Proteassoma
Os inibidores de proteassoma são compostos que inibem o proteassoma, um grande complexo proteico responsável pela degradação de proteínas indesejadas ou danificadas dentro da célula. A inibição do proteassoma leva ao acúmulo de proteínas, o que pode induzir a parada do ciclo celular e a apoptose, especialmente em células de rápida divisão, como as células cancerosas. Os inibidores de proteassoma são cruciais na pesquisa e terapia do câncer, especialmente no tratamento do mieloma múltiplo e outras malignidades hematológicas. Na CymitQuimica, oferecemos inibidores de proteassoma para apoiar sua pesquisa em oncologia, biologia celular e desenvolvimento de fármacos.
Foram encontrados 91 produtos para "Proteassoma".
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Phepropeptin C
CAS:Phepropeptin C is a microbial secondary metabolite that acts as a proteasome (proteasome) inhibitor, with an IC50 of 12.5 μg/mL.Fórmula:C38H60N6O6Cor e Forma:SolidPeso molecular:696.92Proteasome-IN-7
Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.Fórmula:C48H56N6O10SCor e Forma:SolidPeso molecular:909.06Calpastatin subdomain B
CAS:Calpastatin subdomain B is a bioactive peptide that inhibits calpain activity.Fórmula:C140H227N35O44SPureza:98%Cor e Forma:SolidPeso molecular:3136.57Acetyl-Calpastatin(184-210)(human)
CAS:Calpain inhibitor, Ki 0.2 nM for calpain I/II, doesn't affect papain/trypsin/cat L. Raises Aβ42, Aβ40 secretion & Aβ42/Aβ40 ratio.Fórmula:C142H230N36O44SPureza:98%Cor e Forma:SolidPeso molecular:3177.65Dazcapistat
CAS:Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.Fórmula:C21H18FN3O4Pureza:99.11%Cor e Forma:SolidPeso molecular:395.38Ref: TM-T9710
1mg92,00€5mg192,00€1mL*10mM (DMSO)212,00€10mg289,00€25mg522,00€50mg732,00€100mg1.018,00€β5i-IN-1
β5i-IN-1 is a selective inhibitor of β5i, exhibiting potent activity with an IC50 of 8.463 nM.Pureza:98%Cor e Forma:Odour SolidDPP-4-IN-14
DPP-4-IN-14 (compound 30) is an inhibitor of DPP-4, with an IC50 value of 12.82 nM.Fórmula:C33H27N7O3Cor e Forma:SolidPeso molecular:569.613Protease Inhibitor Library
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;Cor e Forma:Odour SolidRef: TM-L1100
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarLXE408 fumarate
LXE408 fumarate: orally available, selective kinetoplastid proteasome inhibitor with IC50/EC50 of 0.04 μM for L. donovani; potentially aids in VL research.Fórmula:C27H22FN7O6Pureza:99.89%Cor e Forma:SolidPeso molecular:559.51Ref: TM-T39214L
1mg299,00€2mg447,00€5mg563,00€1mL*10mM (DMSO)830,00€10mg897,00€25mg1.324,00€50mg1.791,00€100mg2.412,00€SGLT2-IN-6
SGLT2-IN-6 (Compound 101) is an orally active SGLT2 inhibitor with IC₅₀ values of 0.8 nM, 6.7 nM, and 72 nM for SGLT2, SGLT1, and DPP4, respectively. In diabetic rat models, SGLT2-IN-6 controls blood glucose levels and increases active GLP-1 levels. It is suitable for research on type 2 diabetes.Acetyl-Calpastatin(184-210)(human), Negative Control
Acetyl-Calpastatin(184-210)(human), Negative Control is a control scrambled peptide corresponding to Acetyl-Calpastatin(184-210)(human). Acetyl-Calpastatin(184-210)(human) functions as a potent, selective, and reversible calpain inhibitor.Fórmula:C142H230N36O44SCor e Forma:SolidPeso molecular:3175.65874DPP8/9-IN-1
DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.Cor e Forma:Odour SolidVAMP
VAMP is a tetrapeptide that acts as a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor, exhibiting an IC50 of 1.00 μM and a Kd of 6.89 μM. It effectively targets the DPP-IV-GLP-1 axis and is utilized in the research of type 2 diabetes.Fórmula:C18H32N4O5SCor e Forma:SolidPeso molecular:416.535Phepropeptin A
CAS:Phepropeptin A is a secondary metabolite produced by microorganisms and acts as a proteasome (proteasome) inhibitor, with an IC50 of 21 μg/mL.Fórmula:C37H58N6O6Cor e Forma:SolidPeso molecular:682.89Z-Gly-Pro-Phe-Leu-CHO
CAS:Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde serving as a selective and potent proteasome inhibitor, demonstrating inhibition constants (Ki) ofFórmula:C30H38N4O6Pureza:98%Cor e Forma:SolidPeso molecular:550.65Iso-VQA-ACC acetate
Iso-VQA-ACC acetate serves as a substrate for the constitutive proteasome.Cor e Forma:Odour SolidAcetyl-Calpastatin(184-210)(human) TFA
Acetyl-Calpastatin(184-210)(human) TFA inhibits μ-calpain (Ki 0.2 nM) and cathepsin L (Ki 6 μM) selectively and reversibly.Fórmula:C144H231F3N36O46SCor e Forma:SolidPeso molecular:3291.65Alogliptin-13CD3
CAS:Alogliptin (SYR-322) 13CD3 is the deuterium-labeled Alogliptin. Alogliptin is a selective inhibitor of DPP-4.Fórmula:C18H21N5O2Pureza:98%Cor e Forma:SolidPeso molecular:343.4Teneligliptin-D8
CAS:Teneligliptin D8 a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting inhibitor of DPP-4.Fórmula:C22H30N6OSPureza:98%Cor e Forma:SolidPeso molecular:434.635-Amino-8-hydroxyquinoline
CAS:5-Amino-8-hydroxyquinoline(5A8HQ),Proteasome inhibitor. Potential anticancer agent.Fórmula:C9H8N2OPureza:99.69%Cor e Forma:SolidPeso molecular:160.17
