GluR
Inibidores do Receptor de Glutamato são compostos que bloqueiam a atividade dos receptores de glutamato, os principais receptores de neurotransmissores excitatórios no cérebro. Esses receptores desempenham um papel crucial na transmissão sináptica, plasticidade, aprendizado e memória. A desregulação da sinalização do glutamato está associada a vários distúrbios neurológicos, como epilepsia, AVC e doenças neurodegenerativas. Os inibidores dos receptores de glutamato são essenciais para investigar os mecanismos de excitotoxicidade e desenvolver estratégias neuroprotetoras. Na CymitQuimica, oferecemos uma gama de inibidores de receptores de glutamato para apoiar sua pesquisa em função sináptica, neuroproteção e distúrbios cognitivos.
Foram encontrados 261 produtos de "GluR"
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MTPG
CAS:Group II/group III metabotropic glutamate receptor antagonistFórmula:C10H11N5O2Pureza:98%Cor e Forma:SolidPeso molecular:233.23AMPA receptor modulator-2
CAS:<p>AMPA receptor modulator-2 is a modulator of AMPA receptor. The pIC50 value for TARPγ2 dependent AMPA receptor is 10.1.</p>Fórmula:C15H6F6N4OSPureza:99.8%Cor e Forma:SolidPeso molecular:404.29JNJ-46281222
CAS:JNJ-46281222: mGlu2-selective, potent PAM, Kd = 1.7 nM, pEC50 = 7.71.Fórmula:C23H25F3N4Cor e Forma:SolidPeso molecular:414.47VU6005649
CAS:VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).Fórmula:C16H12F5N3OPureza:99.87%Cor e Forma:SolidPeso molecular:357.28L-AP4
CAS:L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).Fórmula:C4H10NO5PPureza:98%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:183.1mGluR5 antagonist-1
CAS:<p>mGluR5 antagonist-1 (compound 10) is a potent mGluR5 inhibitor exhibiting an IC50 of 11.5 nM and demonstrates antidepressant effects [1].</p>Fórmula:C23H18N4O2Cor e Forma:SolidPeso molecular:382.41cis-PDA
CAS:<p>cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.</p>Fórmula:C7H11NO4Pureza:98.71%Cor e Forma:White SolidPeso molecular:173.17VU0360172
CAS:VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).Fórmula:C18H15FN2OPureza:99.56%Cor e Forma:SolidPeso molecular:294.32(2R,4R)-APDC
CAS:(2R,4R)-APDC is a selective group II metabotropic glutamate receptors (mGluRs) agonist. It has anticonvulsant and neuroprotective effects.Fórmula:C6H10N2O4Pureza:98%Cor e Forma:SolidPeso molecular:174.15Biphenylindanone A
CAS:Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders.Fórmula:C30H30O4Pureza:98%Cor e Forma:SolidPeso molecular:454.56MFZ 10-7
CAS:MFZ 10-7 is anegative allosteric modulator of the mGluR5.Fórmula:C15H9FN2Pureza:99.80%Cor e Forma:SolidPeso molecular:236.24Licostinel
CAS:<p>Licostinel (CGP 63446) is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.</p>Fórmula:C8H3Cl2N3O4Pureza:98.02%Cor e Forma:SolidPeso molecular:276.03Pomaglumetad methionil hydrochloride
CAS:<p>LY2140023 hydrochloride: oral methionine prodrug of LY404039, a selective mGlu2/3 agonist, studied for schizophrenia.</p>Fórmula:C12H19ClN2O7S2Pureza:98.57%Cor e Forma:SolidPeso molecular:402.87MK-8768
CAS:MK-8768 is a potent, selective, and orally bioavailable negative allosteric modulator of the mGluR2 class, exhibiting an IC50 of 9.6 nM and characterized byFórmula:C21H22F3N5O2Cor e Forma:SolidPeso molecular:433.43VU0029251
CAS:VU0029251 serves as a partial antagonist of mGluR5, exhibiting a binding affinity with a K i of 1.07 μM.Fórmula:C10H11N3S2Cor e Forma:SolidPeso molecular:237.34Philanthotoxin 74 dihydrochloride
CAS:<p>Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.</p>Fórmula:C24H44Cl2N4O3Pureza:99.75%Cor e Forma:SolidPeso molecular:507.54VU6004909
CAS:VU6004909 is an mGlu5 receptor orthosteric modulator that reverses MK801-induced increased cortical activity and cognitive dysfunction.Fórmula:C21H15FN2O4Pureza:96.68% - 98.44%Cor e Forma:SolidPeso molecular:378.35Pomaglumetad methionil
CAS:Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.Fórmula:C12H20N2O8S2Pureza:98%Cor e Forma:SolidPeso molecular:384.43CVN636
CAS:CVN636, a potent and selective allosteric agonist for the mGluR7 receptor, exhibits oral activity and CNS permeability [1], with an EC50 of 7 nM for humanFórmula:C19H20FNO4SCor e Forma:SolidPeso molecular:377.43LY2794193
CAS:LY2794193, a potent and selective mGlu3 receptor agonist, reduces akathisia seizures and increases GAT1, GLAST and GLT-1 protein levels in rats.Fórmula:C16H18N2O6Pureza:98.15%Cor e Forma:SolidPeso molecular:334.32
