COX
Os inibidores da ciclooxigenase (COX) são compostos que bloqueiam a atividade das enzimas COX, envolvidas na produção de prostaglandinas, mediadores chave da inflamação e dor. Em neurociências, os inibidores de COX são estudados por seu potencial em reduzir a neuroinflamação, que está implicada em várias doenças neurodegenerativas, como a doença de Alzheimer, Parkinson e esclerose múltipla. Ao inibir a COX, esses compostos podem ajudar a mitigar os processos inflamatórios no cérebro e proteger contra danos neuronais. Na CymitQuimica, oferecemos uma variedade de inibidores de COX para apoiar sua pesquisa em neuroinflamação, gestão da dor e doenças neurodegenerativas.
Foram encontrados 562 produtos de "COX"
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Tebufelone
CAS:<p>Tebufelone is a potent NSAID, inhibits CO, has anti-inflammatory and analgesic properties, and blocks lipoxygenase products (IC50 ~20-22 microM).</p>Fórmula:C20H28O2Pureza:99.32%Cor e Forma:SolidPeso molecular:300.44Vedaprofen
CAS:<p>Vedaprofen (PM 150) is a COX-1 inhibitor with anti-inflammatory effects, blocking E. coli clamp at IC50 222 μM, Ki 131 μM.</p>Fórmula:C19H22O2Pureza:99.24% - 99.70%Cor e Forma:SolidPeso molecular:282.38COX-1/2-IN-4
<p>COX-1/2-IN-4 (compound 2b) is a dual COX-1 and COX-2 inhibitor with respective IC50 values of 0.239 μM for COX-1 and 0.191 μM for COX-2.</p>Fórmula:C22H24N2O2SPureza:98%Cor e Forma:SolidPeso molecular:380.5COX-2/NLRP3-IN-1
<p>COX-2/NLRP3-IN-1 (Compound 6k) is an inhibitor that targets COX-2 and NLRP3, exhibiting an IC50 value of 1.53 μM for COX-2. This compound exerts anti-inflammatory effects by inhibiting the NF-κB/NLRP3 signaling pathway.</p>Fórmula:C24H19Cl2N5OSPeso molecular:495.06874Anti-inflammatory agent 78
<p>Anti-inflammatory agent 78 (compound L-37) is a potent anti-inflammatory agent. It effectively inhibits PGE2, PGE1, COX-2, and COX-1. Additionally, Anti-inflammatory agent 78 suppresses the release of NO in LPS-stimulated RAW 264.7 cell lines.</p>Fórmula:C19H14ClNO4Peso molecular:355.06114Akt/NF-κB/MAPK-IN-1
<p>Akt/NF-κB/MAPK-IN-1 (compound 2m) serves as a potent, orally active inhibitor targeting NO with an IC50 of 7.70 μM and demonstrates low toxicity.</p>Fórmula:C38H56N2O4Pureza:98%Cor e Forma:SolidPeso molecular:604.86Anti-inflammatory agent 53
<p>Anti-inflammatory agent 52 (compound 7c) is an orally active, selective COX-2 inhibitor with demonstrated anti-HT29 metastatic activity, causing periodic arrest</p>Fórmula:C24H22N2O4SPureza:98%Cor e Forma:SolidPeso molecular:434.51Lonazolac Calcium
CAS:<p>Lonazolac Calcium, a nonsteroidal anti-inflammatory drug (NSAID), is used to treat inflammation and pain.</p>Fórmula:C34H24CaCl2N4O4Pureza:98%Cor e Forma:SolidPeso molecular:663.56COX-2-IN-35
<p>COX-2-IN-35 (compound 7) is a selective inhibitor of COX-2, demonstrating anti-inflammatory activity, with an inhibitory concentration (IC 50) of 4.37 nM [1].</p>Fórmula:C22H19NO2S2Pureza:98%Cor e Forma:SolidPeso molecular:393.52Cafestol palmitate
CAS:<p>Cafestol palmitate is an active compound found in green coffee beans. It can enhance the activity of glutathione S-transferase (GST) in mice and also exhibits weak COX-2 inhibitory activity.</p>Fórmula:C36H58O4Cor e Forma:SolidPeso molecular:554.843Amfenac sodium
CAS:<p>Amfenac is a nonsteroidal anti-inflammatory drug. Amfenac also has acetic acid moiety.</p>Fórmula:C15H12NNaO3Pureza:98%Cor e Forma:SolidPeso molecular:277.26Bermoprofen
