amyloid-β (A4) precursor protein.</p>Cor e Forma:LiquidSQ-3
<p>SQ-3, a quinoline analogue, prefers α-syn (Ki=39.3nM) to Aβ (Ki=230nM), and [18F]SQ3 is a lead for α-syn probes. [1]</p>Fórmula:C21H21FN2OCor e Forma:SolidPeso molecular:336.4Davunetide
CAS:<p>Davunetide: neuroprotective 8-amino acid peptide, improves daily function in schizophrenia, boosts memory in mild cognitive impairment.</p>Fórmula:C36H60N10O12Pureza:98%Cor e Forma:SolidPeso molecular:824.92SEN177
CAS:<p>SEN177 shows the potential in the research of Huntington's disease that is a potent inhibitor of glutaminyl cyclase (QPCT) with an IC 50 of 0.013μM for glutaminyl-peptide cyclotransferase-like (QPCTL). The Ki value of SEN177 for human glutaminyl cyclase (hQC) is 20 nM. SEN177 significantly reduces the early stages of mutant HTT oligomerisation and reduces the percentage of neurons with Q80 aggregates [1].</p>Fórmula:C18H19FN6Cor e Forma:SolidPeso molecular:338.38TH-237A
CAS:<p>TH-237A is a novel neuroprotective agent exhibiting favorable permeation across the blood-brain barrier.</p>Fórmula:C18H17F2NO3Pureza:98%Cor e Forma:SolidPeso molecular:333.335(Rac)-Z-Phe-Phe-FMK
CAS:<p>(Rac)-Z-Phe-Phe-FMK (Cathepsin L-IN-2) is a cathepsin L inhibitor that inhibits the tendency of β-amyloid to induce apoptotic changes .</p>Fórmula:C27H27FN2O4Pureza:98.27%Cor e Forma:SolidPeso molecular:462.51Begacestat
CAS:Begacestat (GSI-953) is a potent and selective gamma-secretase inhibitor that inhibits Amyloid-beta, inhibits cleavage of APP,,Alzheimer's disease.Fórmula:C9H8ClF6NO3S2Cor e Forma:SolidPeso molecular:391.74AZD4694
CAS:<p>Flutafuranol (AZD4694/NAV4694) binds beta-amyloid, potential PET tracer for Alzheimer's. Non-F18 version supplied.</p>Fórmula:C14H11FN2O2Cor e Forma:SolidPeso molecular:258.25Cu(II)GTSM
CAS:<p>Cu(II)GTSM is a cell permeable copper complex inhibits GSK3β activity and suppresses levels of neurotoxic amyloid β-trimers and phosphorylated tau.</p>Fórmula:C6H10CuN6S2Pureza:99.21%Cor e Forma:SolidPeso molecular:293.86EUK-134
CAS:<p>EUK-134, a synthetic SOD/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.</p>Fórmula:C18H18ClMnN2O4Pureza:98.39%Cor e Forma:SolidPeso molecular:416.74LY2811376
CAS:<p>LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM).</p>Fórmula:C15H14F2N4SPureza:99% - 99.01%Cor e Forma:SolidPeso molecular:320.36Anle138b
CAS:<p>Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease</p>Fórmula:C16H11BrN2O2Pureza:98.88% - 99.82%Cor e Forma:SolidPeso molecular:343.17Frentizole
CAS:<p>Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction</p>Fórmula:C15H13N3O2SPureza:99.82%Cor e Forma:SolidPeso molecular:299.35TAE-1
CAS:<p>TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.</p>Fórmula:C39H51I3N6O9Pureza:94.58%Cor e Forma:SolidPeso molecular:1128.57JLK6
CAS:<p>JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling</p>Fórmula:C10H8ClNO3Pureza:96.50%Cor e Forma:SolidPeso molecular:225.63PBD-150
CAS:PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)Fórmula:C15H20N4O2SPureza:99.68%Cor e Forma:SolidPeso molecular:320.41CRANAD 2
CAS:<p>CRANAD-2, a near-infrared probe, detects amyloid-beta in vivo, increasing fluorescence 70x and shifting blue 90 nm upon binding.</p>Fórmula:C23H25BF2N2O2Pureza:99.44%Cor e Forma:Dark Blue To Black PowderPeso molecular:410.271,1'-Methylenedi-2-naphthol
