AChR
Os inibidores do receptor de acetilcolina (AChR) são compostos que bloqueiam a atividade dos receptores de acetilcolina, essenciais para a neurotransmissão nos sistemas nervosos central e periférico. Os AChRs desempenham um papel vital na contração muscular, memória e funções cognitivas. Os inibidores de AChRs são usados para estudar condições como miastenia gravis, doença de Alzheimer e outros distúrbios neurológicos. Ao modular a atividade dos AChRs, esses inibidores podem ajudar a desvendar as complexidades da sinalização colinérgica no cérebro. Na CymitQuimica, oferecemos uma gama de inibidores de AChRs para apoiar sua pesquisa em neurociência, farmacologia e doenças neurodegenerativas.
Foram encontrados 575 produtos de "AChR"
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(±)-Darifenacin
CAS:<p>(±)-Darifenacin is the racemate of Darifenacin. Darifenacin is a selective antagonist of M3 muscarinic receptor.</p>Fórmula:C28H30N2O2Cor e Forma:SolidPeso molecular:426.55ABT-107
CAS:<p>ABT-107: α7 neuronal receptor agonist; protects rats' brains from 6-OHDA-induced damage.</p>Fórmula:C19H20N4OCor e Forma:SolidPeso molecular:320.396VU0467485
CAS:<p>VU0467485 boosts ACh at M4 receptors (EC50: 26.6 nM rat, 78.8 nM human), selective for M4 over M1/2/3/5.</p>Fórmula:C17H17FN4O2SPureza:98%Cor e Forma:SolidPeso molecular:360.41Clorprenaline
CAS:<p>Clorprenaline is a β-adrenergic receptor agonist that activates adenylate cyclase, relaxation of bronchial smooth muscle cells. anti-inflammatory.</p>Fórmula:C11H16ClNOPureza:98.9%Cor e Forma:SolidPeso molecular:213.7NSC 23766
CAS:<p>NSC 23766 is a Rac1 GTPase inhibitor by targeting GEFs, inhibiting cell proliferation.NSC23766 competitively inhibits M2 mAChR-induced Rac1 activation.</p>Fórmula:C24H35N7Pureza:99.49%Cor e Forma:SolidPeso molecular:421.58NKH477
CAS:<p>NKH477 (Colforsin dapropate hydrochloride) is a derivative of forskolin with antidepressant activity.</p>Fórmula:C27H44ClNO8Pureza:98% - 98%Cor e Forma:SolidPeso molecular:546.09Cevimeline
CAS:<p>Cevimeline: muscarinic agonist, treats dry mouth & Sjögren's, boosts saliva post-cancer radiotherapy.</p>Fórmula:C10H17NOSCor e Forma:Off-White SolidPeso molecular:199.31Pirmenol hydrochloride
CAS:<p>Pirmenol hydrochloride functions by inhibiting I_K.ACh through the blockade of muscarinic receptors, demonstrating a potent effect with an IC_50 value of 0.1 μM</p>Fórmula:C22H31ClN2OCor e Forma:SolidPeso molecular:374.95Tolterodine
CAS:<p>Tolterodine ((R)-(+)-Tolterodine) is an mACh antagonist used in the treatment of detrusor instability and overactive bladder syndrome.</p>Fórmula:C22H31NOPureza:99.71%Cor e Forma:White Like Or Light Brown Crystalline PowderPeso molecular:325.49Sabcomeline hydrochloride
CAS:<p>Sabcomeline is a selective M1 receptor partial agonist.</p>Fórmula:C10H16ClN3OCor e Forma:SolidPeso molecular:229.71DL-Cystine
CAS:<p>DL-Cystine is a cysteine derivative that inhibits endothelial cell proliferation by regulating TGFβ1. a GPR inhibitor and nAChR agonist .</p>Fórmula:C6H12N2O4S2Cor e Forma:SolidPeso molecular:240.3NS3861 fumarate
CAS:<p>NS3861 fumarate, a partial α3β4 nAChR agonist, binds α3β2, α4β4, α4β2 with Ki values of 0.62, 25, 7.8, 55 nM.</p>Fórmula:C16H18BrNO4SCor e Forma:SolidPeso molecular:400.29Tebanicline dihydrochloride
CAS:<p>Tebanicline dihydrochloride: oral analgesic, nAChR modulator, Ki=37 pM at α4β2 receptors, inhibits cytisine binding.</p>Fórmula:C9H13Cl3N2OCor e Forma:SolidPeso molecular:271.57Tebanicline hydrochloride
CAS:<p>Tebanicline hydrochloride (Ebanicline hydrochloride) , is an effective synthetic nicotinic (non-opioid) analgesic drug.</p>Fórmula:C9H12Cl2N2OPureza:91.74% - 98.71%Cor e Forma:SolidPeso molecular:235.11VU0119498
