Protease serina
Os inibidores de serina protease são compostos que inibem as serina proteases, um grupo de enzimas caracterizado por um resíduo de serina no seu sítio ativo. Essas proteases estão envolvidas em vários processos fisiológicos, incluindo digestão, resposta imunológica, coagulação sanguínea e inflamação. Os inibidores de serina protease são importantes para o estudo de doenças onde essas enzimas estão desreguladas, como doenças cardiovasculares, câncer e condições inflamatórias. Na CymitQuimica, oferecemos inibidores de serina protease para apoiar sua pesquisa em enzimologia, mecanismos de doenças e intervenções terapêuticas.
Foram encontrados 56 produtos para "Protease serina".
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BAY-85-8501
CAS:BAY-85-8501 is a selective, reversible and potent inhibitor of Human Neutrophil Elastase (HNE; IC50 of 65 pM)Fórmula:C22H17F3N4O3SPureza:99.16%Cor e Forma:SolidPeso molecular:474.46Ref: TM-T12613L
1mg92,00€2mg122,00€5mg200,00€1mL*10mM (DMSO)208,00€10mg298,00€25mg535,00€50mg750,00€100mg1.035,00€TAO Kinase inhibitor 2
CAS:TAO Kinase inhibitor 2 is a TAO kinase inhibitor with an IC50 of 50-500 nM. TAO Kinase inhibitor 2 inhibits KIAA1361 and JIK with IC50s of 50-500 nM.Fórmula:C25H24N2O3Pureza:98.58%Cor e Forma:SolidPeso molecular:400.47Kallikrein 5-IN-2 TFA
Kallikrein5-IN-2 TFA is the trifluoroacetate salt form of Kallikrein5-IN-2. It acts as a selective inhibitor of kallikrein5 (KLK5), with a pIC50 value of 7.1. Kallikrein5-IN-2 TFA exhibits no phototoxicity at 100 μg/mL and is non-irritating. The compound remains stable in non-oxidative conditions within a pH range of 4 to 8. Kallikrein5-IN-2 shows potential for improving Netherton syndrome.Fórmula:C25H23F3N6O3Cor e Forma:SolidPeso molecular:512.17837hCAXII-IN-10
hCAXII-IN-10 (Compound 18b) acts as a dual inhibitor of human carbonic anhydrase isoenzyme XII (hCAXII) and cathepsin B, with a Ki value of 2.2 nM. It inhibits the function of hCAXII in creating a pH microenvironment conducive to tumor growth, showing promise for use in cancer research.Cor e Forma:Odour SolidZ-APF-CMK
CAS:Z-APF-CMK is a selective inhibitor of the calcium (Ca2+)-regulated nuclear scaffold protease (CRNSP), as reported in reference [1].Fórmula:C26H30ClN3O5Cor e Forma:SolidPeso molecular:499.99AE-3763
CAS:AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 nM).Fórmula:C23H34F3N5O7Pureza:98%Cor e Forma:SolidPeso molecular:549.54Protease Inhibitor Library
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;Cor e Forma:Odour SolidRef: TM-L1100
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarα-Methyl-DL-aspartic acid
CAS:α-Methyl-DL-aspartic acid specifically inhibits argininosuccinate synthase (ASS), the rate-limiting enzyme in 1-citrulline-to-1-arginine recycling.Fórmula:C5H9NO4Pureza:99.91%Cor e Forma:SolidPeso molecular:147.13CDD-3290
CDD-3290 serves as a functional therapeutic tool specifically designed to enable the precise detection and inhibition of the proteolytic activity of PSA which plays a pivotal role in the progression of prostate cancer during strictly monitored laboratory observation periods and molecular investigations to evaluate the pharmacological potential of targeted kallikrein inhibition in specialized preclinical research environments.Fórmula:C17H14N6O2Pureza:99.13%Cor e Forma:White SolidPeso molecular:334.33Lonodelestat TFA