CAS:<p>1,1'-Methylenedi-2-naphthol target CYP2C19 - cytochrome P450 family 2 subfamily C member 19 (human).</p>Fórmula:C21H16O2Pureza:98.91%Cor e Forma:Light Pink To Light Brown Crystalline PowderPeso molecular:300.35Azeliragon HCl
CAS:<p>Azeliragon: potent oral RAGE inhibitor, blocks Alzheimer's-linked amyloid brain entry.</p>Fórmula:C32H40Cl3N3O2Cor e Forma:SolidPeso molecular:605.04Semagacestat
CAS:<p>Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).</p>Fórmula:C19H27N3O4Pureza:97.1% - 99.9%Cor e Forma:SolidPeso molecular:361.44FPS-ZM1
CAS:<p>FPS-ZM1 is a high-affinity RAGE specific inhibitor that blocks Aβ binding to the V domain of RAGE.</p>Fórmula:C20H22ClNOPureza:99.32% - 99.52%Cor e Forma:SolidPeso molecular:327.85Dihydroergocristine mesylate
CAS:<p>DHEC mesylate is a vasodilator and α-adrenergic antagonist used for vascular dementia and as a geroprotector.</p>Fórmula:C36H45N5O8SPureza:98.9% - 99.65%Cor e Forma:SolidPeso molecular:707.84Miridesap
CAS:<p>Miridesap (GSK2315698) rapidly depletes SAP in blood, cerebrospinal fluid, and amyloid deposits via liver clearance.</p>Fórmula:C16H24N2O6Pureza:≥95%Cor e Forma:SolidPeso molecular:340.37Pyridoxal 5'-phosphate hydrate
CAS:<p>Pyridoxal 5'-phosphate hydrate (PLP)(1:x), the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions,</p>Fórmula:C8H10NO6PPureza:97.52%Cor e Forma:SolidPeso molecular:247.14PiB
CAS:<p>PiB (Pittsburgh Compound-B) is a standard for analysis of 11C-PiB. 11C-PiB is a β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.</p>Fórmula:C14H12N2OSPureza:97.02%Cor e Forma:SolidPeso molecular:256.32Cromoglicic acid
CAS:<p>Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells.</p>Fórmula:C23H16O11Pureza:99.55% - >99.99%Cor e Forma:Colorless Crystals From Ethanol + Ether Physical Description Solid (Ntp 1992)Peso molecular:468.37Benzenesulfonamide
CAS:<p>Benzenesulfonamide (Benzosulfonamide) ia an inhibitor of carbonic anhydrases.</p>Fórmula:C6H7NO2SPureza:99.42% - 99.99%Cor e Forma:White Crystalline PowderPeso molecular:157.19Semax acetate(80714-61-0 free base)
CAS:<p>Semax acetate is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) that has neuroprotective, analgesic, and anxiolytic properties.</p>Fórmula:C39H55N9O12SPureza:99.46%Cor e Forma:SolidPeso molecular:873.98Azeliragon
CAS:<p>Azeliragon (TTP488) is an antagonist at the Receptor for Advanced Glycation End products; is evaluated as a potential treatment for patients with mild-to-</p>Fórmula:C32H38ClN3O2Pureza:96.7% - 98.33%Cor e Forma:SolidPeso molecular:532.12ARN2966
CAS:<p>ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.</p>Fórmula:C12H12N2OPureza:99.52% - 99.86%Cor e Forma:SolidPeso molecular:200.24Edonerpic maleate
CAS:<p>Edonerpic maleate (T-817 maleate) is a neurotrophic agent which can inhibit amyloid-β peptides (Aβ).</p>Fórmula:C20H25NO6SPureza:98.24%Cor e Forma:SolidPeso molecular:407.48LX2343
CAS:<p>LX2343 inhibits BACE1 (IC50: 11.43 μM) and PI3K non-competitively (IC50: 15.99 μM), and enhances autophagy for Aβ removal.</p>Fórmula:C22H19ClN2O6SPureza:99.45%Cor e Forma:SolidPeso molecular:474.91Aftin-4
CAS:<p>Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor.</p>Fórmula:C20H28N6OPureza:98.51%Cor e Forma:SolidPeso molecular:368.48RO4929097
CAS:<p>RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).</p>Fórmula:C22H20F5N3O3Pureza:98.5% - 99.51%Cor e Forma:SolidPeso molecular:469.4MK-0752