CAS:<p>VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.</p>Fórmula:C15H10BrNO2Pureza:97.56%Cor e Forma:SolidPeso molecular:316.15VU0152100
CAS:<p>VU0152100 is an effective and selective allosteric potentiator of M4 mAChR (EC50: 380 ± 93 nM).</p>Fórmula:C18H19N3O2SPureza:99.56%Cor e Forma:SolidPeso molecular:341.43Nitrobenzylthioinosine
CAS:<p>Nitrobenzylthioinosine (NBMPR) is an inhibitor of ENT1 transporter that binds to ENT1 transporter with high affinity.</p>Fórmula:C17H17N5O6SPureza:99.69% - 99.74%Cor e Forma:Off-White SolidPeso molecular:419.41VU0467154
CAS:<p>VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor.</p>Fórmula:C17H15F3N4O3S2Pureza:98.28% - 99.51%Cor e Forma:SolidPeso molecular:444.45NS9283
CAS:<p>NS9283, a positive allosteric modulator selective for the α4β2 form, reduces ethanol consumption.</p>Fórmula:C14H8N4OPureza:99.12%Cor e Forma:SolidPeso molecular:248.24BNC210
CAS:<p>BNC210 (IW-2143) is a α7 nAChR negative allosteric modulator. BNC210 has potent activity in animal models of anxiety and depression.</p>Fórmula:C17H23N3O3Pureza:97.05% - >99.99%Cor e Forma:SolidPeso molecular:317.38ML380
CAS:<p>ML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM).</p>Fórmula:C23H25F3N4O3SPureza:99.69%Cor e Forma:SolidPeso molecular:494.53Isopropamide Iodide
CAS:<p>Isopropamide iodide: long-acting anticholinergic, treats peptic ulcers, GI disorders, Alzheimer's.</p>Fórmula:C23H33IN2OPureza:99.67%Cor e Forma:SolidPeso molecular:480.43Mc-Val-Ala-PAB
CAS:<p>Mc-Val-Ala-PAB, an effective linker, is utilized in antibody-drug-conjugate (ADC).</p>Fórmula:C25H34N4O6Pureza:98.34% - 99.24%Cor e Forma:SolidPeso molecular:486.56Donepezil Hydrochloride
CAS:<p>Donepezil HCl(Aricept) is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).</p>Fórmula:C24H29NO3·HClPureza:99.55% - 99.8%Cor e Forma:White To Off-White Crystalline SolidPeso molecular:415.96Nitenpyram
CAS:<p>Nitenpyram (Capstar) is a nicotinic acetylcholine receptor (AchR) agonist, used as veterinary medicine to treat parasites of livestock and pets.</p>Fórmula:C11H15ClN4O2Pureza:99.03%Cor e Forma:Light-Yellow CrystalPeso molecular:270.72Mecamylamine hydrochloride
CAS:<p>Mecamylamine hydrochloride (Mevasin) is a nicotinic antagonist, used as a ganglionic blocker in hypertension.</p>Fórmula:C11H22ClNPureza:99.76% - >99.99%Cor e Forma:White SolidPeso molecular:203.75Solifenacin hydrochloride
CAS:<p>Solifenacin Hcl is a muscarinic receptor antagonist.</p>Fórmula:C23H27ClN2O2Pureza:98%Cor e Forma:SolidPeso molecular:398.93Encenicline
CAS:<p>Encenicline (EVP-6124), a selective α7 nAChRs agonist, targets cognitive impairment in schizophrenia and Alzheimer's.</p>Fórmula:C16H17ClN2OSPureza:99.20%Cor e Forma:SolidPeso molecular:320.84VU0238441
CAS:<p>VU0238441 is agonist of Muscarinic acetylcholine receptor M5 (human) with EC50 of 2.1μM.</p>Fórmula:C16H9ClF3NO2Pureza:100%Cor e Forma:SolidPeso molecular:339.7Solifenacin
CAS:Solifenacin (YM905 free base) (YM905 free base) is a novel muscarinic receptor antagonist, its pKis for M1, M2 and M3 receptors is of 7.6, 6.9 and 8.0,Fórmula:C23H26N2O2Pureza:99.87%Cor e Forma:SolidPeso molecular:362.46Pempidine
CAS:<p>Pempidine (1,2,2,6,6-Pentamethylpiperidine) is a nicotinic antagonist, has been used as a ganglionic blocker in the treatment of hypertension.</p>Fórmula:C10H21NPureza:98.18% - 99.28%Cor e Forma:Colorless - Light Yellow Clear LiquidPeso molecular:155.28Oxyphencyclimine Hydrochloride
CAS:<p>Oxyphencyclimine Hydrochloride (Ulcociclinina) is a synthetic tertiary amine and antimuscarinic agent with antispasmodic and antisecretory activities.</p>Fórmula:C20H29ClN2O3Pureza:99.55%Cor e Forma:SolidPeso molecular:380.91Mecamylamine
