GluR
Inibidores do Receptor de Glutamato são compostos que bloqueiam a atividade dos receptores de glutamato, os principais receptores de neurotransmissores excitatórios no cérebro. Esses receptores desempenham um papel crucial na transmissão sináptica, plasticidade, aprendizado e memória. A desregulação da sinalização do glutamato está associada a vários distúrbios neurológicos, como epilepsia, AVC e doenças neurodegenerativas. Os inibidores dos receptores de glutamato são essenciais para investigar os mecanismos de excitotoxicidade e desenvolver estratégias neuroprotetoras. Na CymitQuimica, oferecemos uma gama de inibidores de receptores de glutamato para apoiar sua pesquisa em função sináptica, neuroproteção e distúrbios cognitivos.
Foram encontrados 255 produtos de "GluR"
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Troriluzole
CAS:<p>Troriluzole is a glutamate modulator with anticancer activity and is used in the study of spinocerebellar ataxia.</p>Fórmula:C15H16F3N5O4SPureza:97.14%Cor e Forma:SolidPeso molecular:419.38Dipraglurant
CAS:<p>Dipraglurant: a blood-brain permeable mGluR5 NAM, orally active, selective, IC50 = 21 nM, treats PD-LID.</p>Fórmula:C16H12FN3Pureza:98.7%Cor e Forma:SolidPeso molecular:265.29LSN2463359
CAS:<p>LSN2463359 is a positive allosteric modulators of the mGlu5 receptor.</p>Fórmula:C16H15N3OPureza:99.26%Cor e Forma:SolidPeso molecular:265.31(E/Z)-SIB-1893
CAS:<p>(E/Z)-SIB-1893 (SIB 1893) is the racemate of (E)-SIB-1893 and (Z)-SIB-1893.</p>Fórmula:C14H13NPureza:99.92%Cor e Forma:SolidPeso molecular:195.26Dasolampanel
CAS:Dasolampanel (NGX-426) is an ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders.Fórmula:C17H20ClN5O3Pureza:98.70%Cor e Forma:SolidPeso molecular:377.83LY-2300559
CAS:<p>LY-2300559 is an agonist of metabotropic glutamate receptor 2 (mGluR2) and can be used in studies about the treatment of migraine.</p>Fórmula:C26H26O6Pureza:99.51%Cor e Forma:SolidPeso molecular:434.48Valiglurax
CAS:<p>Valiglurax (VU2957), potent mGlu4 PAM, crosses blood-brain barrier, orally available; promising for Parkinson's treatment.</p>Fórmula:C16H10F3N5Pureza:98.29%Cor e Forma:SolidPeso molecular:329.28CBiPES hydrochloride
CAS:<p>CBiPES hydrochloride (CBiPES HCl) is an orthosteric modulator of the mGlu2 receptor and is used to study neurological disorders like epilepsy.</p>Fórmula:C21H20ClN3O2SPureza:99.66%Cor e Forma:SolidPeso molecular:413.92CPCCOEt
CAS:<p>CPCCOEt is a low affinity, selective, non-competitive and reversible antagonist of mGluR1b</p>Fórmula:C13H13NO4Pureza:99.91%Cor e Forma:SolidPeso molecular:247.25S 18986
CAS:<p>S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors, showcasing cognitive-enhancing properties in</p>Fórmula:C10H12N2O2SPureza:99.64%Cor e Forma:SolidPeso molecular:224.28VU 0285683
CAS:<p>VU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity.</p>Fórmula:C14H7FN4OPureza:99.98%Cor e Forma:SolidPeso molecular:266.23ABP688
CAS:<p>ABP688 is a non-competitive and selective mGluR5 antagonist(Ki = 1.7 nM). ABP688 can be used as a PET tracer for clinical imaging.</p>Fórmula:C15H16N2OPureza:98.63%Cor e Forma:SolidPeso molecular:240.3AZD 9272
CAS:<p>AZD 9272 is a brain-permeable mGluR5 antagonist for the study of gastroesophageal reflux.</p>Fórmula:C14H6F2N4OPureza:98.29%Cor e Forma:SolidPeso molecular:284.22AZD6538
CAS:<p>AZD6538 is an mGluR5 negative allosteric modulator used in the study of CNS-related diseases such as Alzheimer's disease.</p>Fórmula:C15H6FN5OPureza:98.68%Cor e Forma:SolidPeso molecular:291.24MNI 137
CAS:<p>MNI 137 is a negative allosteric modulator of mGlu2. MNI 137 inhibits glutamate-induced calcium mobilization with IC50s of 8.3 and 12.6 nM for human and rat.</p>Fórmula:C15H9BrN4OPureza:97.49%Cor e Forma:SolidPeso molecular:341.16VU0029251