CAS:<p>MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).</p>Fórmula:C21H21ClF2O4SPureza:98% - 99.55%Cor e Forma:SolidPeso molecular:442.9PE859
CAS:<p>PE859 is a potent inhibitor of both tau and Aβ aggregation.</p>Fórmula:C28H24N4O2Pureza:98.8% - 99.09%Cor e Forma:SolidPeso molecular:448.52Solanezumab
CAS:<p>Solanezumab (LY 2062430) is a monoclonal antibody that binds preferentially to soluble amyloid and promotes its clearance from the brain.</p>Pureza:96.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 96.3% (SDS-PAGE); 97.5% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:144.1 (kDa)γ-Secretase modulator 13
CAS:<p>γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that can be used to study Alzheimer's disease and tumors.</p>Fórmula:C22H23FN6SPureza:99.79%Cor e Forma:SolidPeso molecular:422.52Remternetug
CAS:<p>Remternetug is a humanized IgG1-kappa monoclonal antibody that targets the N3pGlu peptide of the amyloid beta A4 precursor protein (APP) Aβ42.</p>Pureza:95% - 95%Cor e Forma:LiquidBapineuzumab
CAS:<p>Bapineuzumab (AAB-001) is a humanised monoclonal antibody targeting amyloid-beta (Aβ), soluble and oligomeric forms of amyloid β, Alzheimer's disease (AD).</p>Pureza:95%Cor e Forma:LiquidDezamizumab
CAS:<p>Dezamizumab is a humanized antibody targeting the serum amyloid P component (SAP) to clear amyloid fibrils via macrophage phagocytosis, for research in systemic amyloid diseases.</p>Pureza:95% - 95%Cor e Forma:LiquidHomotaurine-d6
CAS:<p>Homotaurine-d6 is a deuterated compound of Homotaurine. Homotaurine has a CAS number of 3687-18-1. Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant. Homotaurine has also been investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain. However, clinical trials failed to show improvement compared to placebo.</p>Fórmula:C3D6H3NO3SCor e Forma:SolidPeso molecular:145.214-(6-Bromo-2-benzothiazolyl)benzenamine
CAS:<p>4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET tracer and can be used in the diagnosis of neurological diseases.</p>Fórmula:C13H9BrN2SPureza:98%Cor e Forma:SolidPeso molecular:305.19Aftin-5
CAS:<p>Aftin-5 is an inducer of amyloid beta protein 42 (Aβ42). It functions by modifying the ultrastructure of mitochondria, leading to an upregulation of Aβ42 and a downregulation of Aβ38 through a β-secretase and γ-secretase-dependent mechanism. Aftin-5 exhibits mild cytotoxicity in SH-SY5Y, HT22, N2a, and N2a-AβPP695 cells, with IC50 values of 180, 194, 178, and 150 μM, respectively.</p>Fórmula:C19H26N6OCor e Forma:SolidPeso molecular:354.454-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
CAS:<p>4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).</p>Fórmula:C14H11BrN2SPureza:98%Cor e Forma:SolidPeso molecular:319.22Nicardipine pyridine metabolite II
CAS:<p>Nicardipine pyridine metabolite II is a biaoctive chemical.</p>Fórmula:C26H27N3O6Cor e Forma:SolidPeso molecular:477.51SEN-1269
CAS:<p>SEN-1269 prevents amyloid-β aggregation, shields neurons, and improves memory by hindering Aβ(1-42)-induced issues.</p>Fórmula:C18H18N4O2Pureza:98%Cor e Forma:SolidPeso molecular:322.36RU-505
CAS:<p>RU-505 is an interaction inhibitor of Aβ-fibrinogen that acts by rescuing altered thrombosis and cognitive decline in Alzheimer's disease mice.</p>Fórmula:C28H32FN5OPureza:98%Cor e Forma:SolidPeso molecular:473.58Astrophloxine