CAS:<p>Mecamylamine: oral, noncompetitive nAChR blocker, crosses blood-brain barrier, for neuropsychiatric and hypertension research.</p>Fórmula:C11H21NCor e Forma:SolidPeso molecular:167.29Propiverine
CAS:<p>Propiverine reduces muscle spasms by limiting calcium influx, targeting bladder smooth muscles, aiding OAB research.</p>Fórmula:C23H29NO3Cor e Forma:SolidPeso molecular:367.48DMAB-anabaseine dihydrochloride
CAS:<p>DMAB-anabaseine dihydrochloride (N,N-dimethyl-4-[(E)-(6-pyridin-3-yl-3,4-dihydro-2H-pyridin-5-ylidene)methyl]aniline;dihydrochloride) is an α7-containing</p>Fórmula:C19H23Cl2N3Pureza:99.91%Cor e Forma:SolidPeso molecular:364.31NS 1738
CAS:<p>NS 1738 (NSC-213859) is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs)</p>Fórmula:C14H9Cl2F3N2O2Pureza:99.11%Cor e Forma:SolidPeso molecular:365.13Ethyl (triphenylphosphoranylidene) acetate
CAS:<p>Ethyl (triphenylphosphoranylidene) acetate ((Carbethoxymethylene)triphenylphosphorane) may act as an cholinesterase inhibitor that inhibits AChE and BChE.</p>Fórmula:C22H21O2PPureza:97.985%Cor e Forma:White Or Slight Yellow PowderPeso molecular:348.37Oxyphenonium bromide
CAS:<p>Oxyphenonium bromide is an anticholinergic used to study and treat ulcers and relieve visceral spasms.</p>Fórmula:C21H34BrNO3Pureza:98.96%Cor e Forma:SolidPeso molecular:428.404Propantheline
CAS:<p>Propantheline: oral muscarinic receptor blocker for smooth muscle issues, hyperhidrosis, and bladder control.</p>Fórmula:C23H30NO3Cor e Forma:SolidPeso molecular:368.49MC-Val-Cit-PABC-PNP
CAS:<p>MC-Val-Cit-PABC-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker.</p>Fórmula:C35H43N7O11Pureza:97.2% - 98.055%Cor e Forma:SolidPeso molecular:737.76Mivacurium dichloride
CAS:<p>Mivacurium dichloride: non-depolarizing, quick-acting muscle relaxant for minor surgeries and tracheal intubation.</p>Fórmula:C58H80Cl2N2O14Pureza:99.2% - 99.48%Cor e Forma:Off-White SolidPeso molecular:1100.17Bestim
CAS:<p>Bestim is an immunomodulatory dipeptide that is synthetic.</p>Fórmula:C16H19N3O5Pureza:99.76%Cor e Forma:SolidPeso molecular:333.34Fesoterodine
CAS:<p>Fesoterodine is an oral mAChR blocker (pKi: 7.3-8.0) for M1-M5, used to treat OAB.</p>Fórmula:C26H37NO3Pureza:97.1%Cor e Forma:SolidPeso molecular:411.58Cyclopentolate Hydrochloride
CAS:<p>Cyclopentolate Hydrochloride is a muscarinic acetylcholine receptors antagonist with Kis of 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively.</p>Fórmula:C17H26ClNO3Pureza:99.91%Cor e Forma:SolidPeso molecular:327.85Rivanicline hemioxalate
<p>Rivanicline hemioxalate is a selective α4β2 nicotinic receptor agonist (K i =26 nM), over 1,000x preference to α7 (K i =3.6 μM), with limited side effects.</p>Fórmula:C12H16N2O4Pureza:98%Cor e Forma:SolidPeso molecular:207.23A-867744
CAS:<p>A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).</p>Fórmula:C20H19ClN2O3SPureza:95.66%Cor e Forma:SolidPeso molecular:402.89VU0152099
CAS:<p>VU0152099 is a potent and selective M4 mAChR allosteric potentiator(EC50 = 380 ± 93 nM).</p>Fórmula:C18H17N3O3SPureza:98.46%Cor e Forma:SolidPeso molecular:355.41Encenicline hydrochloride
CAS:<p>Encenicline hydrochloride (EVP-6124 hydrochloride) is a new-type partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).</p>Fórmula:C16H17ClN2OS·HClPureza:98.34% - 99.85%Cor e Forma:SolidPeso molecular:357.3Coluracetam
CAS:<p>Coluracetam (MKC-231)(MKC-231) is a Choline Uptake Enhancer.</p>Fórmula:C19H23N3O3Pureza:99.96%Cor e Forma:SolidPeso molecular:341.4suvn-911
CAS:<p>suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity.</p>Fórmula:C11H14Cl2N2OPureza:98.88%Cor e Forma:SolidPeso molecular:261.15
