GluR
Inibidores do Receptor de Glutamato são compostos que bloqueiam a atividade dos receptores de glutamato, os principais receptores de neurotransmissores excitatórios no cérebro. Esses receptores desempenham um papel crucial na transmissão sináptica, plasticidade, aprendizado e memória. A desregulação da sinalização do glutamato está associada a vários distúrbios neurológicos, como epilepsia, AVC e doenças neurodegenerativas. Os inibidores dos receptores de glutamato são essenciais para investigar os mecanismos de excitotoxicidade e desenvolver estratégias neuroprotetoras. Na CymitQuimica, oferecemos uma gama de inibidores de receptores de glutamato para apoiar sua pesquisa em função sináptica, neuroproteção e distúrbios cognitivos.
Foram encontrados 263 produtos de "GluR"
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HexylHIBO
CAS:HexylHIBO is a type I mGluR antagonist that inhibits mGlu1a and mGlu5a, with Kb values of 140 and 110 μM, respectively.HexylHIBO decreases sEPSC in rats.Fórmula:C12H20N2O4Pureza:99.55%Cor e Forma:SolidPeso molecular:256.3(S)-MCPG
CAS:(S)-MCPG is the active isomer of (RS)-MCPG, non-selective group I/group II metabotropic glutamate receptor antagonist.Fórmula:C10H11NO4Pureza:98.72%Cor e Forma:SolidPeso molecular:209.20DMeOB
CAS:DMeOB (3,3'-Dimethoxybenzaldazine) is a negative regulator with mGluR5 agonist activity and is used in the study of neurological disorders.Fórmula:C16H16N2O2Pureza:98.34%Cor e Forma:SolidPeso molecular:268.31A-794282
CAS:A-794282 is a selective antagonist of mGluR1.Fórmula:C19H18N4OSPureza:99.87%Cor e Forma:SolidPeso molecular:350.44CBiPES hydrochloride
CAS:CBiPES hydrochloride (CBiPES HCl) is an orthosteric modulator of the mGlu2 receptor and is used to study neurological disorders like epilepsy.Fórmula:C21H20ClN3O2SPureza:99.66%Cor e Forma:SolidPeso molecular:413.92CPCCOEt
CAS:CPCCOEt is a low affinity, selective, non-competitive and reversible antagonist of mGluR1bFórmula:C13H13NO4Pureza:99.91%Cor e Forma:SolidPeso molecular:247.25S 18986
CAS:S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors, showcasing cognitive-enhancing properties inFórmula:C10H12N2O2SPureza:99.64%Cor e Forma:SolidPeso molecular:224.28VU 0285683
CAS:VU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity.Fórmula:C14H7FN4OPureza:99.98%Cor e Forma:SolidPeso molecular:266.23Dasolampanel
CAS:Dasolampanel (NGX-426) is an ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders.Fórmula:C17H20ClN5O3Pureza:98.70%Cor e Forma:SolidPeso molecular:377.83AZD6538
CAS:AZD6538 is an mGluR5 negative allosteric modulator used in the study of CNS-related diseases such as Alzheimer's disease.Fórmula:C15H6FN5OPureza:98.68%Cor e Forma:SolidPeso molecular:291.24Dipraglurant
CAS:Dipraglurant: a blood-brain permeable mGluR5 NAM, orally active, selective, IC50 = 21 nM, treats PD-LID.Fórmula:C16H12FN3Pureza:98.7%Cor e Forma:SolidPeso molecular:265.29Troriluzole
CAS:Troriluzole is a glutamate modulator with anticancer activity and is used in the study of spinocerebellar ataxia.Fórmula:C15H16F3N5O4SPureza:97.14%Cor e Forma:SolidPeso molecular:419.38Valiglurax
CAS:Valiglurax (VU2957), potent mGlu4 PAM, crosses blood-brain barrier, orally available; promising for Parkinson's treatment.Fórmula:C16H10F3N5Pureza:98.29%Cor e Forma:SolidPeso molecular:329.28LSN2463359