CAS:<p>VU0029251 serves as a partial antagonist of mGluR5, exhibiting a binding affinity with a K i of 1.07 μM.</p>Fórmula:C10H11N3S2Cor e Forma:SolidPeso molecular:237.34MTPG
CAS:Group II/group III metabotropic glutamate receptor antagonistFórmula:C10H11N5O2Pureza:98%Cor e Forma:SolidPeso molecular:233.23L-AP4
CAS:<p>L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).</p>Fórmula:C4H10NO5PPureza:98%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:183.1mGluR5 antagonist-1
CAS:<p>mGluR5 antagonist-1 (compound 10) is a potent mGluR5 inhibitor exhibiting an IC50 of 11.5 nM and demonstrates antidepressant effects [1].</p>Fórmula:C23H18N4O2Cor e Forma:SolidPeso molecular:382.41VU0360172
CAS:<p>VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).</p>Fórmula:C18H15FN2OPureza:99.56%Cor e Forma:SolidPeso molecular:294.32Biphenylindanone A
CAS:<p>Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders.</p>Fórmula:C30H30O4Pureza:98%Cor e Forma:SolidPeso molecular:454.56MFZ 10-7
CAS:<p>MFZ 10-7 is anegative allosteric modulator of the mGluR5.</p>Fórmula:C15H9FN2Pureza:99.80%Cor e Forma:SolidPeso molecular:236.24JNJ-46281222
CAS:JNJ-46281222: mGlu2-selective, potent PAM, Kd = 1.7 nM, pEC50 = 7.71.Fórmula:C23H25F3N4Cor e Forma:SolidPeso molecular:414.47MGS-0039
CAS:<p>MGS-0039: Group II mGluR2/3 antagonist, non-serotonergic antidepressant-like effect, AMPA involvement, regulates dopamine in NAc.</p>Fórmula:C15H14Cl2FNO5Pureza:98%Cor e Forma:SolidPeso molecular:378.18FPTQ
CAS:<p>FPTQ is a highly effective antagonist of mGluR 1, displaying IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively [1].</p>Fórmula:C17H12FN5Pureza:99.68% - 99.88%Cor e Forma:SolidPeso molecular:305.31VU6005649
CAS:<p>VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).</p>Fórmula:C16H12F5N3OPureza:99.87%Cor e Forma:SolidPeso molecular:357.28VU6012962
CAS:<p>VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).</p>Fórmula:C21H19F3N4O4Pureza:99.61% - 99.74%Cor e Forma:SolidPeso molecular:448.4Pomaglumetad methionil hydrochloride
CAS:<p>LY2140023 hydrochloride: oral methionine prodrug of LY404039, a selective mGlu2/3 agonist, studied for schizophrenia.</p>Fórmula:C12H19ClN2O7S2Pureza:98.57%Cor e Forma:SolidPeso molecular:402.87Licostinel
CAS:<p>Licostinel (CGP 63446) is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.</p>Fórmula:C8H3Cl2N3O4Pureza:98.02%Cor e Forma:SolidPeso molecular:276.03cis-PDA
CAS:<p>cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.</p>Fórmula:C7H11NO4Pureza:98.71%Cor e Forma:White SolidPeso molecular:173.17(2R,4R)-APDC
CAS:(2R,4R)-APDC is a selective group II metabotropic glutamate receptors (mGluRs) agonist. It has anticonvulsant and neuroprotective effects.Fórmula:C6H10N2O4Pureza:98%Cor e Forma:SolidPeso molecular:174.15AMPA receptor modulator-2
CAS:<p>AMPA receptor modulator-2 is a modulator of AMPA receptor. The pIC50 value for TARPγ2 dependent AMPA receptor is 10.1.</p>Fórmula:C15H6F6N4OSPureza:99.8%Cor e Forma:SolidPeso molecular:404.29MK-8768
CAS:<p>MK-8768 is a potent, selective, and orally bioavailable negative allosteric modulator of the mGluR2 class, exhibiting an IC50 of 9.6 nM and characterized by</p>Fórmula:C21H22F3N5O2Cor e Forma:SolidPeso molecular:433.43Philanthotoxin 74 dihydrochloride
CAS:<p>Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.</p>Fórmula:C24H44Cl2N4O3Pureza:99.75%Cor e Forma:SolidPeso molecular:507.54VU6004909
CAS:<p>VU6004909 is an mGlu5 receptor orthosteric modulator that reverses MK801-induced increased cortical activity and cognitive dysfunction.</p>Fórmula:C21H15FN2O4Pureza:96.68% - 98.44%Cor e Forma:SolidPeso molecular:378.35Azotomycin
