Protease serina
Os inibidores de serina protease são compostos que inibem as serina proteases, um grupo de enzimas caracterizado por um resíduo de serina no seu sítio ativo. Essas proteases estão envolvidas em vários processos fisiológicos, incluindo digestão, resposta imunológica, coagulação sanguínea e inflamação. Os inibidores de serina protease são importantes para o estudo de doenças onde essas enzimas estão desreguladas, como doenças cardiovasculares, câncer e condições inflamatórias. Na CymitQuimica, oferecemos inibidores de serina protease para apoiar sua pesquisa em enzimologia, mecanismos de doenças e intervenções terapêuticas.
Foram encontrados 50 produtos de "Protease serina"
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TAO Kinase inhibitor 2
CAS:<p>TAO Kinase inhibitor 2 is a TAO kinase inhibitor with an IC50 of 50-500 nM. TAO Kinase inhibitor 2 inhibits KIAA1361 and JIK with IC50s of 50-500 nM.</p>Fórmula:C25H24N2O3Pureza:98.58%Cor e Forma:SoildPeso molecular:400.47BAY-85-8501
CAS:<p>BAY-85-8501 is a selective, reversible and potent inhibitor of Human Neutrophil Elastase (HNE; IC50 of 65 pM)</p>Fórmula:C22H17F3N4O3SPureza:99.16%Cor e Forma:SolidPeso molecular:474.46PMSF
CAS:<p>PMSF (Phenylmethylsulfonyl fluoride) is an irreversible inhibitor of serine/cysteine protease , preparation of cell lysates. High-Quality, Low-Cost!</p>Fórmula:C7H7FO2SPureza:97.75% - 99.88%Cor e Forma:White To Cream SolidPeso molecular:174.19Tilpisertib fosmecarbil TFA
CAS:<p>Tilpisertib fosmecarbil TFA, the TFA salt form of Tilpisertib, acts as an inhibitor of serine/threonine kinases. This compound also exhibits anti-inflammatory activity.</p>Fórmula:C37H37ClF3N8O9PCor e Forma:SolidPeso molecular:861.16Ala-Phe-Pro-pNA TFA
<p>Ala-Phe-Pro-pNA TFA serves as a chromogenic substrate for tripeptidyl peptidase and can be utilized to assess the enzyme's activity.</p>Cor e Forma:Odour SolidBCX 1470 hydrochloride
<p>BCX 1470 hydrochloride is a serine protease inhibitor with anti-inflammatory activity that inhibits factor D hemolytic activity and may be used to study edema.</p>Fórmula:C14H11ClN2O2S2Pureza:99.71%Cor e Forma:SoildPeso molecular:338.83Protease Inhibitor Library
<p>A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;</p>Cor e Forma:Odour SolidKKI-5
CAS:<p>KKI 5: Serine protease inhibitor, blocks kallikrein & plasmin, potential for cancer therapy & angioedema treatment.</p>Fórmula:C35H55N11O9Pureza:98%Cor e Forma:SolidPeso molecular:773.88AE-3763
CAS:<p>AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 nM).</p>Fórmula:C23H34F3N5O7Pureza:98%Cor e Forma:SolidPeso molecular:549.54Patamostat HCl
CAS:<p>Patamostat HCl is a highly potent and selective small molecule protease (protease) inhibitor that inhibits trypsin, fibrinolytic enzymes, and thrombin with IC50</p>Fórmula:C20H21ClN4O4SPureza:99.15% - 99.76%Cor e Forma:SoildPeso molecular:448.92MeOSuc-AAPA-CMK
<p>MeOSuc-AAPA-CMK is a potent inhibitor of human neutrophil elastase (HNE) [1].</p>Fórmula:C20H31ClN4O8Cor e Forma:SolidPeso molecular:490.94α 1 Antichymotrypsin, Human Plasma
CAS:<p>Alpha 1 Antichymotrypsin, Human Plasma is an inhibitor of serine proteases. This compound is present in amyloid lesions associated with Alzheimer's disease and can be utilized in Alzheimer's research.</p>Cor e Forma:SolidRoseltide rT1
CAS:<p>Roseltide rT1 is a neutrophil elastase inhibitor (IC50=0.47 μM) and is rich in cysteine, classified as one of the Roseltides (rT1-rT8). It has the potential to inhibit related diseases by improving neutrophil elastase-stimulated cAMP accumulation in vitro.</p>Fórmula:C110H177N31O31S6Cor e Forma:SolidPeso molecular:2622.16Lonodelestat TFA
<p>Lonodelestat TFA, an oral peptide, selectively inhibits hNE, potentially aiding in CF research.</p>Fórmula:C73H112F3N15O21Cor e Forma:SolidPeso molecular:1592.75Tiprelestat
