COX
Os inibidores da ciclooxigenase (COX) são compostos que bloqueiam a atividade das enzimas COX, envolvidas na produção de prostaglandinas, mediadores chave da inflamação e dor. Em neurociências, os inibidores de COX são estudados por seu potencial em reduzir a neuroinflamação, que está implicada em várias doenças neurodegenerativas, como a doença de Alzheimer, Parkinson e esclerose múltipla. Ao inibir a COX, esses compostos podem ajudar a mitigar os processos inflamatórios no cérebro e proteger contra danos neuronais. Na CymitQuimica, oferecemos uma variedade de inibidores de COX para apoiar sua pesquisa em neuroinflamação, gestão da dor e doenças neurodegenerativas.
Foram encontrados 562 produtos de "COX"
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SC57666
CAS:<p>SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.</p>Fórmula:C18H17FO2SPureza:98.83%Cor e Forma:SolidPeso molecular:316.39FR-188582
CAS:<p>FR-188582 is a highly selective cyclooxygenase (COX)-2 inhibitor (IC50: 17 nM).</p>Fórmula:C16H13ClN2O2SPureza:98%Cor e Forma:SolidPeso molecular:332.8Anti-inflammatory agent 56
CAS:<p>Anti-inflammatory agent 56 (Compound 9), a selective COX-2 inhibitor with an IC50 of 0.54 μM, exhibits anti-oxidant and anti-inflammatory properties by</p>Fórmula:C21H15F3N4O4SPureza:98%Cor e Forma:SolidPeso molecular:476.43COX/5-LO-IN-1
CAS:<p>COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states.</p>Fórmula:C16H15FN2O2SPureza:98%Cor e Forma:SolidPeso molecular:318.37MK-0703
CAS:<p>MK-0703 is a selective cyclooxygenase-2 inhibitor.</p>Fórmula:C17H22O5SPureza:98%Cor e Forma:SolidPeso molecular:338.42COX-2/15-LOX-IN-1
CAS:<p>COX-2/15-LOX-IN-1 is a dual inhibitor for COX-2/15-LOX with anti-inflammatory properties (IC50: COX-1 10.65μM, COX-2 0.075μM, 15-LOX 2.98μM).</p>Fórmula:C21H21N7S3Cor e Forma:SolidPeso molecular:467.63COX-2-IN-17
CAS:<p>COX-2-IN-17 is a potent, blood-brain barrier permeable COX-2 (cyclooxygenase-2) inhibitor (IC50: 0.02 μM) with anti-inflammatory and analgesic activity.</p>Fórmula:C20H23ClN6O2Cor e Forma:SolidPeso molecular:414.89COX-2-IN-23
CAS:<p>COX-2-IN-23 selectively inhibits COX-2 (IC50=0.28μM), weakly affects COX-1 (IC50=20.14μM), and has anti-inflammatory and low ulcerogenic properties.</p>Fórmula:C24H25N5O3S2Cor e Forma:SolidPeso molecular:495.62COX-1/2-IN-3
CAS:<p>COX-1/2-IN-3 (Compound 7a) is a dual inhibitor of COX-1 and COX-2. COX-1/2-IN-3 has anti-inflammatory activity with low toxicity [1].</p>Fórmula:C14H8N2O8Cor e Forma:SolidPeso molecular:332.22COX-1/2-IN-1
CAS:<p>"COX-1/2-IN-2: Strong dual inhibitor of COX-1 (IC50 = 13.9 μM) and COX-2 (IC50 = 6.4 μM)."</p>Fórmula:C15H10BrClN2OCor e Forma:SolidPeso molecular:349.61K-80001
CAS:<p>K-80001 is a selective RXRα ligand and a COX-1/2 inhibitor, exhibiting IC50 values of 82.9μM for RXRα, 3.4μM for COX-1, and 1.2μM for COX-2, respectively [1].</p>Fórmula:C20H17FO2Cor e Forma:SolidPeso molecular:308.35Anti-inflammatory agent 8
CAS:<p>Anti-inflammatory agent 8 targets COX-2 over COX-1, IC50 of 0.09 nM, orally bioavailable.</p>Fórmula:C18H15N5OS2Cor e Forma:SolidPeso molecular:381.47Apricoxib
CAS:<p>Apricoxib: oral NSAID with antiangiogenic, antineoplastic properties; inhibits COX-2, may reduce tumor growth and angiogenesis.</p>Fórmula:C19H20N2O3SCor e Forma:SolidPeso molecular:356.44COX-2/sEH-IN-1
