AChR
Os inibidores do receptor de acetilcolina (AChR) são compostos que bloqueiam a atividade dos receptores de acetilcolina, essenciais para a neurotransmissão nos sistemas nervosos central e periférico. Os AChRs desempenham um papel vital na contração muscular, memória e funções cognitivas. Os inibidores de AChRs são usados para estudar condições como miastenia gravis, doença de Alzheimer e outros distúrbios neurológicos. Ao modular a atividade dos AChRs, esses inibidores podem ajudar a desvendar as complexidades da sinalização colinérgica no cérebro. Na CymitQuimica, oferecemos uma gama de inibidores de AChRs para apoiar sua pesquisa em neurociência, farmacologia e doenças neurodegenerativas.
Foram encontrados 575 produtos de "AChR"
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Pozanicline hydrochloride
<p>Pozanicline hydrochloride is an oral α4β2 nAChR agonist with a 16.7 nM Ki, insignificantly binding to α7 nAChR.</p>Fórmula:C11H17ClN2OPureza:97.13% - 99.81%Cor e Forma:SolidPeso molecular:228.72AC1-IN-1
CAS:<p>AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 µM).</p>Fórmula:C18H18FN5O2Pureza:99.89%Cor e Forma:SolidPeso molecular:355.37Perlapine
CAS:<p>Perlapine is an effective and selective HM3DQ DREADD agonist (EC50 = 2.8 nM).</p>Fórmula:C19H21N3Cor e Forma:SolidPeso molecular:291.39M3/PDE4 modulator-1
<p>M3/PDE4 Modulator-1 (compound 10f) serves as a bifunctional entity functioning both as an M3 mAChR antagonist and a PDE4 inhibitor.</p>Fórmula:C38H41Cl2N3O8SCor e Forma:SolidPeso molecular:770.72α-Conotoxin PIA TFA
<p>α-Conotoxin PIA TFA, targeting nicotinic acetylcholine receptor (nAChR) subtypes with α6 and α3 subunits, acts as an antagonist.</p>Fórmula:C81H126F3N27O27S4Pureza:98.81%Cor e Forma:SolidPeso molecular:2095.3nAChR agonist CMPI hydrochloride
CAS:<p>CMPI hydrochloride: Potent α4:α4 nAChR PAM; EC50 0.26 μM for (α4)3(β2)2 response to ACh; may aid nicotine dependence, neuropsychiatric research.</p>Fórmula:C18H20Cl2N4OCor e Forma:SolidPeso molecular:379.29M 8218
CAS:<p>M 8218 is a bioactive chemical.</p>Fórmula:C20H29NO2Cor e Forma:SolidPeso molecular:315.45Mant-GTPγS
CAS:<p>Mant-GTPγS, an effective GTP analog, displays strong competitive inhibition of adenylyl cyclase (AC). Additionally, it acts as a potent inhibitor of YdeH.</p>Fórmula:C18H23N6O14P3SCor e Forma:SolidPeso molecular:672.39Muscarinic toxin 3
CAS:<p>Muscarinic toxin 3 (MT3), a potent non-competitive antagonist of mAChR and adrenoceptors, exhibits pIC50 values of 6.71 for M1, 8.79 for M4, 8.86 for α1A, 7.57</p>Fórmula:C319H489N89O97S8Pureza:98%Cor e Forma:SolidPeso molecular:7379.35Navafenterol
CAS:<p>AZD-8871, a potential COPD and asthma treatment, may work well with ICS.</p>Fórmula:C38H42N6O6S2Cor e Forma:SolidPeso molecular:742.91Anabaseine
CAS:<p>Anabaseine is a broad nicotinic agonist, favoring alpha-7 AChRs in muscle/brain, and weakly stimulates alpha-4 beta-2 nAChRs.</p>Fórmula:C10H12N2Cor e Forma:SolidPeso molecular:160.22BTMPS
CAS:<p>BTMPS is a usage-dependent nicotinic antagonist capable of reducing acute withdrawal symptoms associated with morphine use.</p>Fórmula:C28H52N2O4Pureza:98.1%Cor e Forma:SolidPeso molecular:480.72Biperiden Hydrochloride
CAS:<p>Biperiden HCl is an anti-Parkinson's drug, blocks M1 receptors, manages all Parkinson's types, and is FDA-approved. Non-toxic at 0.11 mg/kg to rats' cognition.</p>Fórmula:C21H30ClNOPureza:98%Cor e Forma:SolidPeso molecular:347.92Anagyrine hydrochloride
CAS:<p>Anagyrine hydrochloride, a quinolizidine from Lupinus albus, targets muscarinic/nicotinic receptors; IC50: 132/2096 µM. It desensitizes nAChR directly.</p>Fórmula:C15H21ClN2OCor e Forma:SolidPeso molecular:280.79DSPE-PEG1000-RVG29