CAS:<p>Tiprelestat: strong inhibitor of human neutrophil elastase, anti-inflammatory, antimicrobial, used in inflammation/immune research.</p>Fórmula:C254H416N72O75S10Cor e Forma:SolidPeso molecular:5999.09α-Methyl-DL-aspartic acid
CAS:<p>α-Methyl-DL-aspartic acid specifically inhibits argininosuccinate synthase (ASS), the rate-limiting enzyme in 1-citrulline-to-1-arginine recycling.</p>Fórmula:C5H9NO4Pureza:99.91%Cor e Forma:SolidPeso molecular:147.13Recombinant Trypsin
<p>Recombinant Trypsin is a serine protease that hydrolyzes proteins at the carboxyl side of lysine or arginine.</p>Dansyl-Glu-Gly-Arg-Chloromethylketone
CAS:<p>Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor that specifically impedes serine/threonine proteases and has been shown to inhibit activated</p>Fórmula:C26H36ClN7O7SCor e Forma:SolidPeso molecular:626.12Suc-AAP-Abu-pNA
CAS:<p>Suc-AAP-Abu-pNA is a specific substrate for pancreatic elastase (Km = 100 μM; Kcat/Km = 35,300 s-1 M-1 for rat pancreatic elastase; Km = 30 μM; Kcat/Km = 351,</p>Fórmula:C25H34N6O9Cor e Forma:SolidPeso molecular:562.57SFTI-1
CAS:<p>SFTI-1, a cyclic peptide trypsin inhibitor comprising 14 amino acid residues, is a potent Bowman-Birk inhibitor.</p>Fórmula:C67H104N18O18S2Cor e Forma:SolidPeso molecular:1513.78Chymotrypsinogen
CAS:<p>Chymotrypsinogen is an inactive precursor of Chymotrypsin . Chymotrypsin is a serine protease produced by the pancreas [1] [2] .</p>Cor e Forma:SolidPKR-IN-C51
CAS:<p>PKR-IN-C51 is ATP-competitive protein kinase R (PKR) inhibitor that inhibits intracellular PKR activation and autophosphorylation. Ser/Thr kinase.</p>Fórmula:C23H21N5Pureza:98.94%Cor e Forma:SolidPeso molecular:367.45Urokinase
CAS:<p>Urokinase (uPA) is a serine protease that activates plasminogen to plasmin, crucial for thrombolysis and ECM degradation.</p>Cor e Forma:SolidGSK-690693
CAS:<p>GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.</p>Fórmula:C21H27N7O3Pureza:98.07% - 99.77%Cor e Forma:SolidPeso molecular:425.482-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one
CAS:<p>2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one is an human neutrophil elastase inhibitor.</p>Fórmula:C14H7BrClNO2Pureza:97.36%Cor e Forma:SolidPeso molecular:336.57Cetraxate hydrochloride
CAS:<p>Cetraxate hydrochloride (DV10062) is an oral gastrointestinal medication. It has a cytoprotective effect.</p>Fórmula:C17H24ClNO4Pureza:99.75%Cor e Forma:SolidPeso molecular:341.83WNK463
CAS:<p>WNK463 is a pan-WNK-kinase inhibitor. It effectively inhibits the in vitro kinase activity of all four WNK family members (WNK1/2/3/4).</p>Fórmula:C21H24F3N7O2Pureza:>99.99% - ≥95%Cor e Forma:SolidPeso molecular:463.46WNK-IN-11
CAS:<p>WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)</p>Fórmula:C21H21Cl2N5OSPureza:98.32%Cor e Forma:SolidPeso molecular:462.4Alvelestat
CAS:<p>Alvelestat (AZD9668) is an orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity.</p>Fórmula:C25H22F3N5O4SPureza:98% - >99.99%Cor e Forma:SolidPeso molecular:545.53ML281
CAS:<p>ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM.</p>Fórmula:C22H19N3O2SPureza:99.12% - 99.87%Cor e Forma:SolidPeso molecular:389.472,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)-
CAS:<p>2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)- (Ulinastatin) ,as an urinary trypsin inhibitor (UTI), is a glycoprotein that is isolated from healthy human urine</p>Fórmula:C13H16O3Pureza:99.53% - 99.81%Cor e Forma:SolidPeso molecular:220.26Ceritinib
CAS:<p>Ceritinib (LDK378) is an ALK inhibitor with selective, ATP-competitive, and oral activity. Ceritinib has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C28H36ClN5O3SPureza:98.52% - 99.77%Cor e Forma:SolidPeso molecular:558.14Lanadelumab
CAS:<p>Lanadelumab (SHP643), a humanized IgG1 antibody, inhibits plasma kallikrein and its interaction with HMWK, supporting hereditary angioedema research.</p>Pureza:95% - 95%Cor e Forma:LiquidGalegenimab