Lonodelestat TFA, an oral peptide, selectively inhibits hNE, potentially aiding in CF research.Fórmula:C73H112F3N15O21Cor e Forma:SolidPeso molecular:1592.75Tiprelestat
CAS:Tiprelestat: strong inhibitor of human neutrophil elastase, anti-inflammatory, antimicrobial, used in inflammation/immune research.Fórmula:C254H416N72O75S10Cor e Forma:SolidPeso molecular:5999.09MeOSuc-AAPA-CMK
MeOSuc-AAPA-CMK is a potent inhibitor of human neutrophil elastase (HNE) [1].Fórmula:C20H31ClN4O8Cor e Forma:SolidPeso molecular:490.94α 1 Antichymotrypsin, Human Plasma
CAS:Alpha 1 Antichymotrypsin, Human Plasma is an inhibitor of serine proteases. This compound is present in amyloid lesions associated with Alzheimer's disease and can be utilized in Alzheimer's research.Cor e Forma:SolidRoseltide rT1
CAS:Roseltide rT1 is a neutrophil elastase inhibitor (IC50=0.47 μM) and is rich in cysteine, classified as one of the Roseltides (rT1-rT8). It has the potential to inhibit related diseases by improving neutrophil elastase-stimulated cAMP accumulation in vitro.Fórmula:C110H177N31O31S6Cor e Forma:SolidPeso molecular:2622.16Tilpisertib fosmecarbil TFA
CAS:Tilpisertib fosmecarbil TFA, the TFA salt form of Tilpisertib, acts as an inhibitor of serine/threonine kinases. This compound also exhibits anti-inflammatory activity.Fórmula:C37H37ClF3N8O9PCor e Forma:SolidPeso molecular:861.16Phosphorylase Kinase β-Subunit Fragment (420-436)
CAS:Phosphorylase Kinase β-Subunit Fragment (420-436) is a peptide fragment (430-436) derived from the β-Subunit of phosphorylase kinase.Fórmula:C79H131N31O25SPureza:98%Cor e Forma:SolidPeso molecular:1947.14Activated Protein C (390-404), human
CAS:Human Activated Protein C (390-404) peptide derived from serine protease, suppresses APC anticoagulation.Fórmula:C91H130N22O23Pureza:98%Cor e Forma:SolidPeso molecular:1900.14SFTI-1
CAS:SFTI-1, a cyclic peptide trypsin inhibitor comprising 14 amino acid residues, is a potent Bowman-Birk inhibitor.Fórmula:C67H104N18O18S2Cor e Forma:SolidPeso molecular:1513.78Dansyl-Glu-Gly-Arg-Chloromethylketone
CAS:Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor that specifically impedes serine/threonine proteases and has been shown to inhibit activatedFórmula:C26H36ClN7O7SCor e Forma:SolidPeso molecular:626.12KKI-5
CAS:KKI 5: Serine protease inhibitor, blocks kallikrein & plasmin, potential for cancer therapy & angioedema treatment.Fórmula:C35H55N11O9Pureza:98%Cor e Forma:SolidPeso molecular:773.88Nonacog alfa
CAS:Nonacog alfa (BAX326), a recombinant human factor IX, is utilized in the study of hemophilia B [1].Cor e Forma:LiquidMeOSuc-AAPF-CMK
CAS:MeOSuc-AAPF-CMK (MeOSuc-Ala-Ala-Pro-Phe-CH2Cl) is a potent inhibitor of the enzyme proteinase K [1].Fórmula:C26H35ClN4O7Cor e Forma:SolidPeso molecular:551.03Suc-AAP-Abu-pNA
CAS:Suc-AAP-Abu-pNA is a specific substrate for pancreatic elastase (Km = 100 μM; Kcat/Km = 35,300 s-1 M-1 for rat pancreatic elastase; Km = 30 μM; Kcat/Km = 351,Fórmula:C25H34N6O9Cor e Forma:SolidPeso molecular:562.57C1 Esterase Inhibitor (Human)
