AChR
Os inibidores do receptor de acetilcolina (AChR) são compostos que bloqueiam a atividade dos receptores de acetilcolina, essenciais para a neurotransmissão nos sistemas nervosos central e periférico. Os AChRs desempenham um papel vital na contração muscular, memória e funções cognitivas. Os inibidores de AChRs são usados para estudar condições como miastenia gravis, doença de Alzheimer e outros distúrbios neurológicos. Ao modular a atividade dos AChRs, esses inibidores podem ajudar a desvendar as complexidades da sinalização colinérgica no cérebro. Na CymitQuimica, oferecemos uma gama de inibidores de AChRs para apoiar sua pesquisa em neurociência, farmacologia e doenças neurodegenerativas.
Foram encontrados 642 produtos de "AChR"
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Timepidium bromide
CAS:Timepidium bromide is an agent of anticholinergic.Fórmula:C17H22BrNOS2Pureza:98%Cor e Forma:SolidPeso molecular:400.4Tiotropium Bromide hydrate
CAS:Tiotropium Bromide hydrate is a potent, long-lasting anticholinergic bronchodilator for COPD, with high affinity for muscarinic receptors M1, M2, and M3.Fórmula:C19H24BrNO5S2Pureza:98.44% - 99.41%Cor e Forma:SolidPeso molecular:490.43ICL-CCIC-0019
CAS:ICL-CCIC-0019 inhibits ChoKα, causes G1 arrest, ER stress, and cancer cell apoptosis.Fórmula:C26H44Br2N4Pureza:99.54%Cor e Forma:SolidPeso molecular:572.46Ref: TM-T27579
2mg43,00€5mg70,00€10mg92,00€25mg132,00€50mg200,00€100mg344,00€200mg505,00€1mL*10mM (DMSO)88,00€VU0453595
CAS:VU0453595 is a M1 positive allosteric modulator (PAM).
Fórmula:C18H15FN4OPureza:99.91%Cor e Forma:SolidPeso molecular:322.34N-Demethyl MK-6884
CAS:N-Demethyl MK-6884 (compound 34) is an M4 mAChR modulator for Alzheimer's and related disease research.Fórmula:C24H23N5OCor e Forma:SolidPeso molecular:397.47Hydroxy Varenicline
CAS:Hydroxy varenicline, a metabolite of the nicotinic acetylcholine receptor (nAChR) agonist varenicline, functions within the biochemical pathway by interacting with nAChR sites.Fórmula:C13H13N3OCor e Forma:SolidPeso molecular:227.267VU6007477
CAS:VU6007477 is a brain-penetrant M1 muscarinic receptor PAM (EC50 230 nM) used for research on CNS exposure and seizure-related models.Fórmula:C24H26N6O2Pureza:99.67%Cor e Forma:SolidPeso molecular:430.5Tolterodine Dimer
CAS:Tolterodine Dimer is a derivative of Tolterodine -- a muscarinic receptor antagonist that is used to treat patients with overactive bladder.Fórmula:C35H41NO2Cor e Forma:SolidPeso molecular:507.713-Bromocytisine
CAS:3-Bromocytisine ((-)-3-Bromocytisine) is an effective agonist of nAChR (IC50s: 0.28, 0.30 and 31.6 nM for hα4β4, hα4β2, and hα7).Fórmula:C11H13BrN2OPureza:99.974%Cor e Forma:SolidPeso molecular:269.14Ref: TM-T10108
1mg95,00€5mg202,00€10mg293,00€25mg494,00€50mg710,00€100mg973,00€200mg1.305,00€1mL*10mM (DMSO)178,00€ASP8302
CAS:ASP8302 is an allosteric potentiator of the muscarinic M3 receptor. It enhances urination efficiency and reduces residual urine volume in two rat models of voiding dysfunction. ASP8302 is useful for investigating diseases associated with bladder dysfunction.Fórmula:C26H32ClN7O3S2Cor e Forma:SolidPeso molecular:590.16Cynandione A
CAS:Cynandione A is an acetophenone derived from Cynanchum wilfordii with anti-inflammatory activity.Fórmula:C16H14O6Pureza:99.62%Cor e Forma:SolidPeso molecular:302.28APS3