CAS:<p>COX-2/sEH-IN-1, oral dual inhibitor: COX-2 (IC50=1.24 μM), sEH (IC50=0.40 μM); boosts anti-inflammatory action, cuts heart risk.</p>Fórmula:C23H18F3N5O3SCor e Forma:SolidPeso molecular:501.48Naproxen glucuronide
CAS:<p>Naproxen glucuronide: NSAID, propionic class, eases pain, fever, inflammation. Nonselective COX blocker.</p>Fórmula:C20H22O9Cor e Forma:SolidPeso molecular:406.38AL-8417
CAS:<p>AL-8417 is an enzyme inhibitor with antioxidant, anti-inflammatory, and cytostatic properties; prevents vitrectomy-induced lens alterations.</p>Fórmula:C29H34O5Pureza:98%Cor e Forma:SolidPeso molecular:462.58PD 127443
CAS:<p>PD 127443 is a Leukotriene B4 antagonist, it is also a dual inhibitor of cyclooxygenase and 5-lipoxygenase.</p>Fórmula:C20H28N2OCor e Forma:SolidPeso molecular:312.45COX-2-IN-32
CAS:<p>COX-2-IN-32 (Compound 2f) is a dual inhibitor of iNOS and COX-2, known to downregulate NF-κB expression.</p>Fórmula:C25H24O6Pureza:98%Cor e Forma:SolidPeso molecular:420.45Thiazolinobutazone
CAS:<p>Thiazolinobutazone is the 2-amino-2-thiazoline salt of phenylbutazone.</p>Fórmula:C22H26N4O2SCor e Forma:SolidPeso molecular:410.53ASP-6537
CAS:<p>ASP-6537 is a selective and reversible inhibitor of cyclooxygenase-1.</p>Fórmula:C17H17N3O3Pureza:98%Cor e Forma:SolidPeso molecular:311.34COX/5-LOX-IN-1
CAS:<p>Compound 6b is a potent dual inhibitor of COX/5-LOX with IC50s: 1.07μM (COX-1), 0.55μM (COX-2), 0.28μM (5-LOX) for inflammation research.</p>Fórmula:C18H30O3Cor e Forma:SolidPeso molecular:294.43Pifoxime
CAS:<p>Pifoxime: a NSAID with COX-1/2 inhibition, used in anti-inflammatory treatment and neuropsychiatric studies.</p>Fórmula:C15H20N2O3Cor e Forma:SolidPeso molecular:276.33COX-2-IN-16
CAS:<p>COX-2-IN-16: potent, selective oral COX-2 blocker, IC50=102 μM, reduces NO, anti-inflammatory.</p>Fórmula:C19H12BrN3O2Cor e Forma:SolidPeso molecular:394.22COX-2/5-LOX-IN-3
CAS:<p>COX-2/5-LOX-IN-3 inhibits COX-2/5-LOX with IC50s: COX-1 45.73μM, COX-2 5.45μM, 5-LOX 4.33μM; promising for inflammation research.</p>Fórmula:C17H16ClN3O2SCor e Forma:SolidPeso molecular:361.85ATB-337
CAS:<p>S-Diclofenac, an NSAID with H2S-releasing moiety, protects gastric mucosa while inhibiting prostaglandins.</p>Fórmula:C23H15Cl2NO2S3Cor e Forma:SolidPeso molecular:504.47Flosulide
CAS:<p>Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases.</p>Fórmula:C16H13F2NO4SPureza:98%Cor e Forma:SolidPeso molecular:353.34AHR-6293
CAS:<p>AHR-6293 is used to distinguishing the effect of anti-platelet aggregating drug properties and the effect of anti-inflammatory properties.</p>Fórmula:C15H12ClNO3Cor e Forma:SolidPeso molecular:289.71NCX 466
CAS:<p>cyclooxygenase (COX)-inhibiting nitric oxide (NO) donor</p>Fórmula:C20H24N2O9Pureza:98%Cor e Forma:SolidPeso molecular:436.41Etoricoxib HCl
CAS:<p>Etoricoxib HCl is a synthetic NSAID that inhibits COX-2, blocking prostaglandin production.</p>Fórmula:C18H16Cl2N2O2SCor e Forma:SolidPeso molecular:395.30Lobeglitazone Sulfate
CAS:<p>Lobeglitazone Sulfate (CKD-501) is an anti-inflammatory thiazolidinedione that prevents NLRP3 inflammasome activation and is used in T2DM research.</p>Fórmula:C24H26N4O9S2Pureza:98.69%Cor e Forma:SolidPeso molecular:578.61LY 25648
CAS:<p>LY 25648 is an antagonist of leukotriene B4.</p>Fórmula:C19H27NO2SCor e Forma:SolidPeso molecular:333.49ZXX2-77
CAS:<p>ZXX2-77 is a cyclooxygenase-1 inhibitor.</p>Fórmula:C13H13ClN2O2SPureza:98%Cor e Forma:SolidPeso molecular:296.77LY 150310