CAS:<p>Bermoprofen (AD-1590) is an anti-inflammatory compound with anti-inflammatory and analgesic activity used in the study of gastric ulcers.</p>Fórmula:C18H16O4Pureza:98.72% - 99.28%Cor e Forma:SolidPeso molecular:296.32Feladilimab
CAS:<p>Feladilimab (GSK3359609) is an IgG4 monoclonal antibody that is an ICOS agonist.</p>Pureza:SDS-PAGE:95% SEC-HPLC:98%Cor e Forma:LiquidPeso molecular:145.24 kDaAnti-inflammatory agent 93
<p>Compound 2g (Anti-inflammatory agent 93) is an active compound that exhibits analgesic activity.</p>Fórmula:C27H17Cl2N3O2Cor e Forma:SolidPeso molecular:486.35Guaiacol-d3
CAS:<p>Guaiacol-d3 is a deuterated form of Guaiacol, which is a phenolic compound known for its ability to inhibit COX-2 expression and NF-κB activation in response to LPS stimulation, exhibiting anti-inflammatory properties.</p>Fórmula:C7H8O2Cor e Forma:SolidPeso molecular:127.16Flunixin
CAS:<p>Flunixin is a nonsteroidal anti-inflammatory drug (NSAID), antipyretic, and analgesic used in pigs, horses, and cattle.</p>Fórmula:C14H11F3N2O2Cor e Forma:SolidPeso molecular:296.24Antiviral agent 61
<p>Antiviralagent 61 (compound Z40) serves as an effective antiviral agent with activity against Tomato Spotted Wilt Virus (TSWV), exhibiting an EC50 value of 252 µg/mL. It increases the RNA expression of Ndufb9, COX6B, 7.1.2.2, E, COX5B, Ndufs4, and SDHB, while reducing the expression of Ndufb7, Ndufa5, and G.</p>Fórmula:C22H23N5O4SCor e Forma:SolidPeso molecular:453.51Deracoxib
CAS:Fórmula:C17H14F3N3O3SPureza:>98.0%(T)(HPLC)Cor e Forma:White to Brown powder to crystalPeso molecular:397.37Loxoprofen Sodium Salt Dihydrate
CAS:Fórmula:C15H17NaO3·2H2OPureza:>98.0%(T)(HPLC)Cor e Forma:White to Almost white powder to crystalPeso molecular:304.32Butyl 2-[[3-(Trifluoromethyl)phenyl]amino]benzoate
CAS:Fórmula:C18H18F3NO2Pureza:>98.0%(HPLC)(N)Cor e Forma:Colorless to Yellow clear liquidPeso molecular:337.34DL-Lysine Acetylsalicylate
CAS:Fórmula:C9H8O4·C6H14N2O2Pureza:>98.0%(T)(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:326.35SC-560
CAS:Fórmula:C17H12ClF3N2OPureza:>98.0%(HPLC)Cor e Forma:White to Light yellow to Light orange powder to crystalPeso molecular:352.74Piroxicam D3
CAS:<p>Piroxicam D3 is deuterium labeled Piroxicam. Piroxicam is a COX inhibitor(human monocyte COX-1 and COX-2 with IC50s of 47, 25 μM , respectively) .</p>Fórmula:C15H13N3O4SPureza:98%Cor e Forma:SolidPeso molecular:334.37Parecoxib sodium
CAS:<p>Parecoxib: COX2 inhibitor, treats short-term postoperative pain, water-soluble, injectable, valdecoxib prodrug, less GI toxicity than ketorolac.</p>Fórmula:C19H18N2NaO4SPureza:98%Cor e Forma:SolidPeso molecular:393.41Fenbufen
CAS:Fórmula:C16H14O3Pureza:>98.0%(T)(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:254.29Rebamipide-d4
CAS:<p>Rebamipide D4 is deuterium labeled Rebamipide.</p>Fórmula:C19H15ClN2O4Pureza:98%Cor e Forma:SolidPeso molecular:374.81Rontalizumab
CAS:<p>Rontalizumab (RhuMab IFNalpha) is a humanized monoclonal antibody that neutralizes IFNalpha, used in the research of systemic lupus erythematosus.</p>Pureza:96.87% (SEC-HPLC) - 97.73% (SEC-HPLC)Cor e Forma:LiquidSuprofen
CAS:Fórmula:C14H12O3SPureza:>98.0%(GC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:260.31NS-398
CAS:Fórmula:C13H18N2O5SPureza:>98.0%(HPLC)Cor e Forma:White to Light yellow to Light orange powder to crystalPeso molecular:314.36Tenoxicam