CAS:<p>Galegenimab (FHTR 2163; RG 6147; RO 7171009) is an HTRA1 antibody fragment for AMD research.</p>Pureza:95% - 95%Cor e Forma:LiquidMEGA-9
CAS:<p>MEGA-9 (Nonanoyl-N-Methylglucamide) solubilizes membrane protein and can be used as a nonionic detergent.</p>Fórmula:C16H33NO6Pureza:99.9%Cor e Forma:SolidPeso molecular:335.44BMS-363131
CAS:<p>BMS-363131 (BMS363131) is a potent and selective trypsin inhibitor with an IC50 value of <1.7 nM.</p>Fórmula:C28H40N6O5Pureza:97.99%Cor e Forma:SolidPeso molecular:540.65p-Aminobenzamidine dihydrochloride
CAS:<p>4-Aminobenzamidine dihydrochloride (p-Aminobenzamidine dihydrochloride) is a strong trypsin inhibitor and a relatively weak inhibitor of urokinase type</p>Fórmula:C7H11Cl2N3Pureza:99.00% - 99.56%Cor e Forma:SolidPeso molecular:208.088ZD8321
CAS:<p>ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).</p>Fórmula:C18H28F3N3O5Pureza:98%Cor e Forma:SolidPeso molecular:423.43ZD-0892
CAS:<p>ZD-0892: potent, selective neutrophil elastase inhibitor; Ki 6.7 nM (human), 200 nM (porcine).</p>Fórmula:C24H32F3N3O5Pureza:95% - 99.53%Cor e Forma:SolidPeso molecular:499.52APC 366
CAS:<p>APC 366: Mast cell tryptase inhibitor, Ki 7.1 μM. Reduces EAR, LAR, BHR in allergic asthma (sheep model).</p>Fórmula:C22H28N6O4Pureza:99.8%Cor e Forma:SolidPeso molecular:440.5ZM223 hydrochloride (2031177-48-5 free base)
<p>ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.</p>Fórmula:C23H18ClF3N4O2S2Pureza:98%Cor e Forma:SolidPeso molecular:538.99AGLME
CAS:<p>AGLME is used in a direct enzymatic assay for activated Hageman factor measuring the ability of Hageman factor to hydrolyze the cpd.</p>Fórmula:C11H21N3O4Cor e Forma:SolidPeso molecular:259.3WNK1-IN-1
CAS:<p>WNK1-IN-1, a WNK1 inhibitor (IC50: 1.6 μM), also inhibits OSR1 phosphorylation (IC50: 4.3 μM), used in blood pressure and cancer research.</p>Fórmula:C13H15BrCl2N2O4SPureza:98.09%Cor e Forma:SolidPeso molecular:446.14IPR-803
CAS:<p>IPR-803 is an effective inhibitor of the uPAR·uPA protein-protein interaction (PPI) with anti-tumor activity.</p>Fórmula:C27H23N3O4Pureza:95%Cor e Forma:SolidPeso molecular:453.49FK706
CAS:<p>FK706, a human neutrophil elastase inhibitor (IC50: 83 nM, Ki: 4.2 nM), also blocks mouse and porcine elastases. Anti-inflammatory.</p>Fórmula:C26H33F3N4NaO7Cor e Forma:SolidPeso molecular:593.556LM-030
CAS:<p>LM-030, also known as BPR277, is a novel inhibitor of kallikrein-related peptidase 7 (KLK7) and epidermal elastase 2 (ELA2).</p>Fórmula:C46H72N8O12Cor e Forma:SolidPeso molecular:929.11Feniralstat
CAS:<p>Feniralstat (KVD-824) is a selective and potent kallikrein (kallikrein) inhibitor, useful in immune system diseases and cardiovascular disease research.</p>Fórmula:C26H25F2N5O4Pureza:99.52%Cor e Forma:SolidPeso molecular:509.51Matriptase-IN-2 free base
CAS:<p>Matriptase-IN-2 free base, a matriptase inhibitor with a K i of 5 nM, has potential applications in musculoskeletal system disorder research (WO2011023958A1; compound 432) [1].</p>Fórmula:C29H33Cl2N5O3SCor e Forma:SolidPeso molecular:602.58TMPRSS6-IN-1 TFA
<p>TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), a member of the TTSP family (a type of transmembrane serine protease). TMPRSS6 is a type II TTSP, and genetically reduced levels of TMPRSS6 have been shown to improve symptoms of hemochromatosis and β-thalassemia in mice.</p>Fórmula:C35H41F3N8O6S2Cor e Forma:SolidPeso molecular:790.875MeO-Suc-Ala-Ala-Pro-Ala-CMK
CAS:<p>MeO-Suc-Ala-Ala-Pro-Ala-CMK (MSACK) is an inhibitor of human neutrophil elastase (HNE) with an IC50 of 20.3 μM. It effectively inhibits the hydrolysis of substrates like lung tissue elastin by HNE and is applicable in studies related to conditions such as chronic obstructive pulmonary disease (COPD).</p>Fórmula:C20H31ClN4O7Cor e Forma:SolidPeso molecular:474.936