CAS:APS3 is an inhibitor of GABA and nACh receptors, exhibiting an LC50 value of 7.2423 μg/mL against Plutella xylostella [1].Fórmula:C18H7Cl2F6N5O5S2Cor e Forma:SolidPeso molecular:622.31UFP-512
CAS:UFP-512 is a selective delta-opioid (DOP) receptor agonist.Fórmula:C31H33N5O5Pureza:98%Cor e Forma:SolidPeso molecular:555.62A-424274
CAS:A-424274 is a positive allosteric modulator of α4β2 neuronal nicotinic receptor.Fórmula:C14H15N3Pureza:98%Cor e Forma:SolidPeso molecular:225.29Tematropium
CAS:Tematropium (CDDD3602) possesses anticholinergic effects and can be used in neurological studies.Fórmula:C21H31NO8SPureza:99.89%Cor e Forma:SolidPeso molecular:457.54Ref: TM-T10732
1mg147,00€5mg356,00€10mg558,00€25mg880,00€50mg1.179,00€100mg1.603,00€200mg2.152,00€1mL*10mM (DMSO)413,00€(-)-Cevimeline hydrochloride hemihydrate
(-)-Cevimeline HCl hemihydrate, a muscarinic agonist, treats Sjogren's xerostomia. Quick absorption, species-dependent metabolism.Fórmula:C10H19ClNO1·5SPureza:98%Cor e Forma:SolidPeso molecular:244.78Dihydro-β-erythroidine
CAS:Dihydro-β-erythroidine, a competitive nicotinic receptor antagonist, effectively blocks the discriminative stimulus properties and inhibits the anxiolyticFórmula:C16H21NO3Cor e Forma:SolidPeso molecular:275.34TDI-11861
CAS:TDI-11861 is a second-gen sAC (ADCY10) inhibitor with an IC50 of 5.5 nM and slow dissociation.Fórmula:C22H25ClF2N6O3Cor e Forma:SolidPeso molecular:494.92VU6005806
CAS:VU6005806 is a potent M4 PAM with EC50s: 94 nM (human), 28 nM (rat), 87 nM (dog), 68 nM (cyno); studied for neuropsychiatric disorders.Fórmula:C17H16F3N7O2SPureza:98%Cor e Forma:SolidPeso molecular:439.41Dihydro-β-erythroidine hydrobromide
CAS:Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs).Fórmula:C16H22BrNO3Pureza:98%Cor e Forma:White SolidPeso molecular:356.26VU6016235
CAS:VU6016235 is a structurally unique, orally available, and highly selective tricyclic M4 muscarinic acetylcholine receptor positive allosteric modulator.Fórmula:C21H22N4OSCor e Forma:SolidPeso molecular:378.491,9-Dideoxyforskolin
CAS:The compound is an inactive analog of forskolin(an adenylyl cyclase activator).Fórmula:C22H34O5Pureza:98%Cor e Forma:SolidPeso molecular:378.5Acetylethylcholine mustard hydrochloride
CAS:Acetylethylcholine mustard hydrochloride is a choline acetyl-transferase inhibitor that decreases muscle contraction frequency by inhibiting the synthesis of acetyl-beta-methylcholine (Ach), with a half-maximal inhibitory concentration (IC50) of 1.22 mM. It serves as an irreversible ligand for the high-affinity choline transport system and functions as a specific presynaptic long-acting cholinergic toxin. Additionally, acetylethylcholine mustard hydrochloride is a precursor to the ethylcholine mustard aziridinium ion.Fórmula:C8H17Cl2NO2Peso molecular:230.132Lu 26-046
CAS:Lu 26-046 is a muscarinic receptor agonist.Fórmula:C10H12N2OSCor e Forma:SolidPeso molecular:208.28Metoquizine
CAS:Metoquizine is an anticholinergic compound. It is a muscarinic acetylcholine receptor antagonist that has been used to treat ulcers.Fórmula:C22H27N5OPureza:98%Cor e Forma:SolidPeso molecular:377.48VU6007496
CAS:VU6007496 is a highly selective and CNS-penetrating M1 positive allosteric modulator (PAM) that exhibits good pharmacokinetics (PK).Fórmula:C25H27N5O2Cor e Forma:SolidPeso molecular:429.51TAAR1 agonist 2