<p>DSPE-PEG1000-RVG29 is a PEG compound composed of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 can specifically bind to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB) and cross the BBB.</p>Cor e Forma:Odour SolidEmraclidine
CAS:<p>Emraclidine (CVL-231) is a novel, highly selective allosteric modulator of the muscarinic M4 receptor positive receptor.Cost-effective and quality-assured.</p>Fórmula:C20H21F3N4OPureza:99.96%Cor e Forma:SolidPeso molecular:390.4TIP 39, Tuberoinfundibular Neuropeptide
CAS:<p>TIP39 is a synthetic neuropeptide agonist for human and rat PTH2 receptors from the hypothalamus.</p>Fórmula:C202H325N61O54SPureza:98%Cor e Forma:SolidPeso molecular:4504.2Destomycin A
CAS:<p>Destomycin A, an aminoglycoside antibiotic, exhibits activity against bacterial (Gram-positive and Gram-negative), antifungal, and anthelmintic agents. It inhibits peptide synthesis in Escherichia coli cells and stimulates adenylate cyclase in animal tissues.</p>Fórmula:C20H37N3O13Cor e Forma:SolidPeso molecular:527.52PDE4-IN-4
CAS:<p>PDE4-IN-4 is a compound acting as both a potent M3 antagonist (p IC 50 = 10.2) and a PDE4 inhibitor (p IC 50 = 8.8), designed for inhalation-based treatment of</p>Fórmula:C36H37Cl2N3O7SCor e Forma:SolidPeso molecular:726.67MK-0969
CAS:<p>MK-0969 (J-104135) is a possible M3 antagonist for the treatment of chronic obstructive pulmonary disease.</p>Fórmula:C24H30F2N4O2Cor e Forma:SolidPeso molecular:444.52Fentonium bromide
CAS:<p>Fentonium bromide is a biochemical.</p>Fórmula:C31H34BrNO4Cor e Forma:SolidPeso molecular:564.51[D-Trp7,9,10]-Substance P
CAS:<p>Substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors.</p>Fórmula:C79H105N21O13SPureza:98%Cor e Forma:SolidPeso molecular:1588.89Small Cardioactive Peptide B (SCPB)
CAS:<p>SCPB: neurally active peptide, boosts adenylate cyclase in heart/gills, EC50s: 0.1 μM (heart), 1.0 μM (gills).</p>Fórmula:C52H80N14O11S2Pureza:98%Cor e Forma:SolidPeso molecular:1141.41TDI-10229
CAS:<p>TDI-10229: potent oral sAC inhibitor, IC50=195 nM. Good mouse pharmacokinetics for in vivo use.</p>Fórmula:C16H16ClN5Pureza:99.85% - 99.89%Cor e Forma:SoildPeso molecular:313.78DSPE-PEG5000-RVG29
<p>DSPE-PEG5000-RVG29 is a PEG compound comprised of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 specifically binds to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB) and facilitates passage through the BBB.</p>Cor e Forma:Odour SolidAceclidine (hydrochloride)
CAS:<p>agonist of muscarinic receptors</p>Fórmula:C9H16ClNO2Pureza:98%Cor e Forma:SolidPeso molecular:205.68Ebiratide
CAS:<p>Ebiratide is an analog of ACTH 4-9.</p>Fórmula:C48H73N11O10SPureza:98%Cor e Forma:SolidPeso molecular:996.23R-(+)-Cotinine
CAS:<p>R-(+)-Cotinine, an inactive nicotine metabolite, boosts Ach-induced current in human α7 nAChRs.</p>Fórmula:C10H12N2OCor e Forma:SolidPeso molecular:176.22VU6028418
CAS:<p>VU6028418 is a highly selective, potent, orally active M4mAChR antagonist that acts on hM4 (IC50: 4.1 nM).</p>Cor e Forma:SolidThiothixene
CAS:<p>Thiothixene has a wide range of applications in life science related research.</p>Fórmula:C23H29N3O2S2Cor e Forma:SolidPeso molecular:443.62Epiboxidine hydrochloride
CAS:<p>Epiboxidine HCl: potent α4β2 nAChR agonist; Ki 0.46 nM (rat), 1.2 nM (human); Epibatidine analog.</p>Fórmula:C10H15ClN2OCor e Forma:SolidPeso molecular:214.69Dicloromezotiaz
CAS:<p>Dicloromezotiaz: Potent insecticide targeting nAChRs, controls various lepidoptera.</p>Fórmula:C19H12Cl3N3O2SCor e Forma:SolidPeso molecular:452.74Proadrenomedullin (1-20), human