CAS:<p>Astrophloxine is a fluorescent imaging probe that targets antiparallel dimers.Astrophloxine can be used to detect aggregated Aβ in brain tissue and</p>Fórmula:C27H33IN2Pureza:99.89%Cor e Forma:SolidPeso molecular:512.47Aβ Fibrillization modulator 1
CAS:<p>Aβ Fibrillization Modulator 1 stabilizes amyloid-beta (Aβ) monomers, preventing their aggregation into fibrils.</p>Fórmula:C17H12N4O3SSeCor e Forma:SolidPeso molecular:431.33Neuroinflammatory-IN-2
CAS:<p>Neuroinflammatory-IN-2: anti-neuroinflammatory, inhibits MAO-B (IC50: 10.30µM), 96.33% Aβ1-42 aggregation reduction, neuroprotective in PC-12 cells.</p>Fórmula:C25H27FN2O3Cor e Forma:SolidPeso molecular:422.49ELND006
CAS:<p>ELND006, an oral Alzheimer's drug, has improved bioavailability as a nanosuspension, and food doesn't affect it.</p>Fórmula:C20H14F5N3O2SCor e Forma:SolidPeso molecular:455.4THK-523
CAS:<p>THK-523 selectively binds to tau in Alzheimer's, potent in vitro/vivo. 18F-THK523 excels in tau imaging.</p>Fórmula:C17H15FN2OCor e Forma:SolidPeso molecular:282.31TC-E 5006
CAS:<p>γ-secretase modulator</p>Fórmula:C29H29F4NO2Pureza:98%Cor e Forma:SolidPeso molecular:499.54OAB-14
CAS:<p>OAB-14, a Bexarotene derivative, enhances β-amyloid clearance and cognitive function in APP/PS1 mice, improving Alzheimer's symptoms.</p>Fórmula:C32H46N4O2Cor e Forma:SolidPeso molecular:518.73Caprospinol
CAS:<p>Caprospinol inhibits β-Amyloid (Aβ) protein neurotoxicity.</p>Fórmula:C33H52O4Pureza:98%Cor e Forma:SolidPeso molecular:512.76AZ4800
CAS:<p>AZD4800 is a gamma secretase modulators.</p>Fórmula:C24H29N5O3Cor e Forma:SolidPeso molecular:435.52RS-0466
CAS:<p>RS-0466 is an β-amyloid-induced cytotoxicity inhibitor.</p>Fórmula:C17H17N5O2Pureza:98%Cor e Forma:SolidPeso molecular:323.35YIAD-0205
CAS:<p>YIAD-0205, an orally administered inhibitor of Aβ(1-42) aggregation, has exhibited in vivo efficacy in a 5XFAD transgenic mouse model that harbors five familial</p>Fórmula:C26H16Br2ClN3Cor e Forma:SolidPeso molecular:565.69K 01-162
CAS:<p>K 01-162 binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM.</p>Fórmula:C15H14BrNCor e Forma:SolidPeso molecular:288.18KMS88009
CAS:<p>KMS88009 is an amyloid-β aggregation inhibitor that acts by ameliorating neurodegenerative disorder.</p>Fórmula:C19H19NO2Cor e Forma:SolidPeso molecular:293.36Chrysamine G
CAS:<p>Chrysamine G, Congo red analog, blocks Aβ toxicity, probes Alzheimer's amyloid.</p>Fórmula:C26H16N4Na2O6Cor e Forma:SolidPeso molecular:526.416Glutaminyl Cyclase Inhibitor 2
CAS:<p>Glutaminyl Cyclase Inhibitor 2 is a glutaminyl cyclase inhibitor (IC50: 1.23 μM).</p>Fórmula:C19H20FN3Pureza:98%Cor e Forma:SolidPeso molecular:309.38JNJ-40418677
CAS:<p>JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting the processing of Notch.</p>Fórmula:C26H22F6O2Pureza:98%Cor e Forma:SolidPeso molecular:480.44BChE-IN-8
CAS:<p>BChE-IN-8, compound 20, is a potent oral BChE inhibitor effective on eqBChE and hBChE, crosses blood-brain barrier, and may help in Alzheimer's research.</p>Fórmula:C18H12BrN7O2Cor e Forma:SolidPeso molecular:438.24BACE1/2-IN-1
CAS:<p>BACE1/2-IN-1 inhibits BACE1/2 with IC50s of 0.01μM/0.0053μM, has better permeability and lower Pgp efflux but reduced metabolic stability.</p>Fórmula:C21H31N5OSCor e Forma:SolidPeso molecular:401.57Antioxidant agent-2
CAS:<p>Antioxidant agent-2 (3c), BBB-permeable, selectively chelates metals; shows neuroprotection, fights liver damage in Alzheimer's research.</p>Fórmula:C23H26N2O7Cor e Forma:SolidPeso molecular:442.46SV5
