GluR
Inibidores do Receptor de Glutamato são compostos que bloqueiam a atividade dos receptores de glutamato, os principais receptores de neurotransmissores excitatórios no cérebro. Esses receptores desempenham um papel crucial na transmissão sináptica, plasticidade, aprendizado e memória. A desregulação da sinalização do glutamato está associada a vários distúrbios neurológicos, como epilepsia, AVC e doenças neurodegenerativas. Os inibidores dos receptores de glutamato são essenciais para investigar os mecanismos de excitotoxicidade e desenvolver estratégias neuroprotetoras. Na CymitQuimica, oferecemos uma gama de inibidores de receptores de glutamato para apoiar sua pesquisa em função sináptica, neuroproteção e distúrbios cognitivos.
Foram encontrados 255 produtos de "GluR"
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(S)-4CPG
CAS:<p>(S)-4CPG ((S)-4-Carboxyphenylglycine) is a competitive mGlu1 receptor antagonist that attenuates nociceptive hypersensitivity and nociceptive abnormalities associated with sciatic nerve constriction injuries in rats, and may be used in the study of neurological disorders.</p>Fórmula:C9H9NO4Pureza:99.96%Cor e Forma:SolidPeso molecular:195.17CX717
CAS:<p>CX 717 is a positive allosteric modulator of AMPA receptor which has an antidepressant-like effect.</p>Fórmula:C11H11N3O3Pureza:99.81%Cor e Forma:SoildPeso molecular:233.23VU0477886
CAS:<p>VU0477886: Potent mGlu4 PAM, effective in preclinical Parkinson's model HIC.</p>Fórmula:C20H13ClN4O3Pureza:98%Cor e Forma:SolidPeso molecular:392.80IEM 1754 2HBr
CAS:<p>IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.</p>Fórmula:C16H30N2·2HBrPureza:99.71% - 99.72%Cor e Forma:SolidPeso molecular:412.25VU6001966
CAS:<p>VU6001966: potent, selective mGlu2 inhibitor (IC50=78 nM), negative modulator, with good CNS penetration.</p>Fórmula:C17H15FN4O2Pureza:98%Cor e Forma:SolidPeso molecular:326.33BMT-145027
CAS:<p>BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM).</p>Fórmula:C23H14ClF3N4Pureza:99.62%Cor e Forma:SolidPeso molecular:438.83MFZ 10-7 hydrochloride
CAS:MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 NAMFórmula:C15H10ClFN2Pureza:98%Cor e Forma:SolidPeso molecular:272.71NS 1209
CAS:<p>NS 1209 (SPD 502) is a AMPA receptor antagonist.</p>Fórmula:C24H27N4NaO7SPureza:98%Cor e Forma:SolidPeso molecular:538.55LY392098
CAS:<p>LY392098 (AMPA receptor modulator-3) is an allosteric modulator of AMPA receptor with EC50 of 4.4 μM and can be used in studies about mammalian nervous system.</p>Fórmula:C18H22FNO2SPureza:99.86%Cor e Forma:SolidPeso molecular:335.44VU 0469650
CAS:<p>VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).</p>Fórmula:C22H28N4OPureza:98.03%Cor e Forma:SolidPeso molecular:364.48(1R,2S)-VU0155041
CAS:<p>(1R,2S)-VU0155041 is the cis regioisomer of VU0155041 and a partial agonist of mGluR4.</p>Fórmula:C14H15Cl2NO3Pureza:98.85%Cor e Forma:SolidPeso molecular:316.18Methoxy-PEPy
CAS:<p>Methoxy-PEPy is a potent and selective mGlu5 receptor inhibitor with an IC50 value of 1 nM.</p>Fórmula:C13H10N2OPureza:99.22%Cor e Forma:SolidPeso molecular:210.23LYPLAL1-IN-1
