AChR
Os inibidores do receptor de acetilcolina (AChR) são compostos que bloqueiam a atividade dos receptores de acetilcolina, essenciais para a neurotransmissão nos sistemas nervosos central e periférico. Os AChRs desempenham um papel vital na contração muscular, memória e funções cognitivas. Os inibidores de AChRs são usados para estudar condições como miastenia gravis, doença de Alzheimer e outros distúrbios neurológicos. Ao modular a atividade dos AChRs, esses inibidores podem ajudar a desvendar as complexidades da sinalização colinérgica no cérebro. Na CymitQuimica, oferecemos uma gama de inibidores de AChRs para apoiar sua pesquisa em neurociência, farmacologia e doenças neurodegenerativas.
Foram encontrados 616 produtos de "AChR"
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VU6016235
CAS:VU6016235 is a structurally unique, orally available, and highly selective tricyclic M4 muscarinic acetylcholine receptor positive allosteric modulator.Fórmula:C21H22N4OSCor e Forma:SolidPeso molecular:378.49TAAR1 agonist 2
CAS:<p>TAAR1 agonist 2 (compound 30), a full agonist at trace amine-associated receptor 1 (TAAR1) (pEC50=7.5), also displays agonistic properties at H1 receptors and activates various muscarinic acetylcholine receptors, including the M2 receptor (pEC50=5). This compound is utilized in researching neuropsychiatric diseases.</p>Fórmula:C9H11NOCor e Forma:SolidPeso molecular:149.19(-)-Cevimeline hydrochloride hemihydrate
(-)-Cevimeline HCl hemihydrate, a muscarinic agonist, treats Sjogren's xerostomia. Quick absorption, species-dependent metabolism.Fórmula:C10H19ClNO1·5SPureza:98%Cor e Forma:SolidPeso molecular:244.78VU6007496
CAS:<p>VU6007496 is a highly selective and CNS-penetrating M1 positive allosteric modulator (PAM) that exhibits good pharmacokinetics (PK).</p>Fórmula:C25H27N5O2Cor e Forma:SolidPeso molecular:429.51p-F-HHSiD hydrochloride
CAS:p-F-HHSiD (p-Fluorohexahydrosiladifenidol) hydrochloride is a selective M3mAChR antagonist. It is capable of inhibiting acetylcholine-mediated vasodilation in human umbilical vein endothelial cells (HUVEC).Fórmula:C20H33ClFNOSiPeso molecular:386.019LY593093
CAS:LY593093 is a selective partial orthosteric agonist of M1 muscarinic acetylcholine receptor.Fórmula:C32H30FN3O2Pureza:98%Cor e Forma:SolidPeso molecular:507.61,9-Dideoxyforskolin
CAS:The compound is an inactive analog of forskolin(an adenylyl cyclase activator).Fórmula:C22H34O5Pureza:98%Cor e Forma:SolidPeso molecular:378.5Metoquizine
CAS:Metoquizine is an anticholinergic compound. It is a muscarinic acetylcholine receptor antagonist that has been used to treat ulcers.Fórmula:C22H27N5OPureza:98%Cor e Forma:SolidPeso molecular:377.48(+)-Cevimeline hydrochloride hemihydrate
(+)-Cevimeline HCl hemihydrate is a muscarinic agonist for dry mouth in Sjogren's with rapid absorption, differing metabolism in species.Fórmula:C10H19ClNO1·5SPureza:98%Cor e Forma:SolidPeso molecular:244.78Acetylethylcholine mustard hydrochloride
CAS:Acetylethylcholine mustard hydrochloride is a choline acetyl-transferase inhibitor that decreases muscle contraction frequency by inhibiting the synthesis of acetyl-beta-methylcholine (Ach), with a half-maximal inhibitory concentration (IC50) of 1.22 mM. It serves as an irreversible ligand for the high-affinity choline transport system and functions as a specific presynaptic long-acting cholinergic toxin. Additionally, acetylethylcholine mustard hydrochloride is a precursor to the ethylcholine mustard aziridinium ion.Fórmula:C8H17Cl2NO2Peso molecular:230.132nAChR antagonist 1
CAS:Compound B15, a potent α7 nAChR antagonist, IC50 = 3.3 μM, promising for research on schizophrenia, Alzheimer's, and inflammation.Fórmula:C19H22N4O2Cor e Forma:SolidPeso molecular:338.4AChE/BChE-IN-10
CAS:<p>AChE/BChE-IN-10 inhibits AChE/BChE (IC50: 0.176/0.47 μM), crosses the blood-brain barrier, and prevents Aβ-aggregation.</p>Fórmula:C26H30N2O2Pureza:99.55% - 99.88%Cor e Forma:SoildPeso molecular:402.53VU6000918
CAS:<p>VU6000918 is a positive allosteric modulator that targets the muscarinic acetylcholine receptor subtype M4. It exhibits a half maximal effective concentration (EC50) of 19 nM for the human M4 receptor.</p>Fórmula:C18H17F2N5OSCor e Forma:SolidPeso molecular:389.42Lupinine
CAS:<p>Lupinine is an alkaloid capable of counteracting ethanol anesthesia. Lupinine is an AChE and BChE inhibitor and potential CD69 activator found in species of Loranthus, Calia, and Lupinus. It may also inhibit heparin.</p>Fórmula:C10H19NOPureza:99.95%Cor e Forma:SolidPeso molecular:169.26Oxitropium Bromide
CAS:Oxitropium bromide, a mAChR blocker, treats asthma and COPD as an anticholinergic bronchodilator.Fórmula:C19H26BrNO4Pureza:98%Cor e Forma:SolidPeso molecular:412.32