CAS:<p>LY 150310, a histamine H1-receptor antagonist, can alter prostanoid concentrations in vitro and in vivo.</p>Fórmula:C13H14N2Cor e Forma:SolidPeso molecular:198.26PC407-ws
CAS:<p>PC407-ws is a water-soluble novel COX-2 inhibitor.</p>Fórmula:C24H18F3N3Na2O5SPureza:98%Cor e Forma:SolidPeso molecular:563.46Isonixin
CAS:<p>Isonixin is used for the treatment of inflammation and pain associated with musculoskeletal and joint disorders.</p>Fórmula:C14H14N2O2Pureza:98%Cor e Forma:SolidPeso molecular:242.27Prostaglandin G/H synthase 1 inhibitor
CAS:<p>Prostaglandin G/H synthase 1 inhibitor (CP 74006) is a selective D5D inhibitor with an IC(50) value of 20 nM.</p>Fórmula:C13H11ClN2OPureza:99.76%Cor e Forma:SolidPeso molecular:246.69Tenosal
CAS:<p>Tenosal obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid, and with analgesic and antipyretic properties, anti-inflammatory.</p>Fórmula:C12H8O4SPureza:98%Cor e Forma:SolidPeso molecular:248.25LY 178002
CAS:<p>LY 178002 inhibits 5-LPO (IC50: 0.6 μM), PLA2, and LTB4 production; weak on cyclooxygenase.</p>Fórmula:C18H25NO2SPureza:98%Cor e Forma:SolidPeso molecular:319.46L 748780
CAS:<p>L 748780 is a selective inducible COX-2 inhibitor.</p>Fórmula:C19H14Cl3NO4Pureza:98%Cor e Forma:SolidPeso molecular:426.68Eicosatetraynoic acid
CAS:<p>ETYA activates PPARα/γ at 10μM, inhibits cyclooxygenase (ID50=8μM) and lipoxygenase (ID50=4μM).</p>Fórmula:C20H24O2Pureza:98%Cor e Forma:SolidPeso molecular:296.4COX-2-IN-20
CAS:<p>COX-2-IN-20 (Compound 5d) is a selective and orally active inhibitor of COX-2 (IC 50 = 17.9 nM) with anti-inflammatory activity [1].</p>Fórmula:C11H9ClFN3O2Cor e Forma:SolidPeso molecular:269.66Feprazone
CAS:<p>Feprazone (DA-2370) possesses anti-inflammatory and antiadipogenic properties. Feprazone can be used in studies about the treatment of joint and muscular pain.</p>Fórmula:C20H20N2O2Pureza:99.6% - 99.89%Cor e Forma:SolidPeso molecular:320.39Tilmacoxib
CAS:<p>Tilmacoxib is a highly selective, time-dependent, and irreversible inhibitor of human COX-2 ( IC50: 85 nM in an enzyme assay).</p>Fórmula:C16H19FN2O3SPureza:98%Cor e Forma:SolidPeso molecular:338.4COX-2-IN-1
CAS:<p>COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).</p>Fórmula:C18H14ClF3N4O2SPureza:>99.99%Cor e Forma:SolidPeso molecular:442.84Carpro-AM1
CAS:<p>Carpro-AM1, dual FAAH/COX inhibitor, IC50: 94 nM.</p>Fórmula:C21H18ClN3OCor e Forma:SolidPeso molecular:363.84Enflicoxib
CAS:<p>Enflicoxib is an effective treatment for canine osteoarthritis pain and inflammation, with faster onset than mavacoxib, improving veterinary outcomes.</p>Fórmula:C16H12F5N3O2SPureza:99.88%Cor e Forma:SolidPeso molecular:405.34Insulin levels modulator
CAS:<p>Insulin level regulators can be used to treat diabetes.</p>Fórmula:C21H23N7OSPureza:98%Cor e Forma:SolidPeso molecular:421.52SC58451
CAS:<p>SC58451 is a novel potent, orally active and selective COX-2 inhibitor.SC58451 showed anti-inflammatory activity in a rat model of arthritis.</p>Fórmula:C20H19FO2SPureza:>99.99%Cor e Forma:SolidPeso molecular:342.43COX-2-IN-21
CAS:<p>COX-2-IN-21 (Compound 5c) is an orally active, selective COX-2 inhibitor (IC50: 0.039 μM). COX-2-IN-21 has good anti-inflammatory potential.</p>Fórmula:C21H22N6O4Cor e Forma:SolidPeso molecular:422.44APHS
CAS:<p>APHS is a cyclooxygenase-2 (COX-2) inhibitor with anti-inflammatory action. It also more potent than aspirin in the inhibition of COX-1.</p>Fórmula:C15H18O2SCor e Forma:SolidPeso molecular:262.37