CAS:TAAR1 agonist 2 (compound 30), a full agonist at trace amine-associated receptor 1 (TAAR1) (pEC50=7.5), also displays agonistic properties at H1 receptors and activates various muscarinic acetylcholine receptors, including the M2 receptor (pEC50=5). This compound is utilized in researching neuropsychiatric diseases.Fórmula:C9H11NOCor e Forma:SolidPeso molecular:149.19(+)-Cevimeline hydrochloride hemihydrate
(+)-Cevimeline HCl hemihydrate is a muscarinic agonist for dry mouth in Sjogren's with rapid absorption, differing metabolism in species.Fórmula:C10H19ClNO1·5SPureza:98%Cor e Forma:SolidPeso molecular:244.78WIN 62577
CAS:WIN 62577 is a species-selective tachykinin NK1 receptor antagonist and also serves as an allosteric enhancer with micromolar potency at M3 receptors. Additionally, WIN 62577 demonstrates potent antiviral activity against SARS-CoV-2.Fórmula:C29H31N3OCor e Forma:SolidPeso molecular:437.576p-F-HHSiD hydrochloride
CAS:p-F-HHSiD (p-Fluorohexahydrosiladifenidol) hydrochloride is a selective M3mAChR antagonist. It is capable of inhibiting acetylcholine-mediated vasodilation in human umbilical vein endothelial cells (HUVEC).Fórmula:C20H33ClFNOSiPeso molecular:386.019YM-49598 iodide
CAS:YM-49598 iodide is a tachykinin NK-1 receptor antagonist. It inhibits drug-induced bladder contractions in rats with an IC50 of 11 μg/kg.Fórmula:C36H45Cl2IN2O2Cor e Forma:SolidPeso molecular:735.57LY593093
CAS:LY593093 is a selective partial orthosteric agonist of M1 muscarinic acetylcholine receptor.Fórmula:C32H30FN3O2Pureza:98%Cor e Forma:SolidPeso molecular:507.6CHF-6366
CAS:CHF-6366: M3 antagonist & β2 agonist (pKi 10.4/11.4), mild Ca channel blocker, used in COPD study.Fórmula:C42H48N6O8Cor e Forma:SolidPeso molecular:764.87(+)-Sparteine sulfate pentahydrate
(+)-sparteine (sulfate pentahydrate) is a ganglion blocker that competitively blocks nicotinic acetylcholine receptors in neurons.Fórmula:C15H38N2O9SCor e Forma:SolidPeso molecular:422.54nAChR antagonist 1
CAS:Compound B15, a potent α7 nAChR antagonist, IC50 = 3.3 μM, promising for research on schizophrenia, Alzheimer's, and inflammation.Fórmula:C19H22N4O2Cor e Forma:SolidPeso molecular:338.4(S)-Albuterol
CAS:(S)-Albuterol functions as a muscarinic receptor and phospholipase C activator, enhancing the intracellular free calcium concentration in airway smooth muscle cells.Fórmula:C13H21NO3Cor e Forma:SolidPeso molecular:239.311UB 165
CAS:Subtype-selective nicotinic agonistFórmula:C13H15ClN2Pureza:98%Cor e Forma:SolidPeso molecular:234.72AChE/BChE-IN-10
CAS:AChE/BChE-IN-10 inhibits AChE/BChE (IC50: 0.176/0.47 μM), crosses the blood-brain barrier, and prevents Aβ-aggregation.
Fórmula:C26H30N2O2Pureza:99.55% - 99.88%Cor e Forma:SoildPeso molecular:402.53VU6000918
CAS:VU6000918 is a positive allosteric modulator that targets the muscarinic acetylcholine receptor subtype M4. It exhibits a half maximal effective concentration (EC50) of 19 nM for the human M4 receptor.Fórmula:C18H17F2N5OSCor e Forma:SolidPeso molecular:389.42Lupinine
CAS:Lupinine is an alkaloid capable of counteracting ethanol anesthesia. Lupinine is an AChE and BChE inhibitor and potential CD69 activator found in species of Loranthus, Calia, and Lupinus. It may also inhibit heparin.
Fórmula:C10H19NOPureza:99.95%Cor e Forma:SolidPeso molecular:169.26Oxitropium Bromide
CAS:Oxitropium bromide, a mAChR blocker, treats asthma and COPD as an anticholinergic bronchodilator.Fórmula:C19H26BrNO4Pureza:98%Cor e Forma:SolidPeso molecular:412.32
