GluR
Inibidores do Receptor de Glutamato são compostos que bloqueiam a atividade dos receptores de glutamato, os principais receptores de neurotransmissores excitatórios no cérebro. Esses receptores desempenham um papel crucial na transmissão sináptica, plasticidade, aprendizado e memória. A desregulação da sinalização do glutamato está associada a vários distúrbios neurológicos, como epilepsia, AVC e doenças neurodegenerativas. Os inibidores dos receptores de glutamato são essenciais para investigar os mecanismos de excitotoxicidade e desenvolver estratégias neuroprotetoras. Na CymitQuimica, oferecemos uma gama de inibidores de receptores de glutamato para apoiar sua pesquisa em função sináptica, neuroproteção e distúrbios cognitivos.
Foram encontrados 263 produtos para "GluR".
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Decoglurant
CAS:Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3 and it also is developed as an antidepressant.Fórmula:C21H11F6N5Pureza:99.77%Cor e Forma:SolidPeso molecular:447.34Ref: TM-T15090
1mg52,00€5mg111,00€1mL*10mM (DMSO)152,00€10mg164,00€25mg294,00€50mg411,00€100mg572,00€200mg772,00€(R)-ADX-47273
CAS:(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator(EC50 of 168 nM for potentiation ).Fórmula:C20H17F2N3O2Pureza:99.87%Cor e Forma:SolidPeso molecular:369.36Ref: TM-T13441
2mg39,00€5mg62,00€1mL*10mM (DMSO)67,00€10mg88,00€25mg161,00€50mg245,00€100mg370,00€200mg515,00€KM02894
CAS:KM02894 inhibits glutamate release, potentially reducing cancer-induced bone pain in tumor studies.Fórmula:C7H9N3OS2Pureza:99.98%Cor e Forma:SolidPeso molecular:215.3Basimglurant
CAS:Basimglurant (CTEP Derivative) is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM).Fórmula:C18H13ClFN3Pureza:98.35%Cor e Forma:SolidPeso molecular:325.77Ref: TM-T12717
1mg71,00€5mg152,00€1mL*10mM (DMSO)167,00€10mg222,00€25mg358,00€50mg532,00€100mg665,00€200mg898,00€ML353
ML353 activates TREK-1/2, binds mGlu5 SAM (Ki=18.2 nM), surpasses 5mpep, may address SAM activity/blocking.Fórmula:C19H15FN2OPureza:99.98% - 99.98%Cor e Forma:SolidPeso molecular:306.33Ref: TM-T67917
5mg50,00€1mL*10mM (DMSO)50,00€10mg74,00€25mg114,00€50mg156,00€100mg219,00€200mg298,00€Org-26576
CAS:Org-26576 is a positive allosteric modulator of the AMPA receptor.Fórmula:C11H12N2O2Pureza:99.67%Cor e Forma:White SolidPeso molecular:204.23LY339434 HCl
LY339434 HCl is a low affinity GluR5 erythrocyte receptor agonist.LY339434 HCl causes rapid neuronal death primarily by affecting N-methyl-D-aspartate (NMDA)Fórmula:C18H20ClNO4Pureza:97.10% - 97.19%Cor e Forma:SoildPeso molecular:349.81NBQX disodium
CAS:NBQX Disodium (FG9202 disodium) is a highly selective, competitive AMPA receptor antagonist with neuroprotective and anticonvulsant activity.Fórmula:C12H6N4Na2O6SPureza:97.32% - 97.6%Cor e Forma:Brown SolidPeso molecular:380.2415VU0483605
CAS:VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively.Fórmula:C20H10Cl3N3O3Pureza:99.61%Cor e Forma:SolidPeso molecular:446.67Ref: TM-T21747