CAS:<p>SV5: potent anti-Alzheimer's, protects SHSY-5Y from Aβ1-42 death, stable with optimal pharmacology in plasma, antioxidant, neuroprotective.</p>Fórmula:C21H30N2O4S2Cor e Forma:SolidPeso molecular:438.6γ-Secretase modulator 12
CAS:<p>γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM.</p>Fórmula:C25H23N3O2Cor e Forma:SolidPeso molecular:397.47AY1511
CAS:<p>AY1511 is a low cytotoxic inhibitor of amyloid β (Aβ) aggregation [1].</p>Fórmula:C17H14O6Cor e Forma:SolidPeso molecular:314.29TML-6
CAS:<p>TML-6, an oral derivative of curcumin, may help in Alzheimer's research by targeting amyloid production and various molecular pathways.</p>Fórmula:C30H37NO7Pureza:99.71%Cor e Forma:SolidPeso molecular:523.62BuChE-IN-2
CAS:<p>BuChE-IN-2 inhibits BuChE (IC50: 1.28 μM), NO (0.67 μM), Aβ, ROS, chelates Cu2+, penetrates BBB, used in Alzheimer's research.</p>Fórmula:C28H20F4N6O3Cor e Forma:SolidPeso molecular:564.49Glutaminyl Cyclase Inhibitor 5
<p>Glutaminyl Cyclase Inhibitor 5 is a potent, selective inhibitor of human glutaminyl cyclase (hQC), demonstrating an inhibition concentration half-max (IC 50) of</p>Fórmula:C22H30N6OCor e Forma:SolidPeso molecular:394.51Aleplasinin
CAS:<p>Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolytic</p>Fórmula:C28H27NO3Pureza:99.21%Cor e Forma:SolidPeso molecular:425.52Buntanetap
CAS:<p>Buntanetap ((+)-Phenserine) is an inhibitor of TINAPs used in the study of neurological disorders, endocrine and metabolic disorders, and cardiovascular disease</p>Fórmula:C20H23N3O2Pureza:98.2%Cor e Forma:SolidPeso molecular:337.42Glutaminyl Cyclase Inhibitor 1
CAS:Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor (IC50: 0.5 μM) that can be used to study neurological disorders.Fórmula:C21H24FN3O2Pureza:99.81%Cor e Forma:SolidPeso molecular:369.43Aβ-IN-1
CAS:<p>Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM).</p>Fórmula:C35H49NPureza:99.1%Cor e Forma:SoildPeso molecular:483.77amyloid P-IN-1
CAS:<p>amyloid P-IN-1 can be used in studies about diseases with depletion of serum amyloid P components such as Alzheimer's disease, amyloidosis, osteoarthritis, and</p>Fórmula:C30H44N2O14Pureza:99.76%Cor e Forma:SolidPeso molecular:656.68Fenlean
CAS:<p>"Fenlean (FLZ) in phase I trial at Chinese Academy's Institute of Pharmacy for Parkinson's treatment."</p>Fórmula:C26H27NO6Pureza:98.99%Cor e Forma:SolidPeso molecular:449.5Ezeprogind disulfate
CAS:<p>Ezeprogind disulfate: neurotrophic inducer targeting neurodegeneration causes like Abeta, tau; for neurological disorder research.</p>Fórmula:C25H48N6O8S2Pureza:99.72%Cor e Forma:SolidPeso molecular:624.81DSS30
CAS:<p>DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid secretion to help prevent Alzheimer's.</p>Fórmula:C16H14ClNO3S2Pureza:99.19% - 99.4%Cor e Forma:SolidPeso molecular:367.87MAO-B-IN-9
CAS:<p>MAO-B-IN-9 is a monoamine oxidase B MAO-B inhibitor (IC50: 0.18 μM) that crosses the blood-brain barrier with potency, selectivity and time-dependence.</p>Fórmula:C18H24N2O2Pureza:99.93%Cor e Forma:SolidPeso molecular:300.4BI-1408
CAS:<p>BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).</p>Fórmula:C22H23FN6Pureza:99.63%Cor e Forma:SolidPeso molecular:390.46MK-3328