CAS:<p>Endogenous peptide; agonist of MRGPRX2 (EC50=251 nM); noncompetitive inhibitor of nicotinic receptors; reduces catecholamine secretion; antihypertensive.</p>Fórmula:C112H178N36O27Pureza:98%Cor e Forma:SolidPeso molecular:2460.84(+)-Coclaurine hydrochloride
CAS:<p>(+)-Coclaurine hydrochloride, also known as (+)-(R)-Coclaurine, is a benzyltetrahydroisoquinoline alkaloid extracted from multiple plant species.</p>Fórmula:C17H20ClNO3Pureza:98%Cor e Forma:SolidPeso molecular:321.8LtIA-F
<p>LtIA-F, a fluorescent LtIA derivative, aids study of α3β2 nAChR's structure, distribution, and binding domain.</p>Fórmula:C86H121N25O22S4Cor e Forma:SolidPeso molecular:1985.31(S)-Dinotefuran
CAS:<p>(S)-Dinotefuran, a neonicotinoid, more toxic to bees than its R-isomer, targets α8 nAChR.</p>Fórmula:C7H14N4O3Cor e Forma:SolidPeso molecular:202.21nAChR agonist 2
CAS:<p>Compound 8, identified as a selective alpha4beta2 (α4β2) neuronal acetylcholine receptor (nAChR) agonist, demonstrates a dissociation constant (Kd) of 26 nM,</p>Fórmula:C11H16N2Cor e Forma:SolidPeso molecular:176.263M4 mAChR agonist-1
CAS:<p>M4 mAChR agonist-1 (4-Piperidinecarboxamide, 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-) is an effective agonist of M4 mAChR (EC50 >10 μM).</p>Fórmula:C14H18N4OSPureza:99.14%Cor e Forma:SolidPeso molecular:290.38ANQ-9040
CAS:<p>ANQ-9040 is a nondepolarizing neuromuscular relaxant of the steroid class.</p>Fórmula:C36H58N2O5SCor e Forma:SolidPeso molecular:630.92Oxotremorine
CAS:<p>Oxotremorine acts as an agonist of mAChR, specifically activating the M1 and M3 acetylcholine receptors. In drug discrimination experiments with macaques, it exhibits effects similar to nicotine.</p>Fórmula:C12H18N2OCor e Forma:SolidPeso molecular:206.28Br-PBTC
CAS:<p>Br-PBTC modulates nAChRs; targets α2/β2,4 subtypes; potent with 0.1-0.6 μM EC50; binds α subunit c-tail.</p>Fórmula:C14H15BrN2OSCor e Forma:SolidPeso molecular:339.25Guanylyl Imidodiphosphate (lithium salt)
CAS:<p>Guanylyl Imidodiphosphate (lithium salt) is a non-hydrolyzable GTP analog that increases adenylate cyclase activity.</p>Fórmula:C10H13Li4N6O13P3Cor e Forma:SolidPeso molecular:545.93nAChR modulator-2
CAS:<p>nAChR modulator-2, a insecticide, is a insect nAChR orthosteric modulator [1] .</p>Fórmula:C12H8ClN3O2Cor e Forma:SolidPeso molecular:261.66Irsogladine maleate
CAS:<p>Compound PDK0375, with CAS No. 84504-69-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0375 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Fórmula:C9H7Cl2N5Cor e Forma:SolidPeso molecular:256.09trans-Cevimeline hydrochloride
CAS:<p>AF 102A hydrochloride is a biochemical.</p>Fórmula:C10H18ClNOSCor e Forma:SolidPeso molecular:235.77Albanin A
<p>Albanin A is a useful organic compound for research related to life sciences and the catalog number is T124310.</p>Fórmula:C20H18O6Cor e Forma:SolidPeso molecular:354.358Hydroxybupropion
CAS:<p>Hydroxybupropion is the major active metabolite of Bupropion and an antagonist of nACh receptor. Hydroxybupropion inhibits norepinephrine uptake (IC50 = 1.7 μM).</p>Fórmula:C13H18ClNO2Pureza:99.73%Cor e Forma:Off-White SolidPeso molecular:255.74nAChR modulator-1
CAS:<p>nAChR modulator-1, a insecticide, is a insect nAChR orthosteric modulator [1] .</p>Fórmula:C12H8ClN3O2Cor e Forma:SolidPeso molecular:261.66bPiDDB
CAS:<p>bPiDDB (N,N'-Dodecylbis-Picolinium Bromide) is a nicotinic receptor (nAChR) antagonist.</p>Fórmula:C24H38Br2N2Pureza:98.72%Cor e Forma:SolidPeso molecular:514.38Octamylamine
CAS:<p>Octamylamine is a bioactive chemical.</p>Fórmula:C13H29NCor e Forma:SolidPeso molecular:199.3761
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