2mg39,00€5mg60,00€1mL*10mM (DMSO)73,00€10mg92,00€25mg173,00€50mg269,00€100mg404,00€200mg532,00€(R)-3,4-DCPG HCl
(R)-3,4-DCPG HCl is a potent and selective mGlu8a receptor agonist that activates metabotropic glutamate receptors on primary afferent terminals in the neonatalFórmula:C10H10ClNO6Pureza:99.74% - 99.83%Cor e Forma:SolidPeso molecular:275.64γ-DGG acetate(6729-55-1 free base)
CAS:gamma-DGG acetate(6729-55-1 free base) (γ-D-Glutamylglycine) is a competitive blocker of AMPA receptor.Fórmula:C9H16N2O7Pureza:99.92%Cor e Forma:SolidPeso molecular:264.23AZD-8529 mesylate
CAS:AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM).Fórmula:C25H28F3N5O6SPureza:99.19%Cor e Forma:SolidPeso molecular:583.58DHPG
CAS:DHPG is a potent Group I mGluR agonist; doesn't affect Group II/III; linked to phospholipase D.Fórmula:C8H9NO4Pureza:99.55%Cor e Forma:SolidPeso molecular:183.16Piracetam
CAS:Piracetam (UCB-6215), a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders.Fórmula:C6H10N2O2Pureza:97.16%Cor e Forma:Crystals From Isopropanol SolidPeso molecular:142.16VU0650786
CAS:VU0650786: selective mGlu3 NAM, CNS-penetrant, IC50 392 nM, shows antidepressant/anxiolytic effects in rodents.Fórmula:C18H15ClFN5O2Pureza:99.09%Cor e Forma:SolidPeso molecular:387.8Ref: TM-T13318
1mg90,00€5mg222,00€1mL*10mM (DMSO)245,00€10mg313,00€25mg530,00€50mg757,00€100mg1.044,00€MGS0028
CAS:MGS0028 is a selective agonist of metabotropic glutamate 2/3 receptor, it could reverse abnormal behaviors in mice induced by isolation rearing.Fórmula:C8H8FNO5Cor e Forma:SolidPeso molecular:217.15LY2812223
CAS:LY2812223: selective mGlu2 agonist; binds mGlu2/mGlu3 (Ki=144/156 nM).Fórmula:C10H12N4O4SPureza:98%Cor e Forma:SolidPeso molecular:284.29mGluR3 modulator-1
CAS:1-ethyl-3-morpholin-4-yl tetrahydroisoquinoline: mGluR3 modulator, potential for Parkinson's.Fórmula:C16H21N3OPureza:98.99%Cor e Forma:Cyan SolidPeso molecular:271.36LY3027788 hydrochloride
CAS:LY3027788 HCl, potent oral prodrug of LY3020371, targets mGlu2/3 with antidepressant effects.Fórmula:C25H32ClF2NO11SCor e Forma:SolidPeso molecular:628.03(S)-3,4-DCPG HCl
(S)-3,4-DCPG HCl is a selective mGluR8a agonist, impacting AV12-664 cells with an EC50 of 31 nM.Fórmula:C10H10ClNO6Pureza:99.53% - 99.86%Cor e Forma:SolidPeso molecular:275.64Ref: TM-T23288L
1mg173,00€1mL*10mM (DMSO)394,00€5mg437,00€10mg625,00€25mg982,00€50mg1.341,00€100mg1.773,00€500mg3.565,00€DD205-291
CAS:DD205-291 is an orally active PROTAC HPK1 degrader with a DC50 of 5.3 nM. It inhibits SLP-76 phosphorylation and induces IL-2 and IFN-γ.Fórmula:C38H38ClF3N10O3Cor e Forma:SolidPeso molecular:775.22(S)-AMPA HCl
(S)-AMPA HCl (L-AMPA HCl) is a selective AMPA receptor agonist with potential antidepressant activity. It can be used in research on Parkinson's disease.Fórmula:C7H11ClN2O4Pureza:99.18%Cor e Forma:SolidPeso molecular:222.63GYKI-47261 dihydrochloride
CAS:GYKI-47261 dihydrochloride is an AMPA receptor antagonist and CYP2E1 inducer, demonstrating broad-spectrum anticonvulsant and neuroprotective activities.Fórmula:C18H17Cl3N4Pureza:98.32% - 99.14%Cor e Forma:SolidPeso molecular:395.71STX-107
