GluR
Inibidores do Receptor de Glutamato são compostos que bloqueiam a atividade dos receptores de glutamato, os principais receptores de neurotransmissores excitatórios no cérebro. Esses receptores desempenham um papel crucial na transmissão sináptica, plasticidade, aprendizado e memória. A desregulação da sinalização do glutamato está associada a vários distúrbios neurológicos, como epilepsia, AVC e doenças neurodegenerativas. Os inibidores dos receptores de glutamato são essenciais para investigar os mecanismos de excitotoxicidade e desenvolver estratégias neuroprotetoras. Na CymitQuimica, oferecemos uma gama de inibidores de receptores de glutamato para apoiar sua pesquisa em função sináptica, neuroproteção e distúrbios cognitivos.
Foram encontrados 263 produtos para "GluR".
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NS-102
CAS:NS-102 is a glutamate receptor and NMDA receptor antagonist that inhibits erythrocyanine (GluK2) and inhibits specific binding to the glur6 receptor.Fórmula:C12H11N3O4Pureza:98.48% - 98.95%Cor e Forma:SolidPeso molecular:261.23LY341495
CAS:LY341495 is a potent metabotropic glutamate receptor antagonist and can be used to study neurological disorders.Fórmula:C20H19NO5Pureza:98.53% - 99.37%Cor e Forma:SolidPeso molecular:353.37(RS)-3-Hydroxyphenylglycine
CAS:(RS)-3-Hydroxyphenylglycine is a PI-linked metabotropic glutamate receptors agonist.Fórmula:C8H9NO3Pureza:99.29%Cor e Forma:SolidPeso molecular:167.16VU-29
CAS:VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes.Fórmula:C22H16N4O3Pureza:99.63%Cor e Forma:White SolidPeso molecular:384.39Ref: TM-T23515
2mg33,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg86,00€25mg161,00€50mg259,00€100mg371,00€200mg530,00€(S)-ATPO
CAS:(S)-ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.Fórmula:C11H19N2O7PPureza:98.37% - 99.41%Cor e Forma:White SolidPeso molecular:322.25XAP044
CAS:XAP044 blocks mGlu7, inhibiting long-term potentiation in mouse brain with a half-maximal effect at 88nm.Fórmula:C15H9IO4Pureza:97.41%Cor e Forma:SolidPeso molecular:380.13Ref: TM-T21995
1mg58,00€2mg82,00€5mg107,00€1mL*10mM (DMSO)146,00€10mg197,00€25mg350,00€50mg528,00€100mg755,00€Farampator
CAS:Farampator (CX-691) (CX-691;Org24448) is a positive modulator of AMPA receptor.Fórmula:C12H13N3O2Pureza:99.84% - >99.99%Cor e Forma:SolidPeso molecular:231.25ADX-47273
CAS:ADX-47273 (BA 94673139) is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).Fórmula:C20H17F2N3O2Pureza:97% - 99.22%Cor e Forma:White SolidPeso molecular:369.36AZD-8529
CAS:AZD-8529: selective, oral mGluR2 modulator, EC50 285 nM; inactive on mGluR1,3-8 at 20-25 M.Fórmula:C24H24F3N5O3Cor e Forma:SolidPeso molecular:487.47VU0361737
CAS:VU0361737 (ML-128) is a mGlu4 PAM; EC50 is 240 nM (human) and 110 nM (rat), weak at mGlu5/8, inactive at mGlu1/2/3/6/7, CNS-penetrant.Fórmula:C13H11ClN2O2Pureza:99.60% - 99.85%Cor e Forma:SolidPeso molecular:262.69CX614
CAS:CX614 is a positive allosteric modulator of the AMPA receptor concerning AMPA.Fórmula:C13H13NO4Pureza:97.37%Cor e Forma:White SolidPeso molecular:247.25Ref: TM-T19698
5mg52,00€1mL*10mM (DMSO)55,00€10mg78,00€25mg119,00€50mg172,00€100mg259,00€200mg388,00€FTIDC
CAS:FTIDC: potent, selective mGluR1 allosteric antagonist, weak on mGluR5. IC50: human 5.8 nM, mouse 3.1 nM. Noncompetitive.Fórmula:C18H23FN6OPureza:95.39%Cor e Forma:SolidPeso molecular:358.41Ref: TM-T3483
1mg100,00€2mg145,00€5mg215,00€1mL*10mM (DMSO)236,00€10mg340,00€25mg565,00€50mg797,00€100mg1.071,00€PHCCC
CAS:PHCCC is a Group I mGluR antagonist and enhances mGluR4 function; also blocks mGluR2/8.Fórmula:C17H14N2O3Pureza:99.97%Cor e Forma:SolidPeso molecular:294.3CTEP