CAS:<p>MK-3328, a potential Alzheimer's drug, binds β-Amyloid with strong affinity (IC50:10.5 nM) and may serve as a PET ligand to gauge plaque load.</p>Fórmula:C14H9FN4OPureza:99.70% - >99.99%Cor e Forma:SolidPeso molecular:268.25PPI-1019
CAS:<p>PPI-1019 is an APP (β-amyloid A4) inhibitor for the treatment of neurological disorders and the study of Alzheimer's disease (AD).</p>Fórmula:C36H54N6O5Pureza:95.16% - 98.16%Cor e Forma:SolidPeso molecular:650.85QM-FN-SO3
CAS:<p>QM-FN-SO3 is a blood-brain barrier (BBB)-penetrable, near-infrared (NIR) probe with aggregation-induced emission (AIE) activity, specifically designed for the detection of Aβ plaques. It exhibits ultra-high signal-to-noise (S/N) ratio, binding affinity, and high-performance NIR emission, making it suitable for in vivo detection of Aβ plaques [1].</p>Fórmula:C29H25N4NaO3S2Cor e Forma:SolidPeso molecular:564.65Anti-amyloid agent-1
CAS:<p>Anti-amyloid agent-1 is a potent compound that inhibits amyloid aggregation, offering a promising approach for research into the treatment of amyloidosis [1].</p>Fórmula:C21H17F3N2O3Cor e Forma:SolidPeso molecular:402.37PQM130
CAS:<p>PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity.</p>Fórmula:C23H27NO4Pureza:98.73%Cor e Forma:SolidPeso molecular:381.46ELND007
CAS:<p>ELND007 is a Gamma secretase inhibitor.</p>Fórmula:C19H14F4N4O2SCor e Forma:SolidPeso molecular:438.4Aβ/tau aggregation-IN-3
CAS:<p>Aβ/tau aggregation-IN-3 is a potent inhibitor of amyloid protein aggregation, exhibiting an IC50 value of 0.85 µM in an Aβ-Thioflavin T (Aβ-ThT) functional</p>Fórmula:C23H22N4O3Cor e Forma:SolidPeso molecular:402.45TRV-1387
CAS:<p>TRV-1387, a benzofurazan derivative, inhibits the aggregation of tau and amyloid-β [1].</p>Fórmula:C23H25F3N4O2Cor e Forma:SolidPeso molecular:446.47BMS 433796
CAS:<p>BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease.</p>Fórmula:C21H20F2N4O4Pureza:99.17%Cor e Forma:SolidPeso molecular:430.4RAGE/SERT-IN-1
CAS:<p>RAGE/SERT-IN-1 is a potent, orally active inhibitor of advanced glycation end products (RAGE) and serotonin transporter (SERT), with IC50 values of 8.26 μM and</p>Fórmula:C38H41ClN4OSCor e Forma:SolidPeso molecular:637.28QR-0217
CAS:<p>QR-0217 is a potent inhibitor of both Aβ1-40 and α-synuclein aggregation, exhibiting an IC50 of 7.5 µM for Aβ1-40.</p>Fórmula:C19H13NO3Cor e Forma:SolidPeso molecular:303.31NNC 26-9100
CAS:<p>Somatostatin sst4 receptor agonist</p>Fórmula:C22H25BrCl2N6SPureza:98%Cor e Forma:SolidPeso molecular:556.35γ-Secretase-IN-1
CAS:<p>γ-Secretase-IN-1 is a γ-secretase inhibitor that displays partial antiproliferative activity against T-47D cells.</p>Fórmula:C27H24F2N4O3Pureza:99.56%Cor e Forma:SolidPeso molecular:490.5MDR-1339
CAS:<p>MDR-1339 is a blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.</p>Fórmula:C20H22O4Pureza:98.57%Cor e Forma:SolidPeso molecular:326.39Glutaminyl Cyclase Inhibitor 3
CAS:<p>Designed anti-Alzheimer’s compound; potent Glutaminyl Cyclase inhibitor; IC50 at 4.5 nM; reduces brain Aβ; improves cognition.</p>Fórmula:C24H32N6O2SPureza:98%Cor e Forma:SolidPeso molecular:468.61Antioxidant agent-8
<p>Antioxidant agent-8, an oral Aβ 1-42 inhibitor, reduces fibril aggregation & promotes disaggregation; it's neuroprotective & BBB permeable.</p>Fórmula:C13H12O5Cor e Forma:SolidPeso molecular:248.23Amilo-5MER