CAS:STX-107 is a potent and selective mGluR5 agonist for the study of Fragile X Syndrome.Fórmula:C18H10FN3SPureza:99.17%Cor e Forma:SolidPeso molecular:319.36mGluR5 modulator 1
CAS:mGluR5 modulator 1 is a positive modulator for mGluR5, used in schizophrenia and cognitive research.Fórmula:C18H19ClFN3O2Cor e Forma:SolidPeso molecular:363.821H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)-
CAS:1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)- is a low activity isomer of S 18986.Fórmula:C10H12N2O2SPureza:99.96%Cor e Forma:SoildPeso molecular:224.28(S,S)-BMS-984923
CAS:(S,S)-BMS-984923 is a weak mGluR5 modulator with EC50 >1μM; less active than its potent counterpart.Fórmula:C22H15ClN2O2Cor e Forma:SolidPeso molecular:374.82mGluR1 activator-1
mGluR1activator-1 is a stable vitamin K analog and mGluR1 activator capable of crossing the blood-brain barrier. It strongly activates transcription through steroid and xenobiotic receptors and retinoic acid receptors, effectively inducing neurogenesis in neural progenitor cells in mice. mGluR1activator-1 is applicable in studying neurodegenerative diseases, such as Alzheimer's.Cor e Forma:Odour SolidL-AP3
CAS:L-AP3 blocks mGluR, inhibits D/L-phosphoserine (IC50: 368/2087 μM).Fórmula:C3H8NO5PCor e Forma:White Hygroscopic SolidPeso molecular:169.073MMPIP hydrochloride
CAS:MMPIP hydrochloride is a selective antagonist of allosteric mGluR7.Fórmula:C19H16ClN3O3Pureza:99.88%Cor e Forma:Yellow SolidPeso molecular:369.8Ref: TM-T23008L
1mg56,00€5mg119,00€1mL*10mM (DMSO)133,00€10mg192,00€25mg394,00€50mg585,00€100mg833,00€200mg1.134,00€(±)-LY367385
CAS:(±)-LY367385 is the racemic form of LY367385, and LY367385 is a highly potent and selective mGluR1a antagonist.Fórmula:C10H11NO4Cor e Forma:SolidPeso molecular:209.201MPPG
CAS:MPPG is a selective L-AP4-sensitive receptor antagonist (kD=9.2 μM).Fórmula:C9H12NO5PCor e Forma:SolidPeso molecular:245.171JF-NP-26
Releases pain-blocking raseglurant under 405 nm light. Inhibits Quisqualate. Analgesic in vivo. Quantum yield: 0.18.Cor e Forma:SolidLY3027788
CAS:LY3027788, potent oral prodrug of LY3020371, is a strong mGlu2/3 antagonist with notable antidepressant effects.Fórmula:C25H31F2NO11SCor e Forma:SolidPeso molecular:591.58(S)-3,4-DCPG
CAS:(S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a selective agonist of human metabotropic glutamate receptor 8a (mGluR8a).Fórmula:C10H9NO6Pureza:98%Cor e Forma:SolidPeso molecular:239.18DL-AP4
CAS:DL-AP4, also known as 2-Amino-4-phosphonobutyric acid, is a competitive glutamate antagonist with defined binding affinity that is widely used to selectively inhibit glutamatergic neurotransmission, making it an essential experimental compound for probing synaptic signaling mechanisms and functional circuitry in central nervous system and visual system research.Fórmula:C4H10NO5PPureza:99.98%Cor e Forma:White SolidPeso molecular:183.1MGS0274