CAS:CTEP (RO 4956371) (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-foldFórmula:C19H13ClF3N3OPureza:99.17%Cor e Forma:SolidPeso molecular:391.77Ref: TM-T6457
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg88,00€25mg138,00€50mg244,00€100mg330,00€200mg470,00€Ro 67-7476
CAS:Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors.Fórmula:C17H18FNO2SPureza:99.69%Cor e Forma:SolidPeso molecular:319.39JNJ16259685
CAS:JNJ16259685 (TN.T 16259685) is a selective mGluR1 antagonist, and inhibits the synaptic activation of mGluR1 in a concentration-dependent manner with IC50 of 19Fórmula:C20H23NO3Pureza:98.31%Cor e Forma:SolidPeso molecular:325.4Ref: TM-T5512
1mg46,00€2mg62,00€5mg95,00€1mL*10mM (DMSO)95,00€10mg133,00€25mg278,00€50mg424,00€100mg620,00€MPEP
CAS:MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.Fórmula:C14H11NPureza:99.54%Cor e Forma:White SolidPeso molecular:193.24HBT1
CAS:HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neuronsFórmula:C16H17F3N4O2SPureza:99.52%Cor e Forma:White SolidPeso molecular:386.39(RS)-MCPG
CAS:(RS)-MCPG ((±)-MCPG) is a non-selective group I/II metabotropic glutamate receptor antagonist.Fórmula:C10H11NO4Pureza:99.07%Cor e Forma:SolidPeso molecular:209.2SIB-1757
CAS:SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM)Fórmula:C12H11N3OPureza:97.37%Cor e Forma:SolidPeso molecular:213.24E4CPG
CAS:E4CPG is a novel group I/II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG.Fórmula:C11H13NO4Pureza:98.05%Cor e Forma:White SolidPeso molecular:223.23VU-1545
CAS:VU-1545 is mGlu5 positive allosteric modulator.Fórmula:C22H15FN4O3Pureza:98.8%Cor e Forma:Yellow SolidPeso molecular:402.38TAT-GluA2 3Y acetate(1404188-93-7 free base)
TAT-GluA2 3Y acetate is an inhibitor of AMPA receptor endocytosis.Systemic administration of Tat-GluA2(3Y) during the induction phase of d-amphetamine blockedFórmula:C115H185N43O29Pureza:99.43%Cor e Forma:SolidPeso molecular:2634.02IDRA-21
CAS:IDRA-21 is a positive AMPA receptor modulator.Fórmula:C8H9ClN2O2SPureza:99.73%Cor e Forma:White SolidPeso molecular:232.69pep2-SVKI acetate
Pep2-SVKI acetate(pep2-SVKI acetate (328944-75-8 free base)) is a synthetic peptide salt that prevents internalization of AMPA-type glutamate receptor.Fórmula:C62H97N13O20Pureza:97.14%Cor e Forma:SolidPeso molecular:1344.511-BCP
CAS:1-BCP (Piperonylic acid piperidide) is a centrally active drug that modulates AMPA receptor gated currents.Fórmula:C13H15NO3Pureza:99.60%Cor e Forma:SolidPeso molecular:233.26MTEP hydrochloride
CAS:MTEP hydrochloride (MTEP) is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively)Fórmula:C11H9ClN2SPureza:99.58%Cor e Forma:SolidPeso molecular:236.72(S)-3-Hydroxyphenylglycine
CAS:(S)-3-Hydroxyphenylglycine is an agonist of group I metabotropic glutamate receptors (mGluRs).Fórmula:C8H9NO3Pureza:99.65%Cor e Forma:White SolidPeso molecular:167.16TCN238
CAS:TCN238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).Fórmula:C12H11N3Pureza:99.9% - 99.92%Cor e Forma:White SolidPeso molecular:197.24LY-404187
CAS:LY404187 is a positive allosteric modulator of AMPA receptorsFórmula:C19H22N2O2SPureza:99.34%Cor e Forma:White SolidPeso molecular:342.46Ref: TM-T7706
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg86,00€25mg156,00€50mg225,00€100mg321,00€200mg447,00€CX516
CAS:CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and MCI.Fórmula:C14H15N3OPureza:99.57% - ≥95%Cor e Forma:Tan SolidPeso molecular:241.293-MATIDA
CAS:3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a).Fórmula:C8H9NO4SPureza:99.75% - 99.96%Cor e Forma:SolidPeso molecular:215.23Ref: TM-T3486
2mg34,00€5mg49,00€1mL*10mM (DMSO)49,00€10mg79,00€25mg145,00€50mg227,00€100mg339,00€200mg482,00€VU 0364439
