GluR
Inibidores do Receptor de Glutamato são compostos que bloqueiam a atividade dos receptores de glutamato, os principais receptores de neurotransmissores excitatórios no cérebro. Esses receptores desempenham um papel crucial na transmissão sináptica, plasticidade, aprendizado e memória. A desregulação da sinalização do glutamato está associada a vários distúrbios neurológicos, como epilepsia, AVC e doenças neurodegenerativas. Os inibidores dos receptores de glutamato são essenciais para investigar os mecanismos de excitotoxicidade e desenvolver estratégias neuroprotetoras. Na CymitQuimica, oferecemos uma gama de inibidores de receptores de glutamato para apoiar sua pesquisa em função sináptica, neuroproteção e distúrbios cognitivos.
Foram encontrados 263 produtos para "GluR".
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VU-29
CAS:VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes.Fórmula:C22H16N4O3Pureza:99.63%Cor e Forma:White SolidPeso molecular:384.39Ref: TM-T23515
2mg33,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg86,00€25mg161,00€50mg259,00€100mg371,00€200mg530,00€FTIDC
CAS:FTIDC: potent, selective mGluR1 allosteric antagonist, weak on mGluR5. IC50: human 5.8 nM, mouse 3.1 nM. Noncompetitive.Fórmula:C18H23FN6OPureza:95.39%Cor e Forma:SolidPeso molecular:358.41Ref: TM-T3483
1mg100,00€2mg145,00€5mg215,00€1mL*10mM (DMSO)236,00€10mg340,00€25mg565,00€50mg797,00€100mg1.071,00€(RS)-3-Hydroxyphenylglycine
CAS:(RS)-3-Hydroxyphenylglycine is a PI-linked metabotropic glutamate receptors agonist.Fórmula:C8H9NO3Pureza:99.29%Cor e Forma:SolidPeso molecular:167.16E4CPG
CAS:E4CPG is a novel group I/II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG.Fórmula:C11H13NO4Pureza:98.05%Cor e Forma:White SolidPeso molecular:223.23Chelidamic acid
CAS:Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM.Fórmula:C7H5NO5Pureza:98.11%Cor e Forma:SolidPeso molecular:183.12VU-1545
CAS:VU-1545 is mGlu5 positive allosteric modulator.Fórmula:C22H15FN4O3Pureza:98.8%Cor e Forma:Yellow SolidPeso molecular:402.38CX717
CAS:CX 717 is a positive allosteric modulator of AMPA receptor which has an antidepressant-like effect.Fórmula:C11H11N3O3Pureza:99.81%Cor e Forma:White SolidPeso molecular:233.23(S)-4CPG
CAS:(S)-4CPG ((S)-4-Carboxyphenylglycine) is a competitive mGlu1 receptor antagonist that attenuates nociceptive hypersensitivity and nociceptive abnormalities associated with sciatic nerve constriction injuries in rats, and may be used in the study of neurological disorders.Fórmula:C9H9NO4Pureza:99.96%Cor e Forma:SolidPeso molecular:195.17Raseglurant
CAS:Raseglurant (ADX-10059) is a negative allosteric modulator of the mGlu5 receptor that demonstrates efficacy against migraine and significantly reduces haloperidol-induced catalepsy in mice, Raseglurant is widely used in neuropharmacology research to study glutamatergic modulation, motor side effects of antipsychotics, and migraine-related signaling pathways.Fórmula:C15H13FN2Pureza:99.80%Cor e Forma:White SolidPeso molecular:240.28VU0477886
CAS:VU0477886: Potent mGlu4 PAM, effective in preclinical Parkinson's model HIC.Fórmula:C20H13ClN4O3Pureza:98%Cor e Forma:SolidPeso molecular:392.80IEM 1754 2HBr