CAS:LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.Fórmula:C29H29N7O4Pureza:98%Cor e Forma:SolidPeso molecular:539.59(RS)-MCPG disodium salt
CAS:group I/group II metabotropic glutamate receptor antagonistFórmula:C10H11NNaO4Pureza:98%Cor e Forma:SolidPeso molecular:232.193,3'-Difluorobenzaldazine
CAS:<p>allosteric potentiator of mGlu5</p>Fórmula:C14H10F2N2Pureza:98%Cor e Forma:SolidPeso molecular:244.24VU0366248
CAS:<p>VU0366248 is a mGlu5 negative allosteric modulator.</p>Fórmula:C14H7ClF2N2OPureza:98%Cor e Forma:SolidPeso molecular:292.67L-AP4 monohydrate
CAS:<p>L-AP4 (L-APB) is a group III mGluR agonist with EC50s: 0.13μM (mGlu4), 0.29μM (mGlu8), 1.0μM (mGlu6), 249μM (mGlu7).</p>Fórmula:C4H12NO6PCor e Forma:SolidPeso molecular:201.115VU 0360223
CAS:<p>VU 0360223 is a negative allosteric modulator of mGlu5.</p>Fórmula:C15H9FN2SPureza:98%Cor e Forma:SolidPeso molecular:268.31ADX71743
CAS:<p>ADX71743 is a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7.</p>Fórmula:C17H19NO2Cor e Forma:SolidPeso molecular:269.34mGlu4 receptor agonist 1
CAS:<p>Compound 62, an mGlu4 agonist, has a 308 nM EC50 with anxiolytic and antipsychotic effects.</p>Fórmula:C21H15ClN4O2Cor e Forma:SolidPeso molecular:390.82MAP4
CAS:<p>metabotropic glutamate receptor modulator</p>Fórmula:C5H12NO5PPureza:98%Cor e Forma:White SolidPeso molecular:197.13GRN-529
CAS:<p>GRN-529 is a selective negative allosteric modulator of the mGluR5 receptor.</p>Fórmula:C22H15F2N3O2Pureza:98%Cor e Forma:SolidPeso molecular:391.37DFMTI
CAS:<p>DFMTI can completely block the rmGlu1 L757V glutamate response.</p>Fórmula:C20H18F2N4OCor e Forma:SolidPeso molecular:368.38Z-Cyclopentyl-AP4
CAS:Group III mGlu receptor agonistFórmula:C6H12NO5PPureza:98%Cor e Forma:SolidPeso molecular:209.14LY456066
CAS:<p>LY456066 is a mGluR1 receptor-selective, negative allosteric modulator.</p>Fórmula:C19H23N3OSPureza:98%Cor e Forma:SolidPeso molecular:341.47JNJ-40068782
CAS:<p>JNJ-40068782 is a potent, selective and systemically active positive allosteric modulator of the mGlu2 receptor.</p>Fórmula:C21H23N3OPureza:98%Cor e Forma:SolidPeso molecular:333.43TASP0433864
CAS:<p>TASP0433864 enhances mGlu2 activity; EC50: 199 nM (human), 206 nM (rat); not an agonist.</p>Fórmula:C18H23N3O3Pureza:98%Cor e Forma:SolidPeso molecular:329.39(S)-3,5-DHPG
CAS:<p>group I mGlu receptor agonist</p>Fórmula:C8H9NO4Pureza:98%Cor e Forma:SolidPeso molecular:183.16HTL14242
CAS:<p>HTL14242 is a mGlu5 Negative Allosteric Modulator.</p>Fórmula:C16H8ClFN4Cor e Forma:SolidPeso molecular:310.71(RS)-PPG
CAS:<p>(RS)-PPG: Potent, selective III mGluRs agonist; EC50s: hmGluR4a 5.2μM, hmGluR6 4.7μM, hmGluR7b 185μM, hmGluR8a 0.2μM; neuroprotective, anticonvulsive.</p>Fórmula:C8H10NO5PPureza:98%Cor e Forma:SolidPeso molecular:231.14VU0431316
CAS:<p>VU0431316 is a negative mGlu5 allosteric modulator. It has activity in a mouse model of anxiety.</p>Fórmula:C14H9ClN6O2Pureza:98%Cor e Forma:SolidPeso molecular:328.71DCG-IV