CAS:VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM).Fórmula:C18H13Cl2N3O3SPureza:97.9%Cor e Forma:White SolidPeso molecular:422.29CNQX
CAS:CNQX (FG9065) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)Fórmula:C9H4N4O4Pureza:99.70%Cor e Forma:SolidPeso molecular:232.15FITM
CAS:FITM is a potent negative allosteric modulator of mGlu1 receptor(Ki : 2.5 nM).Fórmula:C18H18FN5OSPureza:97.25% - 99.23%Cor e Forma:White SolidPeso molecular:371.43Ref: TM-T7292
1mg34,00€2mg44,00€1mL*10mM (DMSO)62,00€5mg66,00€10mg92,00€25mg177,00€50mg268,00€100mg394,00€trans-ACPD
CAS:trans-ACPD ((±)-trans-ACPD) is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD.Fórmula:C7H11NO4Pureza:99.98%Cor e Forma:White SolidPeso molecular:173.17Ref: TM-T3484
1mg46,00€2mg59,00€1mL*10mM (DMSO)71,00€5mg94,00€10mg140,00€25mg264,00€50mg477,00€100mg692,00€VU 0357121
CAS:VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.Fórmula:C17H17F2NO2Pureza:99% - 99.98%Cor e Forma:SolidPeso molecular:305.32pep2-EVKI acetate(1315378-67-6 free base)
Pep2-EVKI acetate, a cell-permeable peptide, disrupts PICK1-GluR2 AMPA receptor binding.Fórmula:C64H99N13O21Pureza:99.85%Cor e Forma:SolidPeso molecular:1386.55AMN082 free base
CAS:AMN082 free base is a metabotropic glutamate receptor 7 allosteric agonist.Fórmula:C28H28N2Pureza:97.75% - 97.79%Cor e Forma:SolidPeso molecular:392.54Ref: TM-T21935L
5mg48,00€1mL*10mM (DMSO)50,00€10mg71,00€25mg128,00€50mg200,00€100mg323,00€200mg450,00€JNJ-42153605
CAS:JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).Fórmula:C22H23F3N4Pureza:97.25% - 98.57%Cor e Forma:SolidPeso molecular:400.44Ref: TM-T3451
2mg34,00€5mg54,00€1mL*10mM (DMSO)55,00€10mg78,00€25mg124,00€50mg185,00€100mg263,00€200mg369,00€MTEP
CAS:MTEP: potent, selective mGluR5 antagonist; IC50=5 nM, Ki=16 nM; may have antidepressant/anxiolytic effects; useful in Parkinson's research.Fórmula:C11H8N2SCor e Forma:SolidPeso molecular:200.26Lu AF21934
CAS:Lu AF21934 is a brain-penetrant and selective mGlu4 receptor positive allosteric modulator (IC50: 500 nM, human).Fórmula:C14H16Cl2N2O2Pureza:99.01%Cor e Forma:SolidPeso molecular:315.2MPEP hydrochloride
CAS:MPEP hydrochloride is an effective and highly specific non-competitive antagonist at the mGlu5 receptor subtype (IC50: 36 nM).Fórmula:C14H12ClNPureza:99.87% - >99.99%Cor e Forma:SolidPeso molecular:229.7Caroverine hydrochloride
CAS:Caroverine HCL: Blocks NMDA/AMPA receptors, antioxidant, calcium-blocker, and vasorelaxant, used for tinnitus research.Fórmula:C22H28ClN3O2Pureza:98.37% - 99.85%Cor e Forma:SolidPeso molecular:401.9VU0364770
CAS:VU0364770 (VU 0364770)(EC50=1.1 μM), a positive allosteric modulator(PAM) of mGlu4, shows insignificant activity at 68 other receptors, including other mGluFórmula:C12H9ClN2OPureza:99.65% - 99.96%Cor e Forma:White SolidPeso molecular:232.67Ro0711401
CAS:Ro0711401 is an agonist of mGlu1 receptor.Fórmula:C18H11F3N2O3Pureza:97.57%Cor e Forma:SolidPeso molecular:360.29YM90K
CAS:YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor.Fórmula:C11H8ClN5O4Pureza:98.23%Cor e Forma:SolidPeso molecular:309.66Ref: TM-T8435
1mg73,00€5mg160,00€1mL*10mM (DMSO)170,00€10mg245,00€25mg404,00€50mg567,00€100mg767,00€200mg1.018,00€NBQX
CAS:NBQX (FG9202) is a potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.Fórmula:C12H8N4O6SPureza:97.66% - 99.93%Cor e Forma:SolidPeso molecular:336.28Ref: TM-T4113
1mg38,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)92,00€10mg114,00€25mg222,00€50mg334,00€100mg497,00€200mg717,00€VU0155041
CAS:VU0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).Fórmula:C14H15Cl2NO3Pureza:99.52% - 99.56%Cor e Forma:SolidPeso molecular:316.18Ref: TM-T3565
2mg38,00€5mg55,00€1mL*10mM (DMSO)60,00€10mg80,00€25mg138,00€50mg178,00€100mg285,00€200mg413,00€
