AChR
Os inibidores do receptor de acetilcolina (AChR) são compostos que bloqueiam a atividade dos receptores de acetilcolina, essenciais para a neurotransmissão nos sistemas nervosos central e periférico. Os AChRs desempenham um papel vital na contração muscular, memória e funções cognitivas. Os inibidores de AChRs são usados para estudar condições como miastenia gravis, doença de Alzheimer e outros distúrbios neurológicos. Ao modular a atividade dos AChRs, esses inibidores podem ajudar a desvendar as complexidades da sinalização colinérgica no cérebro. Na CymitQuimica, oferecemos uma gama de inibidores de AChRs para apoiar sua pesquisa em neurociência, farmacologia e doenças neurodegenerativas.
Foram encontrados 575 produtos de "AChR"
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M4 mAChR agonist-1
CAS:<p>M4 mAChR agonist-1 (4-Piperidinecarboxamide, 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-) is an effective agonist of M4 mAChR (EC50 >10 μM).</p>Fórmula:C14H18N4OSPureza:99.14%Cor e Forma:SolidPeso molecular:290.38Muscarine
CAS:<p>Muscarine is a toxic alkaloid found in Amanita muscaria and other fungi of the Inocybe species.</p>Fórmula:C9H20NO2Pureza:98%Cor e Forma:SolidPeso molecular:174.26M3/PDE4 modulator-1
<p>M3/PDE4 Modulator-1 (compound 10f) serves as a bifunctional entity functioning both as an M3 mAChR antagonist and a PDE4 inhibitor.</p>Fórmula:C38H41Cl2N3O8SCor e Forma:SolidPeso molecular:770.725-AMAM-2-CP
CAS:<p>5-AMAM-2-CP, a significant metabolite of Acetamiprid, serves as a global insecticide within the neonicotinoid class and acts as an nAChR agonist [1] [2].</p>Fórmula:C9H11ClN2OCor e Forma:SolidPeso molecular:198.65(R)-Dinotefuran
CAS:<p>(R)-Dinotefuran, a neonicotinoid, is 1.7-2.4x more effective against pests like Aphis gossypii and safer for bees.</p>Fórmula:C7H14N4O3Cor e Forma:SolidPeso molecular:202.21Ebiratide TFA
<p>Ebiratide (HOE-427) TFA is a derivative of ACTH4-9 that exerts its effect directly on the central nervous system, enhancing memory. Ebiratide TFA also promotes the metabolism of acetylcholine (ACh) in the rat brain.</p>Fórmula:C48H73N11O10S·xC2HF3O2Cor e Forma:SolidPeso molecular:996.23 (free base)TDI-10229
CAS:<p>TDI-10229: potent oral sAC inhibitor, IC50=195 nM. Good mouse pharmacokinetics for in vivo use.</p>Fórmula:C16H16ClN5Pureza:99.85% - 99.89%Cor e Forma:SoildPeso molecular:313.78BTMPS
CAS:<p>BTMPS is a usage-dependent nicotinic antagonist capable of reducing acute withdrawal symptoms associated with morphine use.</p>Fórmula:C28H52N2O4Pureza:98.1%Cor e Forma:SolidPeso molecular:480.72Anabaseine
CAS:<p>Anabaseine is a broad nicotinic agonist, favoring alpha-7 AChRs in muscle/brain, and weakly stimulates alpha-4 beta-2 nAChRs.</p>Fórmula:C10H12N2Cor e Forma:SolidPeso molecular:160.22N-Ethyl-N-(3-pyridylmethyl)amine
CAS:<p>N-Ethyl-N-(3-pyridylmethyl)amine has affinity for nAChR (Ki = 0.97 µM) and can be used in related research in the field of life sciences.</p>Fórmula:C8H12N2Pureza:99.65%Cor e Forma:SolidPeso molecular:136.19Soclenicant
CAS:<p>Soclenicant is a negative-altering modulator of α 7 -nAChR for anxiety, depression, and PTSD, due to its high selectivity, oral availability</p>Fórmula:C24H26N4O3Pureza:99.57%Cor e Forma:SoildPeso molecular:418.49Rivanicline 2HCl
<p>Rivanicline 2HCl is a selective neuronal nicotinic receptor inhibitor with a high affinity for the α4β2 subtype.</p>Fórmula:C10H16Cl2N2Pureza:99.4%Cor e Forma:SoildPeso molecular:235.15Proadrenomedullin (1-20), human
CAS:<p>Endogenous peptide; agonist of MRGPRX2 (EC50=251 nM); noncompetitive inhibitor of nicotinic receptors; reduces catecholamine secretion; antihypertensive.</p>Fórmula:C112H178N36O27Pureza:98%Cor e Forma:SolidPeso molecular:2460.84TC-2559 difumarate