CAS:Fórmula:C13H11N3O4S2Pureza:>98.0%(HPLC)(N)Cor e Forma:White to Yellow to Green powder to crystalPeso molecular:337.37Tolmetin
CAS:Fórmula:C15H15NO3Pureza:>98.0%(T)(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:257.29Etoricoxib-d4
CAS:<p>Etoricoxib-d4 is the 2H-labeled form of Etoricoxib. Etoricoxib is a COX-2 inhibitor with antipyretic, analgesic, and potential anticancer properties.</p>Fórmula:C18H11D4ClN2O2SPureza:>99.99%Cor e Forma:SolidPeso molecular:362.87Ketorolac Tromethamine
CAS:Fórmula:C15H13NO3·C4H11NO3Pureza:>98.0%(T)(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:376.41Ibuprofen Impurity F
CAS:<p>Ibuprofen Impurity F, anti-inflammatory, inhibits COX-1 and COX-2 with IC50 of 13 μM and 370 μM.</p>Fórmula:C13H18O2Cor e Forma:SolidPeso molecular:206.28Parecoxib Sodium
CAS:Fórmula:C19H17N2NaO4SPureza:>95.0%(T)(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:392.40Tryptanthrin
CAS:Fórmula:C15H8N2O2Pureza:>98.0%(GC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:248.24Valeroyl Salicylate
CAS:<p>Valeroyl Salicylate is a NSAID that extends lifespan, boosts mobility with age, and enhances stress resilience.</p>Fórmula:C12H14O4Pureza:97.512%Cor e Forma:SolidPeso molecular:222.24Ibuprofen Impurity K
CAS:<p>Ibuprofen Impurity K, an Ibuprofen contaminate; targeting COX-1 (IC50: 13 μM) & COX-2 (IC50: 370 μM).</p>Fórmula:C10H10O3Cor e Forma:SolidPeso molecular:178.18Oxaprozin
CAS:Fórmula:C18H15NO3Pureza:>98.0%(T)(HPLC)Cor e Forma:White to Almost white powder to crystalPeso molecular:293.32Etofenamate
CAS:Fórmula:C18H18F3NO4Pureza:>98.0%(GC)(T)Cor e Forma:Colorless to Yellow clear liquidPeso molecular:369.34Etoricoxib
CAS:Fórmula:C18H15ClN2O2SPureza:>95.0%(T)(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:358.84Floctafenine
CAS:<p>Floctafenine (R-4318) is a non-steroidal anti-inflammatory compound that is a COX-I and COX-2 inhibitor with analgesic activity for the study of pain.</p>Fórmula:C20H17F3N2O4Pureza:97.73%Cor e Forma:SolidPeso molecular:406.36Tyrphostin AG 1478
CAS:Fórmula:C16H14ClN3O2Pureza:>98.0%(HPLC)Cor e Forma:Light orange to Yellow to Green powder to crystalPeso molecular:315.76Xanthomicrol
CAS:<p>Xanthomicrol is a useful organic compound for research related to life sciences. The catalog number is T125642 and the CAS number is 16545-23-6.</p>Fórmula:C18H16O7Cor e Forma:SolidPeso molecular:344.319(S)-(+)-Ibuprofen D3
CAS:<p>(S)-(+)-Ibuprofen D3, deuterium-labeled S-enantiomer, COX-1/2 inhibitor with IC50s of 2.1 and 1.6 μM.</p>Fórmula:C13H18O2Pureza:98%Cor e Forma:SolidPeso molecular:209.3Loxoprofen sodium
CAS:<p>Loxoprofen sodium is a COX-1/COX-2 inhibitor (IC50: 6.5/13.5 μM) used orally for anti-inflammatory and antitumor effects.</p>Fórmula:C15H17NaO3Pureza:99.88%Cor e Forma:SolidPeso molecular:268.2834Bardoxolone Methyl
CAS:Fórmula:C32H43NO4Pureza:>95.0%(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:505.70Valdecoxib
CAS:Fórmula:C16H14N2O3SPureza:>98.0%(HPLC)(N)Cor e Forma:White to Almost white powder to crystalPeso molecular:314.362-(6-Methoxynaphthalen-2-yl)acetic Acid
CAS:Fórmula:C13H12O3Pureza:>95.0%(GC)(qNMR)Cor e Forma:White to Light yellow powder to crystalPeso molecular:216.24Licofelone
CAS:Fórmula:C23H22ClNO2Pureza:>95.0%(HPLC)Cor e Forma:White to Almost white powder to crystalPeso molecular:379.88
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