CAS:Azotomycin is an antagonist of L-glutamine and may be used as an immunosuppressant.Fórmula:C17H23N7O8Pureza:98%Cor e Forma:SolidPeso molecular:453.41CVN636
CAS:<p>CVN636, a potent and selective allosteric agonist for the mGluR7 receptor, exhibits oral activity and CNS permeability [1], with an EC50 of 7 nM for human</p>Fórmula:C19H20FNO4SCor e Forma:SolidPeso molecular:377.43LY2794193
CAS:LY2794193, a potent and selective mGlu3 receptor agonist, reduces akathisia seizures and increases GAT1, GLAST and GLT-1 protein levels in rats.Fórmula:C16H18N2O6Pureza:98.15%Cor e Forma:SolidPeso molecular:334.32LY367385 hydrochloride
CAS:<p>LY367385 hydrochloride: selective mGluR1a antagonist, IC50 = 8.8 μM, neuroprotective, anticonvulsant, antiepileptic.</p>Fórmula:C10H12ClNO4Cor e Forma:SolidPeso molecular:245.66AZD 2066 hydrate
<p>AZD 2066 hydrate is a selective, orally active, and brain-penetrant antagonist of mGluR5. It exhibits antinociceptive effects [1].</p>Fórmula:C19H18ClN5O3Cor e Forma:SolidPeso molecular:386.33CPPG
CAS:CPPG: potent group II/III mGlu receptor antagonist, 20x more selective for group III (IC50: 2.2 nM) than II (46.2 nM) in rat cortex.Fórmula:C11H14NO5PCor e Forma:SolidPeso molecular:271.21FP0429
CAS:FP0429 is an agonist of mGlu4.Fórmula:C10H12N2O7Pureza:98%Cor e Forma:SolidPeso molecular:272.21LY 541850
CAS:<p>LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human</p>Fórmula:C9H13NO4Pureza:98%Cor e Forma:SolidPeso molecular:199.2LY3020371 hydrochloride
CAS:LY3020371 HCl: potent mGlu2/3 antagonist, antidepressant-like; Ki: 5.3/2.5 nM, IC50: 16.2 nM for cAMP inhibition.Fórmula:C15H16ClF2NO5SCor e Forma:SolidPeso molecular:395.81PF470
CAS:<p>PF470 (PF-06297470) is a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), which demonstrated significant therapeutic effects in Parkinson's disease models. However, its clinical development was halted due to potential issues identified in toxicological studies.</p>Fórmula:C18H16N6OCor e Forma:SolidPeso molecular:332.36Pomaglumetad methionil
CAS:<p>Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.</p>Fórmula:C12H20N2O8S2Pureza:98%Cor e Forma:SolidPeso molecular:384.43YM 202074
CAS:<p>metabotropic glutamate receptor type 1 (mGlu1) antagonist</p>Fórmula:C56H72N8O16S2Pureza:98%Cor e Forma:SolidPeso molecular:1177.34LY2979165
CAS:<p>LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.</p>Fórmula:C13H22N6O6SPureza:98.41%Cor e Forma:SolidPeso molecular:390.42Eglumegad
CAS:Eglumegad is a highly effective and selective agonist of group II (mGlu2/3) receptor (IC50s: 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively).Fórmula:C8H11NO4Cor e Forma:SolidPeso molecular:185.18YM-298198 hydrochloride
CAS:mGlu1 receptor antagonistFórmula:C18H23ClN4OSPureza:98%Cor e Forma:SolidPeso molecular:378.919(RS)-APICA
CAS:group II metabotropic glutamate receptor antagonistFórmula:C10H12NO5PCor e Forma:SolidPeso molecular:257.18Eglumegad hydrochloride
<p>Eglumegad (LY354740) hydrochloride is a potent, selective agonist for group II (mGlu2/3) receptors, showing IC50 values of 5 nM for mGlu2 and 24 nM for mGlu3 receptors in transfected human cells. This compound provides neuroprotection against NMDA-induced toxicity and exhibits anxiolytic- and antipsychotic-like properties [1].</p>Fórmula:C8H12ClNO4Cor e Forma:SolidPeso molecular:221.64VU0080241
CAS:<p>VU0080241 is a positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4).</p>Fórmula:C19H23N5Cor e Forma:SolidPeso molecular:321.42CMPDA
CAS:<p>CMPDA is a positive allosteric modulator of AMPA receptors [EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor].</p>Fórmula:C16H28N2O4S2Pureza:98%Cor e Forma:SolidPeso molecular:376.53UBP1112
CAS:<p>group III mGlu receptor antagonist</p>Fórmula:C10H14NO5PPureza:98%Cor e Forma:SolidPeso molecular:259.2