C1 Esterase Inhibitor (Human) is a glycoprotein derived from human plasma and acts as a serine protease inhibitor. It inactivates enzymes like C1r, C1s, and mannose-binding lectin-associated serine proteases (MASP) through covalent binding. This compound possesses anti-inflammatory properties and is utilized to prevent angioedema attacks associated with hereditary angioedema.Cor e Forma:Odour LiquidChymotrypsinogen
CAS:Chymotrypsinogen is an inactive precursor of Chymotrypsin . Chymotrypsin is a serine protease produced by the pancreas [1] [2] .Cor e Forma:SolidPKR-IN-C51
CAS:PKR-IN-C51 is ATP-competitive protein kinase R (PKR) inhibitor that inhibits intracellular PKR activation and autophosphorylation. Ser/Thr kinase.Fórmula:C23H21N5Pureza:98.94%Cor e Forma:Yellow SolidPeso molecular:367.45Ref: TM-T24647
2mg82,00€5mg120,00€1mL*10mM (DMSO)133,00€10mg192,00€25mg356,00€50mg530,00€100mg755,00€2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)-
CAS:2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)- (Ulinastatin) ,as an urinary trypsin inhibitor (UTI), is a glycoprotein that is isolated from healthy human urineFórmula:C13H16O3Pureza:99.53% - 99.81%Cor e Forma:SolidPeso molecular:220.26Ref: TM-T8802
1mg82,00€1mL*10mM (DMSO)146,00€5mg168,00€10mg244,00€25mg404,00€50mg567,00€100mg767,00€500mg1.521,00€WNK463
CAS:WNK463 is a pan-WNK-kinase inhibitor. It effectively inhibits the in vitro kinase activity of all four WNK family members (WNK1/2/3/4).Fórmula:C21H24F3N7O2Pureza:>99.99% - ≥95%Cor e Forma:SolidPeso molecular:463.46Benzamidine hydrochloride
CAS:Benzamidine hydrochloride (Benzamidine HCl) is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin.Fórmula:C7H9ClN2Pureza:99.64% - 99.97%Cor e Forma:SolidPeso molecular:156.612-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one
CAS:2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one is an human neutrophil elastase inhibitor.Fórmula:C14H7BrClNO2Pureza:97.36%Cor e Forma:SolidPeso molecular:336.57ML281
CAS:ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM.Fórmula:C22H19N3O2SPureza:99.12% - 99.87%Cor e Forma:SolidPeso molecular:389.47Ref: TM-T3423
1mg34,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg92,00€25mg178,00€50mg295,00€100mg474,00€500mg1.035,00€WNK-IN-11
CAS:WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)Fórmula:C21H21Cl2N5OSPureza:98.32%Cor e Forma:SolidPeso molecular:462.4Ref: TM-T5456
1mg87,00€5mg172,00€1mL*10mM (DMSO)188,00€10mg280,00€25mg474,00€50mg683,00€100mg964,00€500mg1.918,00€KKI-5 acetate(97145-43-2 free base)
KKI-5 acetate: Serine protease inhibitor, targets kallikrein/plasmin, potential anticancer and angioedema therapy.Fórmula:C37H59N11O11Pureza:99.74%Cor e Forma:White SolidPeso molecular:833.95Cetraxate hydrochloride
CAS:Cetraxate hydrochloride (DV10062) is an oral gastrointestinal medication. It has a cytoprotective effect.Fórmula:C17H24ClNO4Pureza:99.75%Cor e Forma:SolidPeso molecular:341.83Alvelestat
CAS:Alvelestat (AZD9668) is an orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity.Fórmula:C25H22F3N5O4SPureza:98% - >99.99%Cor e Forma:White SolidPeso molecular:545.53Ref: TM-T3107