CAS:DCG-IV: Class II mGluR agonist; anticonvulsant; neuroprotective; EC50: mGlu2R-0.35μM, mGlu3R-0.09μM; antagonizes Group I/III mGluRs.Fórmula:C7H9NO6Pureza:98%Cor e Forma:SolidPeso molecular:203.15VU0410425
CAS:VU0410425 is a metabotropic glutamate receptor subtype 1 negative allosteric modulator.Fórmula:C19H16ClN3O3Pureza:98%Cor e Forma:SolidPeso molecular:369.8AZ12216052
CAS:<p>AZ12216052 is a GRP8 antagonist with anxiolytic and anti-inflammatory activity and can be used to study obesity and metabolic disorders.</p>Fórmula:C19H22BrNOSPureza:99.29%Cor e Forma:SolidPeso molecular:392.35LY487379 hydrochloride
CAS:Positive allosteric modulator of mGlu2 receptorsFórmula:C21H20ClF3N2O4SPureza:98%Cor e Forma:SolidPeso molecular:488.91VU0361747
CAS:<p>VU0361747 is a positive allosteric modulators (PAM) of metabotropic glutamate receptor subtype 5 (mGlu5).</p>Fórmula:C19H17FN2O2Cor e Forma:SolidPeso molecular:324.35Auglurant
CAS:<p>Auglurant is a novel and selective mGlu5 antagonist (IC50: 11 nM (rat) and an IC50: 14 nM (human)). Auglurant has an acceptable CNS penetration.</p>Fórmula:C16H12FN5O2Cor e Forma:SolidPeso molecular:325.3Desmethyl-YM 298198
CAS:mGlu1-selective antagonistFórmula:C17H21ClN4OSPureza:98%Cor e Forma:SolidPeso molecular:364.89Foliglurax monohydrochloride
CAS:Foliglurax monohydrochloride, an antiparkinsonian, is a selective brain-penetrant mGluR4 PAM with an EC50 of 79 nM.Fórmula:C23H24ClN3O3SCor e Forma:SolidPeso molecular:457.97L-CCG-l
CAS:<p>group II metabotropic glutamate receptor agonist</p>Fórmula:C6H9NO4Pureza:98%Cor e Forma:SolidPeso molecular:159.14(1S,3R)-ACPD
CAS:<p>(1S,3R)-ACPD is a group I and II mGlu receptor agonist.</p>Fórmula:C7H11NO4Pureza:98%Cor e Forma:SolidPeso molecular:173.17VU0404251
CAS:<p>VU0404251 is a positive allosteric modulator of mGlu5.</p>Fórmula:C19H23FN2O2Cor e Forma:SolidPeso molecular:330.4Mavoglurant racemate
CAS:<p>Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist. Mavoglurant (racemate) is the racemate of mavoglurant.</p>Fórmula:C19H23NO3Pureza:98%Cor e Forma:SolidPeso molecular:313.39ACPT-II
CAS:<p>metabotropic receptor antagonist</p>Fórmula:C8H11NO6Pureza:98%Cor e Forma:SolidPeso molecular:217.18DL-AP4 Sodium salt
CAS:Broad spectrum EAA ligandFórmula:C4H10NNaO5PPureza:98%Cor e Forma:SolidPeso molecular:206.09UPF-523
CAS:group I metabotropic glutamate receptors (mGlu1a) antagonistFórmula:C11H11NO4Pureza:98%Cor e Forma:White SolidPeso molecular:221.21JNJ-46356479
CAS:<p>JNJ-46356479: Selective, oral mGlu2 receptor PAM, EC50=78 nM, Emax=256%.</p>Fórmula:C22H22F5N5Cor e Forma:SolidPeso molecular:451.44ACPT-I
CAS:<p>Agonist for group III mGlu receptors</p>Fórmula:C8H11NO6Pureza:98%Cor e Forma:SolidPeso molecular:217.18VU0364289
CAS:<p>VU0364289 is a positive allosteric modulator of mGlu5.</p>Fórmula:C20H21N3O2Cor e Forma:SolidPeso molecular:335.4(S)-4C3HPG
CAS:<p>group I mGlu1a/1a receptor antagonist and mGluR2 agonist</p>Fórmula:C9H9NO5Pureza:98%Cor e Forma:SolidPeso molecular:211.17