CAS:<p>TC-2559 difumarate: Oral α4β2 nAChR partial agonist, CNS-selective, EC50 0.18 μM, prefers α4β2 over α2β4/α4β4/α3β4, antinociceptive.</p>Fórmula:C20H26N2O9Cor e Forma:SolidPeso molecular:438.43Bensultap
CAS:<p>Bensultap is an agricultural chemical typically used as a pesticide.</p>Fórmula:C17H21NO4S4Pureza:98%Cor e Forma:SolidPeso molecular:431.61Ebiratide
CAS:<p>Ebiratide is an analog of ACTH 4-9.</p>Fórmula:C48H73N11O10SPureza:98%Cor e Forma:SolidPeso molecular:996.23GeX-2
CAS:<p>GeX-2 is a truncated analogue of αO-conotoxin. It has the ability to activate GABAB receptors and inhibit α9α10nAChR as well as CaV2.2 channels. Additionally, GeX-2 is effective in alleviating pain in a rat model of chronic constriction injury.</p>Fórmula:C103H169N43O27Cor e Forma:SolidPeso molecular:2441.72Aceclidine (hydrochloride)
CAS:<p>agonist of muscarinic receptors</p>Fórmula:C9H16ClNO2Pureza:98%Cor e Forma:SolidPeso molecular:205.68Tropicamide
CAS:<p>Tropicamide (Ro 1-7683), a synthetic atropine-like muscarinic antagonist, dilates pupils and paralyzes eye muscles for diagnostic use.</p>Fórmula:C17H20N2O2Pureza:99.78% - 99.94%Cor e Forma:White PowderPeso molecular:284.35Navafenterol
CAS:<p>AZD-8871, a potential COPD and asthma treatment, may work well with ICS.</p>Fórmula:C38H42N6O6S2Cor e Forma:SolidPeso molecular:742.91α-Conotoxin PIA
CAS:<p>Selective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC50 values are 0.95 and 74.2 nM</p>Fórmula:C79H125N27O25S4Pureza:98%Cor e Forma:SolidPeso molecular:1981.3(-)-OPC-51803
CAS:<p>(-)-OPC-51803 is an antidiuretic hormone V2 receptor agonist used in the treatment of nocturia and urinary incontinence.</p>Fórmula:C26H32ClN3O2Pureza:98.73% - 99.59%Cor e Forma:SoildPeso molecular:454(rel)-Asperparaline A
CAS:<p>Aspergillimide, from A. japonicus, inhibits silkworm neuron nAChRs (IC50s: 20.2/39.6 nM), not affecting chicken nAChRs, and paralyzes silkworm larvae.</p>Fórmula:C20H29N3O3Cor e Forma:SolidPeso molecular:359.47sabcomeline
CAS:<p>Sabcomeline: potent, selective M1 agonist; boosts cognition; for Alzheimer's study.</p>Fórmula:C10H15N3OCor e Forma:SolidPeso molecular:193.25DSPE-PEG2000-RVG29
<p>DSPE-PEG2000-RVG29 is a PEG compound composed of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 specifically binds to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB) and can traverse the BBB.</p>Cor e Forma:Odour SolidLu AE51090
CAS:<p>Lu AE51090 is a selective muscarinic M1 receptor agonist with minimal off-target effects, receptor function and selective pharmacological modulation.</p>Fórmula:C24H29N3O3Pureza:99.57%Cor e Forma:SolidPeso molecular:407.515-AAM-2-CP
CAS:<p>5-AAM-2-CP is one of the major metabolites of Acetamiprid. Acetamiprid, a nAChR agonist, is a neonicotinoid insecticide used worldwide.</p>Fórmula:C8H9ClN2OPureza:99.58%Cor e Forma:SolidPeso molecular:184.62(R)-(+)-Anatabine
CAS:<p>(R)-(+)-Anatabine is an less active R-enantiomer of Anatabine. Anatabine is a potent agonist of α4β2 nAChR.</p>Fórmula:C10H12N2Pureza:98%Cor e Forma:SolidPeso molecular:160.22(Rac)-Sabcomeline
CAS:<p>(Rac)-Sabcomeline ((Rac)-SB-202026) is an M1/M4 muscarinic agonist used in the study of neurologic disorders such as schizophrenia.</p>Fórmula:C10H15N3OPureza:99.14%Cor e Forma:SolidPeso molecular:193.25LAS190792
CAS:<p>LAS190792 (AZD8999) is a dual muscarinic antagonist/β2-agonist, pIC50s (M1-M5, β1-β3): 8.9-5.6; used as a bronchodilator.</p>Fórmula:C39H43ClN4O9S2Cor e Forma:SolidPeso molecular:811.36Br-PBTC
CAS:<p>Br-PBTC modulates nAChRs; targets α2/β2,4 subtypes; potent with 0.1-0.6 μM EC50; binds α subunit c-tail.</p>Fórmula:C14H15BrN2OSCor e Forma:SolidPeso molecular:339.25β2AR/M-receptor agonist-1