CAS:LSN2463359 is a positive allosteric modulators of the mGlu5 receptor.Fórmula:C16H15N3OPureza:99.26%Cor e Forma:SolidPeso molecular:265.31AZD 9272
CAS:AZD 9272 is a brain-permeable mGluR5 antagonist for the study of gastroesophageal reflux.Fórmula:C14H6F2N4OPureza:98.29%Cor e Forma:SolidPeso molecular:284.22MNI 137
CAS:<p>MNI 137 is a negative allosteric modulator of mGlu2. MNI 137 inhibits glutamate-induced calcium mobilization with IC50s of 8.3 and 12.6 nM for human and rat.</p>Fórmula:C15H9BrN4OPureza:97.49%Cor e Forma:SolidPeso molecular:341.16ABP688
CAS:ABP688 is a non-competitive and selective mGluR5 antagonist(Ki = 1.7 nM). ABP688 can be used as a PET tracer for clinical imaging.Fórmula:C15H16N2OPureza:98.63%Cor e Forma:SolidPeso molecular:240.3LY-2300559
CAS:<p>LY-2300559 is an agonist of metabotropic glutamate receptor 2 (mGluR2) and can be used in studies about the treatment of migraine.</p>Fórmula:C26H26O6Pureza:99.51%Cor e Forma:SolidPeso molecular:434.48(E/Z)-SIB-1893
CAS:(E/Z)-SIB-1893 (SIB 1893) is the racemate of (E)-SIB-1893 and (Z)-SIB-1893.Fórmula:C14H13NPureza:99.96%Cor e Forma:SolidPeso molecular:195.26VU0029251
CAS:VU0029251 serves as a partial antagonist of mGluR5, exhibiting a binding affinity with a K i of 1.07 μM.Fórmula:C10H11N3S2Cor e Forma:SolidPeso molecular:237.34JNJ-46281222
CAS:JNJ-46281222: mGlu2-selective, potent PAM, Kd = 1.7 nM, pEC50 = 7.71.Fórmula:C23H25F3N4Cor e Forma:SolidPeso molecular:414.47VU6012962
CAS:VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).Fórmula:C21H19F3N4O4Pureza:99.61% - 99.74%Cor e Forma:SolidPeso molecular:448.4FPTQ
CAS:FPTQ is a highly effective antagonist of mGluR 1, displaying IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively [1].Fórmula:C17H12FN5Pureza:99.68% - 99.88%Cor e Forma:SolidPeso molecular:305.31Licostinel
CAS:<p>Licostinel (CGP 63446) is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.</p>Fórmula:C8H3Cl2N3O4Pureza:98.02%Cor e Forma:SolidPeso molecular:276.03Pomaglumetad methionil hydrochloride
CAS:LY2140023 hydrochloride: oral methionine prodrug of LY404039, a selective mGlu2/3 agonist, studied for schizophrenia.Fórmula:C12H19ClN2O7S2Pureza:98.57%Cor e Forma:SolidPeso molecular:402.87MK-8768
CAS:MK-8768 is a potent, selective, and orally bioavailable negative allosteric modulator of the mGluR2 class, exhibiting an IC50 of 9.6 nM and characterized byFórmula:C21H22F3N5O2Cor e Forma:SolidPeso molecular:433.43Biphenylindanone A
CAS:Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders.Fórmula:C30H30O4Pureza:98%Cor e Forma:SolidPeso molecular:454.56MGS-0039
CAS:MGS-0039: Group II mGluR2/3 antagonist, non-serotonergic antidepressant-like effect, AMPA involvement, regulates dopamine in NAc.Fórmula:C15H14Cl2FNO5Pureza:98%Cor e Forma:SolidPeso molecular:378.18VU6005649
CAS:VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).Fórmula:C16H12F5N3OPureza:99.87%Cor e Forma:SolidPeso molecular:357.28AMPA receptor modulator-2
CAS:<p>AMPA receptor modulator-2 is a modulator of AMPA receptor. The pIC50 value for TARPγ2 dependent AMPA receptor is 10.1.</p>Fórmula:C15H6F6N4OSPureza:99.8%Cor e Forma:SolidPeso molecular:404.29cis-PDA