CAS:IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.Fórmula:C16H30N2·2HBrPureza:99.04% - 99.72%Cor e Forma:SolidPeso molecular:412.25VU 0360223
CAS:VU 0360223 is a negative allosteric modulator of mGlu5.Fórmula:C15H9FN2SPureza:98%Cor e Forma:SolidPeso molecular:268.31LSN2814617
CAS:LSN2814617: oral, brain-penetrant mGlu5 PAM, EC50 = 52 nM (human), 42 nM (rat). Promotes wakefulness, useful in schizophrenia study.Fórmula:C18H20FN5OPureza:98%Cor e Forma:SolidPeso molecular:341.38RO4988546
CAS:RO4988546 is a potent negative allosteric modulator of mGlu₂/₃.Fórmula:C21H10F6N4O3SPureza:98%Cor e Forma:SolidPeso molecular:512.38mGluR2 modulator 1
CAS:Potent mGluR2 modulator 1 crosses blood-brain barrier, EC50: 0.03 μM, useful for psychiatric research.Fórmula:C21H20F3N3O3Cor e Forma:SolidPeso molecular:419.4NPEC-caged-LY379268
CAS:NPEC-caged-LY379268 is a type II mGluR agonist [1].Fórmula:C16H16N2O9Cor e Forma:SolidPeso molecular:380.31A 841720
CAS:Potent, selective mGlu1 antagonist A-841720; IC50: 10 nM; 34x selectivity vs mGlu5; analgesic potential.Fórmula:C17H21N5OSCor e Forma:SolidPeso molecular:343.45RO5488608
CAS:RO5488608 is a new type of high-efficiency mGlu2/3 NAM.Fórmula:C23H17F3N2O4SCor e Forma:SolidPeso molecular:474.45Talaglumetad hydrochloride
CAS:Talaglumetad hydrochloride, a prodrug of Eglumegad, targets mGluR2/3 to treat psychiatric disorders.Fórmula:C11H17ClN2O5Cor e Forma:SolidPeso molecular:292.72mGluR2 modulator 2
CAS:mGluR2 modulator 2: potent, selective, oral, EC50 = 0.13 μM, for antipsychotic research.Fórmula:C20H22FN3Cor e Forma:SolidPeso molecular:323.41L-AP4 monohydrate
CAS:L-AP4 (L-APB) is a group III mGluR agonist with EC50s: 0.13μM (mGlu4), 0.29μM (mGlu8), 1.0μM (mGlu6), 249μM (mGlu7).Fórmula:C4H12NO6PCor e Forma:SolidPeso molecular:201.115VU0418506
CAS:VU0418506 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGlu4).Fórmula:C12H8ClFN4Pureza:98%Cor e Forma:SolidPeso molecular:262.67ACDPP
CAS:mGlu5 receptor antagonistFórmula:C12H13ClN6OPureza:98%Cor e Forma:SolidPeso molecular:292.72ML289
CAS:ML289 is a potent CNS-penetrant mGlu3 modulator with IC50 of 0.66 μM, >15-fold selectivity over mGlu2, and inactive against mGlu5.Fórmula:C22H23NO3Pureza:99.54%Cor e Forma:Yellow SolidPeso molecular:349.42Ref: TM-T23000
5mg48,00€1mL*10mM (DMSO)49,00€10mg75,00€25mg138,00€50mg212,00€100mg320,00€200mg445,00€VU6001966
CAS:VU6001966: potent, selective mGlu2 inhibitor (IC50=78 nM), negative modulator, with good CNS penetration.Fórmula:C17H15FN4O2Pureza:98%Cor e Forma:SolidPeso molecular:326.33VU6010572
CAS:VU6010572: potent, selective mGlu3 modulator, IC50 245 nM, high CNS penetration.Fórmula:C20H18FNO3Cor e Forma:SolidPeso molecular:339.36VU0463841
CAS:VU0463841 is a mGlu5 negative allosteric modulators.Fórmula:C13H8ClFN4OCor e Forma:SolidPeso molecular:290.68VU 0360172 hydrochloride
CAS:positive allosteric modulator of mGlu5 receptorsFórmula:C18H16ClFN2OPureza:98%Cor e Forma:SolidPeso molecular:330.78mGluR2 modulator 4
CAS:Compound 47 is a potent mGluR2 enhancer with an EC50 of 0.8 μM, potentially useful for antipsychotic research.Fórmula:C18H18BrN3Cor e Forma:SolidPeso molecular:356.26VU0400195
CAS:VU0400195 is a oral effective, positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)).Fórmula:C21H16ClN3O3Pureza:98%Cor e Forma:SolidPeso molecular:393.82(RS)-4-Carboxy-3-hydroxyphenylglycine