CAS:<p>β2AR/M-receptor agonist-1 (example 131), a muscarinic antagonist and β2 adrenoceptor agonist (MABA), exhibits dual potency towards β2 adrenoceptor and</p>Fórmula:C43H56BrN3O7Cor e Forma:SolidPeso molecular:806.82Dexetimide
CAS:<p>Dexetimide, a muscarinic receptor antagonist, treats neuroleptic-induced parkinsonism.</p>Fórmula:C23H26N2O2Cor e Forma:SolidPeso molecular:362.46Metixene hydrochloride hydrate
CAS:<p>Metixene HCl hydrate is a potential anticholinergic for Parkinson's with IC50 of 55 nM and Ki of 15 nM against muscarine receptors.</p>Fórmula:C20H26ClNOSPureza:99.88%Cor e Forma:SolidPeso molecular:363.95Fipexide hydrochloride
CAS:<p>Fipexide (hydrochloride) is a kind of psychoactive drug of the piperazine class.</p>Fórmula:C20H22Cl2N2O4Cor e Forma:SolidPeso molecular:425.31NKH477
CAS:<p>NKH477 (Colforsin dapropate hydrochloride) is a derivative of forskolin with antidepressant activity.</p>Fórmula:C27H44ClNO8Pureza:98% - 98%Cor e Forma:SolidPeso molecular:546.09Tolterodine
CAS:<p>Tolterodine ((R)-(+)-Tolterodine) is an mACh antagonist used in the treatment of detrusor instability and overactive bladder syndrome.</p>Fórmula:C22H31NOPureza:99.71%Cor e Forma:White Like Or Light Brown Crystalline PowderPeso molecular:325.49YM-58790 hydrochloride
CAS:<p>YM-58790 is a potent M3 muscarinic receptor antagonist(Ki of 15 nM).</p>Fórmula:C27H32ClN3O2Pureza:98%Cor e Forma:SolidPeso molecular:466.02Palmatine hydroxide
CAS:<p>Palmatine hydroxide: oral IDO-1 inhibitor (IC50: 3-157μM), targets WNV protease, has anti-cancer/viral and neuroprotective properties.</p>Fórmula:C21H23NO5Cor e Forma:SolidPeso molecular:369.41Cevimeline
CAS:<p>Cevimeline: muscarinic agonist, treats dry mouth & Sjögren's, boosts saliva post-cancer radiotherapy.</p>Fórmula:C10H17NOSCor e Forma:Off-White SolidPeso molecular:199.31Pirmenol hydrochloride
CAS:<p>Pirmenol hydrochloride functions by inhibiting I_K.ACh through the blockade of muscarinic receptors, demonstrating a potent effect with an IC_50 value of 0.1 μM</p>Fórmula:C22H31ClN2OCor e Forma:SolidPeso molecular:374.95Varenicline Hydrochloride
CAS:<p>Varenicline Hydrochloride (CP 526555) is an orally active partial agonist of the α4β2 nicotinic acetylcholine receptor (α4β2 nAChR, IC50 = 250 nM).</p>Fórmula:C13H14ClN3Pureza:99.854%Cor e Forma:SolidPeso molecular:247.72Cevimeline hydrochloride
CAS:<p>Cevimeline HCl is a muscarinic agonist enhancing salivary and sweat gland secretion.</p>Fórmula:C10H18ClOSCor e Forma:SolidPeso molecular:235.77Glycerophosphoinositol choline
CAS:<p>Glycerophosphoinositol choline is the salt of choline and glycerophosphoinositol.</p>Fórmula:C14H32NO12PCor e Forma:SolidPeso molecular:437.38Ispronicline
CAS:<p>Ispronicline (TC-1734) An orally active, selective, and potent α4β2 nAChR partial agonist with antidepressant, neuroprotective, and long-lasting cognitive</p>Fórmula:C14H22N2OPureza:97.70% - 99.16%Cor e Forma:SolidPeso molecular:234.34Sabcomeline hydrochloride
CAS:<p>Sabcomeline is a selective M1 receptor partial agonist.</p>Fórmula:C10H16ClN3OCor e Forma:SolidPeso molecular:229.71(±)-Darifenacin
CAS:<p>(±)-Darifenacin is the racemate of Darifenacin. Darifenacin is a selective antagonist of M3 muscarinic receptor.</p>Fórmula:C28H30N2O2Cor e Forma:SolidPeso molecular:426.55VU0467485
CAS:<p>VU0467485 boosts ACh at M4 receptors (EC50: 26.6 nM rat, 78.8 nM human), selective for M4 over M1/2/3/5.</p>Fórmula:C17H17FN4O2SPureza:98%Cor e Forma:SolidPeso molecular:360.41Clorprenaline
CAS:<p>Clorprenaline is a β-adrenergic receptor agonist that activates adenylate cyclase, relaxation of bronchial smooth muscle cells. anti-inflammatory.</p>Fórmula:C11H16ClNOPureza:98.9%Cor e Forma:SolidPeso molecular:213.7ABT-107
CAS:<p>ABT-107: α7 neuronal receptor agonist; protects rats' brains from 6-OHDA-induced damage.</p>Fórmula:C19H20N4OCor e Forma:SolidPeso molecular:320.396