CAS:cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.Fórmula:C7H11NO4Pureza:98.71%Cor e Forma:White SolidPeso molecular:173.17(2R,4R)-APDC
CAS:(2R,4R)-APDC is a selective group II metabotropic glutamate receptors (mGluRs) agonist. It has anticonvulsant and neuroprotective effects.Fórmula:C6H10N2O4Pureza:98%Cor e Forma:SolidPeso molecular:174.15MTPG
CAS:Group II/group III metabotropic glutamate receptor antagonistFórmula:C10H11N5O2Pureza:98%Cor e Forma:SolidPeso molecular:233.23mGluR5 antagonist-1
CAS:mGluR5 antagonist-1 (compound 10) is a potent mGluR5 inhibitor exhibiting an IC50 of 11.5 nM and demonstrates antidepressant effects [1].Fórmula:C23H18N4O2Cor e Forma:SolidPeso molecular:382.41VU0360172
CAS:VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).Fórmula:C18H15FN2OPureza:99.56%Cor e Forma:SolidPeso molecular:294.32L-AP4
CAS:L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).Fórmula:C4H10NO5PPureza:98%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:183.1MFZ 10-7
CAS:MFZ 10-7 is anegative allosteric modulator of the mGluR5.Fórmula:C15H9FN2Pureza:99.80%Cor e Forma:SolidPeso molecular:236.24VU6004909
CAS:VU6004909 is an mGlu5 receptor orthosteric modulator that reverses MK801-induced increased cortical activity and cognitive dysfunction.Fórmula:C21H15FN2O4Pureza:96.68% - 98.44%Cor e Forma:SolidPeso molecular:378.35Philanthotoxin 74 dihydrochloride
CAS:Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.Fórmula:C24H44Cl2N4O3Pureza:99.75%Cor e Forma:SolidPeso molecular:507.54LY2794193
CAS:LY2794193, a potent and selective mGlu3 receptor agonist, reduces akathisia seizures and increases GAT1, GLAST and GLT-1 protein levels in rats.Fórmula:C16H18N2O6Pureza:98.15%Cor e Forma:SolidPeso molecular:334.32PF470
CAS:PF470 (PF-06297470) is a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), which demonstrated significant therapeutic effects in Parkinson's disease models. However, its clinical development was halted due to potential issues identified in toxicological studies.Fórmula:C18H16N6OCor e Forma:SolidPeso molecular:332.36YM 202074
CAS:metabotropic glutamate receptor type 1 (mGlu1) antagonistFórmula:C56H72N8O16S2Pureza:98%Cor e Forma:SolidPeso molecular:1177.34CVN636
CAS:CVN636, a potent and selective allosteric agonist for the mGluR7 receptor, exhibits oral activity and CNS permeability [1], with an EC50 of 7 nM for humanFórmula:C19H20FNO4SCor e Forma:SolidPeso molecular:377.43mG2N001
CAS:mG2N001, a negative allosteric modulator (NAM) of the metabotropic glutamate receptor mGluR2, has an IC50 of 93 nM and binds to mGluR2 as an antagonist with a Ki of 63 nM. This compound is microparticle- and plasma-stable, and its radioisotope [11C] mG2N001 can be utilized in PET imaging. [11C] mG2N001 exhibits good brain heterogeneity and penetration, selectively accumulating in mGluR2-rich regions to produce high-contrast brain images [1].Fórmula:C18H19FN2O3Cor e Forma:SolidPeso molecular:330.35Pomaglumetad methionil
CAS:Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.Fórmula:C12H20N2O8S2Pureza:98%Cor e Forma:SolidPeso molecular:384.43LY367385 hydrochloride
CAS:LY367385 hydrochloride: selective mGluR1a antagonist, IC50 = 8.8 μM, neuroprotective, anticonvulsant, antiepileptic.Fórmula:C10H12ClNO4Cor e Forma:SolidPeso molecular:245.66LY-2979165