1mg34,00€2mg43,00€5mg56,00€1mL*10mM (DMSO)74,00€10mg84,00€25mg148,00€50mg219,00€100mg349,00€500mg830,00€Lanadelumab
CAS:Lanadelumab (SHP643), a humanized IgG1 antibody, inhibits plasma kallikrein and its interaction with HMWK, supporting hereditary angioedema research.Pureza:95% - 97.4% (SDS-PAGE); 99.2% (SEC-HPLC)Cor e Forma:Transparent LiquidPeso molecular:145.70 kDaAnti-Matriptase Antibody
Anti-Matriptase Antibody is a human antibody expressed in CHO cells.Pureza:95.8% (SDS-PAGE); 99.2% (SEC-HPLC) - 95.8% (SDS-PAGE); 99.2% (SEC-HPLC)Cor e Forma:Transparent LiquidPeso molecular:144.27 kDaGalegenimab
CAS:Galegenimab (RG 6147) is an Fab targeting HtrA1, capable of blocking proteolytic cleavage of biglycan (an HtrA1 substrate), suitable for AMD research.Pureza:95% - 95.8% (SDS-PAGE); 99.7% (SEC-HPLC)Cor e Forma:Transparent LiquidPeso molecular:46.87 kDaMEGA-9
CAS:MEGA-9 (Nonanoyl-N-Methylglucamide) solubilizes membrane protein and can be used as a nonionic detergent.Fórmula:C16H33NO6Pureza:99.9%Cor e Forma:White SolidPeso molecular:335.44ZM223 hydrochloride (2031177-48-5 free base)
ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.Fórmula:C23H18ClF3N4O2S2Pureza:98%Cor e Forma:SolidPeso molecular:538.99AGLME
CAS:AGLME is used in a direct enzymatic assay for activated Hageman factor measuring the ability of Hageman factor to hydrolyze the cpd.Fórmula:C11H21N3O4Cor e Forma:SolidPeso molecular:259.3BMS-363131
CAS:BMS-363131 (BMS363131) is a potent and selective trypsin inhibitor with an IC50 value of <1.7 nM.Fórmula:C28H40N6O5Pureza:97.99%Cor e Forma:SolidPeso molecular:540.65Lodelaben
CAS:Lodelaben (Declaben, SC-39026) is a reversible, non-competitive,specific inhibitor of human neutrophil elastase (HNE) with high potency (IC50=0.5 μM).Fórmula:C25H41ClO3Pureza:99.62% - >99.99%Cor e Forma:White SolidPeso molecular:425.04WNK1-IN-1
CAS:WNK1-IN-1, a WNK1 inhibitor (IC50: 1.6 μM), also inhibits OSR1 phosphorylation (IC50: 4.3 μM), used in blood pressure and cancer research.Fórmula:C13H15BrCl2N2O4SPureza:98.09%Cor e Forma:SolidPeso molecular:446.14Ref: TM-T73295
1mg71,00€5mg152,00€1mL*10mM (DMSO)167,00€10mg236,00€25mg485,00€50mg782,00€100mg1.305,00€WNK-IN-11-D3
CAS:WNK-IN-12 is an effective, selective, and orally active WNK1 kinase inhibitor.Fórmula:C21H18Cl2D3N5OSCor e Forma:SolidPeso molecular:465.42APC 366
CAS:APC 366: Mast cell tryptase inhibitor, Ki 7.1 μM. Reduces EAR, LAR, BHR in allergic asthma (sheep model).Fórmula:C22H28N6O4Pureza:99.8%Cor e Forma:Yellow SolidPeso molecular:440.5IPR-803
CAS:IPR-803 is an effective inhibitor of the uPAR·uPA protein-protein interaction (PPI) with anti-tumor activity.Fórmula:C27H23N3O4Pureza:95%Cor e Forma:Red SolidPeso molecular:453.49ZD8321
CAS:ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).Fórmula:C18H28F3N3O5Pureza:98%Cor e Forma:SolidPeso molecular:423.43ZD-0892
CAS:ZD-0892: potent, selective neutrophil elastase inhibitor; Ki 6.7 nM (human), 200 nM (porcine).Fórmula:C24H32F3N3O5Pureza:95% - 99.53%Cor e Forma:SolidPeso molecular:499.52AZD-9819
CAS:AZD-9819 is a neutrophil elastase (HNE) inhibitor applicable for research into chronic obstructive pulmonary disease (COPD).Fórmula:C25H19F3N6O2Pureza:100% - 99.18%Cor e Forma:Yellow SolidPeso molecular:492.45
