GluR
Inibidores do Receptor de Glutamato são compostos que bloqueiam a atividade dos receptores de glutamato, os principais receptores de neurotransmissores excitatórios no cérebro. Esses receptores desempenham um papel crucial na transmissão sináptica, plasticidade, aprendizado e memória. A desregulação da sinalização do glutamato está associada a vários distúrbios neurológicos, como epilepsia, AVC e doenças neurodegenerativas. Os inibidores dos receptores de glutamato são essenciais para investigar os mecanismos de excitotoxicidade e desenvolver estratégias neuroprotetoras. Na CymitQuimica, oferecemos uma gama de inibidores de receptores de glutamato para apoiar sua pesquisa em função sináptica, neuroproteção e distúrbios cognitivos.
Foram encontrados 263 produtos para "GluR".
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LY 541850
CAS:LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from humanFórmula:C9H13NO4Pureza:98%Cor e Forma:SolidPeso molecular:199.2YM 202074
CAS:metabotropic glutamate receptor type 1 (mGlu1) antagonistFórmula:C56H72N8O16S2Pureza:98%Cor e Forma:SolidPeso molecular:1177.34LY3020371 hydrochloride
CAS:LY3020371 HCl: potent mGlu2/3 antagonist, antidepressant-like; Ki: 5.3/2.5 nM, IC50: 16.2 nM for cAMP inhibition.Fórmula:C15H16ClF2NO5SCor e Forma:SolidPeso molecular:395.81LY2794193
CAS:LY2794193, a potent and selective mGlu3 receptor agonist, reduces akathisia seizures and increases GAT1, GLAST and GLT-1 protein levels in rats.Fórmula:C16H18N2O6Pureza:98.15%Cor e Forma:White SolidPeso molecular:334.32PF470
CAS:PF470 (PF-06297470) is a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), which demonstrated significant therapeutic effects in Parkinson's disease models. However, its clinical development was halted due to potential issues identified in toxicological studies.Fórmula:C18H16N6OCor e Forma:SolidPeso molecular:332.36Azotomycin
CAS:Azotomycin is an antagonist of L-glutamine and may be used as an immunosuppressant.Fórmula:C17H23N7O8Pureza:98%Cor e Forma:SolidPeso molecular:453.41Pomaglumetad methionil
CAS:Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.Fórmula:C12H20N2O8S2Pureza:98%Cor e Forma:SolidPeso molecular:384.43mG2N001
CAS:mG2N001, a negative allosteric modulator (NAM) of the metabotropic glutamate receptor mGluR2, has an IC50 of 93 nM and binds to mGluR2 as an antagonist with a Ki of 63 nM. This compound is microparticle- and plasma-stable, and its radioisotope [11C] mG2N001 can be utilized in PET imaging. [11C] mG2N001 exhibits good brain heterogeneity and penetration, selectively accumulating in mGluR2-rich regions to produce high-contrast brain images [1].Fórmula:C18H19FN2O3Cor e Forma:SolidPeso molecular:330.35LY-2979165
CAS:LY-2979165 is a metabotropic glutamate receptor agonist prodrug.Fórmula:C13H17N5O5SCor e Forma:SolidPeso molecular:355.37YM-202074
CAS:YM-202074: Selective mGlu1 antagonist, binds allosteric site (Ki=4.8 nM), inhibits mGlu1 (IC50=8.6 nM).Fórmula:C22H30N4O2SCor e Forma:SolidPeso molecular:414.56FP0429
CAS:FP0429 is an agonist of mGlu4.Fórmula:C10H12N2O7Pureza:98%Cor e Forma:SolidPeso molecular:272.21BTB01303
CAS:BTB01303 is a glutamate release inhibitor that targets the high levels of glutamate released by cancer cells, which disrupts normal bone turnover and can lead to cancer-induced bone pain. BTB01303 has the potential to improve cancer-induced bone pain [1].Fórmula:C15H11Cl2NO3Cor e Forma:SolidPeso molecular:324.16LY2979165
CAS:LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.Fórmula:C13H22N6O6SPureza:98.41%Cor e Forma:SolidPeso molecular:390.42