CAS:LY-2979165 is a metabotropic glutamate receptor agonist prodrug.Fórmula:C13H17N5O5SCor e Forma:SolidPeso molecular:355.37CPPG
CAS:CPPG: potent group II/III mGlu receptor antagonist, 20x more selective for group III (IC50: 2.2 nM) than II (46.2 nM) in rat cortex.Fórmula:C11H14NO5PCor e Forma:SolidPeso molecular:271.21STAT3-IN-36
CAS:STAT3-IN-36 (compound 11g) is a tritarget inhibitor that selectively targets LRPPRC, STAT3, and CDK1, exhibiting potent anticancer activity. This compound binds to LRPPRC, STAT3, and CDK1, demonstrating more effective anticancer effects than those of TMF or Capecitabine. Additionally, STAT3-IN-36 exhibits an IC50 value of 1.8 μM in HGC27 cells.Fórmula:C30H24F2N2O9S2Cor e Forma:SolidPeso molecular:658.65LY3020371 hydrochloride
CAS:LY3020371 HCl: potent mGlu2/3 antagonist, antidepressant-like; Ki: 5.3/2.5 nM, IC50: 16.2 nM for cAMP inhibition.Fórmula:C15H16ClF2NO5SCor e Forma:SolidPeso molecular:395.81Azotomycin
CAS:Azotomycin is an antagonist of L-glutamine and may be used as an immunosuppressant.Fórmula:C17H23N7O8Pureza:98%Cor e Forma:SolidPeso molecular:453.41LY 541850
CAS:LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from humanFórmula:C9H13NO4Pureza:98%Cor e Forma:SolidPeso molecular:199.2FP0429
CAS:FP0429 is an agonist of mGlu4.Fórmula:C10H12N2O7Pureza:98%Cor e Forma:SolidPeso molecular:272.21YM-202074
CAS:YM-202074: Selective mGlu1 antagonist, binds allosteric site (Ki=4.8 nM), inhibits mGlu1 (IC50=8.6 nM).Fórmula:C22H30N4O2SCor e Forma:SolidPeso molecular:414.56LY2979165
CAS:LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.Fórmula:C13H22N6O6SPureza:98.41%Cor e Forma:SolidPeso molecular:390.42YM-298198 hydrochloride
CAS:mGlu1 receptor antagonistFórmula:C18H23ClN4OSPureza:98%Cor e Forma:SolidPeso molecular:378.919Eglumegad
CAS:Eglumegad is a highly effective and selective agonist of group II (mGlu2/3) receptor (IC50s: 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively).Fórmula:C8H11NO4Cor e Forma:SolidPeso molecular:185.18(RS)-APICA
CAS:group II metabotropic glutamate receptor antagonistFórmula:C10H12NO5PCor e Forma:SolidPeso molecular:257.18VU0080241
CAS:VU0080241 is a positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4).Fórmula:C19H23N5Cor e Forma:SolidPeso molecular:321.42Eglumegad hydrochloride
Eglumegad (LY354740) hydrochloride is a potent, selective agonist for group II (mGlu2/3) receptors, showing IC50 values of 5 nM for mGlu2 and 24 nM for mGlu3 receptors in transfected human cells. This compound provides neuroprotection against NMDA-induced toxicity and exhibits anxiolytic- and antipsychotic-like properties [1].Fórmula:C8H12ClNO4Cor e Forma:SolidPeso molecular:221.64CMPDA
CAS:CMPDA is a positive allosteric modulator of AMPA receptors [EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor].Fórmula:C16H28N2O4S2Pureza:98%Cor e Forma:SolidPeso molecular:376.53UBP1112
CAS:group III mGlu receptor antagonistFórmula:C10H14NO5PPureza:98%Cor e Forma:SolidPeso molecular:259.2YM 298198 Hydrochloride
CAS:YM 298198 HCl: non-competitive mGlu1 antagonist, Ki=19 nM. Inactive on mGlu2-7, stronger than CPCCOEt.Fórmula:C18H22N4OSCor e Forma:SolidPeso molecular:342.46