CAS:<p>Amilo-5MER (5-MP) is an orally active and selective inhibitor of serum amyloid A (SAA). It specifically suppresses the release of pro-inflammatory cytokines IL-6 and IL-1β in SAA-activated cells. Amilo-5MER reduces chronic inflammation and alleviates symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). It holds potential for research in autoimmune and chronic inflammatory diseases.</p>Fórmula:C23H40N6O9SCor e Forma:SolidPeso molecular:576.664Amyloid-β-IN-2
CAS:<p>Amyloid-β-IN-2 (Compound EX.112) is a selective inhibitor of γ-secretase. In H4 cells, it demonstrates inhibitory activity on Aβ42 secretion, with an EC50 value of 226 nM. Amyloid-β-IN-2 holds potential for research in Alzheimer's disease (AD) and diseases associated with Aβ deposition.</p>Fórmula:C22H21F2N3O2Cor e Forma:SolidPeso molecular:397.42Anti-Aβ agent 1A
<p>Anti-Aβ agent 1A is a potent anti-amyloid-β agent.</p>Fórmula:C35H49NO4Cor e Forma:SolidPeso molecular:547.77MAO-B-IN-10
<p>MAO-B-IN-10: Potent, selective MAO-B inhibitor; crosses blood-brain barrier; IC50 5.3 μM; reduces Aβ aggregation 58.2%, disaggregates 43.3%.</p>Fórmula:C23H26N2O4Cor e Forma:SolidPeso molecular:394.46Aβ42 agonist-1
CAS:<p>Aβ42 agonist-1 is a small molecule compound with anti-cancer activity and NF-κB inhibitory properties, inducing Aβ42 aggregation.</p>Fórmula:C15H11NO2Pureza:99.77%Cor e Forma:SolidPeso molecular:237.25Aβ aggregation-IN-1
CAS:<p>Aβ aggregation-IN-1 (Compound 1b) is an inhibitor of amyloid-beta precursor protein. It suppresses the aggregation and disaggregation of amyloid-beta fibrils with IC50 values of 3.92 and 7.19 M, respectively. Additionally, Aβ aggregation-IN-1 reduces malondialdehyde formation in neuronal cells, increases intracellular levels of reduced glutathione (GSH), and inhibits caspase 3.</p>Fórmula:C9H8BF3O2Cor e Forma:SolidPeso molecular:215.965Buntanetap L-Tartrate
CAS:<p>Buntanetap (L-Tartrate) functions as an oral small molecule inhibitor targeting multiple neurotoxic proteins. It decreases the production of amyloid precursor protein (APP) by inhibiting the translation of its mRNA [1].</p>Fórmula:C24H29N3O8Cor e Forma:SolidPeso molecular:487.50cSPM
<p>cSPM (Cyclic spermine) is an Aβ42 inhibitor. cSPM inhibits the aggregation of three different peptides, Aβ42, tryptophan and insulin, and reduces cytotoxicity.</p>Fórmula:C27H57N7Cor e Forma:SolidPeso molecular:479.79QP5020
CAS:<p>QP5020 is a QPCTL inhibitor with an IC50 value of 15 nM, demonstrating antitumor efficacy.</p>Fórmula:C20H19FN6Peso molecular:362.40BF-168
CAS:<p>BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).</p>Fórmula:C18H17FN2O2Cor e Forma:SolidPeso molecular:312.342002-G12
CAS:<p>2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. It is applicable in Alzheimer's research.</p>Fórmula:C20H16N6Cor e Forma:SolidPeso molecular:340.381(9R)-RO7185876
CAS:<p>(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.</p>Fórmula:C25H28F3N7Cor e Forma:SolidPeso molecular:483.532IXA62
CAS:<p>IXA62 is an orally active, selective IRE1/XBP1s agonist (EC50= 0.31 μM) that can reduce Aβ secretion.</p>Fórmula:C24H23N3O3Cor e Forma:SolidPeso molecular:401.458Amyloid-β-IN-3
CAS:<p>Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.</p>Fórmula:C22H21F2N3O2Cor e Forma:SolidPeso molecular:397.42γ-secretase modulator 6
CAS:<p>Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.</p>Fórmula:C25H26N6O2Cor e Forma:SolidPeso molecular:442.513
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