CAS:MGS0274, a lipophilic prodrug of mGlu2/3 agonist MGS0008, enhances oral bioavailability, potentially aiding schizophrenia research.Fórmula:C21H32FNO7Cor e Forma:SolidPeso molecular:429.485LY3020371
CAS:LY3020371: potent, selective mGlu 2/3 receptor antagonist with Ki of 5.26 nM (hmGluR2) and 2.50 nM (hmGluR3); key in depression studies.Fórmula:C15H15F2NO5SCor e Forma:SolidPeso molecular:359.34KRP-199 sodium
KRP-199 sodium sodium is highly potent and selective for AMPA-R in vitro and exhibits good neuroprotection in vivo.Fórmula:C22H12F3N5Na2O7Pureza:97.27%Cor e Forma:SoildPeso molecular:561.33Pomaglumetad methionil anhydrous
CAS:LY2140023, potential schizophrenia treatment, is an oral prodrug of LY404039, a selective mGlu2/3 agonist.Fórmula:C12H18N2O7S2Pureza:98%Cor e Forma:SolidPeso molecular:366.41GYKI 53655 hydrochloride
CAS:GYKI 53655 hydrochloride (LY300168 hydrochloride) is an antagonist of AMPA and is used in the study of neurological disorders.Fórmula:C19H21ClN4O3Pureza:98.02%Cor e Forma:SolidPeso molecular:388.85Ro 01-6128
CAS:Positive allosteric modulator of mGlu1 receptorsFórmula:C17H17NO3Pureza:98%Cor e Forma:SolidPeso molecular:283.32JNJ-46778212
CAS:JNJ-46778212 (VU 0409551) is a selective and potent mGlu5 allosteric modulator (EC50: 260 nM) for the study of neurodissection.Fórmula:C20H17FN2O3Pureza:99.79%Cor e Forma:SolidPeso molecular:352.36VU0422288
CAS:VU0422288 (ML396) is a type III mGlu receptor (mGlus) orthosteric modulator with inhibitory effects on mGluR4.VU0422288 can be used to study Rett syndrome.Fórmula:C17H11Cl2N3O2Pureza:99.77%Cor e Forma:SolidPeso molecular:360.19VU0364770 hydrochloride
CAS:VU0364770 hydrochloride: potent, selective mGlu4 PAM; EC50=290 nM (rat), 1.1 μM (human).Fórmula:C12H10Cl2N2OPureza:98%Cor e Forma:SolidPeso molecular:269.13AMN082
CAS:AMN082 is an mGluR7 agonist with antidepressant effects. Neuroprotective effect of AMN082 on neuronal apoptosis in rats with traumatic brain injury.Fórmula:C28H30Cl2N2Pureza:97.13% - 98.63%Cor e Forma:SolidPeso molecular:465.46γ-DGG
CAS:gamma-DGG is a competitive blocker of AMPA receptor.Fórmula:C7H12N2O5Pureza:98%Cor e Forma:SolidPeso molecular:204.18LY487379
CAS:LY487379 is a selective mGluR2 PAM that enhances glutamate signaling. It promotes cognitive flexibility and modulates norepinephrine and serotonin levels in the mPFC, used in research for schizophrenia and cognitive dysfunction.Fórmula:C21H19F3N2O4SPureza:99.94%Cor e Forma:Pink SolidPeso molecular:452.45NS-102
CAS:NS-102 is a glutamate receptor and NMDA receptor antagonist that inhibits erythrocyanine (GluK2) and inhibits specific binding to the glur6 receptor.Fórmula:C12H11N3O4Pureza:98.48% - 98.95%Cor e Forma:SolidPeso molecular:261.23LY341495
CAS:LY341495 is a potent metabotropic glutamate receptor antagonist and can be used to study neurological disorders.Fórmula:C20H19NO5Pureza:98.53% - 99.37%Cor e Forma:SolidPeso molecular:353.37
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