CAS:broad spectrum EAA agonist/antagonistFórmula:C9H9NO5Pureza:98%Cor e Forma:SolidPeso molecular:211.17Ro4491533
CAS:Ro4491533 is a potent and selective negative allosteric modulator for group II of the metabotropic glutamate receptors (mGluR2/3).Fórmula:C24H20F3N3OCor e Forma:SolidPeso molecular:423.43MMPIP
CAS:allosteric mGlu7-selective receptor antagonistFórmula:C19H15N3O3Pureza:98%Cor e Forma:SolidPeso molecular:333.34LSP4-2022
CAS:LSP4-2022, a mGlu4 selective agonist, increases behavioral despair in mouse models of antidepressant action.Fórmula:C13H18NO8PPureza:100%Cor e Forma:White SolidPeso molecular:347.26VU0409106
CAS:VU0409106 is a potent, mGlu5-selective inhibitor.Fórmula:C15H11FN4O2SPureza:99.89%Cor e Forma:White SolidPeso molecular:330.34Remeglurant
CAS:Remeglurant is used as a selective antagonist of the mGlu5 receptor.Fórmula:C17H15BrN4OCor e Forma:SolidPeso molecular:371.23IEM 1925 dihydrobromide
CAS:AMPA receptor antagonistFórmula:C17H30Br2N2Pureza:98%Cor e Forma:SolidPeso molecular:422.24PHCCC(4Me)
CAS:THCCC, a PHCCC analog, is a dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulator.Fórmula:C18H16N2O3Cor e Forma:SolidPeso molecular:308.33ACPT-I
CAS:Agonist for group III mGlu receptorsFórmula:C8H11NO6Pureza:98%Cor e Forma:SolidPeso molecular:217.18mGlu4 receptor agonist 1
CAS:Compound 62, an mGlu4 agonist, has a 308 nM EC50 with anxiolytic and antipsychotic effects.Fórmula:C21H15ClN4O2Cor e Forma:SolidPeso molecular:390.82VU0364289
CAS:VU0364289 is a positive allosteric modulator of mGlu5.Fórmula:C20H21N3O2Cor e Forma:SolidPeso molecular:335.4(S)-4C3HPG
CAS:group I mGlu1a/1a receptor antagonist and mGluR2 agonistFórmula:C9H9NO5Pureza:98%Cor e Forma:SolidPeso molecular:211.17ADX71743
CAS:ADX71743 is a selective, non-competitive mGlu7 negative allosteric modulator (NAM) that crosses the blood-brain barrier and exhibits anti-anxiety activity.Fórmula:C17H19NO2Pureza:99.27%Cor e Forma:SolidPeso molecular:269.34VU0652835
CAS:VU0652835 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5) (IC50: 81 nM).Fórmula:C16H19N3O3SPureza:98%Cor e Forma:SolidPeso molecular:333.41VU0486321
CAS:VU0486321: potent mGlu1 PAM, rat PK CLp 13.3 mL/min/kg, t1/2 54 min, human fu 0.05, rat fu 0.03, great CNS penetration Kp 1.02.Fórmula:C20H12ClFN2O4Cor e Forma:SolidPeso molecular:398.77A-850002
CAS:A-850002 is a bioactive chemical.Fórmula:C18H16N4OSCor e Forma:SolidPeso molecular:336.41LYPLAL1-IN-1
CAS:LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.Fórmula:C29H29N7O4Pureza:98%Cor e Forma:SolidPeso molecular:539.59LY392098
CAS:LY392098 (AMPA receptor modulator-3) is an allosteric modulator of AMPA receptor with EC50 of 4.4 μM and can be used in studies about mammalian nervous system.Fórmula:C18H22FNO2SPureza:99.86%Cor e Forma:White SolidPeso molecular:335.44Ref: TM-T27951
1mg39,00€5mg93,00€1mL*10mM (DMSO)96,00€10mg133,00€25mg215,00€50mg306,00€100mg414,00€200mg573,00€JNJ-55511118
CAS:JNJ-55511118 is a TARP γ8 allosteric modulator with anticonvulsant activity, which can be used in research on chronic operant alcohol self-administration.Fórmula:C14H8ClF3N2O2Cor e Forma:SolidPeso molecular:328.67
